The role of serum CEA as a prognostic indicator in stage II and III breast cancer patients treated with adjuvant chemotherapy.

Abstract:

:Carcinoembryonic antigen (CEA) values in 529 patients treated in two consecutive adjuvant chemotherapy protocols were analyzed to determine if CEA values correlated with disease-free status or prognostic utility. CEA values were evaluated preoperatively, before chemotherapy, at the conclusion of chemotherapy, and during postchemotherapy followup. The sensitivity of CEA for predicting disease recurrence was low; however, any abnormal CEA at the conclusion of chemotherapy and during followup significantly correlated with reduced disease-free and overall survival. A CEA value greater than or equal to 20 ng/ml at the end of chemotherapy or during followup was highly specific and a strongly positive predictor for the presence of metastases. Abnormal CEA values before chemotherapy that became normal at the conclusion of chemotherapy were associated with a significantly reduced recurrence rate. An abnormal CEA value obtained before or after adjuvant chemotherapy is clinically useful and can provide prognostic information.

journal_name

Cancer

journal_title

Cancer

authors

Theriault RL,Hortobagyi GN,Fritsche HA,Frye D,Martinez R,Buzdar AU

doi

10.1002/1097-0142(19890301)63:5<828::aid-cncr28206

subject

Has Abstract

pub_date

1989-03-01 00:00:00

pages

828-35

issue

5

eissn

0008-543X

issn

1097-0142

journal_volume

63

pub_type

杂志文章

相关文献

CANCER文献大全
  • Impact of the coronavirus disease 2019 (COVID-19) pandemic on pediatric oncology care in the Middle East, North Africa, and West Asia region: A report from the Pediatric Oncology East and Mediterranean (POEM) group.

    abstract:BACKGROUND:Childhood cancer is a highly curable disease when timely diagnosis and appropriate therapy are provided. A negative impact of the coronavirus disease 2019 (COVID-19) pandemic on access to care for children with cancer is likely but has not been evaluated. METHODS:A 34-item survey focusing on barriers to ped...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.33075

    authors: Saab R,Obeid A,Gachi F,Boudiaf H,Sargsyan L,Al-Saad K,Javakhadze T,Mehrvar A,Abbas SS,Abed Al-Agele YS,Al-Haddad S,Al Ani MH,Al-Sweedan S,Al Kofide A,Jastaniah W,Khalifa N,Bechara E,Baassiri M,Noun P,El-Houdzi J,K

    更新日期:2020-09-15 00:00:00

  • Adjuvant immunotherapy and chemoimmunotherapy in colorectal cancer (Dukes' class C): prolongation of disease-free interval and survival.

    abstract::The poor postsurgical prognosis in patients with colorectal cancer of the Dukes' C classification has prompted a clinical trial of adjuvant immunotherapy versus chemoimmunotherapy intended to prolong either the disease-free interval or the overall survival or both. One hundred and twenty-one patients have been entered...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197711)40:5+<2726::aid-cncr28204

    authors: Mavligit GM,Gutterman JU,Malahy MA,Burgess MA,McBride CM,Jubert A,Hersh EM

    更新日期:1977-11-01 00:00:00

  • Disappearance of the predictive value of prognostic variables in childhood acute lymphoblastic leukemia: a report from Childrens Cancer Study Group.

    abstract::The identification of important prognostic factors at diagnosis of childhood leukemia has been very useful in explaining the marked differences in disease outcome. After a complete remission is achieved, it is interesting to determine whether the ability to maintain a complete remission and the patient's survival cont...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19810715)48:2<370::aid-cncr28204

    authors: Sather H,Coccia P,Nesbit M,Level C,Hammond D

    更新日期:1981-07-15 00:00:00

  • Fatal hepatic vascular toxicity of DTIC. Is it really a rare event?

