Early detection of malignancy in ulcerative colitis. A flow-cytometric DNA study.

abstract：BACKGROUND:Because of the structural and biochemical similarities between the antitumor p53 and p73 proteins, the authors hypothesized that individuals who carry high-risk genotypes of p53 codon 72 and p73 G4C14-to-A4T14 polymorphisms have a higher risk of developing second primary malignancy (SPM) after index squamous...

journal_title：Cancer

authors： Zhang Y,Sturgis EM,Huang Z,Zafereo ME,Wei Q,Li G

更新日期：2012-01-15 00:00:00

abstract：BACKGROUND:Surveillance, Epidemiology, and End Results (SEER) data are frequently used to examine receipt of adjuvant radiotherapy (RT), but to the authors' knowledge the accuracy of data regarding second-course treatments is unknown. METHODS:Using SEER-Medicare-linked data, the authors identified a cohort of men who ...

journal_title：Cancer

authors： Wang K,Sheets NC,Basak R,Chen RC

更新日期：2016-10-01 00:00:00

abstract：:Basal cell carcinomas (BCCs) obtained from 22 subjects undergoing microscopically controlled surgery were transplanted to 40 athymic (nude) mice. With no further immunosuppression of the mice, no tumor growth was noted in the first 14 attempts. When mice were further immunosuppressed with anti-lymphocyte serum (ALS) i...

journal_title：Cancer

authors： Grimwood RE,Johnson CA,Ferris CF,Mercill DB,Mellette JR,Huff JC

更新日期：1985-08-01 00:00:00

abstract：:Prior studies have shown that black patients with breast cancer have poorer survival times compared with white patients even when adjusted for stage. Seventy-four black patients treated on six Piedmont Oncology Association (POA) protocols were compared with 74 randomly selected white patients treated with the same pro...

journal_title：Cancer

authors： Kimmick G,Muss HB,Case LD,Stanley V

更新日期：1991-06-01 00:00:00

abstract：:Hereditary cancer represents approximately 5-10% of the total cancer burden and may account for 60,000 to 120,000 new cancer occurrences this year in the United States. New developments in molecular genetics and the cloning of cancer-prone genes have intensely fueled interest in dealing with hereditary forms of cancer...

journal_title：Cancer

authors： Lynch HT,Watson P,Shaw TG,Lynch JF,Harty AE,Franklin BA,Kapler CR,Tinley ST,Liu B

更新日期：1999-12-01 00:00:00

abstract：BACKGROUND:Several studies have demonstrated that abnormal levels of nuclear matrix protein 22 (NMP22) are associated with bladder cancer and have led to the approval of NMP22 as a urinary biomarker by the US Food and Drug Administration. Nonetheless, the clinical significance of NMP22 remains unclear. The objective of...

journal_title：Cancer

authors： Shariat SF,Savage C,Chromecki TF,Sun M,Scherr DS,Lee RK,Lughezzani G,Remzi M,Marberger MJ,Karakiewicz PI,Vickers AJ

更新日期：2011-07-01 00:00:00

abstract：BACKGROUND:Current research is inconclusive regarding the relation between alcohol consumption and prostate cancer risk. In this study, the authors examined the associations of total alcohol, type of alcoholic beverage, and drinking pattern with the risk of total, low-grade, and high-grade prostate cancer. METHODS:Dat...

journal_title：Cancer

authors： Gong Z,Kristal AR,Schenk JM,Tangen CM,Goodman PJ,Thompson IM

更新日期：2009-08-15 00:00:00

abstract：:A clinicopathologic study of 48 cases of pleomorphic lipoma from the files of the Armed Forces Institute of Pathology reveals that this tumor occurs principally in males (83%) in the fifth to seventh decades (mean 57 years) and shows a predilection for the posterior neck, shoulder, and back. Typically, the lesion appe...

journal_title：Cancer

authors： Shmookler BM,Enzinger FM

更新日期：1981-01-01 00:00:00

abstract：:A useful approach to establishing the biologic actions, in vivo, of granulocyte-macrophage colony-stimulating factor (GM-CSF) is to assess the consequences of long-term elevation of the factor in transgenic mice. Two lines of transgenic GM-CSF mice were analyzed. The major abnormality exhibited was an elevation in the...

journal_title：Cancer

authors： Metcalf D

更新日期：1991-05-15 00:00:00

abstract：BACKGROUND:Methotrexate is readily absorbed from the intestinal tract. When given to patients with urinary diversion to the intestinal tract, methotrexate may be reabsorbed into the circulation, thus increasing its serum concentration and potentially increasing its toxicity. METHODS:Forty-eight patients with transitio...

