Treatment with bevacizumab and irinotecan for recurrent high-grade glial tumors.

Abstract:

BACKGROUND:Response rates to second-line chemotherapy in recurrent high-grade glial tumors are low and new effective treatments are needed. The objective of this study was to evaluate response rates and tolerability of chemotherapy with bevacizumab and irinotecan in recurrent high-grade gliomas. METHODS:Twenty patients with recurrent gliomas were treated with bevacizumab 5 mg/kg and irinotecan 125 mg/m(2) every 2 weeks. The response was evaluated by gadolinium-enhanced magnetic resonance imaging performed every 4 cycles of treatment. RESULTS:The patients received 1 to 22 cycles of treatment. Nine of 19 patients available for response evaluation (47.3%) showed an objective radiologic response: 2 patients (10.5%) a complete response (CR), and 7 patients (36.8%) a partial response (PR). Two additional patients showed stable disease (SD) for 2 and 6 months, respectively. Eight patients developed rapid progression after 1 to 4 cycles of treatment. Median time to progression on treatment was 4.7 months. The 6-month progression-free survival (PFS) and overall survival (OS) were 25% and 55%, respectively. The adverse effects were mild and in all but 2 cases were no more than grade 2. There were no thrombotic complications or significant bleeding other than epistaxis. CONCLUSIONS:The preliminary data show a promising high response rate of recurrent high-grade gliomas to chemotherapy with bevacizumab and irinotecan. The regimen is associated with minimal toxicity.

journal_name

Cancer

journal_title

Cancer

authors

Bokstein F,Shpigel S,Blumenthal DT

doi

10.1002/cncr.23401

subject

Has Abstract

pub_date

2008-05-15 00:00:00

pages

2267-73

issue

10

eissn

0008-543X

issn

1097-0142

journal_volume

112

pub_type

杂志文章

相关文献

CANCER文献大全
  • Changes in acquired immunodeficiency syndrome-related non-Hodgkin lymphoma in the era of highly active antiretroviral therapy: incidence, presentation, treatment, and survival.

    abstract:BACKGROUND:The authors sought to determine whether the availability of highly active antiretroviral therapy (HAART) coincided with changes in the epidemiology of acquired immunodeficiency syndrome (AIDS)-related non-Hodgkin lymphoma (NHL). METHODS:Cancer registry data from 1988-2000 were linked with AIDS registry data...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.21562

    authors: Diamond C,Taylor TH,Aboumrad T,Anton-Culver H

    更新日期:2006-01-01 00:00:00

  • Evaluation of fine-needle aspiration cytology of breast masses in males.

    abstract:BACKGROUND:The reliability of fine-needle aspiration cytology (FNAC) of breast masses in males could be compromised by lack of experience because breast carcinoma is rare in males and FNAC is not often used. In addition, FNAC of the more often encountered gynecomastia may lead to overdiagnosis. Therefore, in the curren...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.10483

    authors: Westenend PJ,Jobse C

    更新日期:2002-04-25 00:00:00

  • Percutaneous tumor ablation with radiofrequency.

    abstract:BACKGROUND:Radiofrequency thermal ablation (RFA) is a new minimally invasive treatment for localized cancer. Minimally invasive surgical options require less resources, time, recovery, and cost, and often offer reduced morbidity and mortality, compared with more invasive methods. To be useful, image-guided, minimally i...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/cncr.10234

    authors: Wood BJ,Ramkaransingh JR,Fojo T,Walther MM,Libutti SK

    更新日期:2002-01-15 00:00:00

  • Trends, patterns, and outcomes in the management of malignant colonic polyps in the general population of the United States.

    abstract:BACKGROUND:Colonoscopic screening has increased detection of malignant colonic polyps (MPs). The goal of this study was to analyze trends and patterns in the surgical treatment of MPs and to assess outcomes as measured by lymph node retrieval and patient survival. METHODS:The Surveillance, Epidemiology, and End Result...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.25657

    authors: Wasif N,Etzioni D,Maggard MA,Tomlinson JS,Ko CY

    更新日期:2011-03-01 00:00:00

  • Prognostic factors in the nonsurgical treatment of esophageal carcinoma with radiotherapy or radiochemotherapy: the importance of pretreatment hemoglobin levels.

