Abstract:
BACKGROUND:This study aimed to examine disparities in survival and associated factors for patients with nonsmall-cell lung cancer (NSCLC) and to determine whether racial disparities varied over time (1991-1995, 1996-1999, and 2000-2002). METHODS:The authors studied 70,901 patients aged>or=65 years with stage I-IV NSCLC identified from Surveillance, Epidemiology, and End Results/Medicare data. Multivariate time-to-event survival analyses were completed using Cox proportional regression modeling. RESULTS:The 5-year observed lung cancer-specific survival rates were 52.7% for whites and 47.5% for blacks with stage I-II disease, and 17.7% and 19.6% for whites and blacks, respectively at stages III-IV. After controlling for standard treatment, socioeconomic status (SES), and other factors, there were no significant differences in all-cause mortality, or lung cancer-specific mortality between black and white patients with stage I-II or III-IV lung cancer. However, blacks had an increased risk for overall all-cause mortality at stage I-IV (hazard ratio [HR], 1.24; 95% confidence interval, 1.13-1.35), and during 2000-2002 at stage III-IV for all-cause mortality (HR, 1.22; 95% CI, 1.02-1.47) and lung cancer-specific mortality (HR, 1.24; 95% CI,1.01-1.53). Standard treatment was significantly associated with increased survival, whereas poor SES was associated with increased mortality. CONCLUSIONS:There were no significant differences in survival between blacks and whites with NSCLC within stage stratifications after adjusting for covariates, except for black patients at overall stage for all-cause mortality and at stage III-IV diagnosed in 2000-2002. Receiving stage-specific evidence-based standard therapy was associated with significantly increased survival.
journal_name
Cancerjournal_title
Cancerauthors
Hardy D,Xia R,Liu CC,Cormier JN,Nurgalieva Z,Du XLdoi
10.1002/cncr.24521subject
Has Abstractpub_date
2009-10-15 00:00:00pages
4807-18issue
20eissn
0008-543Xissn
1097-0142journal_volume
115pub_type
杂志文章相关文献
CANCER文献大全abstract::Thyroid function and scans were evaluated in fifty disease-free patients 2 to 16 years after receiving neck irradiation for the treatment of Hodgkin's disease. Twenty-five of 50 patients had abnormal thyroid studies: eight were hypothyroid, two were hypothyroid and had abnormal scans, and fifteen had abnormal scans. O...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197812)42:6<2553::aid-cncr282042
更新日期:1978-12-01 00:00:00
abstract:BACKGROUND:Local recurrence is the most frequent site of failure after resection for pancreatic cancer. Tolerance, local control, and survival obtained by the association of resection and intraoperative radiation therapy (IORT) were reported. METHODS:Between June 1985 and March 1993, 90 resections for pancreatic cance...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/1097-0142(19940615)73:12<2930::aid-cncr282
更新日期:1994-06-15 00:00:00
abstract::Between January 1988 and June 1990, seven previously untreated patients with histologically confirmed and clinically staged IIIa invasive thymoma (IT) were enrolled in a prospective, single treatment arm study of neoadjuvant chemotherapy (NC) followed by surgery and postoperative radiation therapy (4600 to 6000 cGy). ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19910815)68:4<706::aid-cncr28206
更新日期:1991-08-15 00:00:00
abstract::Seventeen patients with disseminated malignant melanoma received a daily oral regimen of tamoxifen, 100 mg/m2. All patients had prior chemotherapy and predominantly visceral involvement. None of the patients had an objective regression and most (71%) had progressive disease at the time of first reassessment. Moderate ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19820401)49:7<1353::aid-cncr2820
更新日期:1982-04-01 00:00:00
abstract::The incidence of long thoracic nerve palsy after radical mastectomy has been documented to be approximately 10%. No cases have been reported after the more recent treatment for breast cancer, lumpectomy with axillary dissection. This more recent surgical procedure is customarily followed by aggressive radiation therap...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19870915)60:6<1247::aid-cncr2820
更新日期:1987-09-15 00:00:00
abstract:BACKGROUND:Partial nephrectomy (PN) is recommended for localized T1a (≤4 cm) renal masses and is preferred over radical nephrectomy (RN) for amenable T1b/T2 (>4 cm) tumors. The objective of the current study was to assess overall survival (OS) differences between PN and RN in patients with T1 and T2 renal cell carcinom...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.31582
更新日期:2018-10-01 00:00:00
abstract::Trichosporon cutaneum is a fungus known to cause superficial nodules over the distal third of hair shafts, mainly scalp hair, and to produce a clinical entity known as piedra. This superficial mycosis occurs mostly in temperate and tropical regions and is rarely seen in North America. Trichosporon cutaneum spesis is d...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197509)36:3<1106::aid-cncr282036
更新日期:1975-09-01 00:00:00
abstract:BACKGROUND:One-carbon metabolism plays a critical role in DNA methylation and DNA synthesis. Variants of genes involved in one-carbon metabolism may result in aberrant methylation and/or DNA synthesis inhibition, and ultimately modulate the initiation and progression of tumors. In this study, the authors hypothesized t...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.25301
更新日期:2010-12-15 00:00:00
abstract::Patients with congenital and acquired immunodeficiencies are at increased risk for the development of B-cell lymphoproliferative disorders. When the appropriate tests have been performed, the Epstein-Barr virus (EBV) nuclear antigen (EBNA) or EBV DNA has been found in tissues from these tumors. These data have provide...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19871215)60:12<2941::aid-cncr282
更新日期:1987-12-15 00:00:00
abstract:BACKGROUND:Recent clinical trials have documented activity for combinations of chemotherapeutic agents that target the microtubular apparatus in patients with hormone-refractory prostate cancer. Taxol has a novel antimicrotubular mechanism, acting by stabilizing polymerized tubulin. METHODS:Twenty-three patients with ...
