Abstract:
BACKGROUND:Studies evaluating the efficacy of routine follow-up testing in detecting disease recurrence in treated lung carcinoma patients are lacking. METHODS:To investigate this subject, the authors studied 115 patients who had previously been entered on North Central Cancer Treatment Group (NCCTG) small cell lung carcinoma clinical trials, had achieved a complete response after chemotherapy/radiotherapy treatment, and subsequently developed disease progression. The authors included 58 patients with limited stage and 57 patients with extensive stage disease. Follow-up testing on these clinical trials was scheduled at 4-month intervals in the first year and every 6 months thereafter. At each visit, testing included a clinical history, physical examination, chest X-ray, chemistry group, and hematology group. Patients' records were evaluated to determine the first test(s) to identify disease recurrence, whether the recurrence was diagnosed at the time of routine follow-up or between scheduled follow-up evaluations, the sites of recurrence, and patient outcome. RESULTS:Recurrences occurred in 56 patients (49%) in the first follow-up year, 51 (44%) in the second year, and 8 (7%) after 2 years. Recurrences were signaled by clinical histories in 71% of patients, by physical examinations in 10%, chest X-rays in 12%, and abnormal chemistry testing in 6%. Although 41% of recurrences were detected at scheduled clinical visits, 59% of patients had disease recurrence signaled by symptoms that prompted interval visits between scheduled appointments. At last follow-up, all the patients in this study had died (median survival, 115 days [range, 1-793 days] after diagnosis of recurrence), supporting the lack of curative therapy for patients with recurrent small cell lung carcinoma. CONCLUSIONS:These data, demonstrating that clinical histories and physical examinations are the most fruitful means of detecting evidence of recurrent lung carcinoma, are consistent with data regarding the follow-up of other curatively treated cancers, such as breast carcinoma and melanoma. Chest X-rays in asymptomatic patients detect recurrences in a small proportion of patients, whereas routine blood tests appear to be of little value.
journal_name
Cancerjournal_title
Cancerauthors
Perez EA,Loprinzi CL,Sloan JA,Owens DT,Novotny PJ,Bonner JAsubject
Has Abstractpub_date
1997-08-15 00:00:00pages
676-80issue
4eissn
0008-543Xissn
1097-0142pii
10.1002/(SICI)1097-0142(19970815)80:4<676::AID-CNCjournal_volume
80pub_type
杂志文章相关文献
CANCER文献大全abstract::Reported are six cases of meningocerebral astrocytomas attached to dura, involving the superficial cortex, in infants under 1 year of age. They represent 1.25% of 483 intracranial tumors in infancy studied at the Children's Hospital in the last 12 years. Five were located in the frontal lobes, with variable extension ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19841201)54:11<2505::aid-cncr282
更新日期:1984-12-01 00:00:00
abstract::This clinicopathologic study concerns 27 cases of "dedifferentiated" soft tissue sarcoma (DSTS), including 14 liposarcomas, six leiomyosarcomas, five chondrosarcomas, and two rhabdomyosarcomas. In addition, the authors conducted an immunohistochemical survey of 23 cases and an electron microscopic examination of three...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19901001)66:7<1578::aid-cncr2820
更新日期:1990-10-01 00:00:00
abstract::The records of 98 children with suprasellar tumors treated between 1950 and 1975, at Columbia-Presbyterian Medical Center, were reviewed. Most of the children with germ cell tumors or posterior chiasmal gliomas irradiated with 5000 rad in six weeks using extended field, children with craniopharyngiomas treated with to...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19821001)50:7<1420::aid-cncr2820
更新日期:1982-10-01 00:00:00
abstract:BACKGROUND:Patients' estimates of their chances of therapeutic benefit from participation in early phase trials greatly exceed historical data. Ethicists worry that this therapeutic misestimation undermines the validity of informed consent. METHODS:The authors interviewed 45 patients enrolled in phase 1 or 2 oncology ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.25201
更新日期:2010-08-01 00:00:00
abstract:BACKGROUND:The purpose of the current study was to examine the surgical management of women with borderline ovarian tumors and the adequacy of initial staging according to the guidelines of the International Federation of Gynecology and Obstetrics; to evaluate the impact of restaging operations; and to identify risk fa...
