Childhood cancer.


BACKGROUND:Cancers of individual organs generally are composed of various histologic types, each with its own frequency and demographic patterns. For childhood cancers in particular, a classification of cancers by histologic type is important for understanding the etiology and progression of the disease. METHODS:Data from the Surveillance, Epidemiology, and End Results (SEER) Program on 9308 microscopically confirmed malignant neoplasms in children younger than age 15, newly diagnosed during 1973-1987, were made available for analysis. Tumors were grouped histologically according to a classification previously utilized in an international volume of childhood cancer incidence. RESULTS:The most frequent histologic types were acute lymphocytic leukemia (23.6%), astrocytoma (9.6%), neuroblastoma (6.6%), and Wilms' tumor (6.4%). Acute lymphocytic leukemia accounted for 75% of childhood leukemia. The most common form of Hodgkin's disease was the nodular sclerosing subtype, which was diagnosed in 56% of all cases. Burkitt's and Burkitt-like disease accounted for approximately one third of non-Hodgkin's lymphoma, the sex ratio (male to female) being unusually high (5.7). Among the brain tumors, glioma was of interest because 198 cases (excluded from this analysis) were diagnosed without histologic confirmation--due, no doubt, to their inaccessibility for biopsy because they were located in the brain stem. The most common histologic type of soft tissue sarcoma was rhabdomyosarcoma, which accounted for 51% of the total, more than half of which were of the embryonal type. To the authors' knowledge, this report offers for the first time the relative frequencies of rare types of leukemias, such as megakaryoblastic leukemia, in childhood. This report also includes the frequencies of 21 rarer forms of soft tissue sarcoma. Five forms of childhood cancer had a 5-year relative survival rate of 85% or better. Of the cancers with the poorest outcome, three had relative survival rates of 46.5-49%; the relative survival rate of acute myelogenous leukemia was only 26.4%. The trends in survival over time for 21 types of childhood cancer also are included in this report. CONCLUSIONS:Further refinements in classification now are available through laboratory techniques utilizing molecular biology, immunology, and cytogenetics, which are of importance in etiologic studies, diagnosis, treatment, and prognosis. It would be important in the future for cancer registries to record the results of relevant laboratory tests for further analysis by subtype.






Miller RW,Young JL Jr,Novakovic B




Has Abstract


1995-01-01 00:00:00




1 Suppl










  • Challenges in the recruitment of adolescents and young adults to cancer clinical trials.

    abstract::The adolescent and young adult (AYA) oncology population has seen inferior progress in cancer survival compared with younger children and older adults over the past 25 years. Previously, AYAs had the best survival rates due to the prevalence of highly curable diseases including Hodgkin lymphoma and germ cell tumors, y...


    pub_type: 杂志文章,评审


    authors: Burke ME,Albritton K,Marina N

    更新日期:2007-12-01 00:00:00

  • The added value of geriatric screening and assessment for predicting overall survival in older patients with cancer.

    abstract:BACKGROUND:The aim of this study was to determine and compare the added prognostic value of screening tools, geriatric assessment (GA) components, and GA summaries to clinical information for overall survival (OS) in older patients with cancer. METHODS:A screening and a 10-item GA were systematically performed in pati...


    pub_type: 杂志文章,多中心研究


    authors: Kenis C,Baitar A,Decoster L,De Grève J,Lobelle JP,Flamaing J,Milisen K,Wildiers H

    更新日期:2018-09-15 00:00:00

  • Quantitative assessment of the impact of chemotherapy on ovarian follicle reserve and stromal function.

    abstract:BACKGROUND:Various chemotherapy agents, especially of the alkylating category, have been associated with premature ovarian failure but there is no quantitative evidence of chemotherapy-induced ovarian damage in humans. The aim was to quantify the impact of chemotherapy on primordial follicle reserve and stromal functio...


