Response to 5-azacytidine in patients with refractory acute nonlymphocytic leukemia and association with chromosome findings.

abstract：:To evaluate the role of chemotherapy in local control of primary breast cancer, the incidence of local failure was evaluated in 768 patients treated with surgery and adjuvant, combination chemotherapy that contained fluorouracil, doxorubicin, and cyclophosphamide (FAC) at our institute between 1974 and 1982. Of these ...

journal_title：Cancer

authors： Buzdar AU,McNeese MD,Hortobagyi GN,Smith TL,Kau S,Fraschini G,Hug V,Ellerbroek N,Holmes FA,Ames F

更新日期：1990-02-01 00:00:00

abstract：BACKGROUND:Prostate carcinoma is often associated with perineural (PN) invasion. The common occurrence of this phenomenon has led to speculation regarding the mechanisms of this association, yet to date there have been no studies that clearly define biologic differences between PN and nonperineural (NPN) carcinoma cell...

journal_title：Cancer

authors： Yang G,Wheeler TM,Kattan MW,Scardino PT,Thompson TC

更新日期：1996-09-15 00:00:00

abstract：:A classification for childhood brain tumors based upon revision of nomenclature of all brain tumors published by the World Health Organization (WHO) in 1979 is proposed. Applicability of the WHO classification scheme was tested in a combined study of the clinical and pathologic features of approximately 3300 brain tum...

journal_title：Cancer

authors： Rorke LB,Gilles FH,Davis RL,Becker LE

更新日期：1985-10-01 00:00:00

abstract：BACKGROUND:The objective of this study was to determine whether a very low presenting prostate-specific antigen (PSA) level was associated with greater prostate cancer-specific mortality (PCSM) among men with a Gleason score (GS) of 8 to 10. METHODS:The Surveillance, Epidemiology, and End Results program was used to i...

journal_title：Cancer

authors： Mahal BA,Aizer AA,Efstathiou JA,Nguyen PL

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:The vast majority of soft tissue sarcomas spread initially to the lungs and then to other sites. The lung has been the most carefully monitored organ system during routine surveillance for a metastasis. Liposarcoma is one of the most common soft tissue sarcomas and has been noted to have extrapulmonary sites...

journal_title：Cancer

authors： Cheng EY,Springfield DS,Mankin HJ

更新日期：1995-03-01 00:00:00

abstract：BACKGROUND:Cancers of individual organs generally are composed of various histologic types, each with its own frequency and demographic patterns. For childhood cancers in particular, a classification of cancers by histologic type is important for understanding the etiology and progression of the disease. METHODS:Data ...

journal_title：Cancer

authors： Miller RW,Young JL Jr,Novakovic B

更新日期：1995-01-01 00:00:00

abstract：BACKGROUND:Several of the large studies addressing prognosis and survival from hepatocellular carcinoma (HCC) have been from Europe and Asia, but only a few have emanated from North America. Survival statistics from other parts of the world may not be applicable to the North American population because of etiologic, de...

journal_title：Cancer

authors： Nzeako UC,Goodman ZD,Ishak KG

更新日期：1995-08-15 00:00:00

abstract：:Cytopathologists recognize that certain Pap smear findings are suspicious for endometrial pathology in menopausal women. To study their prognostic importance in the directed cervical smear, six parameters were used to evaluate smears for evidence of an endometrial lesion: the presence of (1) histiocytes, (2) multinucl...

journal_title：Cancer

authors： Zucker PK,Kasdon EJ,Feldstein ML

更新日期：1985-11-01 00:00:00

abstract：BACKGROUND:Patients with Stage I Grade 1 endometrial carcinoma have an excellent prognosis and a 10-year survival rate of more than 90%. In every clinical series, however, a few patients in this group have recurrence and die of their disease. METHODS:The authors reviewed 80 patients with Stage I Grade 1 endometrial ca...

journal_title：Cancer

authors： Tornos C,Silva EG,el-Naggar A,Burke TW

更新日期：1992-08-15 00:00:00

abstract：:A case of bronchogenic carcinoma with polyostotic metastatasis to the phalanges is presented. The literature has also been extensively reviewed. ...

journal_title：Cancer

authors： Nagendran T,Patel MN,Gaillard WE,Imm F,Walker M

更新日期：1980-02-15 00:00:00

abstract：:The possible influence of histologic grade, necrosis and size of invasive breast cancers on the five year survival rate of women treated in NSABP clinical trials with regimens of L-PAM (P) and L-PAM + 5-FU (PF) and for four years in those receiving L-PAM + 5-FU + methotrexate (PMF) was investigated. Generally, all reg...

