Abstract:
:Acquired myeloperoxidase deficiency has been reported in several hematological malignancies. The clinical course of a patient with acute myelomonocytic leukemia is described which was characterized by staphylococcal infections prior to therapy and again during a period of relapse. Neutropenia was not a feature of these two periods but in vitro studies revealed decreased bacterial killing capacity and decreased neutrophil myeloperoxidase activity. Infectious complications were not observed during drug-induced remission when bacterial killing capacity and myeloperoxidase activity were improved toward normal. These observations suggest that the myeloperoxidase deficient neutrophils were derived from leukemic progenitors.
journal_name
Cancerjournal_title
Cancerauthors
Kitahara M,Kushner JPdoi
10.1002/1097-0142(197912)44:6<2244::aid-cncr282044subject
Has Abstractpub_date
1979-12-01 00:00:00pages
2244-8issue
6eissn
0008-543Xissn
1097-0142journal_volume
44pub_type
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