Abstract:
:A case of multiple myeloma is described that contained two morphologically identical but immunologically diverse subpopulations. One of the subclones produced only kappa chains, whereas the other contained only gamma chains. Additional immunohistologic investigations revealed production by one of the subpopulations of defective gamma chains that were devoid of demonstrable Fd parts. It could not be decided whether this was due to a structural or an antigenetical defect. Furthermore, only the kappa-producing subclone exhibited J-chains. Based upon these findings and their possible cause and on respective findings concerning other B-cell neoplasias, it is concluded that the consequent application of an ever-increasing number of different immunologic markers, in order to better classify malignant lymphomas, will eventually result in the reverse, namely, in a complete breakup of this group of malignancies into individual cases.
journal_name
Cancerjournal_title
Cancerauthors
Metz K,Leder LDdoi
10.1002/1097-0142(19850915)56:6<1392::aid-cncr2820subject
Has Abstractpub_date
1985-09-15 00:00:00pages
1392-5issue
6eissn
0008-543Xissn
1097-0142journal_volume
56pub_type
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