Factors related to survival following resection for gastric carcinoma: analysis of 903 cases.


:This report is based on 903 patients with resections for gastric carcinoma between October 1957, and July 1969, entered in controlled trials of adjuvant therapy with Thio-TEPA and FUDR. Neither Thio-TEPA nor FUDR, as administered, prolonged survival. The extent of disease at the time of curative surgery is related to survival for the first 36 months postoperatively. Involvement of lymph nodes, resection of the esophagus, and serosal penetration are predictive of recurrence up to 36 months. There appear to be three groups of patients: 1) Cured (26%); 2) Slowly growing tumor--23% (median survival, 25 months); and 3) Rapidly growing tumor--51% (median survival, eight months). The absence of blood-vessel invasion, lymphatic invasion, lymph-node involvement, and serosal penetration characterize those patients in Group A.






Serlin O,Keehn RJ,Higgins GA Jr,Harrower HW,Mendeloff GL




Has Abstract


1977-09-01 00:00:00














  • A Phase II trial of pegylated liposomal doxorubicin, vincristine, and reduced-dose dexamethasone combination therapy in newly diagnosed multiple myeloma patients.

    abstract:BACKGROUND:Patients with multiple myeloma (MM) have increased bone marrow angiogenesis, a low plasma cell labeling index, and multidrug resistance (the primary cause of chemotherapy failure). MM patients receiving the vincristine, doxorubicin, and dexamethasone (VAD) regimen develop resistance and cardiac and steroid t...


    pub_type: 临床试验,杂志文章


    authors: Hussein MA,Wood L,Hsi E,Srkalovic G,Karam M,Elson P,Bukowski RM

    更新日期:2002-11-15 00:00:00

  • Restoring platinum sensitivity in recurrent ovarian cancer by extending the platinum-free interval: Myth or reality?

    abstract::The platinum-free interval is the most important predictive factor of a response to subsequent lines of chemotherapy and the most important prognostic factor for progression-free and overall survival in patients with recurrent epithelial ovarian cancer. A nonplatinum regimen is generally considered the most appropriat...


    pub_type: 杂志文章,评审


    authors: Tomao F,D'Incalci M,Biagioli E,Peccatori FA,Colombo N

    更新日期:2017-09-15 00:00:00

  • Two primary carcinomas of the lung: adenocarcinoma and a metachronous squamous cell carcinoma. A case report and review of the literature.

    abstract::The case of a patient who underwent a left lower lobe lobectomy for adenocarcinoma of the lung and developed a metachronous squamous cell carcinoma of the right lung eight years later, is presented. The unusual nature of the case is emphasized utilizing a review of the literature. The criteria for diagnosing metachron...


    pub_type: 杂志文章,评审


    authors: Coffman B,Crum E,Forman WB

    更新日期:1983-01-01 00:00:00

  • Thomsen-Friedenreich antigen presents as a prognostic factor in colorectal carcinoma: A clinicopathologic study of 264 patients.

    abstract:BACKGROUND:Up to now, the expression of the tumor-associated Thomsen-Friedenreich (TF) antigen in colorectal carcinoma has not been thoroughly investigated with particular emphasis on its correlation with established clinicopathologic characteristics and classifications as well as its prognostic relevance. METHODS:For...


    pub_type: 杂志文章


    authors: Baldus SE,Zirbes TK,Hanisch FG,Kunze D,Shafizadeh ST,Nolden S,Mönig SP,Schneider PM,Karsten U,Thiele J,Hölscher AH,Dienes HP

    更新日期:2000-04-01 00:00:00

  • Combination therapy of hormone and cytotoxic agents in advanced breast cancer.

    abstract::The effectiveness of combination therapy with diethylstilbestrol, cyclophosphamide, and 5-fluorouracil (DES + CTx + FU) was compared with DES alone or CTx + FU in 87 postmenopausal women with advanced breast cancer. Therapy was randomized according to the tumor estrogen-receptor (ER) status. In 30 patients with ER-ric...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Kiang DT,Frenning DH,Gay J,Goldman AI,Kennedy BJ

    更新日期:1981-02-01 00:00:00

  • Safety and feasibility of aerobic training on cardiopulmonary function and quality of life in postsurgical nonsmall cell lung cancer patients: a pilot study.

    abstract:BACKGROUND:A feasibility study examining the effects of supervised aerobic exercise training on cardiopulmonary and quality of life (QOL) endpoints among postsurgical nonsmall cell lung cancer (NSCLC) patients was conducted. METHODS:Using a single-group design, 20 patients with stage I-IIIB NSCLC performed 3 aerobic c...


    pub_type: 杂志文章


    authors: Jones LW,Eves ND,Peterson BL,Garst J,Crawford J,West MJ,Mabe S,Harpole D,Kraus WE,Douglas PS

