Anaphylactoid reactions to methotrexate.

Abstract:

BACKGROUND:Methotrexate is a chemotherapeutic agent frequently utilized for the treatment of malignant, rheumatic, and pulmonary diseases. Although this agent has been extensively used for more than 45 years, there are few reports of immediate systemic hypersensitivity reactions. The reported immediate reactions include anaphylaxis, urticaria, and hepatitis. However, these reactions have been reported to occur only after some prior exposure to methotrexate. No immediate hypersensitivity reactions to methotrexate have been reported during the initial exposure. We describe two patients who developed immediate systemic hypersensitivity reactions during the initial administration of methotrexate. METHODS:The clinical outcomes of two patients treated by the Hematology/Oncology department at a tertiary care military medical center are described. The National Library of Medicine in Bethesda, Maryland, was electronically searched for the literature review. RESULTS:Patient 1, a 30-year-old male with localized high grade osteosarcoma of the left distal femur, developed generalized pruritus, urticaria, angioedema, and pharyngeal edema within 10 minutes of receiving the initial administration of intravenous high-dose methotrexate. No other pharmaceutical agents, such as antiemetics, were found to cause symptoms on rechallenge. The severity of this reaction precluded continuation of methotrexate therapy. Patient 2, a 23-year-old male with localized high grade osteosarcoma of the right distal tibia, developed pruritus and urticaria within 30 minutes of receiving the initial administration of intravenous high dose methotrexate. This patient, like most patients with immediate hypersensitivity reactions to methotrexate, developed recurrent symptoms during rechallenge of this agent despite prophylactic premedication. CONCLUSIONS:Unlike prior reports in our literature, our cases demonstrate that anaphylactoid reactions can occur during the initial exposure to methotrexate. Clinicians must be prepared to treat potentially life-threatening reactions with both the initial and subsequent doses of methotrexate.

journal_name

Cancer

journal_title

Cancer

authors

Alkins SA,Byrd JC,Morgan SK,Ward FT,Weiss RB

doi

10.1002/(SICI)1097-0142(19960515)77:10<2123::AID-C

subject

Has Abstract

pub_date

1996-05-15 00:00:00

pages

2123-6

issue

10

eissn

0008-543X

issn

1097-0142

pii

10.1002/(SICI)1097-0142(19960515)77:10<2123::AID-C

journal_volume

77

pub_type

杂志文章,评审

相关文献

CANCER文献大全
  • Evaluation of three cervical cancer detection programs in Japan with special reference to cost-benefit analysis.

    abstract::Three screening programs for early cervical cancer currently in use in Japan were evaluated according to the following criteria: (1) economic effectiveness; (2) screening efficiency; and (3) access to medical care. The mobile program has the highest benefit-cost ratio (BCR, 1.20) and is hence most cost-effective; its ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19850515)55:10<2514::aid-cncr282

    authors: Takenaga N,Kai I,Ohi G

    更新日期:1985-05-15 00:00:00

  • Malignant epithelial tumors in the minor salivary glands, the submandibular gland, and the sublingual gland. Prognostic factors and treatment results.

    abstract::Ninety-five malignant tumors in the submandibular gland, the sublingual gland, and the minor salivary glands seen in a 25-year period were reviewed. The patients were retrospectively staged using the Union Internationale Contre le Cancer (UICC) classification. The most frequent tumor was adenoid cystic carcinoma, foll...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19911201)68:11<2431::aid-cncr282

    authors: Andersen LJ,Therkildsen MH,Ockelmann HH,Bentzen JD,Schiødt T,Hansen HS

    更新日期:1991-12-01 00:00:00

  • Real-time detection of hepatic micrometastases from pancreatic cancer by intraoperative fluorescence imaging: preliminary results of a prospective study.

    abstract:BACKGROUND:Recently, a highly sensitive fluorescent imaging technique was developed for the real-time identification of hepatic tumors. The authors applied this procedure for the intraoperative detection of radiographically occult hepatic micrometastases from pancreatic cancer. METHODS:Forty-nine consecutive patients ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.26594

    authors: Yokoyama N,Otani T,Hashidate H,Maeda C,Katada T,Sudo N,Manabe S,Ikeno Y,Toyoda A,Katayanagi N