    pub_type: 杂志文章


    authors: Oktem O,Oktay K

    更新日期:2007-11-15 00:00:00

  • A case of hepatocellular carcinoma associated with ossification. A case report.

    abstract::A 54-year-old man with hepatocellular carcinoma (HCC) of the typical trabecular pattern exhibiting unusual histologic features, both osteoid and bone formations, is reported. The tumor was associated with well-developed cirrhosis; thus, this may be different from mixed hepatic tumors of adults with bone formations bec...


    pub_type: 杂志文章


    authors: Maeda M,Kanayama M,Uchida T,Hasumura Y,Takeuchi J

    更新日期:1986-01-01 00:00:00

  • Breast cancer and paraneoplastic cerebellar degeneration.

    abstract::Of the remote effects of cancer on the neurologic system, paraneoplastic cerebellar degeneration (PCD), characterized by global cerebellar dysfunction, is second only to paraneoplastic neuropathies in frequency. Recent evidence, including the finding of anti-Purkinje cell (now termed anti-Yo) antibodies directed again...


    pub_type: 杂志文章,评审


    authors: Waterhouse DM,Natale RB,Cody RL

    更新日期:1991-10-15 00:00:00

  • Cerebral metastases as first symptom of bronchogenic carcinoma. A prospective study of 37 cases.

    abstract::Among the patients showing evidence of cerebral metastases without previously known cancer history, lung cancer has been found 37 times as the primary tumor in our institution. There were 34 men and three women and all but two were heavy smokers. Only one presented at diagnosis with thoracic symptoms but the chest rad...


    pub_type: 杂志文章


    authors: Trillet V,Catajar JF,Croisile B,Turjman F,Aimard G,Bourrat C,Bret P,Carrie C,Chassard JL,Chauvin F

    更新日期:1991-06-01 00:00:00

  • Cytophotometric DNA measurements in medullary thyroid carcinoma.

    abstract::The prognostic significance of objectively measured karyometric variables (ploidy pattern, nuclear roundness, area, elongation, chromatin texture, and nearest nucleus distance) was investigated in relation to clinical (stage and type of disease) and morphologic (histologic patterns) variables in 27 patients with the d...


    pub_type: 杂志文章


    authors: Galera-Davidson H,González-Cámpora R,Mora-Marín JA,Matilla-Vincente A,Dytch HE,Bartels PH,Lerma-Puertas E,Andrada-Becerra E,Bibbo M

    更新日期:1990-05-15 00:00:00

  • The elderly population. Opportunities for cancer prevention and detection.

    abstract::Interest in the elderly population, persons 65 years of age or older, as a target group for cancer control has not been great. Age recommendations rarely are made for prevention and early detection of cancer for elderly persons. However, cancer incidence and mortality rates are known to rise rapidly with increasing ag...


    pub_type: 杂志文章


    authors: Yancik R,Kessler L,Yates JW

    更新日期:1988-10-15 00:00:00

  • Does endoscopic follow-up improve the outcome of patients with benign gastric ulcers and gastric cancer?

    abstract::This study investigated whether an endoscopic surveillance program for patients with "benign" gastric ulcers and gastric cancer leads to early detection of neoplasms and improves survival. The clinical course of all patients diagnosed between 1977 and 1986 as having either gastric ulcers or gastric cancer was followed...


    pub_type: 杂志文章


    authors: Eckardt VF,Giessler W,Kanzler G,Bernhard G

    更新日期:1992-01-15 00:00:00

  • Results of a randomized controlled trial to increase colorectal cancer screening in a managed care health plan.

    abstract:BACKGROUND:Colorectal cancer (CRC) is the third most common cause of cancer deaths; however, rates of regular screening for this cancer are low. A quality improvement (QI) program to increase CRC screening was developed for use in a managed care health plan. METHODS:Thirty-six provider organizations (POs) contracting ...


