Clinical application of estrogen receptor in breast cancer.

Abstract:

:Patients with ER positive primary tumors usually have initial metastases at the more favorable sites. Twelve out of 14 patients with ER positive had first site of metastases in either bone or soft tissue. In contrast, 13 of 17 patients with negative ER developed first metastases in viscera. ER positive patients respond better to endocrine therapy and survived twice as long as negative ER patients from the onset of recurrent cancer until death. ER content is not a sufficient criterion for the prediction of the response to endocrine manipulation but serves as useful supplementary information to clinical judgement in to selection of systemic therapy. Prior employment of radiation therapy or the administration of hormones or antihormones, as well as inadequate tumor cells in the specimen and poor procurement of the tumor, can produce spuriously low ER. A protocol to study simultaneous endocrine and chemotherapy in comparison to the sequential approach of endocrine treatment followed by chemotherapy in ER positive patients is desirable.

journal_name

Cancer

journal_title

Cancer

authors

Singhakowinta A,Saunders DE,Brooks SC,Samal B,Vaitkevicius VK

doi

10.1002/1097-0142(19801215)46:12+<2932::aid-cncr28

subject

Has Abstract

pub_date

1980-12-15 00:00:00

pages

2932-8

issue

12 Suppl

eissn

0008-543X

issn

1097-0142

journal_volume

46

pub_type

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