Imaging at diagnosis impacts cancer-specific survival among patients with cancer of the oropharynx.

Abstract:

BACKGROUND:The optimal imaging for the staging of oropharyngeal cancer is not well defined. METHODS:The linked Surveillance, Epidemiology, and End Results (SEER)-Medicare database for 2006 through 2011 was used to compare patient characteristics and hospital region by the initial imaging modality used for patients with oropharyngeal cancer. The primary outcome was 3-year cancer-specific survival (CSS). Cox proportional hazards models were adjusted for imaging, age, sex, region, education, race, American Joint Committee on Cancer stage of disease, and treatment, which were examined using backward elimination. The authors also explored how initial imaging use varied by patient characteristics and hospital region. RESULTS:A total of 1765 patients underwent initial diagnostic imaging. Of those, approximately 11.4% (202 patients) received computed tomography (CT) alone as their initial imaging modality, 5.2% (91 patients) underwent magnetic resonance imaging (MRI) without positron emission tomography (PET), and 83.3% (1472 patients) had initial imaging that included PET. The overall 3-year CSS rate for the entire population was 63.7%. In the adjusted survival models compared by initial imaging modality, patients who underwent a PET examination were found to have higher survival than those who underwent CT alone or MRI, respectively (hazard ratio, 1.337 [95% CI, 1.001-1.785; P = .0491]; and hazard ratio, 1.748 [95% CI, 1.2-2.545; P = .0036]). CONCLUSIONS:Among patients with oropharyngeal cancer, initial staging with PET imaging was associated with improved 3-year CSS compared with initial staging with MRI or CT.

journal_name

Cancer

journal_title

Cancer

authors

Morgan RL,Eguchi MM,Mueller AC,Daugherty SL,Amini A,Karam SD

doi

10.1002/cncr.32148

subject

Has Abstract

pub_date

2019-08-15 00:00:00

pages

2794-2802

issue

16

eissn

0008-543X

issn

1097-0142

journal_volume

125

pub_type

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