    更新日期:2012-06-01 00:00:00

  • The role of serum CEA as a prognostic indicator in stage II and III breast cancer patients treated with adjuvant chemotherapy.

    abstract::Carcinoembryonic antigen (CEA) values in 529 patients treated in two consecutive adjuvant chemotherapy protocols were analyzed to determine if CEA values correlated with disease-free status or prognostic utility. CEA values were evaluated preoperatively, before chemotherapy, at the conclusion of chemotherapy, and duri...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19890301)63:5<828::aid-cncr28206

    authors: Theriault RL,Hortobagyi GN,Fritsche HA,Frye D,Martinez R,Buzdar AU

    更新日期:1989-03-01 00:00:00

  • Acute pancreatitis associated with continuous infusion cytarabine therapy: a case report.

    abstract:BACKGROUND:While acute pancreatitis is a recognized complication of numerous drugs, cytarabine's role in causing this complication is controversial. Approximately 15 cases have been reported to the Food and Drug Administration linking cytarabine with pancreas-related toxicities. Previous case reports have been complica...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/(SICI)1097-0142(19960615)77:12<2588::AID-C

    authors: McBride CE,Yavorski RT,Moses FM,Robson ME,Solimando DA Jr,Byrd JC

    更新日期:1996-06-15 00:00:00

  • Effects of melatonin on physical fatigue and other symptoms in patients with advanced cancer receiving palliative care: A double-blind placebo-controlled crossover trial.

    abstract:BACKGROUND:Patients with advanced cancer often experience fatigue and other symptoms that negatively impact their quality of life. The current trial investigated the effect of melatonin on fatigue and other symptoms in patients with advanced cancer. METHODS:Patients who were aged ≥18 years, had a histologically confir...

    journal_title:Cancer

    pub_type: 杂志文章,随机对照试验

    doi:10.1002/cncr.29563

    authors: Lund Rasmussen C,Klee Olsen M,Thit Johnsen A,Petersen MA,Lindholm H,Andersen L,Villadsen B,Groenvold M,Pedersen L

    更新日期:2015-10-15 00:00:00

  • Serum acute phase reactants and prognosis in renal cell carcinoma.

    abstract:BACKGROUND:Inflammatory parameters as acute phase proteins commonly are elevated in patients with renal cell carcinoma. Some of these acute phase reactants have been proposed to influence survival. METHODS:In 170 patients with renal cell carcinoma, the authors studied six acute phase reactant parameters (erythrocyte s...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19951015)76:8<1435::aid-cncr2820

    authors: Ljungberg B,Grankvist K,Rasmuson T

    更新日期:1995-10-15 00:00:00

  • Incidence of the superficial fascia and its relevance in skin-sparing mastectomy.

    abstract:BACKGROUND:With the move away from classical radical mastectomy to ever more skin-sparing procedures, there has been an ongoing discussion about how much skin and subcutaneous tissue should be resected to perform an adequate mastectomy while leaving viable skin flaps. One of the common recommendations is to dissect jus...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.10429

    authors: Beer GM,Varga Z,Budi S,Seifert B,Meyer VE

    更新日期:2002-03-15 00:00:00

  • Highlights of the evidence of benefit for women aged 40-49 years from the 14-year follow-up of the Breast Cancer Detection Demonstration Project.

    abstract::Randomized breast cancer screening trials are helpful in establishing evidence of benefit when they yield statistically significant results. The results of individual randomized screening trials can vary greatly depending on the quality of the images, the frequency of screening, compliance, contamination, sample size,...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1002/cncr.2820741314

    authors: Smart CR

    更新日期:1994-07-01 00:00:00

  • Recurrent gestational trophoblastic disease. Experience of the Southeastern Regional Trophoblastic Disease Center.

