Driver mutations determine survival in smokers and never-smokers with stage IIIB/IV lung adenocarcinomas.

abstract：BACKGROUND:Tropisetron (ICS 205-930) antagonizes the serotonin type 3 receptor and has antiemetic activity in animals given cisplatin. Its mean serum half-life in 11.1 hours. METHODS:In this dose-ranging trial, 22 patients undergoing anti-cancer chemotherapy received 24 courses of a single intravenous infusion of trop...

journal_title：Cancer

authors： Pisters KM,Kris MG,Tyson LB,Clark RA,Gralla RJ

更新日期：1993-01-01 00:00:00

abstract：BACKGROUND:The widespread use of anthracycline chemotherapy has contributed to improved outcomes in children with cancer. The most feared complication of the anthracyclines is cardiotoxicity. Routine echocardiographic monitoring typically is used before, during, and after treatment to minimize cardiotoxicity. The ideal...

journal_title：Cancer

authors： Watts RG,George M,Johnson WH Jr

更新日期：2012-04-01 00:00:00

abstract：:The case history of a woman with a "female adnexal tumor of probable Wolffian origin" is described in which the neoplasm recurred three times during a 16-year interval and responded with prolonged remission after repeated surgical excision and radiotherapy. Ultrastructural data are given to support the Wolffian nature...

journal_title：Cancer

authors： Brescia RJ,Cardoso de Almeida PC,Fuller AF Jr,Dickersin GR,Robboy SJ

更新日期：1985-09-15 00:00:00

abstract：:This report documents, in seven infants younger than 2 years of age, a previously unrecognized association of a renal embryonal neoplasm (malignant rhabdoid tumor in six patients and a Wilms' tumor in one) with an embryonal primary tumor originating in the central nervous system. The neuroepithelial tumors included th...

journal_title：Cancer

authors： Bonnin JM,Rubinstein LJ,Palmer NF,Beckwith JB

更新日期：1984-11-15 00:00:00

abstract：BACKGROUND:There is limited information on outcomes of prostate carcinoma treatments given to screened patient populations for whom cancer is usually detected at an earlier stage. METHODS:The authors conducted a cross-sectional evaluation of quality-of-life outcomes for men with prostate carcinoma detected in screenin...

journal_title：Cancer

authors： Smith DS,Carvalhal GF,Schneider K,Krygiel J,Yan Y,Catalona WJ

更新日期：2000-03-15 00:00:00

abstract：:A family with histopathologically proven intraocular malignant melanoma involving two generations is reported. A member of third generation was likely involved by history. Intraocular malignant melanoma, its familial occurrence, its occurrence with multiple malignancies, and its relationship to multiple malignancies o...

journal_title：Cancer

authors： Green GJ,Hong WK,Everett JR,Bhutani R,Amick RM

更新日期：1978-06-01 00:00:00

abstract：:The National Breast and Cervical Cancer Early Detection Program (NBCCEDP) of the Centers for Disease Control and Prevention (CDC) is implemented through cooperative agreements with state health departments, US territories, and tribal health organizations (grantees). Grantees typically contract with clinicians and othe...

journal_title：Cancer

authors： Yancy B,Royalty JE,Marroulis S,Mattingly C,Benard VB,DeGroff A

更新日期：2014-08-15 00:00:00

abstract：BACKGROUND:Patients with aggressive non-Hodgkin lymphoma (NHL) require intensive and extensive therapy, which seems impracticable in elderly patients due to hematologic and extrahematologic toxicity. Consequent dose reduction and therapy attenuation can reduce treatment-related toxicity but also decreases therapeutic e...

journal_title：Cancer

authors： Rigacci L,Carpaneto A,Alterini R,Carrai V,Bernardi F,Bellesi G,Longo G,Bosi A,Rossi Ferrini P

更新日期：2003-01-01 00:00:00

abstract：:Radiotherapy was applied to 14 esophageal carcinomas with respiratory tract fistulas using various treatment regimens. Closure of the fistulas was observed in four cases after irradiation at a daily dose of 1.5 Gy. The period of closure was transient in two cases but long-term in the other two. One long-term closure c...

journal_title：Cancer

authors： Yamada S,Takai Y,Ogawa Y,Kakuto Y,Sakamoto K

更新日期：1989-09-01 00:00:00

abstract：:The use of prostate-specific antigen (PSA) as a screening test remains controversial. There have been several attempts to refine PSA measurements to improve its predictive value. These modifications, including PSA density, PSA kinetics, and the measurement of PSA isoforms, have met with limited success. Therefore, com...

journal_title：Cancer

authors： Herman MP,Dorsey P,John M,Patel N,Leung R,Tewari A

更新日期：2009-07-01 00:00:00

abstract：:Between September 1976 and May 1980, 135 patients with operable breast cancer and positive axillary nodes received l-phenylalanine mustard, adjunct to surgery, 0.15 mg/kg for five days, six weekly, and were randomised prospectively to levamisole 150 mg for three days, two weekly, or a placebo. Treatment was continued ...

