Abstract:
:Tumor-bearing patients with breast cancer were assayed for their natural killer (NK) cell activity and for the function of activated cytotoxic T-cells, as assessed by lectin-dependent cellular cytotoxicity (LDCC). Tumor-bearing patients with breast cancer had a significant increase in NK activity and in LDCC, as compared with healthy control individuals. Although the enhanced NK cell activity and LDCC were closely associated with high levels (greater than 31 fmol/mg) of estrogen receptor (ER) content in the primary tumor, no other clinical or histologic correlation between the increase in either parameter of cytotoxic effector cell function could be found. Thus, ER levels greater than 31 fmol/mg might be associated with increased cytotoxic effector cell function in tumor-bearing patients with breast cancer.
journal_name
Cancerjournal_title
Cancerauthors
Zielinski CC,Tichatschek E,Müller C,Kalinowski W,Sevelda P,Czerwenka K,Kubista E,Spona Jdoi
10.1002/1097-0142(19890515)63:10<1985::aid-cncr282subject
Has Abstractpub_date
1989-05-15 00:00:00pages
1985-9issue
10eissn
0008-543Xissn
1097-0142journal_volume
63pub_type
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