journal_title：Cancer

authors： Fisher ER,Redmond C,Fisher B

更新日期：1983-01-15 00:00:00

abstract：BACKGROUND:In preclinical Ewing sarcoma (ES) models, poly(adenosine diphosphate ribose) polymerase (PARP) inhibitors were identified as a potential therapeutic strategy with synergy in combination with cytotoxic agents. This study evaluated the safety and dosing of the PARP1/2 inhibitor niraparib (NIR) with temozolomid...

journal_title：Cancer

authors： Chugh R,Ballman KV,Helman LJ,Patel S,Whelan JS,Widemann B,Lu Y,Hawkins DS,Mascarenhas L,Glod JW,Ji J,Zhang Y,Reinke D,Strauss SJ

更新日期：2020-12-08 00:00:00

abstract：BACKGROUND:It is believed that atypical cells identified by nipple duct lavage (NDL) indicate an increased risk for breast carcinoma similar to atypical ductal hyperplasia diagnosed by tissue biopsy, but many basic performance characteristics of NDL currently are undefined. METHODS:NDL was performed in 108 patients un...

journal_title：Cancer

authors： Johnson-Maddux A,Ashfaq R,Cler L,Naftalis E,Leitch AM,Hoover S,Euhus DM

更新日期：2005-03-15 00:00:00

abstract：:The incidence of long thoracic nerve palsy after radical mastectomy has been documented to be approximately 10%. No cases have been reported after the more recent treatment for breast cancer, lumpectomy with axillary dissection. This more recent surgical procedure is customarily followed by aggressive radiation therap...

journal_title：Cancer

authors： Pugliese GN,Green RF,Antonacci A

更新日期：1987-09-15 00:00:00

abstract：:At the Finsen Institute, Copenhagen, from 1971 to 1981, 134 patients were treated for lymph node metastases from primary cutaneous malignant melanoma of axial localization (e.g., in the head and neck and trunk), where metastases to regional lymph node groups were the first sign of dissemination. Due to the lack of suf...

journal_title：Cancer

authors： Lock-Andersen J,Partoft S,Jensen MG

更新日期：1988-11-01 00:00:00

abstract：BACKGROUND:Although marital distress has been implicated in difficulties with adjustment to a breast cancer diagnosis, its long-term effects, especially on physical recovery, are unknown. METHODS:Longitudinal data from newly diagnosed breast cancer patients (N=100) who were married or cohabiting were used. Patients we...

journal_title：Cancer

authors： Yang HC,Schuler TA

更新日期：2009-01-01 00:00:00

abstract：:Between July 1968 and December 1974, 53 patients with lung cancer were planned for preoperative irradiation and surgery. All patients were considered clinically marginally resectable because of advanced local disease, 4 Stage II patients, with limited pulmonary reserve and 49 Stage III patients. Most patients received...

journal_title：Cancer

authors： Sherman DM,Neptune W,Weichselbaum R,Order SE,Piro AJ

更新日期：1978-05-01 00:00:00

abstract：:Transforming growth factors (TGF) are polypeptides that stimulate anchorage-independent growth of various nontransformed cells in vitro. Transforming growth factors have been found in tumor extracts and in the urine of cancer patients. The specific questions of our study were whether TGF activity can be detected in ma...

journal_title：Cancer

authors： Hanauske AR,Arteaga CL,Clark GM,Buchok J,Marshall M,Hazarika P,Pardue RL,Von Hoff DD

更新日期：1988-05-01 00:00:00

abstract：:To assess the importance of radiation dose fraction size in the treatment of malignant melanomas, the records of 48 patients (83 sites) treated at Tufts-New England Medical Center from 1971 to 1979 have been retrospectively reviewed. During this period, the dose fractionation schemes evolved from standard fraction siz...

journal_title：Cancer

authors： Strauss A,Dritschilo A,Nathanson L,Piro AJ

更新日期：1981-03-15 00:00:00

abstract：:Census data indicate that Cambodian Americans are economically disadvantaged and linguistically isolated. In addition, cancer registry data show that Southeast Asians experience several cancer-related health disparities (e.g., markedly elevated risks of cervical and liver cancer). The Seattle regional Asian American N...

journal_title：Cancer

authors： Seng P,Acorda E,Carey Jackson J,Marchand A,Thai H,Tu SP,Taylor V

更新日期：2005-12-15 00:00:00

abstract：BACKGROUND:Combined transperineal prostate brachytherapy and external beam radiation therapy (EBRT) is widely used for treatment of prostate cancer. Long-term efficacy and toxicity results of a multicenter phase 2 trial assessing combination of EBRT and transperineal prostate brachytherapy boost with androgen deprivati...

