A multicenter phase II study of the intravenous administration of liposomal tretinoin in patients with acquired immunodeficiency syndrome-associated Kaposi's sarcoma.

Abstract:

BACKGROUND:A multicenter trial was conducted to determine the efficacy and toxicity of escalating dosages of liposomal tretinoin (all-trans-retinoic acid) administered once or three times weekly in patients with acquired immunodeficiency syndrome (AIDS)-associated Kaposi sarcoma. METHODS:Seventy-six patients with acquired immunodeficiency syndrome (AIDS)-associated Kaposi sarcoma were randomized to receive the study drug either once (n = 30) or 3 times weekly (n = 46). The starting dosage was 60 mg/m(2), which was escalated to 90 mg/m(2) and then 120 mg/m(2) if the drug was well tolerated (

journal_name

Cancer

journal_title

Cancer

authors

Bernstein ZP,Chanan-Khan A,Miller KC,Northfelt DW,Lopez-Berestein G,Gill PS

doi

10.1002/cncr.11009

subject

Has Abstract

pub_date

2002-12-15 00:00:00

pages

2555-61

issue

12

eissn

0008-543X

issn

1097-0142

journal_volume

95

pub_type

临床试验,杂志文章,多中心研究,随机对照试验

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