Abstract:
:Malignant sweat gland neoplasms are rare tumors. Historically, the principal mode of treatment has been local surgical excision. Eight published studies show that greater than 50% of patients develop either local tumor recurrence after surgery or regional lymph node metastases. Most patients have evidence of locoregional failure before distant metastases are detected. Three patients were recently referred to the University of Arizona Cancer Center for consideration of irradiation after resection of such tumors. In two patients, the tumor was located on the scalp and, in one patient, on the alar surface of the nose. Their ages ranged from 19 to 60 years. All underwent surgical resection followed by high-dose irradiation of the surgical bed (approximately 70 Gy) and regional lymphatic chains (approximately 50 Gy). Two patients remain disease-free at 27 and 35 months, respectively, after completion of treatment; the third died of rapidly progressive systemic metastases. A review of the literature is provided focusing on treatment success and predominant patterns of recurrence. Finally, a rational approach for evaluation of patients that might benefit from local irradiation is presented.
journal_name
Cancerjournal_title
Cancerauthors
Harari PM,Shimm DS,Bangert JL,Cassady JRdoi
10.1002/1097-0142(19900415)65:8<1737::aid-cncr2820subject
Has Abstractpub_date
1990-04-15 00:00:00pages
1737-40issue
8eissn
0008-543Xissn
1097-0142journal_volume
65pub_type
杂志文章,评审相关文献
CANCER文献大全abstract:BACKGROUND:The primary objective of this study was to clarify the significance of p21WAF1/CIP1(p21) gene expression in the tumorgenicity of hepatitis B virus (HBV) and hepatitis C virus (HCV) infected human hepatocelluar carcinoma (HCC). METHODS:The authors performed Northern blot hybridization to compare the p21 mess...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(20010601)91:11<2096::aid-cncr123
更新日期:2001-06-01 00:00:00
abstract:BACKGROUND:Peritoneal metastases are one reason for the poor prognosis of scirrhous gastric cancer. However, the mechanism of peritoneal metastasis remains unclear. We therefore investigated the interaction between gastric cancer cells and peritoneal fibroblasts, in vivo and in vitro. METHODS:A human scirrhous gastric...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0142(19960415)77:8<1668::AID-CN
更新日期:1996-04-15 00:00:00
abstract::The expression of the Thomsen-Friedenreich antigen (T-antigen) in normal and neoplastic urothelium was investigated using paraffin-processed and fresh frozen tissue sections obtained by biopsy from 56 patients. The T-antigen was detected through its binding to the peanut agglutinin (PNA) with two methods: a biotin-avi...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19860915)58:6<1236::aid-cncr2820
更新日期:1986-09-15 00:00:00
abstract::In 95 surgically staged patients with squamous cell carcinoma of the maxillary sinus, multivariate regression analyses were employed to identify prognostic factors. Possible prognostic factors for local control were TNM stage and type of surgical procedures: T2 or T3 tumors and use of total maxillectomy showed better ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19850101)55:1<190::aid-cncr28205
更新日期:1985-01-01 00:00:00
abstract:BACKGROUND:Recently, a highly sensitive fluorescent imaging technique was developed for the real-time identification of hepatic tumors. The authors applied this procedure for the intraoperative detection of radiographically occult hepatic micrometastases from pancreatic cancer. METHODS:Forty-nine consecutive patients ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.26594
更新日期:2012-06-01 00:00:00
abstract:BACKGROUND:In the past 4 years, the weekly 24-hour infusion of high dose 5-fluorouracil (5-FU) and leucovorin in the treatment of patients with advanced gastric carcinoma has been prospectively studied at the authors' institution. This has enabled them to explore the possibility that the level of expression of thymidyl...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/(sici)1097-0142(19980501)82:9<1626::aid-cn
更新日期:1998-05-01 00:00:00
abstract::Fifty-one patients with confirmed bladder cancer have enrolled in a prospective evaluation of BCG immunotherapy. Following resection of existing tumors, patients were stratified according to tumor grade and number of previous recurrences and randomly assigned to control or BCG treatment groups. Immunotherapy consisted...
journal_title:Cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/1097-0142(19810701)48:1<82::aid-cncr282048
更新日期:1981-07-01 00:00:00
abstract:BACKGROUND:The recommended phase 2 dose (RP2D) of anticancer agents is determined traditionally by dose-limiting toxicities. Nontoxicity or biological endpoints such as pharmacokinetics, pharmacodynamics, and efficacy can also be used to identify RP2D, which may be relevant to molecularly targeted agents (MTAs). METHO...