    更新日期:2008-12-15 00:00:00

  • A prospective, observational cohort study comparing cancer clinical trial availability and enrollment between early adolescents/young adults and children.

    abstract:BACKGROUND:Poor enrollment of adolescents and young adults (AYAs) (ages 15-39 years) onto cancer clinical trials (CCTs) may contribute to inferior survival gains compared with children. In this study, the authors assessed whether differences in CCT availability would explain lower CCT enrollment for early AYAs (eAYAs) ...


    pub_type: 杂志文章


    authors: Thomas SM,Malvar J,Tran H,Shows J,Freyer DR

    更新日期:2018-03-01 00:00:00

  • Chemotherapy of disseminated breast cancer. Current status and prospects.

    abstract::Chemotherapy once relegated to end stage patients has markedly improved with the use of combinations. Response rates with single agents have improved from 15 to 35%, to 50 to 70%, using combinations with an increase in complete response rates to about 25%. A series of four studies completed by the Eastern Cooperative ...


    pub_type: 临床试验,杂志文章


    authors: Carbone PP,Bauer M,Band P,Tormey D

    更新日期:1977-06-01 00:00:00

  • Tissue components of weight loss in cancer patients. A new method of study and preliminary observations.

    abstract::A new approach using anthropometric, radiographic, biochemical, and ultrasonic methods allowed partition of body weight into fat, fat-free mass, skeletal muscle, and volume of heart, liver, kidneys, spleen, and tumor. These methods were used to evaluate body composition longitudinally in a pilot group of nine cancer p...


    pub_type: 杂志文章


    authors: Heymsfield SB,McManus CB

    更新日期:1985-01-01 00:00:00

  • The chemotherapy of Hodgkin's disease: past experiences and future directions.

    abstract::From the standpoint of chemotherapy, the first progress in the treatment of Hodgkin's disease was the identification of the activity of nitrogen mustard in the 1940's. The initial antitumor effect of the drug created a great excitement. However, when all patients later relapsed, there was subsequent dejection and skep...


    pub_type: 临床试验,历史文章,杂志文章,评审


    authors: DeVita VT Jr,Lewis BJ,Rozencweig M,Muggia FM

    更新日期:1978-08-01 00:00:00

  • Significance of estrogen and progesterone receptors, disease-free interval, and site of first metastasis on survival of breast cancer patients.

    abstract::Estrogen and progesterone receptors (ER/PR) were measured in primary tumors and metastases of 397 breast cancer patients. Survival following mastectomy was significantly longer in patients with ER and PR positive tumors, as was survival after first recurrence. The prognostic value of ER and PR was compared with such c...


    pub_type: 杂志文章


    authors: Alanko A,Heinonen E,Scheinin T,Tolppanen EM,Vihko R

    更新日期:1985-10-01 00:00:00

  • Focal acinar cell dysplasia in human pancreas.

    abstract::A series of 108 prospectively collected human pancreata were evaluated histologically for the presence of acinar cell and ductal lesions. Foci of dysplastic acinar cells were present in 44% of the series. Some of the focal acinar cell abnormalities were similar to atypical acinar cell nodules which have been described...


    pub_type: 杂志文章


    authors: Longnecker DS,Shinozuka H,Dekker A

    更新日期:1980-02-01 00:00:00

  • Partial nephrectomy is not associated with an overall survival advantage over radical nephrectomy in elderly patients with stage Ib-II renal masses: An analysis of the national cancer data base.

    abstract:BACKGROUND:Partial nephrectomy (PN) is recommended for localized T1a (≤4 cm) renal masses and is preferred over radical nephrectomy (RN) for amenable T1b/T2 (>4 cm) tumors. The objective of the current study was to assess overall survival (OS) differences between PN and RN in patients with T1 and T2 renal cell carcinom...


    pub_type: 杂志文章


    authors: Ristau BT,Handorf EA,Cahn DB,Kutikov A,Uzzo RG,Smaldone MC

    更新日期:2018-10-01 00:00:00

  • Studies on translocation of immunoglobulins across intestinal epithelium.

    abstract::The issue of how immunoglobulins are transported across the intestinal epithelium into the gut lumen was examined by immunohistocytochemical techniques. IgA, IgM, IgG and secretory component (SC) in human small intestine at light and electron microscopic levels were localized by the peroxidase-labeled antibody techniq...


    pub_type: 杂志文章


    authors: Brown WR

    更新日期:1977-11-01 00:00:00

  • Recurrence-free survival in prostate cancer is related to increased stromal TRAIL expression.

    abstract:BACKGROUND:TRAIL (tumor necrosis factor related apoptosis-inducing ligand) is involved in tumor immune surveillance and, thus, may be a potential cancer therapy. TRAIL expression in the tumor microenvironment has been shown to impact cancer survival in multiple tumor types, including ovarian cancer. We studied TRAIL ex...