    abstract::Between 1968 and 1985, 28 patients with recurrent gestational trophoblastic disease (GTD) were treated at the Southeastern Regional Trophoblastic Disease Center. Sixteen patients received primary therapy at this center and had recurrence diagnosed by re-elevation of human chorionic gonadotropin (hCG) levels after thre...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19900901)66:5<978::aid-cncr28206

    authors: Mutch DG,Soper JT,Babcock CJ,Clarke-Pearson DL,Hammond CB

    更新日期:1990-09-01 00:00:00

  • Association between insurance status at diagnosis and overall survival in chronic myeloid leukemia: A population-based study.

    abstract:BACKGROUND:Chronic myeloid leukemia (CML) can be treated effectively with tyrosine kinase inhibitor therapy directed at BCR-ABL, but access to care, medication cost, and adherence may be barriers to treatment. This study was designed to determine whether the insurance status at diagnosis influences CML patient outcomes...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.30639

    authors: Perry AM,Brunner AM,Zou T,McGregor KL,Amrein PC,Hobbs GS,Ballen KK,Neuberg DS,Fathi AT

    更新日期:2017-07-01 00:00:00

  • Birth weight and risk of cancer.

    abstract:BACKGROUND:It is well established that prenatal biologic processes are important for the development of some childhood cancers, whereas less is known regarding their influence on adult cancer risk. High birth weight has been associated with risk of breast cancer, whereas studies of other specific cancers and all cancer...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.22773

    authors: Ahlgren M,Wohlfahrt J,Olsen LW,Sørensen TI,Melbye M

    更新日期:2007-07-15 00:00:00

  • Methotrexate tolerance in patients with ileal conduits and continent diversions.

    abstract:BACKGROUND:Methotrexate is readily absorbed from the intestinal tract. When given to patients with urinary diversion to the intestinal tract, methotrexate may be reabsorbed into the circulation, thus increasing its serum concentration and potentially increasing its toxicity. METHODS:Forty-eight patients with transitio...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:

    authors: Srinivas S,Mahalati K,Freiha FS

    更新日期:1998-03-15 00:00:00

  • A phase 2 study of glembatumumab vedotin, an antibody-drug conjugate targeting glycoprotein NMB, in patients with advanced melanoma.

    abstract:BACKGROUND:Glembatumumab vedotin is an antibody-drug conjugate that produced preliminary clinical activity against advanced melanoma in a phase 1 dose-escalation trial. The objective of the current study was to investigate further the antitumor activity of glembatumumab vedotin at the recommended phase 2 dose in heavil...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.31892

    authors: Ott PA,Pavlick AC,Johnson DB,Hart LL,Infante JR,Luke JJ,Lutzky J,Rothschild NE,Spitler LE,Cowey CL,Alizadeh AR,Salama AK,He Y,Hawthorne TR,Bagley RG,Zhang J,Turner CD,Hamid O

    更新日期:2019-04-01 00:00:00

  • Influence of compartmental involvement on the patterns of morbidity in soft tissue sarcoma of the thigh.

    abstract:BACKGROUND:The authors sought to determine whether differences existed in patterns of outcome and morbidity between the 3 thigh compartments after limb-sparing surgery and postoperative radiation therapy (RT). METHODS:A total of 255 patients with primary soft tissue sarcoma (STS) of the thigh were identified in our sa...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.23975

    authors: Rimner A,Brennan MF,Zhang Z,Singer S,Alektiar KM

    更新日期:2009-01-01 00:00:00

  • IgM-producing gastric plasmacytoma.

    abstract::A case of gastric plasmacytoma is reported in an 81-year-old woman. Immunofluorescent and immunoelectrophoretic studies showed that the tumor cells produced IgM-lambda molecules, whereas no monoclonal immunoglobulin could be detected both in the serum and in the urine. Of more than 60 reported cases of gastric plasmac...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(1984)54:4<638::aid-cncr282054040

    authors: Funakoshi N,Kanoh T,Kobayashi Y,Miyake T,Uchino H,Ochi K

    更新日期:1984-08-15 00:00:00

  • Inhibition of radiogenic mammary carcinoma in rats by estriol or tamoxifen.