    abstract:BACKGROUND:The current study was performed to evaluate prognostic factors for overall survival (OS), distant metastasis (DM), and local failure (LF) in patients with Stage II/III esophageal carcinoma. METHODS:The following potential prognostic factors were retrospectively investigated in 124 patients treated with radi...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.20952

    authors: Rades D,Schild SE,Bahrehmand R,Zschenker O,Alberti WA,Rudat VR

    更新日期:2005-04-15 00:00:00

  • Endometrial stromal sarcomas.

    abstract::This study is a clinicopathologic evaluation of seven patients with endometrial stromal sarcoma of pure homologous type. Histologic distinction from endometrial stromatosis was based on the presence of high mitotic activity and nuclear anaplasia. One sarcoma appeared to have originated from invasive stromatosis. All p...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197708)40:2<898::aid-cncr2820400

    authors: Yoonessi M,Hart WR

    更新日期:1977-08-01 00:00:00

  • Medical oncology and geriatric medicine: is it time for fellowship integration?

    abstract::Although training programs exist in both medical oncology and geriatrics (approved by the American Board of Internal Medicine), neither is adequate to ensure an appropriate supply of physicians to assume a leadership role in the treatment of the increasing number of geriatric patients who have or will develop a malign...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0142(19971001)80:7<1351::aid-cn

    authors: Bennett JM,Sahasrabudhe DM,Hall WJ

    更新日期:1997-10-01 00:00:00

  • Treatment of advanced Hodgkin's disease with B-CAVE following MOPP failure.

    abstract::Between March 1973, and December 1976, 22 patients who developed disease progression during or after MOPP therapy were treated with a new combination, B-CAVe (Bleomycin 5 mg/m2 iv days 1, 28, 35; CCNU 100 mg/m2 po day 1; adriamycin 60 mg/m2 iv day 1; and vinblastine 5 mg/m2 iv day 1). Objective responses were achieved...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197805)41:5<1670::aid-cncr282041

    authors: Porzig KJ,Portlock CS,Robertson A,Rosenberg SA

    更新日期:1978-05-01 00:00:00

  • Successful treatment of metastatic thymic carcinoma with cisplatin, vinblastine, bleomycin, and etoposide chemotherapy.

    abstract::Thymic carcinomas are rare malignant neoplasms of the thymic epithelium that are distinguished from the malignant thymomas by the presence of cytologic atypia. Thymic carcinomas may metastasize outside of the thorax and are associated with a very poor prognosis. Complete responses of thymic carcinoma to chemotherapy a...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章,评审

    doi:10.1002/1097-0142(19901115)66:10<2092::aid-cncr282

    authors: Carlson RW,Dorfman RF,Sikic BI

    更新日期:1990-11-15 00:00:00

  • Significance of blasts in low-cell-count cerebrospinal fluid specimens from children with acute lymphoblastic leukemia.

    abstract::The purpose of this study was to determine whether the presence of more than 5% blasts in a differential count of cytocentrifuged cerebrospinal fluid (CSF) with less than 6 leukocytes/microliter was predictive of central nervous system (CNS) relapse in children with acute lymphoblastic leukemia (ALL). A double concent...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19901015)66:8<1748::aid-cncr2820

    authors: Odom LF,Wilson H,Cullen J,Bank J,Blake M,Jamieson B

    更新日期:1990-10-15 00:00:00

  • Prostate-specific antigen levels from completely sectioned, clinically benign, whole prostates.