    pub_type: 杂志文章


    authors: Anees M,Horak P,El-Gazzar A,Susani M,Heinze G,Perco P,Loda M,Lis R,Krainer M,Oh WK

    更新日期:2011-03-15 00:00:00

  • Nonsteroidal anti-inflammatory drugs and the risk of skin cancer: a population-based case-control study.

    abstract:BACKGROUND:Nonsteroidal anti-inflammatory drugs (NSAIDs) may prevent the development of cancer by inhibiting cyclooxygenase (COX) enzymes, which are involved in carcinogenesis. Therefore, the authors of this report examined the association between NSAID use and the risk of squamous cell carcinoma (SCC), basal cell carc...


    pub_type: 杂志文章


    authors: Johannesdottir SA,Chang ET,Mehnert F,Schmidt M,Olesen AB,Sørensen HT

    更新日期:2012-10-01 00:00:00

  • Human papillomavirus as a prognostic factor in carcinoma of the penis: analysis of 82 patients treated with amputation and bilateral lymphadenectomy.

    abstract:BACKGROUND:Many studies have tried to identify prognostic factors to guide the selection of patients at high risk for metastases in penile carcinoma. The authors evaluated human papillomavirus (HPV) status with respect to clinical features, incidence of metastases, and prognosis of penile carcinoma. METHODS:Human papi...


    pub_type: 杂志文章


    authors: Bezerra AL,Lopes A,Santiago GH,Ribeiro KC,Latorre MR,Villa LL

    更新日期:2001-06-15 00:00:00

  • Lack of significant differences in the corrected activity of lysophospholipase D, producer of phospholipid mediator lysophosphatidic acid, in incubated serum from women with and without ovarian tumors.

    abstract:BACKGROUND:Several studies have shown that lysophosphatidic acid (LPA), a phospholipidic chemical mediator, is relevant to the pathogenesis of ovarian carcinoma. Higher plasma levels of LPA have been reported in patients with ovarian carcinoma than in healthy patients, and LPA is known to activate ovarian carcinoma cel...


    pub_type: 杂志文章


    authors: Tokumura A,Tominaga K,Yasuda K,Kanzaki H,Kogure K,Fukuzawa K

    更新日期:2002-01-01 00:00:00

  • High dose methotrexate followed by citrovorum factor reversal in patients with advanced cancer.

    abstract::High dose methotrexate followed by citrovorum factor reversal has been utilized in twenty-six patients with advanced cancer. Four of 10 patients with head and neck cancer had an objective response. One of 7 patients with metastatic osteosarcoma to the lungs had stabilization with twenty treatments over 23 months. One ...


    pub_type: 杂志文章


    authors: Ambinder EP,Perloff M,Ohnuma T,Biller HF,Holland JF

    更新日期:1979-04-01 00:00:00

  • Acute and delayed nausea and emesis control in pediatric oncology patients.

    abstract:BACKGROUND:To the authors' knowledge there is little information available regarding the effectiveness of standard antiemetic therapy among cancer patients who receive emetogenic chemotherapy in clinical practice, especially in the pediatric population. The current study was undertaken to determine the effectiveness of...


    pub_type: 杂志文章


    authors: Holdsworth MT,Raisch DW,Frost J

    更新日期:2006-02-15 00:00:00

  • Immunologic evaluation of patients with advanced head and neck cancer receiving weekly chemoimmunotherapy.

    abstract::Patients with advanced head and neck cancer have significant reduction in their circulating lymphocyte mass which is reflected in decreased numbers of T cells, Fc receptor cells, and in derangements of T lymphocyte functions, i.e., decreased responsiveness to several dilutions of phytohemagglutinin and lack of develop...


    pub_type: 杂志文章


    authors: Zighelboim J,Dorey F,Parker NH,Calcaterra T,Ward P,Fahey JL

    更新日期:1979-07-01 00:00:00

  • Multifocal breast cancer documented in large-format histology sections: long-term follow-up results by molecular phenotypes.

    abstract:BACKGROUND:The prognostic significance of molecular phenotype in breast cancer is well established in the literature. Recent studies have demonstrated that subgross lesion distribution (unifocal, multifocal, and diffuse) and disease extent also carry prognostic significance in this disease. However, the correlation of ...


    pub_type: 杂志文章


    authors: Pekar G,Hofmeyer S,Tabár L,Tarján M,Chen TH,Yen AM,Chiu SY,Hellberg D,Gere M,Tot T

    更新日期:2013-03-15 00:00:00

  • Long-term outcome of dasatinib first-line treatment in gastrointestinal stromal tumor: A multicenter, 2-stage phase 2 trial (Swiss Group for Clinical Cancer Research 56/07).