journal_title:Cancer
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1002/1097-0142(19931015)72:8<2457::aid-cncr2820
更新日期:1993-10-15 00:00:00
abstract:BACKGROUND:The optimal imaging for the staging of oropharyngeal cancer is not well defined. METHODS:The linked Surveillance, Epidemiology, and End Results (SEER)-Medicare database for 2006 through 2011 was used to compare patient characteristics and hospital region by the initial imaging modality used for patients wit...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.32148
更新日期:2019-08-15 00:00:00
abstract::Kaposi's sarcoma of the gingiva and skin developed in an HIV-negative renal transplant patient while he was receiving cyclosporine therapy. The Kaposi's sarcoma developed shortly after the patient had an acute infection with cytomegalovirus (CMV). Electron microscopy of the tumor's established cell line showed two typ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19900201)65:3<492::aid-cncr28206
更新日期:1990-02-01 00:00:00
abstract::With endometrial adenocarcinoma, several factors, such as stage and histologic grade, are well recognized as having prognostic significance. Other variables, e.g., nuclear grade, probably are also important clinically. A preliminary investigation of the prognostic value of the ploidy, cell cycle kinetics, and sex ster...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19861001)58:7<1518::aid-cncr2820
更新日期:1986-10-01 00:00:00
abstract::Three cases of carcinoid tumor arising in the trachea are reported and contrasted with carcinoids arising in bronchi and carcinoids in general. Only eleven other documented examples of tracheal carcinoids are found in the English literature. The true prevalence of carcinoids primary in the trachea cannot be accurately...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(197812)42:6<2870::aid-cncr282042
更新日期:1978-12-01 00:00:00
abstract:BACKGROUND:Expression of oncofetal fibronectin (oncFN) and normal fibronectin (norFN) in colorectal cancer specimens was examined to investigate the correlation between fibronectin localization and histologic grade, liver metastasis, and prognosis. METHODS:Immunohistochemical staining of oncFN and norFN was performed ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19950615)75:12<2802::aid-cncr282
更新日期:1995-06-15 00:00:00
abstract:BACKGROUND:The authors are interested in identifying molecular markers that can aid in the diagnosis of adrenocortical carcinoma (ACC). The aim of this study was to identify microRNAs (miRNAs or miRs) that are differentially expressed in malignant adrenocortical tumors as compared with benign tumors and assess their po...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.25724
更新日期:2011-04-15 00:00:00
abstract::Because Langerhans' cells (LC) (CD1a-positive epidermal cells) have been discussed to be involved in the pathogenesis of mycosis fungoides and Sézary syndrome, the authors examined the influence of densities of Langerhans' cells and, concurrently, of other phenotypes retrospectively on survival of 35 patients. Cell de...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19900501)65:9<2069::aid-cncr2820
更新日期:1990-05-01 00:00:00
abstract:BACKGROUND:This paper gives an outline of the Casley-Smith method for the treatment of lymphedema of the arm. It includes a brief summary of the development of manual techniques and the terminology applied to them. METHODS:The four principles of this method are skin care, manual lymphatic drainage, compression in the ...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/(sici)1097-0142(19981215)83:12b+<2843::aid
更新日期:1998-12-15 00:00:00
abstract::Almost all patients with prostatic cancer will eventually escape the control of the first-line endocrine therapy and relapse. This escape is attributed to selecting and/or cloning preexisting or de novo appearing hormone-independent or resistant cell lines and occurs in most patients after a median time of 12 to 18 mo...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(19920701)70:1+<329::aid-cncr2820
更新日期:1992-07-01 00:00:00
abstract::111Indium-Bleomycin (111In-Blm), a new radiopharmaceutical, was administered intravenously to 37 patients with benign and malignant breast lesions. Early and delayed images of both the breasts and axillae were made, and results were correlated with physical examination, histopathology of the excised lesion, mammograph...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197601)37:1<36::aid-cncr28203701
