Acquired myeloperoxidase deficiency and recurrent infections in a patient with acute myelomonocytic leukemia.

Abstract:

:Acquired myeloperoxidase deficiency has been reported in several hematological malignancies. The clinical course of a patient with acute myelomonocytic leukemia is described which was characterized by staphylococcal infections prior to therapy and again during a period of relapse. Neutropenia was not a feature of these two periods but in vitro studies revealed decreased bacterial killing capacity and decreased neutrophil myeloperoxidase activity. Infectious complications were not observed during drug-induced remission when bacterial killing capacity and myeloperoxidase activity were improved toward normal. These observations suggest that the myeloperoxidase deficient neutrophils were derived from leukemic progenitors.

journal_name

Cancer

journal_title

Cancer

authors

Kitahara M,Kushner JP

doi

10.1002/1097-0142(197912)44:6<2244::aid-cncr282044

subject

Has Abstract

pub_date

1979-12-01 00:00:00

pages

2244-8

issue

6

eissn

0008-543X

issn

1097-0142

journal_volume

44

pub_type

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