    abstract::A fatal massive hepatic necrosis with widespread thrombotic occlusion of the small hepatic veins developed in two of 68 patients treated with DTIC for advanced melanoma in a randomized study. Thirteen similar reactions, in patients treated with single-agent DTIC, are reported in the literature. Several clinical and pa...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19880515)61:10<1988::aid-cncr282

    authors: Ceci G,Bella M,Melissari M,Gabrielli M,Bocchi P,Cocconi G

    更新日期:1988-05-15 00:00:00

  • Central neurocytomas express photoreceptor differentiation.

    abstract:BACKGROUND:Central neurocytomas are composed of mature neuronal elements, frequently arranged in rosettes similar to those present in pineocytomas. This suggests the possibility of similar patterns of differentiation, including photoreceptor differentiation. The authors analyzed the immunoreactivity of central neurocyt...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:

    authors: Mena H,Morrison AL,Jones RV,Gyure KA

    更新日期:2001-01-01 00:00:00

  • Humoral immunity to herpes simplex viral-induced antigens in smokers.

    abstract::Antibodies to herpes simplex viral-induced antigens (HSVIA) were assayed by an indirect immunofluorescent technique in 93 regular cigarette smokers, 75 of whom also imbibed alcoholic beverages. Controls were 94 nonsmoking, nondrinking volunteers matched with the smoker for age and sex. IgA antibodies to HSVIA were det...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197609)38:3<1155::aid-cncr282038

    authors: Smith HG,Horowitz N,Silverman NA,Henson DE,Chretien PB

    更新日期:1976-09-01 00:00:00

  • Radiation recall dermatitis and pneumonitis in a patient treated with paclitaxel.

    abstract:BACKGROUND:Radiation recall refers to a tissue reaction produced by a chemotherapeutic agent in a previously irradiated field that would not occur in a nonirradiated field. A number of agents have been reported to cause radiation recall. Recently, there have been case reports of recall dermatitis from paclitaxel treatm...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19950915)76:6<1069::aid-cncr2820

    authors: Schweitzer VG,Juillard GJ,Bajada CL,Parker RG

    更新日期:1995-09-15 00:00:00

  • Relationship of inherent resistance to doxorubicin, proliferative activity and expression of P-glycoprotein 170, and glutathione S-transferase-pi in human lung tumors.

    abstract:BACKGROUND:This study analyzed whether proliferative activity and expression of P-glycoprotein 170 (P-170) or glutathione S-transferase-pi (GST-pi) in human non-small cell lung carcinomas (NSCLC) represent independent factors in resistance to doxorubicin or whether an association exists between these factors. METHODS:...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19920815)70:4<764::aid-cncr28207

    authors: Volm M,Mattern J,Samsel B

    更新日期:1992-08-15 00:00:00

  • Carcinoembryonic antigen (CEA) levels in benign gastrointestinal disease states.

    abstract::Elevated circulating CEA levels occur in patients with benign gastrointestinal and hepatic disorders. These are usually less than 10 ng/ml. Of clinical importance is the influence of liver disease on the interpretation of CEA. At least 50% of patients with severe benign hepatic disease have elevated CEA levels, most o...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/1097-0142(197809)42:3+<1412::aid-cncr28204

    authors: Loewenstein MS,Zamcheck N

    更新日期:1978-09-01 00:00:00

  • Young age and outcome for women with early-stage invasive breast carcinoma.

    abstract:BACKGROUND:Patients with invasive breast carcinoma who are ages 35-40 years or younger at the time of diagnosis have been found in several studies to have worse prognosis and higher local failure rates after breast-conserving therapy (BCT) compared with older patients. However, it is uncertain whether specific clinical...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/cncr.20523

    authors: Zhou P,Recht A

    更新日期:2004-09-15 00:00:00

  • Racial and Ethnic Disparities in Travel for Head and Neck Cancer Treatment and the Impact of Travel Distance on Survival.

