Abstract:
:C57B1/6 mice were given intravenous tumor cells on day O. Mice were then given either a brief exposure to halothane anesthesia or given halothane and then underwent a hind limb amputation. Immune testing was done at varying time intervals and correlated with the development of artificial pulmonary metastases. The effects of a single 15 minute exposure to halothane on the immune system are probably short-lived and no effect on cell-mediated cytotoxicity was seen on day 7, nor was an increase in pulmonary metastases observed. However, when anesthesia was combined with surgery, cell-mediated cytotoxicity was impaired and an increase in pulmonary metastases was seen. The use of thiabendazole (TBZ), an nonspecific immunopotentiator, in the perioperative period restored the cell-mediated cytotoxic response and resulted in a significant decrease in pulmonary metastases.
journal_name
Cancerjournal_title
Cancerauthors
Lundy J,Lovett EJ 3rd,Hamilton S,Conran Pdoi
10.1002/1097-0142(197803)41:3<827::aid-cncr2820410subject
Has Abstractpub_date
1978-03-01 00:00:00pages
827-30issue
3eissn
0008-543Xissn
1097-0142journal_volume
41pub_type
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