journal_title：Cancer

authors： Kay RG,Mason BH,Stephens EJ,Arthur JF,Hitchcock GC,Trindall PL,Rodgers R,Mullins P

更新日期：1983-06-01 00:00:00

abstract：BACKGROUND:The objective of this study was to assess whether coregistered whole brain (WB) magnetic resonance imaging-positron emission tomography (MRI-PET) would increase the number of correctly upstaged patients compared with WB PET-computed tomography (PET-CT) plus dedicated brain MRI in patients with nonsmall cell ...

journal_title：Cancer

authors： Yi CA,Lee KS,Lee HY,Kim S,Kwon OJ,Kim H,Choi JY,Kim BT,Hwang HS,Shim YM

更新日期：2013-05-15 00:00:00

abstract：BACKGROUND:Breast conservation is now established treatment for patients with small breast cancers. The authors reviewed a large series of patients with long term follow-up who underwent conservative treatment. Clinical and pathologic factors were analyzed to identify patients at an increased risk of relapse in the bre...

journal_title：Cancer

authors： Dewar JA,Arriagada R,Benhamou S,Benhamou E,Bretel JJ,Pellae-Cosset B,Marin JL,Petit JY,Contesso G,Sarrazin D

更新日期：1995-12-01 00:00:00

abstract：BACKGROUND:Hispanic Americans have been shown to receive fewer cancer screening procedures than nonminority populations. Although lack of insurance or a regular source of care appear to be important determinants, cultural factors also have been suggested. This study examines whether Hispanic patients receive cancer scr...

journal_title：Cancer

authors： Jacobs EA,Lauderdale DS

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND:It has been previously observed that patients with head and neck squamous cell carcinoma or with laryngeal leucoplakia present a significant reduction in plasma folate levels. The current Phase IIA pilot study assessed the effectiveness of folic acid as a chemopreventive agent in patients affected by glottic...

journal_title：Cancer

authors： Almadori G,Bussu F,Navarra P,Galli J,Paludetti G,Giardina B,Maurizi M

更新日期：2006-07-15 00:00:00

abstract：:Two patients diagnosed as having acute promyelocytic leukemia (APL) and disseminated intravascular coagulation (DIC) were closely followed from the day of admission until completion of the first course of chemotherapy with serial coagulation studies including plasma levels of functional antithrombin III activity (AT I...

journal_title：Cancer

authors： Sandler RM,Liebman HA,Patch MJ,Teitelbaum A,Levine AM,Feinstein DI

更新日期：1983-02-15 00:00:00

abstract：:The purpose of this study was to determine (1) the number and activity of natural killer (NK) cells in children with acute leukemia at different stages of their disease; and (2) the effect of interleukin-2 (IL-2) in enhancing NK activity of these patients' cells. The mean percentage of Leu 11+ NK cells in patients at ...

journal_title：Cancer

authors： Mageed AA,Findley HW Jr,Franco C,Singhapakdi S,Alvarado C,Chan WC,Ragab AH

更新日期：1987-12-15 00:00:00

abstract：BACKGROUND:A phase 1 trial was used to evaluate a combination of cisplatin, gemcitabine, and escalating doses of veliparib in patients with untreated advanced pancreatic ductal adenocarcinoma (PDAC) in 2 cohorts: a germline BRCA1/2-mutated (BRCA+) cohort and a wild-type BRCA (BRCA-) cohort. The aims were to determine t...

journal_title：Cancer

authors： O'Reilly EM,Lee JW,Lowery MA,Capanu M,Stadler ZK,Moore MJ,Dhani N,Kindler HL,Estrella H,Maynard H,Golan T,Segal A,Salo-Mullen EE,Yu KH,Epstein AS,Segal M,Brenner R,Do RK,Chen AP,Tang LH,Kelsen DP

更新日期：2018-04-01 00:00:00

abstract：:Two cases of Wilms' tumor in adolescent males are presented. The clinical and radiographic findings were unusual and both presented atypical gross and microscopic features that could be correlated with the radiographic findings. Histologic examination of both tumors showed evidence of tubular and glomerular maturation...

journal_title：Cancer

authors： Merten DF,Yang SS,Bernstein J

更新日期：1976-03-01 00:00:00

abstract：:Three bleomycin-resistant (BLMr) human carcinoma cell lines (HeLa-BLMr, KB-BLMr, and Hepd-uvBLMr) were established in culture by progressively increasing the concentration of bleomycin (BLM). HeLa-BLMr and KB-BLMr were obtained after 5 and 2 months of incubation with BLM, whereas the establishment of Hepd-uvBLMr requi...

