Abstract:
:Giant sections from cystectomy specimens in 45 cases of bladder cancer were examined microscopically after en bloc fixation and processing. There were 35 transitional cell, seven squamous cell, and three mixed transitional cell and squamous carcinomas. Broad front invasion was associated with papillary and superficial tumors while tentacular invasion was associated with solid tumors and a generally poorer prognosis. Carcinoma in situ merged with the invasive cancer in 33 cases, and neoplasia in these cases tended to be multifocal. In 10 cases there was no carcinoma in situ next to the invasive lesion, and the cancer was unifocal. These findings support the concept that there may be two pathogenetic types of bladder cancer, one arising in an extensive field of abnormal epithelium and one arising in a focal area of abnormality. The findings also underscore the importance in clinical management of selected mucosal biopsies adjacent to the site of any visible bladder tumors.
journal_name
Cancerjournal_title
Cancerauthors
Soto EA,Friedell GH,Tiltman AJdoi
10.1002/1097-0142(197702)39:2<447::aid-cncr2820390subject
Has Abstractpub_date
1977-02-01 00:00:00pages
447-55issue
2eissn
0008-543Xissn
1097-0142journal_volume
39pub_type
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