    abstract::Clinically benign whole, untrimmed prostates and pelvic lymph nodes were obtained from 105 patients at autopsy. All 105 patients had premortem serum from which prostate-specific antigen (PSA) levels were obtained. Sixty-eight did not have carcinoma of the prostate (CAP), 28 had CAP less than 1 ml and 9 had CAP larger ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19911001)68:7<1592::aid-cncr2820

    authors: Brawn PN,Speights VO,Kuhl D,Riggs M,Spiekerman AM,McCord RG,Coffield KS,Stewart DT,Lind ML

    更新日期:1991-10-01 00:00:00

  • Diagnosis and subclassification of follicle center and mantle cell lymphomas on fine-needle aspirates: A cytologic and immunocytochemical approach based on the Revised European-American Lymphoma (REAL) classification.

    abstract:BACKGROUND:Cytologic distinction between follicle center lymphoma (FCL) and mantle cell lymphoma (MCL) is difficult with cytomorphology alone and requires immunophenotyping. The current study describes the distinction between follicle center and mantle cell lymphoma made with fine-needle aspiration (FNA) material. MET...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:

    authors: Rassidakis GZ,Tani E,Svedmyr E,Porwit A,Skoog L

    更新日期:1999-08-25 00:00:00

  • Imaging characteristics of large lipoma and angiomyolipoma of the liver. Case reports.

    abstract::A large lipoma and a large angiomyolipoma of the liver, one case each, are described. In the first case, a 24 X 14-cm homogeneous mass demonstrated a fatty density (-96H) on computed tomography (CT), echogenicity on sonography, and fine neovascular vessels on angiography in the right lobe of the liver. Histopathologic...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19870301)59:5<916::aid-cncr28205

    authors: Takayasu K,Shima Y,Muramatsu Y,Moriyama N,Yamada T,Makuuchi M,Hirohashi S

    更新日期:1987-03-01 00:00:00

  • Decision-support networks of women newly diagnosed with breast cancer.

    abstract:BACKGROUND:Little is known about the size and characteristics of the decision-support networks of women newly diagnosed with breast cancer and whether their involvement improves breast cancer treatment decisions. METHODS:A population-based sample of patients newly diagnosed with breast cancer in 2014 and 2015, as repo...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.30848

    authors: Wallner LP,Li Y,McLeod MC,Hamilton AS,Ward KC,Veenstra CM,An LC,Janz NK,Katz SJ,Hawley ST

    更新日期:2017-10-15 00:00:00

  • Resection alone in 58 children with limited stage, lymphocyte-predominant Hodgkin lymphoma-experience from the European network group on pediatric Hodgkin lymphoma.

    abstract:BACKGROUND:Lymphocyte-predominant Hodgkin lymphoma (LPHL) is a rare, CD20-positive, good prognostic lymphoma in children. Patients with early-stage LPHL who underwent successful surgical lymph node resection alone have been reported. To clarify the optimum treatment strategy in children, European study groups were aske...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.22762

    authors: Mauz-Körholz C,Gorde-Grosjean S,Hasenclever D,Shankar A,Dörffel W,Wallace WH,Schellong G,Robert A,Körholz D,Oberlin O,Hall GW,Landman-Parker J

    更新日期:2007-07-01 00:00:00

  • Quantitative imaging of cancer in the postgenomic era: Radio(geno)mics, deep learning, and habitats.

    abstract::Although cancer often is referred to as "a disease of the genes," it is indisputable that the (epi)genetic properties of individual cancer cells are highly variable, even within the same tumor. Hence, preexisting resistant clones will emerge and proliferate after therapeutic selection that targets sensitive clones. He...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/cncr.31630

    authors: Napel S,Mu W,Jardim-Perassi BV,Aerts HJWL,Gillies RJ

    更新日期:2018-12-15 00:00:00

  • Metaanalysis of the accuracy of rapid prescreening relative to full screening of pap smears.

    abstract:BACKGROUND:Efficient quality assurance and improvement measures are essential ingredients in a well organized cytology-based program for cervical carcinoma screening. Various pap smear review procedures, aiming for optimization of accuracy, are described throughout the literature. Evaluation and synthesis of those meth...