    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Ganz PA,Farmer MM,Belman MJ,Garcia CA,Streja L,Dietrich AJ,Winchell C,Bastani R,Kahn KL

    更新日期:2005-11-15 00:00:00

  • Preparation of murine B7.1-glycosylphosphatidylinositol and transmembrane-anchored staphylococcal enterotoxin. A dual-anchored tumor cell vaccine and its antitumor effect.

    abstract:BACKGROUND:The authors have previously reported a tumor cell vaccine modified with superantigen staphylococcal enterotoxin A (SEA) and its antitumor effect. The tumor cell vaccines modified with multiple immune activators frequently elicited stronger immune responses against established tumors than single-modified vacc...


    pub_type: 杂志文章


    authors: Yi P,Yu H,Ma W,Wang Q,Minev BR

    更新日期:2005-04-01 00:00:00

  • Modern prostate brachytherapy. Prostate specific antigen results in 219 patients with up to 12 years of observed follow-up.

    abstract:BACKGROUND:The purported lack of long term modern prostate brachytherapy outcome data continues to lead many physicians to recommend other, more traditional treatments. This concern for long term results has encouraged the authors to supplement their earlier 10-year follow-up of patients receiving brachytherapy; in the...


    pub_type: 杂志文章


    authors: Ragde H,Korb LJ,Elgamal AA,Grado GL,Nadir BS

    更新日期:2000-07-01 00:00:00

  • Expression of vascular endothelial growth factor in early cutaneous melanocytic lesion progression.

    abstract:BACKGROUND:A considerable body of evidence supports the concept that a significant number of cutaneous malignant melanomas progress through a precursor lesion or dysplastic melanocytic nevi (DN). Tumor angiogenesis likely plays a critical role in early development of melanoma, and intermediate biomarkers of angiogenesi...


    pub_type: 杂志文章


    authors: Einspahr JG,Thomas TL,Saboda K,Nickolof BJ,Warneke J,Curiel-Lewandrowski C,Ranger-Moore J,Duckett L,Bangert J,Fruehauf JP,Alberts DS

    更新日期:2007-12-01 00:00:00

  • Cancers associated with BRCA1 and BRCA2 mutations other than breast and ovarian.

    abstract:BACKGROUND:Previous studies have reported additional cancers associated with BRCA mutations; however, the type, magnitude of risk, and sex differences remain to be clarified. The purpose of this study was to evaluate the incidence of cancers other than breast and ovarian cancer in known mutation carriers. METHODS:An i...


    pub_type: 杂志文章


    authors: Mersch J,Jackson MA,Park M,Nebgen D,Peterson SK,Singletary C,Arun BK,Litton JK

    更新日期:2015-01-15 00:00:00

  • Comparison of ureteral washing and biopsy specimens in the community setting.

    abstract:BACKGROUND:Ureteral lesions can be difficult to diagnose. The value of ureteral biopsy in addition to ureteral washings has not been defined clearly. METHODS:All ureteral washings and biopsies with follow-up that were performed at a single institution were reviewed. RESULTS:In total, 39 patients underwent ureteral wa...


    pub_type: 杂志文章


    authors: Renshaw AA

    更新日期:2006-02-25 00:00:00

  • The significance of microsatellite instability in predicting the development of metachronous multiple colorectal carcinomas in patients with nonfamilial colorectal carcinoma.

    abstract:BACKGROUND:Patients with metachronous multiple colorectal carcinomas have been reported to have a higher frequency of a family history of colorectal carcinoma, associated colorectal adenomas, and extracolonic malignancies. These clinicopathologic factors also are considered to be related to the development of metachron...


    pub_type: 临床试验,杂志文章


    authors: Masubuchi S,Konishi F,Togashi K,Okamoto T,Senba S,Shitoh K,Kashiwagi H,Kanazawa K,Tsukamoto T

    更新日期:1999-05-01 00:00:00

  • Cancer screening and aging: research barriers and opportunities.

    abstract::Cancer is the second most common cause of death among those aged > or =65 years, and is a major cause of morbidity. There is some evidence that screening, by detecting precancerous lesions in asymptomatic patients, is effective in reducing cancer-related morbidity and mortality among older men and women. The objective...


