The value of fine-needle aspiration biopsy in the differential diagnosis of adult myxoid sarcoma.

Abstract:

BACKGROUND:The usefulness of fine-needle aspiration biopsy (FNAB) for the histologic subtyping of specific sarcomas still is somewhat controversial but is becoming increasingly popular in the U.S. METHODS:To determine the accuracy and usefulness of FNAB in the differential diagnosis of myxoid sarcoma, the authors retrospectively reviewed 18 FNAB specimens (16 primary tumors, 1 local recurrence, and 1 metastasis) in 18 patients. The study sample included myxoid/round cell liposarcoma in six patients, myxofibrosarcoma in six patients, myxoid chondrosarcoma in five patients, and myxoid leiomyosarcoma in one patient. RESULTS:All but one tumor were recognized correctly as malignant. With regard to primary tumors, a specific cytologic diagnosis was rendered in 13 of 16 patients (81%). Problematic areas included the diagnosis of high grade myxofibrosarcoma with minimal amounts of myxoid stroma, myxoid liposarcoma with a predominant round cell component, and the single case of myxoid leiomyosarcoma. CONCLUSIONS:FNAB represents a valuable diagnostic tool for the differential diagnosis of myxoid sarcoma, especially myxofibrosarcoma, low grade myxoid liposarcoma, and myxoid chondrosarcoma. Due to its prognostic and therapeutic significance, the presence of a predominant round cell component in myxoid liposarcoma should be documented adequately. Other sarcomas (e.g., leiomyosarcoma) rarely may exhibit a prominent myxoid stroma and therefore should be considered in the differential diagnosis of adult myxoid sarcoma.

journal_name

Cancer

journal_title

Cancer

authors

Kilpatrick SE,Ward WG,Bos GD

doi

10.1002/1097-0142(20000625)90:3<167::aid-cncr5>3.0

subject

Has Abstract

pub_date

2000-06-25 00:00:00

pages

167-77

issue

3

eissn

0008-543X

issn

1097-0142

pii

10.1002/1097-0142(20000625)90:3<167::AID-CNCR5>3.0

journal_volume

90

pub_type

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