更新日期:1976-01-01 00:00:00
abstract::A 1.95-kg fetus delivered at 33 weeks' gestational age survived less than 1 hour. Physical examination and autopsy disclosed an enormous, protuberant primary malignant melanoma of the skin, enveloping most of the back. A rim of surrounding hyperpigmented skin proved to be a giant congenital melanocytic nevus (GCMN), f...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19870915)60:6<1371::aid-cncr2820
更新日期:1987-09-15 00:00:00
abstract:BACKGROUND:Although systemic therapy for metastatic breast cancer (MBC) continues to evolve, there are scant data to guide physicians and patients when symptoms develop. In this article, the authors report the frequency and durability of palliative procedures performed in the setting of MBC. METHODS:From July 2002 to ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.25034
更新日期:2010-07-15 00:00:00
abstract::Small cell carcinoma is primarily a pulmonary neoplasm that rarely arises in extrapulmonic sites including salivary glands of the head and neck. Twelve cases of small cell carcinoma of salivary gland origin were retrieved from the Armed Forces Institute of Pathology files. Six tumors occurred in the parotid gland and ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19860801)58:3<705::aid-cncr28205
更新日期:1986-08-01 00:00:00
abstract::While investigating the cause of mild polycythemia in a young man, a testicular seminoma was discovered with unusual and tumor-dependent features: an absolute polycythemia with high plasma erythropoietin (EPO) levels, an overproduction of estradiol and testosterone, and a dramatic Leydig cell hyperplasia surrounding t...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19911115)68:10<2224::aid-cncr282
更新日期:1991-11-15 00:00:00
abstract:BACKGROUND:The authors attempted to obtain shared proteins among lung carcinoma cells by column chromatographies. A glycoprotein with approximately 500 kDa isolated from QG56 cells showed an identical amino acid sequence to 90K/Mac-2 binding protein (M2BP). This protein has been reported to be highly expressed and to m...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.10899
更新日期:2002-11-01 00:00:00
abstract:BACKGROUND:Ideally, screening detects cancer at a more curable stage and, as a result, decreases the rate of subsequent diagnosis at a late stage. Although it is suggested that some cancer screening tests have led to substantial increases in early-stage incidence with only marginal reductions in late-stage incidence (e...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.28794
更新日期:2014-09-15 00:00:00
abstract:BACKGROUND:The question of whether stress poses a risk for cancer progression has been difficult to answer. A randomized clinical trial tested the hypothesis that cancer patients coping with their recent diagnosis but receiving a psychologic intervention would have improved survival compared with patients who were only...
journal_title:Cancer
pub_type: 杂志文章,随机对照试验
doi:10.1002/cncr.23969
更新日期:2008-12-15 00:00:00
abstract:BACKGROUND:Timely delivery of care has been identified by the Institute of Medicine as an indicator for quality health care, and treatment delay is a potentially modifiable obstacle that can contribute to the disparities among African American (AA) and Caucasian patients in prostate cancer recurrence and mortality. Usi...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.27975
更新日期:2013-07-01 00:00:00
abstract::The records of all 27 adult patients (age, greater than or equal to 16 years) diagnosed with cerebellar medulloblastoma between 1968 and 1986 were reviewed. Twenty-four patients (89%) were treated with postoperative megavoltage irradiation. Twenty of these patients underwent craniospinal irradiation. Sixteen patients ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19920415)69:8<2143::aid-cncr2820
更新日期:1992-04-15 00:00:00
abstract:BACKGROUND:Cyclin D1 expression has been reported in a subset of patients with diffuse large B-cell leukemia (DLBCL), but studies have been few and generally small, and they have demonstrated no obvious clinical implications attributable to cyclin D1 expression. METHODS:The authors reviewed 1435 patients who were diag...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.28664
更新日期:2014-06-15 00:00:00