    abstract:BACKGROUND:Patients who travel a long distance (≥50 miles) for cancer care have improved outcomes. However, to the authors' knowledge, the prevalence of long travel distances for treatment by patients with head and neck squamous cell carcinoma (HNSCC), and the effect of travel distance on overall survival (OS), remains...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.31571

    authors: Graboyes EM,Ellis MA,Li H,Kaczmar JM,Sharma AK,Lentsch EJ,Day TA,Hughes Halbert C

    更新日期:2018-08-01 00:00:00

  • Imaging at diagnosis impacts cancer-specific survival among patients with cancer of the oropharynx.

    abstract:BACKGROUND:The optimal imaging for the staging of oropharyngeal cancer is not well defined. METHODS:The linked Surveillance, Epidemiology, and End Results (SEER)-Medicare database for 2006 through 2011 was used to compare patient characteristics and hospital region by the initial imaging modality used for patients wit...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.32148

    authors: Morgan RL,Eguchi MM,Mueller AC,Daugherty SL,Amini A,Karam SD

    更新日期:2019-08-15 00:00:00

  • Risk of venous thromboembolism in patients with non-Hodgkin lymphoma surviving blood or marrow transplantation.

    abstract:BACKGROUND:Patients with non-Hodgkin lymphoma (NHL) have an increased risk of venous thromboembolism (VTE), particularly when they are receiving treatment. Blood or marrow transplantation (BMT) is recommended for relapsed/refractory NHL, and the risk of VTE after these patients undergo BMT is uncertain. METHODS:Patien...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.32488

    authors: Gangaraju R,Chen Y,Hageman L,Wu J,Francisco L,Kung M,Ness E,Parman M,Weisdorf DJ,Forman SJ,Arora M,Armenian SH,Bhatia S

    更新日期:2019-12-15 00:00:00

  • Bladder cancer etiology. A different perspective.

    abstract::The descriptive epidemiologic features of bladder cancer and lung cancer in Los Angeles County were studied for the period 1972-1976, using data from the Los Angeles County/University of Southern California Cancer Surveillance Program. The incidence pattern for bladder cancer was found to differ markedly from the patt...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19830215)51:4<675::aid-cncr28205

    authors: Weinberg DM,Ross RK,Mack TM,Paganini-Hill A,Henderson BE

    更新日期:1983-02-15 00:00:00

  • Mammographically detected recurrent nonpalpable carcinoma developing in a transverse rectus abdominus myocutaneous flap. A case report.

    abstract:BACKGROUND:Breast reconstruction is performed with increasing frequency and has become important in the treatment of mastectomy patients. METHODS:The development of recurrent carcinoma after a mastectomy and transverse rectus abdominus myocutaneous (TRAM) flap procedure is described. RESULTS:The lesion was nonpalpabl...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19941115)74:10<2804::aid-cncr282

    authors: Mund DF,Wolfson P,Gorczyca DP,Fu YS,Love SM,Bassett LW

    更新日期:1994-11-15 00:00:00

  • Hypoxic radiosensitizers in radical radiotherapy for patients with bladder carcinoma: hyperbaric oxygen, misonidazole, and accelerated radiotherapy, carbogen, and nicotinamide.

    abstract:BACKGROUND:In animal models carbogen (normobaric 95% oxygen, 5% carbon dioxide) provides significant enhancement of local tumor control with fractionated radiotherapy. This approach to radiosensitization has been evaluated in the treatment of patients with bladder carcinoma using radical radiotherapy. METHODS:Sixty-on...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Hoskin PJ,Saunders MI,Dische S

    更新日期:1999-10-01 00:00:00

  • Significance of estrogen and progesterone receptors, disease-free interval, and site of first metastasis on survival of breast cancer patients.

    abstract::Estrogen and progesterone receptors (ER/PR) were measured in primary tumors and metastases of 397 breast cancer patients. Survival following mastectomy was significantly longer in patients with ER and PR positive tumors, as was survival after first recurrence. The prognostic value of ER and PR was compared with such c...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19851001)56:7<1696::aid-cncr2820

    authors: Alanko A,Heinonen E,Scheinin T,Tolppanen EM,Vihko R

    更新日期:1985-10-01 00:00:00

  • I. Carcinoma of the rectum and rectosigmoid: cancer specific long-term survival. A series of 1061 cases treated by one surgeon.

