Soluble FAS ligand as a biomarker of disease recurrence in differentiated thyroid cancer.

Abstract:

BACKGROUND:Reliable predictive biomarkers are required to address the challenge of disease recurrence after thyroid cancer surgery. For this study, the authors assessed the association of cellular-based and serum-based immunologic mediators with thyroid cancer recurrence. METHODS:Leukocyte subset counts and immune regulatory cytokine levels were determined in peripheral blood samples using multiparameter flow cytometry and 51-panel, multiplex enzyme-linked immunosorbent assays, respectively. The functional activity of circulating B-lymphocytes, T-lymphocytes, and natural killer lymphocytes was assessed ex vivo. Differences in mean biomarker levels between defined patient groups and correlations between biomarkers and cancer recurrence were assessed using t tests or Wilcoxon tests and by univariate and multivariate analyses with Cox models. Optimal cutoff values of significantly correlated biomarkers that best predicted disease recurrence after surgery were established by receiver operating characteristics and were validated by using an optimal cutpoint determination algorithm. RESULTS:In total, 35 patients were enrolled (median age, 49.4 year), including 24 women and 15 patients with recurrent disease; and there were 21 individuals in the control group. Patients without recurrence had higher levels of soluble FAS (tumor necrosis receptor superfamily, member 6) ligand (sFASL), transforming growth factor-β, regulatory T cells, and programmed death 1/ programmed death ligand 1-expressing leukocytes. sFASL (hazard ratio, 0.60; 95% confidence interval, 0.38-0.95; P = .031) and interferon-α (hazard ratio, 1.55; 95% confidence interval, 1.03-2.34; P = .038) were associated significantly with disease recurrence. There was a significant difference in progression-free survival between patient groups stratified by an sFASL optimal cutpoint of 15 pg/mL (log-rank P = .0009). CONCLUSIONS:sFASL and IFN-α levels were correlated significantly with thyroid cancer recurrence and may be useful for risk-adapted surveillance strategies in patients with thyroid cancer.

journal_name

Cancer

journal_title

Cancer

authors

Owonikoko TK,Hossain MS,Bhimani C,Chen Z,Kim S,Ramalingam SS,Sun SY,Shin DM,Waller EK,Khuri FR

doi

10.1002/cncr.27937

subject

Has Abstract

pub_date

2013-04-15 00:00:00

pages

1503-11

issue

8

eissn

0008-543X

issn

1097-0142

journal_volume

119

pub_type

杂志文章

相关文献

CANCER文献大全
  • Manual dissection of adenocarcinoma of the lower third of the rectum specimens for detection of lymph node metastases smaller than 5 mm.

    abstract:BACKGROUND:The question of whether manual dissection when searching for metastatic lymph nodes from rectal cancer (less than 5 mm) is a reliable method remains controversial. METHODS:We examined 50 consecutive cases of primary adenocarcinoma of the rectum treated with a sphincter-sparing total rectum resection, total ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/(SICI)1097-0142(19960215)77:4<607::AID-CNC

    authors: Andreola S,Leo E,Belli F,Bufalino R,Tomasic G,Lavarino C,Baldini MT,Meroni E

    更新日期:1996-02-15 00:00:00

  • Feasibility study of active immunotherapy in patients with solid tumors.

    abstract::Forty-five immunocompetent patients with solid tumors were immunized with BCG, PPD, and tumor cells. The methods were practical, but the morbidity was significant, including painful draining ulcerations at vaccine sites, possible enhancement of tumor growth in three patients, and the discovery at autopsy of systemic t...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197607)38:1<131::aid-cncr2820380

    authors: Gerner RE,Moore GE

    更新日期:1976-07-01 00:00:00

  • Sarcomas (other than Ewing's) of flat bones in children and adolescents. A clinicopathologic study.