    journal_title:Cancer

    pub_type: 杂志文章,meta分析

    doi:10.1002/cncr.10921

    authors: Arbyn M,Schenck U,Ellison E,Hanselaar A

    更新日期:2003-02-25 00:00:00

  • Angioimmunoblastic lymphadenopathy progressing to immunoblastic lymphoma with prominent gastric involvement.

    abstract::Two unusual cases of angioimmunoblastic lymphadenopathy with dysproteinemia (AILD), with progression to immunoblastic lymphoma (IL) and prominent gastric involvement are presented, and detailed immunohistologic studies described. In one case, Bence Jones proteinuria of the kappa type was observed during the course of ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19821115)50:10<2089::aid-cncr282

    authors: Bauer TW,Mendelsohn G,Humphrey RL,Mann RB

    更新日期:1982-11-15 00:00:00

  • Unexpected long-term survival after low-dose palliative radiotherapy for non-small cell lung cancer.

    abstract:BACKGROUND:Many experienced oncologists have encountered patients with proven non-small cell lung cancer (NCLC) who received modest doses of palliative radiotherapy (RT) and who unexpectedly survived for > 5 years; some were apparently cured. We used a very large prospective database to estimate the frequency of this p...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.21704

    authors: Mac Manus MP,Matthews JP,Wada M,Wirth A,Worotniuk V,Ball DL

    更新日期:2006-03-01 00:00:00

  • Phase 2 Southwest Oncology Group-directed intergroup trial (S0505) of sorafenib in advanced soft tissue sarcomas.

    abstract:BACKGROUND:Patients with advanced soft tissue sarcomas (STS) have limited therapeutic options. Sorafenib (BAY 43-9006) is a multitargeted tyrosine kinase inhibitor of raf, vascular endothelial growth factor receptors 1 (VEGFR1) through 3, platelet-derived growth factor B, fms-like tyrosine kinase 3, and c-kit, and some...

    journal_title:Cancer

    pub_type: 杂志文章,多中心研究

    doi:10.1002/cncr.26334

    authors: von Mehren M,Rankin C,Goldblum JR,Demetri GD,Bramwell V,Ryan CW,Borden E

    更新日期:2012-02-01 00:00:00

  • Treatment of small-cell lung cancer in elderly patients.

    abstract::Small-cell lung cancer (SCLC) represents 15% to 20% of all lung carcinomas. Approximately 30% to 40% of these cases are diagnosed in patients older than 70 years of age. Staging of SCLC classifies patients as having either limited or extensive-stage disease. The standard treatment for limited-stage disease is platinum...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/cncr.24833

    authors: Pallis AG,Shepherd FA,Lacombe D,Gridelli C

    更新日期:2010-03-01 00:00:00

  • Primary adenocarcinoma of the urinary bladder. A clinicopathologic and prognostic study.

    abstract::The study is a clinicopathologic report on 64 patients with primary adenocarcinoma of the urinary bladder and urachus, with particular reference to important prognostic and therapeutic factors. All tumors exhibited adenocarcinomatous features in at least two thirds of the examined tumor area. Pure forms of the differe...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19831001)52:7<1273::aid-cncr2820

    authors: Anderström C,Johansson SL,von Schultz L

    更新日期:1983-10-01 00:00:00

  • Impact of the posttransplant lymphoproliferative disorder subtype on survival.

    abstract:BACKGROUND:Posttransplant lymphoproliferative disorder (PTLD) is a life-threatening complication of solid organ transplantation. Histologic heterogeneity and a lack of treatment standards have made evaluating clinical outcomes in specific patient populations difficult. This systematic literature review investigated the...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.31339

    authors: Koff JL,Li JX,Zhang X,Switchenko JM,Flowers CR,Waller EK

    更新日期:2018-06-01 00:00:00

  • Cancers of the large bowel: associated disorders in individuals.