    pub_type: 杂志文章,评审


    authors: Sheinfeld Gorin S,Gauthier J,Hay J,Miles A,Wardle J

    更新日期:2008-12-15 00:00:00

  • Chemotherapy in patients with recurrent and progressive central neurocytoma.

    abstract:BACKGROUND:Recurrent central neurocytoma is very rare and to the authors' knowledge data regarding its response to chemotherapy currently are not available. METHODS:Three patients with progressive neurocytoma received chemotherapy after their informed consent was obtained. Disease recurred in two patients after surger...


    pub_type: 杂志文章


    authors: Brandes AA,Amistà P,Gardiman M,Volpin L,Danieli D,Guglielmi B,Carollo C,Pinna G,Turazzi S,Monfardini S

    更新日期:2000-01-01 00:00:00

  • Manipulating the chemokine-chemokine receptor network to treat cancer.

    abstract::Chemokines are chemoattractant cytokines that regulate the trafficking and activation of leukocytes and other cell types under a variety of inflammatory and noninflammatory conditions. Over the past few years, studies have increasingly shown that chemokines play an important role in several aspects of tumor progressio...


    pub_type: 杂志文章,评审


    authors: Ruffini PA,Morandi P,Cabioglu N,Altundag K,Cristofanilli M

    更新日期:2007-06-15 00:00:00

  • Developing quality indicators for cancer end-of-life care: proceedings from a national symposium.

    abstract::Quality indicators applicable to cancer end-of-life care exist, but have not been widely implemented. To advance this field, the authors worked with the Agency for Health Care Research and Quality and the National Cancer Institute to organize a national symposium to discuss key issues and future goals, based on a conc...




    authors: Seow H,Snyder CF,Shugarman LR,Mularski RA,Kutner JS,Lorenz KA,Wu AW,Dy SM

    更新日期:2009-09-01 00:00:00

  • Hormones and breast cancer.

    abstract::The exact nature of the association between hormones and the development of breast cancer remains uncertain. Studies of endogenous hormone levels and breast cancer suggest a possible role of estrogens and androgens in the cause of breast cancer. Numerous studies have been conducted to assess the risk of breast cancer ...


    pub_type: 杂志文章,评审


    authors: Helzlsouer KJ,Couzi R

    更新日期:1995-11-15 00:00:00

  • Never-smoking nonsmall cell lung cancer as a separate entity: clinicopathologic features and survival.

    abstract:BACKGROUND:To propose 'never-smoking nonsmall cell lung cancer (NSCLC)' as a separate entity, the clinicopathologic differences of operable NSCLC between never-smoking patients and patients with a history of smoking were investigated. METHODS:The medical records of 1405 patients with primary NSCLC who underwent a comp...


    pub_type: 杂志文章


    authors: Yano T,Miura N,Takenaka T,Haro A,Okazaki H,Ohba T,Kouso H,Kometani T,Shoji F,Maehara Y

    更新日期:2008-09-01 00:00:00

  • The role of 2-deoxy-2-[F-18]fluoro-D-glucose positron emission tomography in disseminated carcinoma of unknown primary site.

    abstract:BACKGROUND:The authors conducted a comprehensive review of the efficacy of 2-deoxy-2-[F-18]fluoro-D-glucose positron emission tomography (FDG-PET) in the detection of primary tumors in patients with disseminated carcinoma of unknown primary site. METHODS:Ten studies (involving a total of 221 patients) tat were publish...


    pub_type: 杂志文章,评审


    authors: Sève P,Billotey C,Broussolle C,Dumontet C,Mackey JR

    更新日期:2007-01-15 00:00:00

  • Investigations on the significance of the adenoma-carcinoma sequence in the small bowel.

