Mitomycin C combination therapy against murine tumor systems. Effectiveness with cyclophosphamide and methotrexate.

abstract：BACKGROUND:Health insurance is a key mediator of health care disparities. Outcomes in bladder cancer, one of the costliest diseases to treat, may be especially sensitive to a patient's insurance status. METHODS:The Surveillance, Epidemiology, and End Results registry and the National Cancer Data Base were used to iden...

journal_title：Cancer

authors： Fletcher SA,Cole AP,Lu C,Marchese M,Krimphove MJ,Friedlander DF,Mossanen M,Kilbridge KL,Kibel AS,Trinh QD

更新日期：2020-02-01 00:00:00

abstract：:One hundred thirty-five hepatocellular carcinomas were examined for the presence of antigenic tumor markers by the avidin-biotin-peroxidase complex method. Ninety-seven were from the US and 38 came from Argentina. The following markers were tested: alpha-fetoprotein (AFP), alpha-1-antitrypsin (AAT), hepatitis B surfac...

journal_title：Cancer

authors： Chedid A,Chejfec G,Eichorst M,Villamil F,Terg R,Telenta M,Hojman R

更新日期：1990-01-01 00:00:00

abstract：BACKGROUND:Adjuvant radiation has been proposed for the treatment of patients with desmoplastic melanoma, who reportedly have local recurrence rates as high as 40-60%. The authors investigated local recurrence rates at a tertiary referral center to determine the success of wide excision alone for patients with desmopla...

journal_title：Cancer

authors： Arora A,Lowe L,Su L,Rees R,Bradford C,Cimmino VC,Chang AE,Johnson TM,Sabel MS

更新日期：2005-10-01 00:00:00

abstract：BACKGROUND:The advantage of whole-body imaging for distribution studies is that it accounts for all activities. The problem, however, is that the classic approach to determining distribution from planar images does not accommodate overlapping structures. That approach assumes implicitly that the sampling region is a pr...

journal_title：Cancer

authors： Goris ML,Knox SA,Nielsen KR,Bouillant O

更新日期：1994-02-01 00:00:00

abstract：BACKGROUND:Metastasectomy is standard of care for pediatric patients with metastatic sarcoma with limited disease. For patients with unresectable disease, stereotactic body radiotherapy (SBRT) may serve as an alternative. Herein, the authors report the results of a prospective, multi-institutional phase 2 trial of SBRT...

journal_title：Cancer

authors： Elledge CR,Krasin MJ,Ladra MM,Alcorn SR,Han P,Gibbs IC,Hiniker SM,Laack NN,Terezakis SA

更新日期：2020-11-10 00:00:00

abstract：BACKGROUND:Multiple early gastric carcinomas were found in 5-15% of patients with early gastric carcinoma. The goals of this study were to clarify the clinicopathologic features of multiple early gastric carcinomas and to investigate their histogenesis. METHODS:Of 724 patients with early gastric carcinoma, there were ...

journal_title：Cancer

authors： Isozaki H,Okajima K,Hu X,Fujii K,Sako S

更新日期：1996-11-15 00:00:00

abstract：:Interleukin-6 (IL-6) plays a major role in the response to injury or infection and is involved in the immune response, inflammation, and hematopoiesis. Its deregulation impacts numerous disease states, including many types of cancer. Consequently, modulating IL-6 may be an innovative therapeutic strategy in several di...

journal_title：Cancer

authors： Hong DS,Angelo LS,Kurzrock R

更新日期：2007-11-01 00:00:00

abstract：BACKGROUND:African Americans are diagnosed more frequently with colorectal carcinoma at a later stage compared with Caucasians. One potential reason for the disparity is a lower rate of screening examinations. METHODS:Using Outpatient and Physician-Supplier claims for all Medicare beneficiaries age > or = 65 years in ...

journal_title：Cancer

authors： Cooper GS,Koroukian SM

更新日期：2004-01-15 00:00:00

abstract：:The various radiologic methods used in the detection of hepatic lesions in the oncologic patient are discussed. The advantages and disadvantages of each imaging technique as well as a new diagnostic approach are also discussed. With the rapid technological advances made in cross-sectional imaging, the authors believe ...

journal_title：Cancer

authors： Bernardino ME,Lewis E

更新日期：1982-12-01 00:00:00

abstract：BACKGROUND:This case-referent study was conducted to elucidate the role of selected exogenous agents in the etiology of head and neck cancer. The factors studied were tobacco smoking, alcohol intake, the use of moist oral snuff, dietary factors, occupational exposures, and oral hygiene. In this first report, the author...

journal_title：Cancer

authors： Lewin F,Norell SE,Johansson H,Gustavsson P,Wennerberg J,Biörklund A,Rutqvist LE

