Beta-benzene hexachloride in breast adipose tissue and risk of breast carcinoma.

Abstract:

BACKGROUND:Epidemiologic studies have recently related benzene hexachloride (BHC) to breast carcinoma risk. Experimental studies have also shown that beta-BHC is weakly estrogenic, hence supporting the alleged association. By directly comparing beta-BHC levels in breast adipose tissue from incident breast carcinoma cases and controls, this study examined the hypothesis that exposure to beta-BHC increases the risk of breast carcinoma in females. METHODS:A total of 490 Connecticut women (304 cases and 186 controls) were enrolled in the study during the period 1994-1997. Cases were patients ages 40-79 years with histologically confirmed incident primary breast carcinoma. Controls were patients with histologically confirmed incident benign breast disease. Breast adipose tissue was collected and analyzed for BHC isomers. A linear logistic regression model was used to adjust for potential confounders in estimating the association of exposure with disease. RESULTS:No significant differences in breast adipose tissue levels of beta-BHC were observed between the cases and their controls overall, nor by menopausal status or estrogen and progesterone receptor status of the breast carcinoma cases. A nonsignificant reduced risk was observed among all subjects and among pre- and postmenopausal women when the highest quartile was compared with the lowest. Parous women with higher beta-BHC levels, regardless of lactation status, had a nonsignificantly reduced breast carcinoma risk, whereas a nonsignificantly increased risk was observed among nulliparous women with higher beta-BHC levels, based on very few study subjects. CONCLUSIONS:The results of this study do not support the hypothesis that increasing adipose tissue levels of beta-BHC are associated with an increased risk of breast carcinoma in females.

journal_name

Cancer

journal_title

Cancer

authors

Zheng T,Holford TR,Mayne ST,Owens PH,Ward B,Carter D,Dubrow R,Zahm SH,Boyle P,Tessari J

doi

10.1002/(sici)1097-0142(19990515)85:10<2212::aid-c

subject

Has Abstract

pub_date

1999-05-15 00:00:00

pages

2212-8

issue

10

eissn

0008-543X

issn

1097-0142

pii

10.1002/(SICI)1097-0142(19990515)85:10<2212::AID-C

journal_volume

85

pub_type

杂志文章

相关文献

CANCER文献大全
  • Cyclophosphamide, vincristine, adriamycin, and prednisone (CHOP) with and without intermediate dose methotrexate for the treatment of non-Hodgkin's lymphomas of diffuse histology.

    abstract::Seventy three patients with disseminated diffuse non-Hodgkin's lymphomas were treated with combinations of cyclophosphamide, vincristine sulfate, prednisone, and doxorubicin with and without 2 weekly doses of oral methotrexate in "intermediate" doses, followed by calcium leucovorin rescue. The addition of methotrexate...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章

    doi:10.1002/1097-0142(19870701)60:1<18::aid-cncr282060

    authors: Gomez GA,Barcos M,Han T,Henderson ES

    更新日期:1987-07-01 00:00:00

  • Risk factors for intrahepatic recurrence of hepatocellular carcinoma in cirrhotic patients treated by percutaneous ethanol injection.

    abstract:BACKGROUND:Hepatocellular carcinoma (HCC) complicating cirrhosis has a high intrahepatic recurrence rate after treatment by surgical resection or percutaneous ethanol injection (PEI). In this study, certain clinical, biochemical, and pathologic parameters were evaluated as risk factors for intrahepatic tumor recurrence...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0142(19970415)79:8<1501::aid-cn

    authors: Pompili M,Rapaccini GL,de Luca F,Caturelli E,Astone A,Siena DA,Villani MR,Grattagliano A,Cedrone A,Gasbarrini G

    更新日期:1997-04-15 00:00:00

  • Micropapillary serous carcinoma of the ovary: cytomorphologic characteristics in peritoneal/pelvic washings.

    abstract:BACKGROUND:Micropapillary serous carcinoma (MPSC), a recently described entity, is an ovarian tumor with a distinctive histologic architecture that lacks a destructive infiltrative growth pattern and behaves like a low-grade neoplasm. The purpose of this study was to determine if specific cytomorphologic features were ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.10619

    authors: Alli PM,Ali SZ

    更新日期:2002-06-25 00:00:00

  • Prognostic value of the proliferation-related antigen Ki-67 in oligodendrogliomas.

