Recent perspectives in the role of chemotherapy in the management of advanced nasopharyngeal carcinoma.

Abstract:

BACKGROUND:Recent advances in the treatment of nasopharyngeal carcinoma (NPC) have transpired into better treatment outcomes for patients with locoregionally advanced NPC, and have broadened the chemotherapeutic options for patients with metastatic disease. METHODS:Data for this review were identified through searches of articles published in PubMed, MEDLINE, and abstracts from selected conference proceedings up to 2004. RESULTS:The results of two meta-analyses and at least six randomized trials supported a survival benefit with the use of concurrent chemotherapy (e.g., platinum, tegafur-uracil [UFT)] and standard fractionated radiotherapy (with or without adjuvant chemotherapy) in the management of patients with locoregionally advanced NPC (nonmetastatic Stage III/IV disease, according to the staging system of the International Union Against Cancer). For those patients with metastatic NPC, platinum-based doublets using newer agents such as gemcitabine and the taxanes are reported to be better tolerated and can yield response rates comparable to those obtained with older, multidrug regimens. CONCLUSIONS:The current study reviewed the latest literature and pertinent issues concerning the role of chemotherapy in the treatment of patients with metastatic and locoregionally advanced NPC.

journal_name

Cancer

journal_title

Cancer

authors

Ma BB,Chan AT

doi

10.1002/cncr.20768

subject

Has Abstract

pub_date

2005-01-01 00:00:00

pages

22-31

issue

1

eissn

0008-543X

issn

1097-0142

journal_volume

103

pub_type

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