    abstract::The long-term cancer specific survival based on individual follow-up and analysis of prospectively collected data from 1061 patients undergoing resection for carcinoma of the rectum is presented. All patients were operated on and managed by one surgeon. Survival data for 978 cases were analyzed according to the method...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19800601)45:11<2902::aid-cncr282

    authors: Pihl E,Hughes ES,McDermott FT,Milne BJ,Korner JM,Price AB

    更新日期:1980-06-01 00:00:00

  • Mitomycin C combination therapy against murine tumor systems. Effectiveness with cyclophosphamide and methotrexate.

    abstract::Mitomycin C (MMC) has been evaluated in combination with several antitumor agents. Full dose response curves were established for all drugs and drug combinations. Synergy was shown with MMC plus either cyclophosphamide (CYC) or methotrexate (MTX). In testing MMC and CYC against P388 leukemia, the combined treatment yi...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19830215)51:4<600::aid-cncr28205

    authors: Mabel JA,Wodinsky I

    更新日期:1983-02-15 00:00:00

  • The equivalence and difference between the English and Chinese versions of two major, cancer-specific, health-related quality-of-life questionnaires.

    abstract:BACKGROUND:English and Chinese are two of the most widely used primary languages in the world. Patients in many cancer centers have a variety of ethnic backgrounds and primary languages. The comparability of version 4 of the English and Chinese versions of the Functional Assessment of Cancer Therapy-General (FACT-G) an...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.20681

    authors: Cheung YB,Thumboo J,Goh C,Khoo KS,Che W,Wee J

    更新日期:2004-12-15 00:00:00

  • Intracerebral delayed hypersensitivity reactions in glioblastoma multiforme patients.

    abstract::Patients with malignant gliomas who had undergone BCG inoculation were injected intratumorally with PPD to induce an intratumoral delayed hypersensitivity reaction. Histopathological examination of the tumor before and after PPD injections revealed that chronic inflammatory responses were increased after injection in ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197703)39:3<1331::aid-cncr282039

    authors: Albright L,Seab JA,Ommaya AK

    更新日期:1977-03-01 00:00:00

  • Preoperative chemotherapy for osteogenic sarcoma: selection of postoperative adjuvant chemotherapy based on the response of the primary tumor to preoperative chemotherapy.

    abstract::Since June 1978, 57 patients with primary osteogenic sarcoma of an extremity were treated with high-dose methotrexate (HDMTX) and citrovorum factor rescue (CFR), Adriamycin, and the combination of bleomycin, cyclophosphamide and dactinomycin (BCD) given for 4-16 weeks prior to definitive surgery. Histologic examinatio...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19820315)49:6<1221::aid-cncr2820

    authors: Rosen G,Caparros B,Huvos AG,Kosloff C,Nirenberg A,Cacavio A,Marcove RC,Lane JM,Mehta B,Urban C

    更新日期:1982-03-15 00:00:00

  • Radiotherapy or surgery for head and neck squamous cell cancer: establishing the baseline for hypopharyngeal carcinoma?

    abstract:BACKGROUND:The authors compared the survival outcomes of radiotherapy+/-salvage surgery to surgery+/-postoperative radiotherapy for patients with squamous cell cancer of the hypopharynx. There was no evidence beyond observational studies and no consensus on the which treatment is most effective for this patient group. ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.24635

    authors: Hall SF,Groome PA,Irish J,O'Sullivan B

    更新日期:2009-12-15 00:00:00

  • Assessment of quality of survival in children with medulloblastoma and cerebellar astrocytoma.

