Dual-tracer scintigraphy and subtraction studies in the diagnosis of hepatocellular carcinoma.

Abstract:

:Dual tracer scintigraphy (DTS) (technetium 99m [99mTc] sulfur colloid and gallium 67 citrate [67 gallium citrate]) of the liver and computer subtraction studies (SS) were performed in 26 patients subsequently proven to have hepatocellular carcinoma (HCC) and 32 patients with cirrhosis and focal defects on the colloid scan, with no evidence for HCC after a complete evaluation and a 2-year follow-up period. Both DTS and SS had a sensitivity of 96% and a specificity of 90.6% for HCC. There were three false positive cases (9.4%), two of which were occult abscesses. The predictive value of a positive test was 89% and that of a negative test was 97%. The smallest tumor detected measured 2 cm in diameter and was only visualized with the SS. In the clinical setting, when HCC is suspected (a situation in which tumors are usually larger than 2 cm and the pretest probability of disease is between 20% and 60%) the DTS and SS is an excellent test for the diagnosis or exclusion of HCC. It does not appear to have a role in screening programs.

journal_name

Cancer

journal_title

Cancer

authors

Sostre S,Villagra D,Morales NE,Rivera JV

doi

10.1002/1097-0142(19880215)61:4<667::aid-cncr28206

subject

Has Abstract

pub_date

1988-02-15 00:00:00

pages

667-72

issue

4

eissn

0008-543X

issn

1097-0142

journal_volume

61

pub_type

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