    abstract::The clinicopathologic features and response to therapy of 28 patients with non-Ewing's flat bone sarcoma treated at St. Jude Children's Research Hospital, Memphis, Tennessee, over a 25-year period were reviewed. Twenty-two patients had osteosarcoma, four malignant fibrous histiocytoma, one chondrosarcoma, and one fibr...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19900215)65:4<1011::aid-cncr2820

    authors: Kellie SJ,Pratt CB,Parham DM,Fleming ID,Meyer WH,Rao BN

    更新日期:1990-02-15 00:00:00

  • Immune hemolytic anemia associated with streptococcal preparation OK-432.

    abstract::In the course of administration of an immunopotentiator, streptococcal agent OK-432, a patient with lung cancer was found to have severe anemia and a strongly positive antiglobulin test. In the absence of the drug, eluates from the patient's erythrocytes reacted strongly by the indirect antiglobulin test with a panel ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19870415)59:8<1409::aid-cncr2820

    authors: Nomura S,Kanoh T

    更新日期:1987-04-15 00:00:00

  • Symptom profiles in children with advanced cancer: Patient, family caregiver, and oncologist ratings.

    abstract:BACKGROUND:Systematic symptom assessment is not routinely performed in pediatric oncology. The objectives of the current study were to characterize the symptoms of pediatric oncology outpatients and evaluate agreement between patient and proxy reports and the association between children's ratings and oncologists' trea...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.29597

    authors: Zhukovsky DS,Rozmus CL,Robert RS,Bruera E,Wells RJ,Chisholm GB,Allo JA,Cohen MZ

    更新日期:2015-11-15 00:00:00

  • Conservative treatment of distal rectal cancer by local excision.

    abstract::From 1954 through 1982, 57 patients with invasive, distal rectal cancer had a full-thickness local excision with curative intent. Prognostic criteria and need for further treatment were based on the histopathologic results of the operative specimen. The overall 5-year survival rate was 83.4%. The rectal cancer-specifi...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19890115)63:2<219::aid-cncr28206

    authors: DeCosse JJ,Wong RJ,Quan SH,Friedman NB,Sternberg SS

    更新日期:1989-01-15 00:00:00

  • Gemcitabine and platinum combinations in pancreatic cancer.

    abstract::Progress in the treatment of pancreatic cancer in the past several decades has been very modest. Several new agents with activity against this disease have been identified. Of these, gemcitabine appears to be the most promising when used in combination with other drugs. Gemcitabine and cisplatin combinations have been...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/cncr.10757

    authors: Philip PA

    更新日期:2002-08-15 00:00:00

  • International staging system and metaphase cytogenetic abnormalities in the era of gene expression profiling data in multiple myeloma treated with total therapy 2 and 3 protocols.

    abstract:BACKGROUND:Myeloma survival varies markedly with International Staging System classification, presence of cytogenetic abnormalities, and, especially, gene expression profiling-based risk and delTP53 status, whose collective impact has not been examined in the context of specific therapies. METHODS:The authors examined...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.25535

    authors: Waheed S,Shaughnessy JD,van Rhee F,Alsayed Y,Nair B,Anaissie E,Szymonifka J,Hoering A,Crowley J,Barlogie B

    更新日期:2011-03-01 00:00:00

  • Adenocarcinomas metastatic to the liver: the value of cytokeratins 20 and 7 in the search for unknown primary tumors.

    abstract:BACKGROUND:Metastatic adenocarcinoma in the liver with an unidentified primary tumor site is a common clinical problem. Pathologists often are asked to identify the primary tumor site. The histologic picture itself usually is not helpful, because the histology may be similar in the metastases of tumors with different p...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/(SICI)1097-0142(19990101)85:1<171::AID-CNC

    authors: Tot T

    更新日期:1999-01-01 00:00:00

  • The epidemiology of cervical carcinogenesis.

    abstract::Epidemiologic and laboratory data suggest that cervical cancer typically arises from a series of causal steps. Each step can be studied separately in the hope of better etiologic understanding and improved cancer prevention. The earliest identified etiologic step is infection of young women with specific types of vene...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/1097-0142(19951115)76:10+<1888::aid-cncr28

    authors: Schiffman MH,Brinton LA

    更新日期:1995-11-15 00:00:00

  • Glomangioma of the trachea.