    abstract::To determine the quality of survival for children with posterior fossa tumors, comprehensive neuropsychological, behavioral, and academic assessment and physician ratings of functional status were obtained on 15 brain tumor patients (ages 6-19 years) at a median of 20 months post-diagnosis. More than 50% of the childr...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19880915)62:6<1215::aid-cncr2820

    authors: LeBaron S,Zeltzer PM,Zeltzer LK,Scott SE,Marlin AE

    更新日期:1988-09-15 00:00:00

  • Techniques and predictive models to improve prostate cancer detection.

    abstract::The use of prostate-specific antigen (PSA) as a screening test remains controversial. There have been several attempts to refine PSA measurements to improve its predictive value. These modifications, including PSA density, PSA kinetics, and the measurement of PSA isoforms, have met with limited success. Therefore, com...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.24357

    authors: Herman MP,Dorsey P,John M,Patel N,Leung R,Tewari A

    更新日期:2009-07-01 00:00:00

  • Effectiveness of once weekly total skin electron beam therapy in mycosis fungoides and Sezary syndrome.

    abstract::During the past eight years, 137 patients with mycosis fungoides were given total skin electron beam therapy (TSEB) using 2.5 to 4 MeV electrons. A single treatment delivers 400 rads to the entire skin surface, and patients are treated once a week for six to eight consecutive weeks. All have been followed for a median...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19810301)47:5<870::aid-cncr28204

    authors: Nisce LZ,Safai B,Kim JH

    更新日期:1981-03-01 00:00:00

  • Effect of the potent aromatase inhibitor fadrozole hydrochloride (CGS 16949A) in postmenopausal women with breast carcinoma.

    abstract:BACKGROUND:Fadrozole hydrochloride (CGS 16949A) is a highly potent, nonsteroidal aromatase inhibitor that significantly lowers estrogen levels in postmenopausal women and can be effective therapy for patients with advanced hormone-dependent breast carcinoma. Circulating estradiol, estrone, and estrone sulfate are reduc...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0142(19990101)85:1<100::aid-cnc

    authors: Costa LA,Kopreski MS,Demers LM,Chinchilli VM,Santen RJ,Harvey HA,Lipton A

    更新日期:1999-01-01 00:00:00

  • Current status of the treatment of epidermoid cancer of the vulva.

    abstract::Epidermoid cancer accounts for 81% of the malignancies of the vulva. Although the etiology has not been delineated, chronic vulvitis is associated with cancer in almost one-third of the patients. The staging system should utilize the most precise and accurate parameters delineated for improved treatment. A new staging...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197607)38:1<587::aid-cncr2820380

    authors: Krupp P,Bohm JW,Lee FY,Collins JH

    更新日期:1976-07-01 00:00:00

  • Randomized controlled study of chemoimmunotherapy of acute myelogenous leukemia (AML) in adults with Nocardia rubra cell-wall skeleton and irradiated allogeneic AML cells.

    abstract::The effect of immunotherapy with Nocardia rubra cell-wall skeleton (N-CWS) on remission duration and survival of adults with acute myelogenous leukemia (AML) was studied in a prospective randomized controlled study. After having been induced into complete remission and having been consolidated, 73 patients were random...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1002/1097-0142(19860415)57:8<1483::aid-cncr2820

    authors: Ohno R,Nakamura H,Kodera Y,Ezaki K,Yokomaku S,Oguma S,Kubota Y,Shibata H,Ogawa N,Masaoka T

    更新日期:1986-04-15 00:00:00

  • Interleukin-2-induced lung permeability is mediated by leukotriene B4.

    abstract::Interleukin (IL)-2 therapy leads to respiratory dysfunction due to increased vascular permeability. This study examines the role of the chemoattractant, immunomodulator, and permeability-promoting agent leukotriene (LT) B4 in this setting. Sheep with chronic lung lymph fistulae were given IL-2, 10(5) U/kg as an IV bol...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/1097-0142(19901201)66:11<2357::aid-cncr282

    authors: Klausner JM,Goldman G,Skornick Y,Valeri R,Inbar M,Shepro D,Hechtman HB

    更新日期:1990-12-01 00:00:00