journal_title：Cancer

authors： Srinivas S,Mahalati K,Freiha FS

更新日期：1998-03-15 00:00:00

abstract：BACKGROUND:Bloody nipple discharge is a significant clue in the detection of ductal carcinoma of the breast. In the past, pathologic diagnoses were obtained exclusively via excision, but recently developed mammoscopic techniques have been found to yield valuable information relating to the diagnosis of intraductal lesi...

journal_title：Cancer

authors： Matsunaga T,Kawakami Y,Namba K,Fujii M

更新日期：2004-11-15 00:00:00

abstract：:Head and neck cancer (H&N CA) patients have known depression of cell-mediated immunity. There is suggestive evidence that prostaglandin (PGE2)-secreting cells may be a major factor. The authors have sought to determine the role of PGE2-releasing monocytes-macrophages in this immune depression by determining the effect...

journal_title：Cancer

authors： Wanebo HJ,Riley T,Katz D,Pace RC,Johns ME,Cantrell RW

更新日期：1988-02-01 00:00:00

abstract：BACKGROUND:Case reports have associated neuroblastoma, a cancer derived from the embryonal neural crest, with aganglionosis coli and neurofibromatosis type I. The aim of the current study was to test the hypothesis that neuroblastoma is part of a global defect in neurodevelopment. METHODS:Neuropathologic findings from...

journal_title：Cancer

authors： Blatt J,Hamilton RL

更新日期：1998-04-15 00:00:00

abstract：:Peripheral B- and T-lymphocyte counts were studied in 50 patients before they received any therapy for their conditions: 16 had carcinoma of the breast; 8 soft tissue sarcoma; and 26, benign disease. Among 11 males, the six patients with advanced soft tissue sarcoma had significantly lower percentages of T lymphocytes...

journal_title：Cancer

authors： Lee YT,Marshall GJ,Weiner J,Bateman JR

更新日期：1977-08-01 00:00:00

abstract：:Unraveling cancer-associated molecular defects is crucial for further pharmacological targeting. Although novel techniques are being developed to elucidate genomic, proteomic, and transcriptomic alterations, the map of protein interactions and aberrations in normal but also in malignant cells is still obscure. It has ...

journal_title：Cancer

authors： Karamouzis MV,Papavassiliou AG

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND:From 1973 to 1991, the incidence of kidney cancer in the United States increased by 35.4%. METHODS:A multicenter, hospital-based case-control study was conducted from 1977 to 1993 through an interview of 788 patients with renal cell carcinoma and 779 control subjects. RESULTS:Compared with those who never ...

journal_title：Cancer

authors： Muscat JE,Hoffmann D,Wynder EL

更新日期：1995-05-15 00:00:00

abstract：:It is rare for small lymphocytic B-cell malignancies to be associated with osteolytic bone lesions and/or hypercalcemia. The authors present an unusual case of well-differentiated lymphocytic lymphoma (DWDL) in a 70-year-old man who had osteolytic bone lesions and subsequently developed severe refractory hypercalcemia...

journal_title：Cancer

authors： Abboud SL,Gordeuk V,Schacter LP,Crum ED,Spitzer TR

更新日期：1985-11-15 00:00:00

abstract：BACKGROUND:RAS/RAF/mitogen-activated protein kinase activation is common in myeloid malignancies. Trametinib, a mitogen-activated protein kinase kinase 1 (MEK1)/MEK2 inhibitor with activity against multiple myeloid cell lines at low nanomolar concentrations, was evaluated for safety and clinical activity in patients wi...

journal_title：Cancer

authors： Borthakur G,Popplewell L,Boyiadzis M,Foran J,Platzbecker U,Vey N,Walter RB,Olin R,Raza A,Giagounidis A,Al-Kali A,Jabbour E,Kadia T,Garcia-Manero G,Bauman JW,Wu Y,Liu Y,Schramek D,Cox DS,Wissel P,Kantarjian H

更新日期：2016-06-15 00:00:00

abstract：:In the treatment of gynecologic malignancies, various combinations of surgery, drugs, and radiation therapy are used with increasing frequency. An examination is made of data dealing with combined modalities in the treatment of tumors of the cervix, endometrium, and ovary. Although the efficacy of such treatments has ...

journal_title：Cancer

authors： Brady LW

更新日期：1975-01-01 00:00:00

abstract：BACKGROUND:Increased soluble human epidermal growth factor receptor 2 (sHER2) is an indicator of a poor prognosis in HER2-positive metastatic breast cancer. In this study, the authors evaluated levels of sHER2 during treatment and at the time of disease recurrence in the adjuvant North Central Cancer Treatment Group N9...

journal_title：Cancer

authors： Moreno-Aspitia A,Hillman DW,Dyar SH,Tenner KS,Gralow J,Kaufman PA,Davidson NE,Lafky JM,Reinholz MM,Lingle WL,Kutteh LA,Carney WP,Dueck AC,Perez EA