journal_title：Cancer

authors： Urade M,Sugi M,Miyazaki T

更新日期：1988-04-15 00:00:00

abstract：:Chemokines are chemoattractant cytokines that regulate the trafficking and activation of leukocytes and other cell types under a variety of inflammatory and noninflammatory conditions. Over the past few years, studies have increasingly shown that chemokines play an important role in several aspects of tumor progressio...

journal_title：Cancer

authors： Ruffini PA,Morandi P,Cabioglu N,Altundag K,Cristofanilli M

更新日期：2007-06-15 00:00:00

abstract：:Three patients with carcinoid tumors of the anterior mediastinum are described. Study of these patients and an analysis of previously reported cases indicates that the thymus is the primary site of these tumors, which are probably related to the presence of Kulchitsky cells in normal thymus. These neoplasms differ cli...

journal_title：Cancer

authors： Salyer WR,Salyer DC,Eggleston JC

更新日期：1976-02-01 00:00:00

abstract：:The observation, in 1980, of a rapid increase in platelet counts as a result of administration of intravenous immunoglobulin (IVIG) in a patient with immune thrombocytopenic purpura (ITP) was followed by clinical studies confirming the efficacy of this new treatment alternative in ITP. Simultaneously, new sensitive as...

journal_title：Cancer

authors： Imbach P

更新日期：1991-09-15 00:00:00

abstract：:The International Breast Cancer Study Group (formerly the Ludwig Group) has conducted nine clinical trials since 1978 (see the Appendix for participants and authors). Biologic hypotheses related to the combined use of chemotherapy and endocrine therapy in women with operable breast cancer were tested. Questions of tim...

journal_title：Cancer

authors： Goldhirsch A,Gelber RD,Castiglione M,Price KN,Rudenstam CM,Lindtner J,Collins J,Senn HJ,Brunner KW,Galligioni E

更新日期：1994-08-01 00:00:00

abstract：:Between 1970 and 1989, 17 children with histologically malignant intracranial ependymomas received treatment at the University of Pennsylvania (Philadelphia, PA). Eleven were treated with prophylactic cranial or craniospinal irradiation plus a local boost (CS-XRT), five with local (L-XRT) irradiation only, and one was...

journal_title：Cancer

authors： Goldwein JW,Corn BW,Finlay JL,Packer RJ,Rorke LB,Schut L

更新日期：1991-06-01 00:00:00

abstract：BACKGROUND:Melanoma vaccine treatment appears to slow the progression of melanoma in some patients, particularly in patients in whom it stimulates cellular antimelanoma immune responses. The relationship of vaccine-induced antibody responses to clinical outcome is less clear. The purpose of this study was to investigat...

journal_title：Cancer

authors： Miller K,Abeles G,Oratz R,Zeleniuch-Jacquotte A,Cui J,Roses DF,Harris MN,Bystryn JC

更新日期：1995-01-15 00:00:00

abstract：BACKGROUND:Molecular genetic studies of ovarian cancer have been limited by the inaccessible location of the ovary, the advanced stage of tumors available for analysis, and the lack of a well-defined precursor lesion. However, genetic alterations important in ovarian tumorigenesis have been identified recently. METHOD...

journal_title：Cancer

authors： Gallion HH,Pieretti M,DePriest PD,van Nagell JR Jr

更新日期：1995-11-15 00:00:00

abstract：BACKGROUND:Despite the widespread use of Papanicolaou (Pap) smear screening, substantial morbidity and mortality from cervical carcinoma continue in the U.S. Although access to screening is a major barrier to use of the Pap smear, invasive cervical carcinoma (ICC) still is observed in health plan members who have compr...

journal_title：Cancer

authors： Sung HY,Kearney KA,Miller M,Kinney W,Sawaya GF,Hiatt RA

更新日期：2000-05-15 00:00:00

abstract：BACKGROUND:Consumers increasingly consult the Internet for breast cancer information. Concerned about accuracy, multiple organizations developed quality criteria for online content. However, the effectiveness of these tools is unknown. The authors determined whether existing quality criteria can identify inaccurate bre...

journal_title：Cancer

authors： Bernstam EV,Walji MF,Sagaram S,Sagaram D,Johnson CW,Meric-Bernstam F

更新日期：2008-03-15 00:00:00

abstract：BACKGROUND:Angiotropic large cell lymphoma (ALCL) is characterized by the intravascular proliferation of malignant lymphoid cells in small and medium-sized blood vessels. In the current study, the authors report an unusual case in which the initial presentation of the ALCL was that of superior vena cava (SVC) syndrome....

journal_title：Cancer

authors： Savarese DM,Zavarin M,Smyczynski MS,Rohrer MJ,Hutzler MJ

更新日期：2000-12-15 00:00:00