    abstract:BACKGROUND:In various neoplasms expression of the proliferation-related Ki-67 antigen has successfully been linked with parameters of progression of disease. While a definite grading scheme for oligodendrogliomas has still not been agreed upon, any parameter of tumor proliferation that might be helpful in predicting cl...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/(SICI)1097-0142(19960901)78:5<1107::AID-CN

    authors: Kros JM,Hop WC,Godschalk JJ,Krishnadath KK

    更新日期:1996-09-01 00:00:00

  • Preoperative or postoperative irradiation as adjunctive treatment with radical mastectomy in breast cancer.

    abstract::Results from the standpoint of survival rates and locoregional failures are compared in three series of patients having had a radical mastectomy for breast cancer: (1) radical mastectomy alone for the patients who had essentially outer quadrant lesions and a negative axilla; (2) postoperative irradiation when the axil...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章

    doi:10.1002/1097-0142(19830415)51:8<1388::aid-cncr2820

    authors: Rodger A,Montague ED,Fletcher G

    更新日期:1983-04-15 00:00:00

  • Opioid pharmacotherapy in the management of cancer pain: a survey of strategies used by pain physicians for the selection of analgesic drugs and routes of administration.

    abstract:BACKGROUND:This survey documents the strategies used by pain control physicians in the selection of opioid drugs and routes of administration in the management of inpatients referred to a cancer pain service. METHODS:The following approaches were prospectively evaluated during the treatment of 100 consecutive inpatien...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19951001)76:7<1283::aid-cncr2820

    authors: Cherny NJ,Chang V,Frager G,Ingham JM,Tiseo PJ,Popp B,Portenoy RK,Foley KM

    更新日期:1995-10-01 00:00:00

  • Use of the lung cancer-specific Quality of Life Questionnaire EORTC QLQ-LC13 in clinical trials: A systematic review of the literature 20 years after its development.

    abstract::The European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire-Lung Cancer 13 (QLQ-LC13) covers 13 typical symptoms of lung cancer patients and was the first module developed in conjunction with the EORTC core quality-of-life (QL) questionnaire. This review investigates how the mo...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/cncr.29682

    authors: Koller M,Warncke S,Hjermstad MJ,Arraras J,Pompili C,Harle A,Johnson CD,Chie WC,Schulz C,Zeman F,van Meerbeeck JP,Kuliś D,Bottomley A,European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Group.,EO

    更新日期:2015-12-15 00:00:00

  • Sequential therapy with sorafenib and sunitinib in renal cell carcinoma.

    abstract:BACKGROUND:Sunitinib and sorafenib are small-molecule tyrosine kinase inhibitors (TKI) with antitumor activity in advanced renal cell carcinoma. A retrospective study was conducted to assess the response of renal cell carcinoma to sequential treatment with these two agents. METHODS:Tumor response was evaluated by usin...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.24009

    authors: Dudek AZ,Zolnierek J,Dham A,Lindgren BR,Szczylik C

    更新日期:2009-01-01 00:00:00

  • Transvaginal sonography as a screening method for ovarian cancer. A report of the first 1000 cases screened.

    abstract::From November 1987 to April 1989, 1000 women 40 years or older underwent screening vaginal sonography at the University of Kentucky Medical Center (Lexington, KY). Patients included in this investigation were all asymptomatic and had no known pelvic abnormalities. Each ovary was measured in three planes and ovarian vo...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19900201)65:3<573::aid-cncr28206

    authors: van Nagell JR Jr,Higgins RV,Donaldson ES,Gallion HH,Powell DE,Pavlik EJ,Woods CH,Thompson EA

    更新日期:1990-02-01 00:00:00

  • Female adnexal tumor of probable Wolffian origin: evidence of a low grade malignancy.

    abstract::A broad ligament tumor with the histologic features of a female adnexal tumor of probable Wolffian origin, as described by Kariminejad and Scully, is reported. Although previous cases were thought to be benign, in the present case, hepatic metastasis occurred 6 years after resection of the primary. Cytologic features ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197605)37:5<2349::aid-cncr282037

    authors: Taxy JB,Battifora H

    更新日期:1976-05-01 00:00:00

  • Malignant histiocytosis with rearrangement of the heavy chain gene and evidence of monocyte-macrophage lineage.