    abstract:BACKGROUND:Tyrosine kinase inhibitors (TKIs) have improved the outcome of patients with gastrointestinal stromal tumors (GISTs), but most patients eventually develop resistance and progress. Dasatinib is a potent inhibitor of BCR-ABL, KIT, and SRC family kinases as well as imatinib-resistant cells. In GISTs, response e...


    pub_type: 杂志文章,多中心研究


    authors: Montemurro M,Cioffi A,Dômont J,Rutkowski P,Roth AD,von Moos R,Inauen R,Toulmonde M,Burkhard RO,Knuesli C,Bauer S,Cassier P,Schwarb H,Le Cesne A,Koeberle D,Bärtschi D,Dietrich D,Biaggi C,Prior J,Leyvraz S

    更新日期:2018-04-01 00:00:00

  • Epidermal growth factor receptor immunohistochemical reactivity in patients with American Joint Committee on Cancer Stage IV colon adenocarcinoma: implications for a standardized scoring system.

    abstract:BACKGROUND:An epidermal growth factor receptor (EGFR) immunohistochemical detection system currently is being developed. The current study attempts to address background EGFR reactivity issues before determining the optimum EGFR scoring system. METHODS:Tissue sections from 102 patients with T3N1-2M1 colon adenocarcino...


    pub_type: 杂志文章


    authors: Goldstein NS,Armin M

    更新日期:2001-09-01 00:00:00

  • Combination chemotherapy and systemic irradiation consolidation for poor prognosis breast cancer.

    abstract::Seventy patients with poor prognosis, metastatic breast cancer were treated with FUVAC induction chemotherapy (5-fluorouracil, vinblastine, Adriamycin [doxorubicin] and cyclophosphamide). Consolidation therapy was given to 30 of 48 responders (63%), of whom 23 received sequential hemibody irradiation (HBI) at 8 cGy, c...


    pub_type: 杂志文章


    authors: Livingston RB,Schulman S,Griffin BR,Tranum BL,Rivkin SE,Goldberg RS,Fabian CJ,Hammond N,Hynes H

    更新日期:1987-04-01 00:00:00

  • Leukemic iritis with hypopyon.

    abstract::A patient with acute lymphoblastic leukemia who had received CNS sanctuary treatment with cranial X-irradiation and intrathecal methotrexate displayed his first sign of relapse as iritis with malignant hypopyon. Treatment included topical and subconjunctival corticosteroids and local X-irradiation. Leukemic infiltrati...


    pub_type: 杂志文章


    authors: Gruenewald RL,Perry MC,Henry PH

    更新日期:1979-10-01 00:00:00

  • Coexistence of leukemic reticuloendotheliosis and histiocytic lymphoma: a case report.

    abstract::A 65-year-old woman had pancytopenia, splenomegaly, and an inaspirable bone marrow. Diagnostic evaluation demonstrated that she had both leukemic reticuloendotheliosis (LRE), or hairy cell leukemia, and an additional lympho-reticular neoplasm, most likely a "histiocytic" lymphoma. The diagnosis of LRE was based on the...


    pub_type: 杂志文章


    authors: Adler SS,Shetty J,Golomb HM

    更新日期:1979-05-01 00:00:00

  • The future of research that promotes cancer screening.

    abstract::The authors draw on the lessons highlighted in preceding articles in the current supplement to provide recommendations for cancer screening intervention research and to highlight some of the many questions that will require further investigation. ...


    pub_type: 杂志文章,评审


    authors: Meissner HI,Vernon SW,Rimer BK,Wilson KM,Rakowski W,Briss PA,Smith RA

    更新日期:2004-09-01 00:00:00

  • Sinusoidal hematolymphoid malignancy ("malignant histiocytosis") presenting as atypical sinusoidal proliferation. A study of nine cases.

    abstract::A number of cases of sinusoidal hematolymphoid malignancy ("malignant histiocytosis") in which early lymph node biopsies have not allowed clear separation from benign histiocytic disorders have been observed. Nine such cases in which only a follow-up lymph node biopsy documented their malignant nature are reported. Se...


    pub_type: 杂志文章


    authors: Weiss LM,Azzi R,Dorfman RF,Warnke RA

    更新日期:1986-10-15 00:00:00

  • Expression of receptor tyrosine kinases epidermal growth factor receptor and HER-2/neu in synovial sarcoma.

    abstract:BACKGROUND:Synovial sarcomas are high-grade soft tissue neoplasms often characterized by a biphasic spindle and epithelioid cell morphology. The majority of synovial sarcomas harbor a specific chromosomal translocation in which the proximal portion of the SYT gene at chromosome 18q11 is fused to the distal portion of o...


    pub_type: 杂志文章


    authors: Thomas DG,Giordano TJ,Sanders D,Biermann S,Sondak VK,Trent JC,Yu D,Pollock RE,Baker L

    更新日期:2005-02-15 00:00:00