    abstract::The individual medical histories in the files of the Oxford Record Linkage Study for the years 1963 to 1967 were analyzed to ascertain any previously unsuspected associations between cancers of the large bowel and other diseases in individuals, and to quantify the relative risks of disorders already known to be associ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197906)43:6<2553::aid-cncr282043

    authors: Adelstein P,Baldwin JA,Fedrich J

    更新日期:1979-06-01 00:00:00

  • Intensity-modulated radiotherapy improves survival and reduces treatment time in squamous cell carcinoma of the anus: A National Cancer Data Base study.

    abstract:BACKGROUND:Chemoradiation with 5-fluorouracil and mitomycin remains the standard of care for squamous cell carcinoma (SCC) of the anal canal. A prolonged treatment time is associated with inferior disease-specific outcomes. Radiation Therapy Oncology Group trial 0529 demonstrated decreased toxicity and fewer treatment ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.31721

    authors: Elson JK,Kachnic LA,Kharofa JR

    更新日期:2018-11-15 00:00:00

  • Favorable prognosis after late relapse of Hodgkin's disease.

    abstract:BACKGROUND:Most relapses of Hodgkin's disease (HD) occur within the first 2 years after diagnosis, but they may develop after a longer observation period. The aim of this study was to define the incidence, clinical course, and prognostic factors for late relapse (LR) of Hodgkin's disease. For this purpose, the authors ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:

    authors: Garcia-Carbonero R,Paz-Ares L,Arcediano A,Lahuerta J,Bartolome A,Cortes-Funes H

    更新日期:1998-08-01 00:00:00

  • In vivo metabolism of childhood posterior fossa tumors and primitive neuroectodermal tumors before and after treatment.

    abstract:BACKGROUND:Despite an increasing interest in the clinical application of positron emission tomography (PET) in tumors of the adult patient as a diagnostic and prognostic tool, only a few studies have been concerned with the usefulness of PET with [18F]2-deoxy-2-fluoro-D-glucose (FDG) in childhood tumors. METHODS:Fifte...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19930815)72:4<1394::aid-cncr2820

    authors: Holthoff VA,Herholz K,Berthold F,Widemann B,Schröder R,Neubauer I,Heiss WD

    更新日期:1993-08-15 00:00:00

  • A correlation of argyrophilic nucleolar organizer regions with stages of hepatocellular carcinoma.

    abstract:BACKGROUND:Recently, the number and morphologic features of argyrophilic nucleolar organizer regions (AgNOR), silver-stained nucleolar organizer regions, were thought to reflect the cellular proliferative activity and the grade of malignancy. In liver diseases, it has been reported that AgNOR scores for hepatocellular ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19930101)71:1<44::aid-cncr282071

    authors: Shiro T,Seki T,Naitoh Y,Inoue K,Okamura A

    更新日期:1993-01-01 00:00:00

  • Overexpression of caldesmon is associated with lymph node metastasis and poorer prognosis in patients with oral cavity squamous cell carcinoma.

    abstract:BACKGROUND:A previous comparative tissue proteomics study by the authors of the current study led to the identification of caldesmon (CaD) as one of the proteins associated with cervical metastasis of oral cavity squamous cell carcinoma (OSCC). In the current investigation, the authors focused on the potential function...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.28300

    authors: Chang KP,Wang CL,Kao HK,Liang Y,Liu SC,Huang LL,Hseuh C,Hsieh YJ,Chien KY,Chang YS,Yu JS,Chi LM

    更新日期:2013-11-15 00:00:00

  • Disseminated coagulopathy in chronic myelomonocytic leukemia.

    abstract::The clinical and laboratory features of nine patients with chronic myelomonocytic leukemia are described. Hepatic or splenic enlargement accompanied by an absolute monocytosis in an older patient with an elevated serum or urine lysozyme and serum vitamin B12 levels were characteristic of the majority of patients in th...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197912)44:6<2249::aid-cncr282044

    authors: Gingrich RD,Burns CP

    更新日期:1979-12-01 00:00:00