    abstract::A unique case of malignant histiocytosis (MH) is reported. Its origin from the monocyte-macrophage system was indicated by expression of highly specific myeloid cell markers (My4, MCS2, and cytoplasmic lysozyme), diffuse activity of acid phosphatase and NaF-sensitive alpha-naphthyl acetate esterase, lack of immunologi...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19881001)62:7<1306::aid-cncr2820

    authors: Kamesaki H,Koya M,Miwa H,Kita K,Doi S,Tatsumi E,Hatanaka M,Uchino H

    更新日期:1988-10-01 00:00:00

  • Chinese expert consensus on the clinical diagnosis and treatment of advanced breast cancer (2018).

    abstract::Breast cancer is the most common malignant tumor among women in the world. In 2005, there were approximately 272,000 new cases diagnosed and more than 70,000 deaths from breast cancer in China. Of the patients who are newly diagnosed with breast cancer each year, approximately 3% to 10% have distant metastases at the ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.32832

    authors: Xu B,Hu X,Feng J,Geng C,Jin F,Li H,Li M,Li Q,Liao N,Liu D,Liu J,Liu Q,Lu J,Liu Z,Ma F,Ouyang Q,Pan Y,Shen K,Sun T,Teng Y,Tong Z,Wang B,Wang H,Wang S,Wang S,Wang T,Wang X,Wang X,Wang Y,Wang Z,Wu

    更新日期:2020-08-15 00:00:00

  • Role of fine needle aspiration in the diagnosis of lesions of the oral cavity, oropharynx, and nasopharynx.

    abstract::The oral cavity, oropharynx and nasopharynx are readily accessible to fine needle aspiration (FNA). This study reviews the author's experience with 93 FNA from these sites: 76 from the oral cavity, eight from the oropharynx, and eight from the nasopharynx. Thirty-nine (42%) of the FNA were positive for malignancy with...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19881215)62:12<2602::aid-cncr282

    authors: Scher RL,Oostingh PE,Levine PA,Cantrell RW,Feldman PS

    更新日期:1988-12-15 00:00:00

  • Anastrozole alone or in combination with tamoxifen versus tamoxifen alone for adjuvant treatment of postmenopausal women with early-stage breast cancer: results of the ATAC (Arimidex, Tamoxifen Alone or in Combination) trial efficacy and safety update ana

    abstract:BACKGROUND:The first analysis of the ATAC (Arimidex, Tamoxifen Alone or in Combination) trial (median follow-up, 33 months) demonstrated that in adjuvant endocrine therapy for postmenopausal patients with early-stage breast cancer, anastrozole was superior to tamoxifen in terms of disease-free survival (DFS), time to r...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1002/cncr.11745

    authors: Baum M,Buzdar A,Cuzick J,Forbes J,Houghton J,Howell A,Sahmoud T,ATAC (Arimidex, Tamoxifen Alone or in Combination) Trialists' Group.

    更新日期:2003-11-01 00:00:00

  • Reproducibility of cytologic atypia in repeat nipple duct lavage.

    abstract:BACKGROUND:It is believed that atypical cells identified by nipple duct lavage (NDL) indicate an increased risk for breast carcinoma similar to atypical ductal hyperplasia diagnosed by tissue biopsy, but many basic performance characteristics of NDL currently are undefined. METHODS:NDL was performed in 108 patients un...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.20884

    authors: Johnson-Maddux A,Ashfaq R,Cler L,Naftalis E,Leitch AM,Hoover S,Euhus DM

    更新日期:2005-03-15 00:00:00

  • Importance of quality-of-life priorities and preferences surrounding treatment decision making in patients with cancer and oncology clinicians.

    abstract:BACKGROUND:Shared decision-making (SDM) occurs when a patient partners with their oncologist to integrate personal preferences and values into treatment decisions. A key component of SDM is the elicitation of patient preferences and values, yet little is known about how and when these are elicited, communicated, priori...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.32961

    authors: Williams CP,Miller-Sonet E,Nipp RD,Kamal AH,Love S,Rocque GB

    更新日期:2020-08-01 00:00:00

  • Biliary cystadenocarcinoma: Case report of hepatic malignancy originating in benign cystadenoma.