journal_title：Cancer

authors： Hurwitz MD,Halabi S,Archer L,McGinnis LS,Kuettel MR,DiBiase SJ,Small EJ

更新日期：2011-12-15 00:00:00

abstract：:In 14 patients by bilateral retroperitoneal lymph node dissection for nonseminoma tumors of the testes, several sexual functions before and after node dissection were compared. All patients had normal sexual function before the operation. After the operation, antegrade ejaculation was found to have disappeared complet...

journal_title：Cancer

authors： Nijman JM,Jager S,Boer PW,Kremer J,Oldhoff J,Koops HS

更新日期：1982-12-15 00:00:00

abstract：:High dose methotrexate followed by citrovorum factor reversal has been utilized in twenty-six patients with advanced cancer. Four of 10 patients with head and neck cancer had an objective response. One of 7 patients with metastatic osteosarcoma to the lungs had stabilization with twenty treatments over 23 months. One ...

journal_title：Cancer

authors： Ambinder EP,Perloff M,Ohnuma T,Biller HF,Holland JF

更新日期：1979-04-01 00:00:00

abstract：:Approximately 25% of women with early stage breast cancer and negative axillary nodes will eventually die of metastatic disease. Some studies have shown a recurrence rate of 40% or more at 10 years in this relatively good prognostic group. The incidence of breast cancer continues to increase approximately 1% per year ...

journal_title：Cancer

authors： Cooper MR

更新日期：1991-03-15 00:00:00

abstract：BACKGROUND:Inactivation of the PTEN suppressor gene has been shown to occur in the majority of endometrial cancer cases. Somatic PTEN inactivation by deletion and/or mutation, the first detectible change of endometrial carcinogenesis, has been reported to occur at a high frequency in the endometrium of normal premenopa...

journal_title：Cancer

authors： Lin MC,Burkholder KA,Viswanathan AN,Neuberg D,Mutter GL

更新日期：2009-05-15 00:00:00

abstract：:Between March 1973, and December 1976, 22 patients who developed disease progression during or after MOPP therapy were treated with a new combination, B-CAVe (Bleomycin 5 mg/m2 iv days 1, 28, 35; CCNU 100 mg/m2 po day 1; adriamycin 60 mg/m2 iv day 1; and vinblastine 5 mg/m2 iv day 1). Objective responses were achieved...

journal_title：Cancer

authors： Porzig KJ,Portlock CS,Robertson A,Rosenberg SA

更新日期：1978-05-01 00:00:00

abstract：BACKGROUND:9-Aminocamptothecin (9AC) and its parent compound, camptothecin, have shown outstanding preclinical activity against colorectal carcinoma. Irinotecan (CPT-11), another camptothecin derivative, has demonstrated clinical activity in patients with 5-fluorouracil (5-FU)-refractory colorectal carcinoma. METHODS:...

journal_title：Cancer

authors： Saltz LB,Kemeny NE,Tong W,Harrison J,Berkery R,Kelsen DP

更新日期：1997-11-01 00:00:00

abstract：:The validity of current staging systems for malignant melanoma was analyzed in a prospective study on 220 patients with extremity melanoma. Patients were followed 2 to 9 years after a wide excision of the primary, regional cytostatic perfusion and dissection of regional lymph nodes. The "original three-stage" system y...

journal_title：Cancer

authors： Ghussen F,Krüger I,Groth W

更新日期：1990-07-15 00:00:00

abstract：:Eighty-nine patients were studied for the incidence and nature of phantom breast sensations (PBS) after a modified mastectomy. Twenty-nine (33%) reported experiencing pain or itching in the breast or the more vague sensation that the breast was still present. Phantom breast sensations appeared generally within the fir...

journal_title：Cancer

authors： Staps T,Hoogenhout J,Wobbes T

更新日期：1985-12-15 00:00:00

abstract：:Non-Hodgkin's lymphoma localized to the mediastinum and adjacent structures occurred in 12 of 215 (6+) non-Hodgkin's lymphoma patients seen at the Massachusetts General Hospital between 1975 and 1979. Lymphangiography, radionuclide scanning and whole body computerized tomography were used to exclude patients with extr...

journal_title：Cancer

authors： Levitt LJ,Aisenberg AC,Harris NL,Linggood RM,Poppema S

更新日期：1982-12-01 00:00:00