journal_title:Cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/cncr.20098
更新日期:2004-03-15 00:00:00
abstract:BACKGROUND:In late reproductive-aged breast cancer survivors, there is a need for real-time biomarkers of postchemotherapy ovarian function. The objective was to determine whether antimullerian hormone (AMH) and inhibin B are such biomarkers. The authors tested whether AMH and inhibin B were impacted by breast cancer t...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.24746
更新日期:2010-02-01 00:00:00
abstract::A retrospective study was done of all patients who were seen for definitive treatment of adenocarcinoma of the pancreas at the Massachusetts General Hospital from 1963 to 1973. There were a total of 145 patients. Thirty-one patients were treated with radical surgery, with a 16% operative mortality, a 5-year crude surv...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197603)37:3<1519::aid-cncr282037
更新日期:1976-03-01 00:00:00
abstract:BACKGROUND:Radiotherapy with its advantage of organ preservation has been used to treat laryngeal cancer (LC) for several decades. However, the impact of radiation on overall survival (OS) in a large population-based study has not been evaluated to date. METHODS:The authors analyzed all patients who had localized and/...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.26357
更新日期:2012-03-01 00:00:00
abstract::Gonadal dosimetry and spermatogenic activity was monitored in patients given radiation therapy (RT) after unilateral orchiectomy for seminoma. The RT given was, with minor variations, 3200 rad in 16 fractions in four weeks to the para-aortic and ipsilateral pelvic inguinal lymphatics in order to include the orchiectom...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19820715)50:2<337::aid-cncr28205
更新日期:1982-07-15 00:00:00
abstract::Fifteen patients with acute nonlymphocytic leukemia (ANLL) who either had a relapse after a previous complete remission (nine patients) or progressive disease after initial induction attempts with combination chemotherapy (six patients) were treated with 5-azacytidine. Five patients (33%) achieved a complete remission...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19820601)49:11<2222::aid-cncr282
更新日期:1982-06-01 00:00:00
abstract:BACKGROUND:There is accumulating evidence that galanin receptors (GALRs) may be tumor suppressors in head and neck squamous cell carcinoma (HNSCC). Promoter methylation status and gene expression were assessed in a large panel of head and neck primary tumors, based on the hypothesis that cytosine-guanine dinucleotide (...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.28411
更新日期:2014-01-15 00:00:00
abstract::Of 55 patients with Ollier's disease seen at the Mayo Clinic between 1907 and 1985, 16 had malignant bone neoplasms: 12 chondrosarcomas, two dedifferentiated chondrosarcomas, one chordoma, and one osteosarcoma. One patient had a chondrosarcoma in two different bones. These findings suggest that approximately 30% of pa...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19870401)59:7<1376::aid-cncr2820
更新日期:1987-04-01 00:00:00
abstract::We measured des-gamma-carboxyglutamic acid prothrombin (protein induced by vitamin K absence or antagonist-Factor II: [PIVKA-II]) in plasmas of normal subjects, patients with thrombotic disease, those with hepatic disease including hepatocellular carcinoma, and those with carcinoma of other tissues, and compared the r...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19891215)64:12<2546::aid-cncr282
更新日期:1989-12-15 00:00:00
abstract::Aspergillus infection can be a major cause of morbidity in immunocompromised patients, especially when there is pulmonary involvement. Diagnosis of aspergillosis is often complicated by the varied clinical presentation and compromised medical status of such patients. Four cases of head and neck Aspergillus infections ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19860315)57:6<1092::aid-cncr2820
更新日期:1986-03-15 00:00:00
abstract:BACKGROUND:Genomic testing is increasingly performed in oncology, but concerns remain regarding the clinician's ability to interpret results. In the current study, the authors sought to determine the agreement between physicians and genomic annotators from the Precision Oncology Decision Support (PODS) team at The Univ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.31112
更新日期:2018-03-01 00:00:00
abstract:BACKGROUND:The prognostic significance and optimal care of children with differentiated thyroid cancer and pulmonary metastases are not well established. METHODS:Of 209 patients younger than 25 years of age who were treated at University of Texas M. D. Anderson Cancer Center between 1960 and 1990 and for whom there wa...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19930215)71:4<1348::aid-cncr2820
更新日期:1993-02-15 00:00:00
abstract:BACKGROUND:Patients with advanced cancer often experience frequent and prolonged hospitalizations; however, the factors associated with greater health care utilization have not been described. We sought to investigate the relation between patients' physical and psychological symptom burden and health care utilization. ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.30912
更新日期:2017-12-01 00:00:00
abstract::The predictive value of estrogen receptor (ER) level for response to chemotherapy was studied in 182 patients with metastatic breast cancer in a prospective study. Patients were stratified according to ER status and dominant site of disease and randomized to one of three regimens: cyclophosphamide, 5-Fluorouracil, and...