更新日期：1998-04-01 00:00:00

abstract：:Prostate cancer is the most common male malignancy and the second or third leading cause of cancer death among men in the West. The descriptive epidemiology of prostate cancer suggests that it is a preventable disease. Prevention has the theoretical advantage of not only saving lives, but also reduce the morbidity of ...

journal_title：Cancer

authors： Fleshner N,Zlotta AR

更新日期：2007-11-01 00:00:00

abstract：BACKGROUND:The prognostic relevance of activated oncogenes and oncoproteins has not been well studied in papillary thyroid cancer, which is slow-growing, with only regional spread in most cases. Therefore, the influence of some protein markers and tumor cell proliferation on disease progress in a series of patients wit...

journal_title：Cancer

authors： Akslen LA,Varhaug JE

更新日期：1995-11-01 00:00:00

abstract：:Review of the consultation records of the Gastrointestinal Surgical Oncology service at Roswell Park Memorial Institute from 1982 to 1987 revealed 22 patients with a clinical diagnosis of neutropenic enterocolitis. Ninety-one percent of the patients had hematologic malignancies, and 95% were receiving cytotoxic chemot...

journal_title：Cancer

authors： Wade DS,Nava HR,Douglass HO Jr

更新日期：1992-01-01 00:00:00

abstract：:A 17-year-old girl was operated for a solitary well-circumscribed pulmonary parenchymal tumor and reoperated ten times for multiple recurrent similar pulmonary tumors during 24 years. Histologic examination revealed the so-called intravascular bronchioloalveolar tumor (IVBAT) in all instances. The patient died from pn...

journal_title：Cancer

authors： Miettinen M,Collan Y,Halttunen P,Maamies T,Vilkko P

更新日期：1987-11-15 00:00:00

abstract：:A tumor colony assay (TCA) was evaluated for its ability to predict anticancer drug responses in an N-[4-(5-nitro-2-furyl)-2-thiazolyl]-formamide (FANFT)-induced murine bladder tumor (MBT) model. Ten anticancer drugs were evaluated in vivo and in vitro using four MBT cell lines (40 drug responses). Using the optimum c...

journal_title：Cancer

authors： Niell HB,Soloway MS,Wood CA,McCallum LW,Webster K

更新日期：1983-08-15 00:00:00

abstract：:Interleukin-2 (IL2) is essential for the expansion of antigen-triggered lymphocytes and cytotoxic T-cells, processes necessary for tumor control that are frequently depressed in malignancy. The authors measured certain aspects of IL2 function in cancer patients and controls and correlated the findings with the general...

journal_title：Cancer

authors： Wanebo HJ,Pace R,Hargett S,Katz D,Sando J

更新日期：1986-02-01 00:00:00

abstract：:Because Forssman antigen, one of the most well-known heteroantigens, has been noted in certain cancerous tissues, it would seem that the serum levels of the Forssman antibody of patients with these cancers would be low, owing to the absorption of the naturally occurring antibody by the Forssman antigen-containing canc...

journal_title：Cancer

authors： Hirayama R,Hirokawa K,Takagi Y,Utsuyama M,Maejima S,Takemura K,Mishima Y,Makinodan T

更新日期：1989-04-15 00:00:00

abstract：:In a pathologic review of 1224 cases of endometrial carcinoma, 1023 were confirmed cases of endometrial carcinoma. Fifty-six (5.5%) were clear-cell adenocarcinoma (CCE). Fifteen cases of "secretory carcinoma" (SCE) were examined for comparison. Fifty-five patients with CCE and all with SCE were followed for at least f...

journal_title：Cancer

authors： Christopherson WM,Alberhasky RC,Connelly PJ

更新日期：1982-04-15 00:00:00

abstract：BACKGROUND:Primary T-cell lymphomas of the central nervous system are uncommon neoplasms. METHODS:A case of a primary central nervous system T-cell lymphoma in a 66-year-old female who died 8 months after surgery is described. The biopsy specimen was evaluated by routine histology, immunohistochemistry, flow cytometry...

journal_title：Cancer

authors： Novak JA,Katzin WE

更新日期：1995-04-15 00:00:00

abstract：:A previously unreported association of Brenner and adenomatoid tumor found in the tunica vaginalis testis is presented. Many ultrastructural features found in mesothelial cells such as intercellular spaces, deeply indented nuclei, tonofilaments and tight desmosomes, were also shared by cells present in both neoplastic...

journal_title：Cancer

authors： Nogales FF Jr,Matilla A,Ortega I,Alvarez T

更新日期：1979-02-01 00:00:00

abstract：BACKGROUND:Brain metastases from soft tissue sarcoma (STS) are uncommon. To the authors' knowledge limited information is available regarding the influence of the initial STS site, the significance of parenchymal versus leptomeningeal metastases, and the role of surgical resection. METHODS:STS patients evaluated betwe...