    abstract::A case of biliary cystadenoma undergoing malignant dedifferentiation is presented. Biliary cystadenocarcinoma is an infrequently occurring neoplasm; fewer than 20 cases have been reported in the literature. This case is the first in which there is documentation of cystadenocarcinoma arising from a previously diagnosed...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19810615)47:12<2936::aid-cncr282

    authors: Woods GL

    更新日期:1981-06-15 00:00:00

  • Does multisomy of chromosome 1q confer a proliferative advantage in B-cell acute lymphoblastic leukemia?

    abstract::Two patients fulfilled the clinical and hematologic criteria for B-cell acute lymphoblastic leukemia: the malignant cells had L3 morphology, bore B-cell markers, and carried the specific t(8;14) translocation. The leukemic cells of one patient were tetrasomic for 1q, and those of the other patient showed several separ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19840701)54:1<48::aid-cncr282054

    authors: Morris CM,Fitzgerald PH,Neville MA,Wyld PJ,Beard ME

    更新日期:1984-07-01 00:00:00

  • Genetic and pathologic findings in a kindred with hereditary sarcoma, breast cancer, brain tumors, leukemia, lung, laryngeal, and adrenal cortical carcinoma.

    abstract::A familial cancer aggregation comprising sarcomas, brain tumors, leukemias, and carcinomas of breast, larynx, lung, adrenal, cortex, and other sites has been studied from a pathologic--genetic standpoint. Based upon sibships segregating for cancer, the genetic segregation parameter is estimated to be 45.6 +/- 11% whi...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197805)41:5<2055::aid-cncr282041

    authors: Lynch HT,Mulcahy GM,Harris RE,Guirgis HA,Lynch JF

    更新日期:1978-05-01 00:00:00

  • Frequency of gastrointestinal involvement and its clinical significance in mantle cell lymphoma.

    abstract:BACKGROUND:The reported frequency of gastrointestinal (GI) tract involvement in patients with mantle cell lymphoma (MCL) is 15-30%. However, this figure most likely is an underestimate because most patients with MCL involving the GI tract previously reported were examined endoscopically only if they had GI tract sympto...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.11096

    authors: Romaguera JE,Medeiros LJ,Hagemeister FB,Fayad LE,Rodriguez MA,Pro B,Younes A,McLaughlin P,Goy A,Sarris AH,Dang NH,Samaniego F,Brown HM,Gagneja HK,Cabanillas F

    更新日期:2003-02-01 00:00:00

  • Recurrent gestational trophoblastic disease. Experience of the Southeastern Regional Trophoblastic Disease Center.

    abstract::Between 1968 and 1985, 28 patients with recurrent gestational trophoblastic disease (GTD) were treated at the Southeastern Regional Trophoblastic Disease Center. Sixteen patients received primary therapy at this center and had recurrence diagnosed by re-elevation of human chorionic gonadotropin (hCG) levels after thre...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19900901)66:5<978::aid-cncr28206

    authors: Mutch DG,Soper JT,Babcock CJ,Clarke-Pearson DL,Hammond CB

    更新日期:1990-09-01 00:00:00

  • Prognostic impact of discordant results from cytogenetics and flow cytometry in patients with acute myeloid leukemia undergoing hematopoietic cell transplantation.

    abstract:BACKGROUND:Cytogenetics and multicolor flow cytometry (MFC) are useful tools for monitoring outcome of treatment in acute myeloid leukemia (AML). However, no data are available regarding the meaning of results when the 2 tests do not agree. METHODS:The authors of this report analyzed 1464 pairs of concurrent cytogenet...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.26539

    authors: Fang M,Storer B,Wood B,Gyurkocza B,Sandmaier BM,Appelbaum FR

    更新日期:2012-05-01 00:00:00

  • Transbronchial lung biopsy in the diagnosis of lymphangitic carcinomatosis.

    abstract::The clinical diagnosis of lymphangitic carcinomatosis of the lung has generally been confirmed by open lung or transthoracic needle biopsy, precedures with significant morbidity and mortality, particularly in patients with respiratory insufficiency. We present six cases of lymphangitic carcinomatosis diagnosed by tran...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197810)42:4<1995::aid-cncr282042

    authors: Aranda C,Sidhu G,Sasso LA,Adams FV

    更新日期:1978-10-01 00:00:00

  • External radiotherapy in thyroid cancers.