    abstract::A case of a glomus tumor arising in an unusual site, the trachea, is described. The tumor was composed of a mixture of glomus cells and mast cells. At the ultrastructural level, the glomus cells exhibited features of modified smooth-muscle cells. ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19800501)45:9<2337::aid-cncr2820

    authors: Fabich DR,Hafez GR

    更新日期:1980-05-01 00:00:00

  • The role of lymph node dissection in the treatment of gallbladder carcinoma.

    abstract:BACKGROUND:Lymph node involvement is an important prognostic factor in gallbladder carcinoma (GBC). The lymph node involvement pattern, extent, and indications for systematic lymph node dissection for patients with advanced GBC were investigated. METHODS:Forty-one patients with GBC who underwent radical resection with...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0142(19970301)79:5<892::aid-cnc

    authors: Shimada H,Endo I,Togo S,Nakano A,Izumi T,Nakagawara G

    更新日期:1997-03-01 00:00:00

  • Efficacy and safety of clofarabine in relapsed and/or refractory non-Hodgkin lymphoma, including rituximab-refractory patients.

    abstract:BACKGROUND:Currently, no standard therapy exists for patients with relapsed and/or refractory non-Hodgkin lymphoma (NHL) who are ineligible for transplantation or who have failed after bone marrow transplantation. The authors of this report investigated the safety and efficacy of clofarabine (CLO) in these patients. M...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.25603

    authors: Nabhan C,Davis N,Bitran JD,Galvez A,Fried W,Tolzien K,Foss S,Dewey WM,Venugopal P

    更新日期:2011-04-01 00:00:00

  • Misdiagnosis of bronchogenic carcinoma: the role of cigarette smoking, surveillance bias, and other factors.

    abstract::The effects of cigarette smoking and other factors on the accuracy of clinical diagnosis of bronchogenic carcinoma were studied retrospectively in 14,074 autopsies performed over 26 years (1948-1973) at University Hospitals of Cleveland. Within a selected study group of 415 cases diagnosed as bronchogenic carcinoma ei...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19800701)46:1<190::aid-cncr28204

    authors: Cechner RL,Chamberlain W,Carter JR,Milojkovic-Mirceta L,Nash NP

    更新日期:1980-07-01 00:00:00

  • Gastrointestinal stromal tumor: 5 years later.

    abstract::There is now considerable interest in gastrointestinal stromal tumor (GIST) because it can be treated effectively with a targeted molecular agent. The majority of GISTs contain an activating mutation in the KIT protooncogene or, occasionally, in the platelet-derived growth factor-alpha (PDGFRA) gene. Five years ago, i...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/cncr.21419

    authors: van der Zwan SM,DeMatteo RP

    更新日期:2005-11-01 00:00:00

  • Chemotherapy for adenocystic carcinoma.

    abstract::Seventeen patients with adenocystic carcinoma have received 34 adequate trials of chemotherapy at Princess Margaret Hospital since 1969. There have been five objective responses to chemotherapy in 4 cases, lasting from five to 24 months, and 3 other patients have had stabilized disease for a period of five to seven mo...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19800801)46:3<452::aid-cncr28204

    authors: Tannock IF,Sutherland DJ

    更新日期:1980-08-01 00:00:00

  • A human liposarcoma cell line producing hyaluronic acid.

    abstract::A human liposarcoma cell line COLO 222, derived from a primary tumor in a 62-year-old male, elaborates hyaluronic acid. COLO 222 is characterized on the basis of histochemical, ultramorphological, and cytogenetic properties, along with isozyme phenotype and cell products. A chromosome mode of 53 predominates and uniqu...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19800315)45:6<1400::aid-cncr2820

    authors: Morgan RT,Quinn LA,Moore GE,Semple TU,Woods LK

    更新日期:1980-03-15 00:00:00

  • Estrogen receptor assay on breast cancer microsamples: implications of percent carcinoma estimation.