journal_title：Cancer

authors： Espat NJ,Bilsky M,Lewis JJ,Leung D,Brennan MF

更新日期：2002-05-15 00:00:00

abstract：:To evaluate the utility of nuclear morphometry as a prognostic indicator in lung cancer, 5-year follow-up information was obtained in 46 cases of surgically resected Stage I non-small cell lung cancer (NSCLC). Nuclear area, perimeter, major diameter, minor diameter, and nuclear shape factor were determined from repres...

journal_title：Cancer

authors： Cagle PT,Langston C,Fraire AE,Roggli VL,Greenberg SD

更新日期：1992-05-15 00:00:00

abstract：BACKGROUND:Studies evaluating the efficacy of routine follow-up testing in detecting disease recurrence in treated lung carcinoma patients are lacking. METHODS:To investigate this subject, the authors studied 115 patients who had previously been entered on North Central Cancer Treatment Group (NCCTG) small cell lung c...

journal_title：Cancer

authors： Perez EA,Loprinzi CL,Sloan JA,Owens DT,Novotny PJ,Bonner JA

更新日期：1997-08-15 00:00:00

abstract：BACKGROUND:Although >70% of younger women with nonmetastatic breast cancer (BC) received adjuvant chemotherapy, only approximately 15% to 20% of elderly women with BC received chemotherapy. The decision to treat may be associated with nonmedical factors, such as patient, physician, or practice characteristics. In the c...

journal_title：Cancer

authors： Hershman DL,Buono D,McBride RB,Tsai WY,Neugut AI

更新日期：2009-09-01 00:00:00

abstract：BACKGROUND:There are currently no systemic treatments for stage IV melanoma, which have been proven in randomized trials to benefit overall survival (OS). Lenalidomide has efficacy against melanoma in animal models and safety in phase 1 trials. The authors reported the results of a phase 2/3 study comparing the safety ...

journal_title：Cancer

authors： Glaspy J,Atkins MB,Richards JM,Agarwala SS,O'Day S,Knight RD,Jungnelius JU,Bedikian AY

更新日期：2009-11-15 00:00:00

abstract：:Glucocorticoid and progesterone receptors, tyrosine aminotransferase, gamma-glutamyltransferase and alpha-fetoprotein levels were determined in human hepatocellular carcinoma (HCC) and adjacent liver tissues. Glucocorticoid receptor was present in seven of ten HCC samples, values ranged from 1.9 to 66.8 fmol/mg protei...

journal_title：Cancer

authors： P'eng FK,Lui WY,Chang TJ,Kao HL,Wu LH,Liu TY,Chi CW

更新日期：1988-11-15 00:00:00

abstract：BACKGROUND:This study was performed to develop a sensitive method for the detection of circulating hepatocellular carcinoma (HCC) cells in peripheral blood, in advance of the diagnosis of distant metastasis of HCC by conventional means. METHODS:Peripheral blood (5 ml) samples were obtained from 64 patients with HCC an...

journal_title：Cancer

authors： Komeda T,Fukuda Y,Sando T,Kita R,Furukawa M,Nishida N,Amenomori M,Nakao K

更新日期：1995-05-01 00:00:00

abstract：BACKGROUND:Inactivation of the PTEN suppressor gene has been shown to occur in the majority of endometrial cancer cases. Somatic PTEN inactivation by deletion and/or mutation, the first detectible change of endometrial carcinogenesis, has been reported to occur at a high frequency in the endometrium of normal premenopa...

journal_title：Cancer

authors： Lin MC,Burkholder KA,Viswanathan AN,Neuberg D,Mutter GL

更新日期：2009-05-15 00:00:00

abstract：:The expression of the Thomsen-Friedenreich antigen (T-antigen) in normal and neoplastic urothelium was investigated using paraffin-processed and fresh frozen tissue sections obtained by biopsy from 56 patients. The T-antigen was detected through its binding to the peanut agglutinin (PNA) with two methods: a biotin-avi...

journal_title：Cancer

authors： Limas C,Lange P

更新日期：1986-09-15 00:00:00

abstract：:Major advances have been made in melanoma treatment with the use of molecularly targeted therapies and immunotherapies, and numerous regimens are now approved by the US Food and Drug Administration for patients with stage IV disease. However, therapeutic resistance remains an issue to both classes of agents, and relia...

journal_title：Cancer

authors： Szczepaniak Sloane RA,Gopalakrishnan V,Reddy SM,Zhang X,Reuben A,Wargo JA

更新日期：2017-06-01 00:00:00