    abstract::Surgery is the most effective treatment for thyroid cancer; however, in some subsets of patients, the role of radiotherapy (RT) is important. The main indication for external-beam RT is incomplete surgery. When neoplastic tissue is left behind at operation, RT must be considered, but only if an experienced surgeon fee...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19850501)55:9+<2062::aid-cncr282

    authors: Tubiana M,Haddad E,Schlumberger M,Hill C,Rougier P,Sarrazin D

    更新日期:1985-05-01 00:00:00

  • Measuring financial toxicity as a clinically relevant patient-reported outcome: The validation of the COmprehensive Score for financial Toxicity (COST).

    abstract:BACKGROUND:Cancer and its treatment lead to increased financial distress for patients. To the authors' knowledge, to date, no standardized patient-reported outcome measure has been validated to assess this distress. METHODS:Patients with AJCC Stage IV solid tumors receiving chemotherapy for at least 2 months were recr...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.30369

    authors: de Souza JA,Yap BJ,Wroblewski K,Blinder V,Araújo FS,Hlubocky FJ,Nicholas LH,O'Connor JM,Brockstein B,Ratain MJ,Daugherty CK,Cella D

    更新日期:2017-02-01 00:00:00

  • C-cell disease of the thyroid gland in multiple endocrine neoplasia, type 2b.

    abstract::Multiple endocrine neoplasia, type 2b (MEN 2b) is a disorder characterized by C-cell disease of the thyroid gland (medullary carcinoma or C-cell hyperplasia, or both), pheochromocytoma, ganglioneuromatosis, and skeletal and connective tissue abnormalities. The medullary thyroid carcinoma (MTC) is bilateral and multice...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/1097-0142(197912)44:6<2173::aid-cncr282044

    authors: Carney JA,Sizemore GW,Hayles AV

    更新日期:1979-12-01 00:00:00

  • Racial differences in cervical cancer survival in the Detroit metropolitan area.

    abstract:BACKGROUND:African-American (AA) women have lower survival rates from cervical cancer compared with white women. The objective of this study was to examine the influence of socioeconomic status (SES) and other variables on racial disparities in overall survival among women with invasive cervical cancer. METHODS:One th...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.23310

    authors: Movva S,Noone AM,Banerjee M,Patel DA,Schwartz K,Yee CL,Simon MS

    更新日期:2008-03-15 00:00:00

  • The fine structure of astroblastoma.

    abstract::An astroblastoma in the cerebrum was investigated with the electron microscope. A distinctive feature of the tumor was the radial arrangement of astrocytic cells around the blood vessels. The blood vessels in the tumor commonly exhibited fenestrated endothelial cells. The endothelium was generally surrounded by lamell...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19850215)55:4<745::aid-cncr28205

    authors: Kubota T,Hirano A,Sato K,Yamamoto S

    更新日期:1985-02-15 00:00:00

  • A prospective study comparing touch imprint cytology, frozen section analysis, and rapid cytokeratin immunostain for intraoperative evaluation of axillary sentinel lymph nodes in breast cancer.

    abstract:BACKGROUND:The intraoperative evaluation of axillary sentinel lymph nodes (SLNs) allows the surgeon to complete axillary dissection in 1 setting at the time of the primary breast surgery. However, to the authors' knowledge, there is no consensus regarding the optimal method for intraoperative evaluation of SLNs in brea...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.24182

    authors: Krishnamurthy S,Meric-Bernstam F,Lucci A,Hwang RF,Kuerer HM,Babiera G,Ames FC,Feig BW,Ross MI,Singletary E,Hunt KK,Bedrosian I

    更新日期:2009-04-01 00:00:00

  • Follicular variant of papillary thyroid carcinoma. A clinicopathologic study.

    abstract:BACKGROUND:A retrospective clinicopathologic study was performed to identify the influence of diagnostic and therapeutic procedures on the outcomes of patients with the follicular variant of papillary thyroid carcinoma (FVPTC). METHODS:The results of 37 patients with FVPTC were compared with those of 37 randomly selec...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19940115)73:2<424::aid-cncr28207

    authors: Tielens ET,Sherman SI,Hruban RH,Ladenson PW

    更新日期:1994-01-15 00:00:00