    abstract::Mammary carcinomas have been induced by 3.5 Gy whole-body gamma radiation administered at age 40 to 50 days to virgin female Sprague-Dawley rats. In 142 irradiated controls carcinoma incidence averaged 7.8% in survivors observed less than 300 days and 38.3% of those surviving longer (P less than 0.001 by t test). Mamm...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19900501)63:9<1685::aid-cncr2820

    authors: Lemon HM,Kumar PF,Peterson C,Rodriguez-Sierra JF,Abbo KM

    更新日期:1989-05-01 00:00:00

  • Overexpression of p53 and prognosis in breast cancer.

    abstract:BACKGROUND:Assessment of prognostic markers in breast cancer independent of the axillary lymph node status is of major concern for the application of adjuvant treatment regimens. The current treatment decision is based mainly on the axillary lymph node status. Because of improved screening methods, the number and propo...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19931215)72:12<3641::aid-cncr282

    authors: Friedrichs K,Gluba S,Eidtmann H,Jonat W

    更新日期:1993-12-15 00:00:00

  • Colorectal cancer stage at diagnosis by socioeconomic and urban/rural status in California, 1988-2000.

    abstract:BACKGROUND:Rural residence has been associated with increased risk of late stage cancer diagnosis, but it is unknown if this is related to lower socioeconomic status (SES) of rural residents or to other factors. This study examined the impacts of SES and urban/rural status on colorectal cancer (CRC) stage at diagnosis ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.22016

    authors: Parikh-Patel A,Bates JH,Campleman S

    更新日期:2006-09-01 00:00:00

  • Fas (CD95/APO-1) and Fas ligand expression in normal pancreas and pancreatic tumors. Implications for immune privilege and immune escape.

    abstract:BACKGROUND:Fas (CD95/APO-1) and Fas ligand (FasL) play key roles in immunologic homeostasis and immune privilege and may regulate normal cell turnover. Earlier studies had suggested that FasL-positive pancreatic carcinoma cell lines can induce apoptosis in T cells, thereby evading host immune surveillance. In the curre...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.10549

    authors: Bernstorff WV,Glickman JN,Odze RD,Farraye FA,Joo HG,Goedegebuure PS,Eberlein TJ

    更新日期:2002-05-15 00:00:00

  • Expression and immunogenicity of a tumor-associated antigen, 90K/Mac-2 binding protein, in lung carcinoma.

    abstract:BACKGROUND:The authors attempted to obtain shared proteins among lung carcinoma cells by column chromatographies. A glycoprotein with approximately 500 kDa isolated from QG56 cells showed an identical amino acid sequence to 90K/Mac-2 binding protein (M2BP). This protein has been reported to be highly expressed and to m...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.10899

    authors: Ozaki Y,Kontani K,Hanaoka J,Chano T,Teramoto K,Tezuka N,Sawai S,Fujino S,Yoshiki T,Okabe H,Ohkubo I

    更新日期:2002-11-01 00:00:00

  • Chemotherapy followed by lung resection in inoperable non-small cell lung carcinomas due to locally far-advanced disease.

    abstract::From 1977, 29 patients with inoperable non-small cell lung carcinoma due to locally far-advanced disease underwent lung resection after receiving two to eight courses of chemotherapy. After the surgery was performed, three additional courses of chemotherapy were given. The overall median survival from onset of the che...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19860201)57:3<630::aid-cncr28205

    authors: Takita H,Regal AM,Antkowiak JG,Rao UN,Botsoglou NK,Lane WW

    更新日期:1986-02-01 00:00:00

  • Bone marrow magnetic resonance studies in childhood leukemia. Evaluation of osteonecrosis.

    abstract::In 25 patients under treatment or during follow-up for acute lymphoblastic leukemia magnetic resonance imaging (MRI) of both knees was compared to history and physical examination to detect osteonecrosis. Results of MRI were classified as: O, normal bone marrow (BM); 1, diffuse decrease in signal intensity; 2, circums...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19871215)60:12<2994::aid-cncr282

    authors: Pieters R,van Brenk AI,Veerman AJ,van Amerongen AH,van Zanten TE,Golding RP

