Abstract:
:A fatal massive hepatic necrosis with widespread thrombotic occlusion of the small hepatic veins developed in two of 68 patients treated with DTIC for advanced melanoma in a randomized study. Thirteen similar reactions, in patients treated with single-agent DTIC, are reported in the literature. Several clinical and pathologic features distinguish this DTIC toxicity from Budd-Chiari syndrome and veno-occlusive disease (both well-known types of possibly drug-related hepatic vascular disease) and make it a distinctive syndrome. We were impressed by the repeated occurrence of this complication in a relatively small set of patients, in contrast with the rarity of the literature reports. We suggest that this dramatic complication could occur more frequently than commonly thought. Therefore, caution should be used with DTIC, particularly in curable patients.
journal_name
Cancerjournal_title
Cancerauthors
Ceci G,Bella M,Melissari M,Gabrielli M,Bocchi P,Cocconi Gdoi
10.1002/1097-0142(19880515)61:10<1988::aid-cncr282subject
Has Abstractpub_date
1988-05-15 00:00:00pages
1988-91issue
10eissn
0008-543Xissn
1097-0142journal_volume
61pub_type
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