journal_title:Cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/1097-0142(19890701)64:1<6::aid-cncr2820640
更新日期:1989-07-01 00:00:00
abstract:BACKGROUND:It has been established that comparative genomic hybridization (CGH) on Papanicolaou-stained cervical smears can be used to identify chromosomal imbalances. METHODS:In this study, the authors identified normal and dysplastic squamous epithelial cells cytologically, eliminated surrounding bacteria or leukocy...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19981225)84:6<375::aid-cnc
更新日期:1998-12-25 00:00:00
abstract:BACKGROUND:Metastasectomy is standard of care for pediatric patients with metastatic sarcoma with limited disease. For patients with unresectable disease, stereotactic body radiotherapy (SBRT) may serve as an alternative. Herein, the authors report the results of a prospective, multi-institutional phase 2 trial of SBRT...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.33306
更新日期:2020-11-10 00:00:00
abstract:BACKGROUND:The influence of HER-2/neu on prognosis of breast cancer is controversial. The authors investigated by immunohistochemistry in node-positive disease the influence of the pattern of immunostaining (membranous or cytoplasmic) on outcome and the prognostic significance of this marker in patients receiving or no...
journal_title:Cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/1097-0142(19940501)73:9<2359::aid-cncr2820
更新日期:1994-05-01 00:00:00
abstract::This review presents our experience with the use of estrogen receptors (ER) and progesterone receptors (PgR) in the prediction of response to endocrine therapy in stage IV breast cancer. Presence of ER (> 3 fmol/mg cytosol protein) significantly predicted response to the antiestrogen tamoxifen and to hypophysectomy. E...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19801215)46:12+<2838::aid-cncr28
更新日期:1980-12-15 00:00:00
abstract::Patients with unresectable, previously untreated head and neck cancer were given cis-diamminedichloroplatinum (II) (DDP), 3 mg/kg, with mannitol diuresis (day 1), followed by a continuous infusion of bleomycin, 0.25 mg/kg/day, days 3 through 10, after an initial loading dose of 0.25 mg/kg by rapid IV injection on day ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197802)41:2<460::aid-cncr2820410
更新日期:1978-02-01 00:00:00
abstract:BACKGROUND:This study aimed to examine disparities in survival and associated factors for patients with nonsmall-cell lung cancer (NSCLC) and to determine whether racial disparities varied over time (1991-1995, 1996-1999, and 2000-2002). METHODS:The authors studied 70,901 patients aged>or=65 years with stage I-IV NSCL...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.24521
更新日期:2009-10-15 00:00:00
abstract:BACKGROUND:For many childhood cancers, survival is lower among non-Hispanic blacks and Hispanics in comparison with non-Hispanic whites, and this may be attributed to underlying socioeconomic factors. However, prior childhood cancer survival studies have not formally tested for mediation by socioeconomic status (SES). ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.31560
更新日期:2018-10-15 00:00:00
abstract::Evaluation and radiotherapy implications of chest relapse patterns in small cell lung carcinoma treated with chemotherapy and radiotherapy to the chest and brain. Emphasis was placed on analysis of patterns of chest disease relapse, chest complications, and sites of initial chest disease relapse in relation to volume ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19801215)46:12<2557::aid-cncr282
更新日期:1980-12-15 00:00:00
abstract::A low-dose maintenance schedule of Adriamycin was evaluated in six children whose metastatic solid tumors regressed following toxic induction therapy with Adriamycin. Three of these children are now disease-free more than one year following discontinuation of therapy. Adriamycin can be given on a low-dose maintenance ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197706)39:6<2411::aid-cncr282039
更新日期:1977-06-01 00:00:00
abstract::One hundred fifty-six evaluable patients with metastatic breast cancer were treated with vincristine, Adriamycin and cyclophosphamide alternating at fixed intervals with 5-FU and methotrexate. Immunotherapy with BCG or MER-BCG was administered to all patients in two consecutive treatment programs. Overall objective re...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/1097-0142(19800215)45:4<742::aid-cncr28204
更新日期:1980-02-15 00:00:00
abstract:BACKGROUND:The term poorly differentiated (PD) carcinoma was proposed 20 years ago to define aggressive, follicular-derived thyroid carcinomas with behavior intermediate between follicular/papillary and anaplastic carcinomas. Among the variable histologic patterns recognized in such tumors, trabecular-insular-solid (TI...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.20087
更新日期:2004-03-01 00:00:00
abstract:BACKGROUND:Fluorescence in situ hybridization (FISH) and immunohistochemistry (IHC) tests are commonly used to assess human epidermal growth factor 2 (HER2) status of tumors in patients with breast cancer. This analysis evaluates the likely cost-effectiveness of expanded retesting to assess HER2 tumor status in women w...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.28196
更新日期:2013-09-01 00:00:00