    更新日期:1987-12-15 00:00:00

  • Ultrastructural studies of xenografted human germ cell tumors.

    abstract::Xenografts have been established in immune-suppressed mice from three embryonal cell carcinomas, two yolk sac carcinomas, and a 'seminoma-like' tumor that produces alphafetoprotein. The ultrastructural features of these xenografts have been studied in detail and compared with human germ cell tumors removed from patien...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19820215)49:4<683::aid-cncr28204

    authors: Monaghan P,Raghavan D,Neville AM

    更新日期:1982-02-15 00:00:00

  • Autologous stem cell transplantation for patients with chronic myeloid leukemia. The Argentine Group of Bone Marrow Transplantation (GATMO) experience.

    abstract:BACKGROUND:The objective of this analysis was to evaluate the role of autologous stem cell transplantation (ASCT) in prolonging disease free survival (DFS) and overall survival (OS) in patients with chronic myeloid leukemia (CML) who received autografts of Philadelphia chromosome (Ph) positive or Ph negative cell harve...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.10931

    authors: Koziner B,Dengra C,Lucero G,Klein G,Cánepa C,Milovic V,Milone G,Robinson A,Cerutti I,Saporito G,Kusminsky G,Milone J,Bordone J,Lastiri F,Argentine Group of Bone Marrow Transplantation.

    更新日期:2002-12-01 00:00:00

  • Cytologic features of renal medullary carcinoma.

    abstract:BACKGROUND:Renal medullary carcinoma is a rare tumor that is most common in young black men with sickle cell disease or trait. Patients often present with advanced disease at the time of diagnosis, and their prognosis is poor, even with aggressive therapy. The clinical and pathologic features of renal medullary carcino...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.20764

    authors: Assad L,Resetkova E,Oliveira VL,Sun W,Stewart JM,Katz RL,Caraway NP

    更新日期:2005-02-25 00:00:00

  • International staging system and metaphase cytogenetic abnormalities in the era of gene expression profiling data in multiple myeloma treated with total therapy 2 and 3 protocols.

    abstract:BACKGROUND:Myeloma survival varies markedly with International Staging System classification, presence of cytogenetic abnormalities, and, especially, gene expression profiling-based risk and delTP53 status, whose collective impact has not been examined in the context of specific therapies. METHODS:The authors examined...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.25535

    authors: Waheed S,Shaughnessy JD,van Rhee F,Alsayed Y,Nair B,Anaissie E,Szymonifka J,Hoering A,Crowley J,Barlogie B

    更新日期:2011-03-01 00:00:00

  • Ascertainment of postprostatectomy radiotherapy for prostate cancer in the Surveillance, Epidemiology, and End Results database.

    abstract:BACKGROUND:Surveillance, Epidemiology, and End Results (SEER) data are frequently used to examine receipt of adjuvant radiotherapy (RT), but to the authors' knowledge the accuracy of data regarding second-course treatments is unknown. METHODS:Using SEER-Medicare-linked data, the authors identified a cohort of men who ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.30154

    authors: Wang K,Sheets NC,Basak R,Chen RC

    更新日期:2016-10-01 00:00:00

  • Cost-effectiveness of systemic and regional chemotherapy for the treatment of patients with unresectable colorectal liver metastases.

    abstract:BACKGROUND:Management of unresectable colorectal liver metastases (CLM) can be by regional (hepatic arterial infusion [HAI]) or systemic chemotherapy, or by symptom control alone. In this study the costs of each type of management were related to clinical outcome in 134 patients with CLM. METHODS:The costs (both in te...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:

    authors: Durand-Zaleski I,Earlam S,Fordy C,Davies M,Allen-Mersh TG

    更新日期:1998-09-01 00:00:00

  • The past 60 years in liver surgery.

    abstract::The anniversary of the first publication of Cancer provides an opportunity to review the progress in liver cancer surgery in the past 60 years. Indeed, the past half century has been witness to remarkable advances in liver surgery that have provided benefit to so many patients afflicted with primary or secondary liver...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/cncr.23652

    authors: Tanabe KK

    更新日期:2008-10-01 00:00:00