Bladder cancer as seen in giant histologic sections.

Abstract:

:Giant sections from cystectomy specimens in 45 cases of bladder cancer were examined microscopically after en bloc fixation and processing. There were 35 transitional cell, seven squamous cell, and three mixed transitional cell and squamous carcinomas. Broad front invasion was associated with papillary and superficial tumors while tentacular invasion was associated with solid tumors and a generally poorer prognosis. Carcinoma in situ merged with the invasive cancer in 33 cases, and neoplasia in these cases tended to be multifocal. In 10 cases there was no carcinoma in situ next to the invasive lesion, and the cancer was unifocal. These findings support the concept that there may be two pathogenetic types of bladder cancer, one arising in an extensive field of abnormal epithelium and one arising in a focal area of abnormality. The findings also underscore the importance in clinical management of selected mucosal biopsies adjacent to the site of any visible bladder tumors.

journal_name

Cancer

journal_title

Cancer

authors

Soto EA,Friedell GH,Tiltman AJ

doi

10.1002/1097-0142(197702)39:2<447::aid-cncr2820390

subject

Has Abstract

pub_date

1977-02-01 00:00:00

pages

447-55

issue

2

eissn

0008-543X

issn

1097-0142

journal_volume

39

pub_type

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