Association of increased lytic effector cell function with high estrogen receptor levels in tumor-bearing patients with breast cancer.

Abstract:

:Tumor-bearing patients with breast cancer were assayed for their natural killer (NK) cell activity and for the function of activated cytotoxic T-cells, as assessed by lectin-dependent cellular cytotoxicity (LDCC). Tumor-bearing patients with breast cancer had a significant increase in NK activity and in LDCC, as compared with healthy control individuals. Although the enhanced NK cell activity and LDCC were closely associated with high levels (greater than 31 fmol/mg) of estrogen receptor (ER) content in the primary tumor, no other clinical or histologic correlation between the increase in either parameter of cytotoxic effector cell function could be found. Thus, ER levels greater than 31 fmol/mg might be associated with increased cytotoxic effector cell function in tumor-bearing patients with breast cancer.

journal_name

Cancer

journal_title

Cancer

authors

Zielinski CC,Tichatschek E,Müller C,Kalinowski W,Sevelda P,Czerwenka K,Kubista E,Spona J

doi

10.1002/1097-0142(19890515)63:10<1985::aid-cncr282

subject

Has Abstract

pub_date

1989-05-15 00:00:00

pages

1985-9

issue

10

eissn

0008-543X

issn

1097-0142

journal_volume

63

pub_type

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