    abstract::In view of the rarity of small-bowel epithelial neoplasms as compared with the case for the large bowel, evidence for an adenoma-carcinoma sequence in the small bowel was studied based on a search for data in the medical literature for the years 1927 through 1986. Sufficiently defined data were found for comparison of...


    pub_type: 杂志文章,评审


    authors: Sellner F

    更新日期:1990-08-15 00:00:00

  • Combined therapy for metastatic extradural tumors of the spine.

    abstract::The effectiveness of combined modality therapy was studied in 29 patients with metastatic extradural spinal tumor who had had a previous diagnosis of malignancy. Dexamethasone was begun upon suspicion of the diagnosis in a dose of 40 mg daily. Following emergency myelography, in all patients without rapid progression,...


    pub_type: 临床试验,杂志文章


    authors: Marshall LF,Langfitt TW

    更新日期:1977-11-01 00:00:00

  • Clinical application of intratumoral blood flow study in patients with endometrial carcinoma.

    abstract:BACKGROUND:The objective of this study was to evaluate the correlation between intratumoral blood flow as assessed by color Doppler ultrasound with stage, tumor grade, depth of invasion, and lymph node metastasis in endometrial carcinoma and determine its clinical usefulness. METHODS:Sixty-six patients with endometria...


    pub_type: 临床试验,杂志文章


    authors: Cheng WF,Chen TM,Chen CA,Wu CC,Huang KT,Hsieh CY,Hsieh FJ

    更新日期:1998-05-15 00:00:00

  • Well-differentiated lymphocytic lymphoma with peripheral blood involvement, osteolytic bone lesions, and hypercalcemia. A case report and review of the literature.

    abstract::It is rare for small lymphocytic B-cell malignancies to be associated with osteolytic bone lesions and/or hypercalcemia. The authors present an unusual case of well-differentiated lymphocytic lymphoma (DWDL) in a 70-year-old man who had osteolytic bone lesions and subsequently developed severe refractory hypercalcemia...


    pub_type: 杂志文章


    authors: Abboud SL,Gordeuk V,Schacter LP,Crum ED,Spitzer TR

    更新日期:1985-11-15 00:00:00

  • Alpha 1 isoenzyme of alkaline phosphatases. Clinical importance and value for the detection of liver metastases.

    abstract::Measurement of the alpha 1 (fast liver) fraction of alkaline phosphatases in the serum for 217 cancer patients, 92 patients with nonmalignant hepatic affections and 131 controls, revealed that the alpha 1 fraction offers better global value (94%), sensitivity (96%), and specificity (93%) than gamma GT or total alkalin...


    pub_type: 杂志文章


    authors: Viot M,Thyss A,Schneider M,Viot G,Ramaioli A,Cambon P,Lalanne CM

    更新日期:1983-07-01 00:00:00

  • Misdiagnosis of bronchogenic carcinoma: the role of cigarette smoking, surveillance bias, and other factors.

    abstract::The effects of cigarette smoking and other factors on the accuracy of clinical diagnosis of bronchogenic carcinoma were studied retrospectively in 14,074 autopsies performed over 26 years (1948-1973) at University Hospitals of Cleveland. Within a selected study group of 415 cases diagnosed as bronchogenic carcinoma ei...


    pub_type: 杂志文章


    authors: Cechner RL,Chamberlain W,Carter JR,Milojkovic-Mirceta L,Nash NP

    更新日期:1980-07-01 00:00:00

  • Long-term results of simple and radical nephrectomy for renal cell carcinoma.

    abstract::From 1974 to 1983, simple and radical nephrectomies were performed at the Chaim Sheba Medical Center (Tel Hashomer, Israel) for renal cell carcinoma. The authors reviewed 109 cases that were followed for a period ranging from 5 to 14 years. Simple nephrectomy was performed in 55 patients, and 54 patients underwent rad...


    pub_type: 杂志文章


    authors: Ramon J,Goldwasser B,Raviv G,Jonas P,Many M

    更新日期:1991-05-15 00:00:00