更新日期：2013-08-01 00:00:00

abstract：:Meningeal myeloid metaplasia (MM) is very rarely observed in patients with myelofibrosis. We report the occurrence of meningeal MM causing exophthalmus and fever in a patient with myelofibrosis secondary to polycythemia vera. A computerized tomography (CT) scan showed multiple intracranial and intraorbital enhancing m...

journal_title：Cancer

authors： Landolfi R,Colosimo C Jr,De Candia E,Castellana MA,De Cristofaro R,Trodella L,Leone G

更新日期：1988-12-01 00:00:00

abstract：BACKGROUND:Carcinomas of the small intestine are rare, but the risk is greatly increased in patients with hereditary nonpolyposis colorectal cancer (HNPCC) due to an inherited mismatch repair (MMR) gene mutation, most commonly affecting the genes MLH1 or MSH2. Defective MMR is characterized by microsatellite instabilit...

journal_title：Cancer

authors： Planck M,Ericson K,Piotrowska Z,Halvarsson B,Rambech E,Nilbert M

更新日期：2003-03-15 00:00:00

abstract：:The authors have performed a clinical and statistical analysis of the presenting features of adult acute leukemia classified according to the French-American-British (FAB) hematopathologic criteria. Observations were made on 70 variables of history, physical examination, and laboratory examination recorded for 195 pat...

journal_title：Cancer

authors： Burns CP,Armitage JO,Frey AL,Dick FR,Jordan JE,Woolson RF

更新日期：1981-05-15 00:00:00

abstract：:The case of a 41-year-old man with testicular mixed germ cell-sex cord stroma tumor is reported. The patient noticed a gradual, painless, right-sided testicular enlargement 4 years before being treated by radical orchiectomy. The testis contained a centrally located tumor. There was no evidence of metastases. An histo...

journal_title：Cancer

authors： Matoŝka J,Talerman A

更新日期：1989-11-15 00:00:00

abstract：:Interest in the elderly population, persons 65 years of age or older, as a target group for cancer control has not been great. Age recommendations rarely are made for prevention and early detection of cancer for elderly persons. However, cancer incidence and mortality rates are known to rise rapidly with increasing ag...

journal_title：Cancer

authors： Yancik R,Kessler L,Yates JW

更新日期：1988-10-15 00:00:00

abstract：BACKGROUND:The objective of this study was to assess the value of combined-modality therapy in elderly patients by comparing the differences in outcome between patients who received radiotherapy (RT) alone and patients who received RT plus chemotherapy for stage III nonsmall cell lung cancer (NSCLC). METHODS:The North...

journal_title：Cancer

authors： Schild SE,Mandrekar SJ,Jatoi A,McGinnis WL,Stella PJ,Deming RL,Jett JR,Garces YI,Allen KL,Adjei AA,North Central Cancer Treatment GroupThis study was conducted as a collaborative trial of the North Central Cancer Treatment Group and

更新日期：2007-07-15 00:00:00

abstract：:This is a statistical analysis of the use of mammography in the symptomatic patient. Eighty-eight percent of women older than 50 years who had a palpable cancer of the breast had a positive mammogram; only 57% of women younger than 51 years of age had a positive mammogram. When the cancer presented as nipple discharge...

journal_title：Cancer

authors： Edeiken S

更新日期：1989-04-01 00:00:00

abstract：BACKGROUND:Patient navigation may reduce cancer disparities associated with socioeconomic status (SES) and household factors. This study examined whether these factors were associated with delays in diagnostic resolution among patients with cancer screening abnormalities and whether patient navigation ameliorated these...

journal_title：Cancer

authors： Rodday AM,Parsons SK,Snyder F,Simon MA,Llanos AA,Warren-Mears V,Dudley D,Lee JH,Patierno SR,Markossian TW,Sanders M,Whitley EM,Freund KM

更新日期：2015-11-15 00:00:00

abstract：:Whether malignant cells can be detected in the bowel movements induced by oral gut lavage solution administration was studied in patients with known colonic adenocarcinomas. The induced bowel movements were collected in 27 patients, nine of whom had cancer proven by anatomic pathologic examination. The cells present w...

journal_title：Cancer

authors： Gordon IL,Rypins EB,Wuerker RB,Jakowatz JJ

更新日期：1991-07-01 00:00:00

abstract：BACKGROUND:Postprostatectomy adjuvant or salvage radiotherapy, when using standard fractionation, requires 6.5 to 8 weeks of treatment. The authors report on the safety and efficacy of an expedited radiotherapy course for salvage prostate radiotherapy. METHODS:A total of 108 consecutive patients were treated with salv...

journal_title：Cancer

authors： Kruser TJ,Jarrard DF,Graf AK,Hedican SP,Paolone DR,Wegenke JD,Liu G,Geye HM,Ritter MA

更新日期：2011-06-15 00:00:00