    abstract::Forty-milligram strips of malignant breast tissue were divided longitudinally into 20-mg microsamples. Soluble protein concentration was determined for one-half, and histologic evaluation for viable carcinoma content was made on its sister half. The correlation coefficient for 88 such comparisons was 0.330. This sugge...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19820601)49:11<2383::aid-cncr282

    authors: van Netten JP,Algard FT,Coy P,Carlyle SJ,Brigden ML,Thornton KR,To MP

    更新日期:1982-06-01 00:00:00

  • Adriamycin, BCNU plus cyclophosphamide (ABC) in advanced carcinoma of the head and neck.

    abstract::Forty-four patients with advanced carcinoma of the head and neck were treated with cyclophosphamide, 400 mg/m2 plus BCNU, 100 mg/m2 day 1 followed by adriamycin 40 mg/m2 day 2, with therapy repeated every 4 weeks. Of 31 evaluable patients, there were 1 complete response, and 10 partial responses (35%). Four of 8 patie...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197911)44:5<1571::aid-cncr282044

    authors: Presant CA,Ratkin G,Klahr C,Brown C

    更新日期:1979-11-01 00:00:00

  • Anti-human T-cell lymphotrophic virus type I antibody-positive adult T-cell leukemia/lymphoma with no monoclonal proviral DNA. A clinicopathologic and immunologic study.

    abstract::Proviral DNA of adult T-cell leukemia virus (HTLV-I) was examined by the standard Southern blotting method in lymph nodes of 45 patients with anti-HTLV-I antibody (ATLA)-positive adult T-cell leukemia/lymphoma (ATLL). Six of these patients revealed no monoclonal proviral HTLV-I DNA in tumor cells. These six patients s...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19891215)64:12<2515::aid-cncr282

    authors: Yoshida T,Kikuchi M,Ooshima K,Takeshita M,Kimura N,Kozuru M,Satoh H

    更新日期:1989-12-15 00:00:00

  • Combination therapy with transcatheter arterial chemoembolization and percutaneous ethanol injection compared with percutaneous ethanol injection alone for patients with small hepatocellular carcinoma: a randomized control study.

    abstract:BACKGROUND:To assess whether the effectiveness of a combination of transcatheter arterial chemoembolization (TACE) and percutaneous ethanol injection (PEI) is superior to PEI alone in the treatment of patients with small hepatocellular carcinoma (HCC), a randomized controlled study was performed. METHODS:Fifty-two pat...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1002/1097-0142(20010915)92:6<1516::aid-cncr1477

    authors: Koda M,Murawaki Y,Mitsuda A,Oyama K,Okamoto K,Idobe Y,Suou T,Kawasaki H

    更新日期:2001-09-15 00:00:00

  • College athletics, body size, and cancer mortality.

    abstract::Data are presented on mortality from neoplasms as determined from death certificates in a cohort of 8393 college men, according to athletic status in college. Major athletes (lettermen) died significantly more often from neoplasms than nonathletes. Mean age at death from neoplasms (underlying cause) was significantly ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197607)38:1<382::aid-cncr2820380

    authors: Polednak AP

    更新日期:1976-07-01 00:00:00

  • CEA levels in patients with carcinoma of the esophagus.

    abstract::Serum CEA levels were determined serially by the Hansen Z gel technique on 41 patients with carcinoma of the esophagus and compared to 276 controls. Seventy percent of patients with carcinomas of the esophagus had elevated CEA levels. CEA levels greater than 10.0 ng/ml after therapy correlated with significantly short...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197809)42:3+<1492::aid-cncr28204

    authors: Alexander JC Jr,Chretien PB,Dellon AL,Synder J

    更新日期:1978-09-01 00:00:00

  • Results of a multicenter, randomized, double-blind, dose-evaluating phase 2/3 study of lenalidomide in the treatment of metastatic malignant melanoma.

    abstract:BACKGROUND:There are currently no systemic treatments for stage IV melanoma, which have been proven in randomized trials to benefit overall survival (OS). Lenalidomide has efficacy against melanoma in animal models and safety in phase 1 trials. The authors reported the results of a phase 2/3 study comparing the safety ...

    journal_title:Cancer

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1002/cncr.24576

    authors: Glaspy J,Atkins MB,Richards JM,Agarwala SS,O'Day S,Knight RD,Jungnelius JU,Bedikian AY

    更新日期:2009-11-15 00:00:00

  • Detection of DCC and Ki-ras gene alterations in colorectal carcinoma tissue as prognostic markers for liver metastatic recurrence.

    abstract:BACKGROUND:The mortality of patients with colorectal carcinoma depends mainly upon subsequent liver metastasis even after curative operation. However, it is very difficult to predict the incidence of liver metastasis by analyzing conventional tumor markers or pathologic findings. In the current study, the authors exami...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/(SICI)1097-0142(19960415)77:8<1729::AID-CN

    authors: Kato M,Ito Y,Kobayashi S,Isono K

    更新日期:1996-04-15 00:00:00

  • Hodgkin's disease at autopsy: 1972-1977.

    abstract::The autopsies of 80 patients with Hodgkin's disease (HD) were reviewed. Nearly one-third of the patients died without evidence of HD at autopsy. Four patients died with clinically unsuspected HD. Infection was the most common cause of death but a significant number of patients died of complications of therapy, both be...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19810401)47:7<1852::aid-cncr2820

    authors: Colby TV,Hoppe RT,Warnke RA

    更新日期:1981-04-01 00:00:00

  • Fertility-related experiences after breast cancer diagnosis in the Sister and Two Sister Studies.

    abstract:BACKGROUND:Commonly used chemotherapies can be toxic to the ovaries. To the authors' knowledge, the majority of studies evaluating receipt of fertility counseling for women in their reproductive years have been performed in specific settings, thereby limiting generalizability. METHODS:A nationwide sample of US women d...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.32126

    authors: Hawkins Bressler L,Mersereau JE,Anderson C,Rodriguez JL,Hodgson ME,Weinberg CR,Sandler DP,Nichols HB

    更新日期:2019-08-01 00:00:00

  • How will we recruit, train, and retain physicians and scientists to conduct translational cancer research?

    abstract::Advances in clinical medicine require effective translational research. Ideally, this research will be performed by multidisciplinary teams that include both physicians and basic scientists. However, the current system does not appropriately train either physicians or basic scientists for these careers. In addition, t...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/cncr.29033

    authors: Pickering CR,Bast RC Jr,Keyomarsi K

    更新日期:2015-03-15 00:00:00

  • The culture of faith and hope: patients' justifications for their high estimations of expected therapeutic benefit when enrolling in early phase oncology trials.

    abstract:BACKGROUND:Patients' estimates of their chances of therapeutic benefit from participation in early phase trials greatly exceed historical data. Ethicists worry that this therapeutic misestimation undermines the validity of informed consent. METHODS:The authors interviewed 45 patients enrolled in phase 1 or 2 oncology ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.25201

    authors: Sulmasy DP,Astrow AB,He MK,Seils DM,Meropol NJ,Micco E,Weinfurt KP

    更新日期:2010-08-01 00:00:00

  • Patient variables that predict atypical cytology by nipple duct lavage.

    abstract:BACKGROUND:Nipple duct lavage (NDL) may be useful for breast cancer risk stratification. Published guidelines recommend that women with a 5-year Gail risk >/=1.7% should consider undergoing lavage for any fluid-yielding ducts, but it is not known whether increased breast cancer risk or nipple fluid production predict l...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.22538

    authors: Bushnaq ZI,Ashfaq R,Leitch AM,Euhus D

    更新日期:2007-04-01 00:00:00