journal_title:Cancer
pub_type: 杂志文章,meta分析
doi:10.1002/cncr.30579
更新日期:2017-04-15 00:00:00
abstract:BACKGROUND:The carboplatin-based chemotherapeutic regimen M-CAVI (methotrexate, carboplatin, and vinblastine) is active against bladder carcinoma and can be administered to patients who are ineligible to receive cisplatin or doxorubicin. The authors designed a randomized study to evaluate whether M-CAVI offers a therap...
journal_title:Cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/(sici)1097-0142(19971115)80:10<1966::aid-c
更新日期:1997-11-15 00:00:00
abstract:BACKGROUND:The AJCC staging system and post-operative nomograms use patient and tumor characteristics to provide prognostic estimates after resection of retroperitoneal sarcoma (RPS). While these variables help to predict survival at the time of diagnosis and resection, the applicability of these prognostic factors to ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.26665
更新日期:2012-07-01 00:00:00
abstract:BACKGROUND:Although significant advances have been made in the treatment of some malignancies, the prognosis of patients with metastatic tumors remains poor. Differentiating agents redirect cells toward their normal phenotype and therefore may reverse or suppress evolving malignant lesions or prevent cancer invasion. I...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/(sici)1097-0142(19981015)83:8<1471::aid-cn
更新日期:1998-10-15 00:00:00
abstract:BACKGROUND:Cancer patients with single tumors live longer today due to earlier detection and improved treatment methods. For this reason, the authors see more patients who develop a second primary tumor. The etiology of the second tumor can be the same as the first, whether treatment-induced or unknown. The prognoses o...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19990501)85:9<2073::aid-cn
更新日期:1999-05-01 00:00:00
abstract:BACKGROUND:The Tecumseh Community Health Study (TCHS), initiated in 1959 at the University of Michigan School of Public Health, has provided a resource for long term prospective studies of the incidence of cancer in the setting of a midwestern rural farming community. METHODS:A survey of total and site specific cancer...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.1996.2820770402
更新日期:1996-02-15 00:00:00
abstract::One hundred ninety patients who had advanced active Hodgkin's disease, lymphosarcoma, or reticulum cell sarcoma were treated with a combination of cyclophosphamide, vincristine, procarbazine, and prednisone (COPP) given in a cyclical fashion every month. Complete remission was produced in 91 of 138 (66%) patients with...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197510)36:4<1241::aid-cncr282036
更新日期:1975-10-01 00:00:00
abstract:BACKGROUND:Image-directed biopsies may be collected as histologic or cytologic specimens. METHODS:In 34 patients, the results of aspiration cytologic examination were compared prospectively with core tissue biopsy findings obtained and diagnosed independently using the same image-guided procedure. RESULTS:Cytologic e...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19921015)70:8<2187::aid-cncr2820
更新日期:1992-10-15 00:00:00
abstract:BACKGROUND:Previous studies have demonstrated an association between a diagnosis of cancer and the risk of suicide; however, they failed to account for psychiatric care before a cancer diagnosis, which may confound this relationship. The objective of this study was to assess the effect of a cancer diagnosis on the risk...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.32146
更新日期:2019-08-15 00:00:00
abstract::From November 1987 to April 1989, 1000 women 40 years or older underwent screening vaginal sonography at the University of Kentucky Medical Center (Lexington, KY). Patients included in this investigation were all asymptomatic and had no known pelvic abnormalities. Each ovary was measured in three planes and ovarian vo...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19900201)65:3<573::aid-cncr28206
更新日期:1990-02-01 00:00:00
abstract:BACKGROUND:Because of the small number of cases (five) reported between 1929 and 1969 and a significant increase reported in the decade of the 1970s, the Familial Ovarian Cancer Registry was established in 1981 to study the occurrence of familial ovarian cancer in the United States. METHODS:Any woman (with or without ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.2820710214
更新日期:1993-01-15 00:00:00
abstract::In certain experimental tumor models, tumor growth is less pronounced in immune deficient animals. Characteristically, tumors such as the murine B16 melanoma and Lewis lung carcinoma (3LL) are weakly antigenic. We proposed that with such tumors that are weakly antigenic, growth is enhanced by T-cell factors. Young mic...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19880501)61:9<1792::aid-cncr2820
更新日期:1988-05-01 00:00:00
abstract:BACKGROUND:Adjuvant chemotherapy after surgical resection improves outcomes for patients with early-stage non-small cell lung cancer (NSCLC). To the authors' knowledge, there are no published prospective trials to date of adjuvant chemotherapy after surgical resection administered exclusively in older patients. In the ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.29360
更新日期:2015-08-01 00:00:00
abstract:BACKGROUND:Upfront autologous hematopoietic stem cell transplantation (AHCT) remains an important therapy in the management of patients with multiple myeloma (MM), a disease of older adults. METHODS:The authors investigated the outcomes of AHCT in patients with MM who were aged ≥70 years. The Center for International ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.33171
更新日期:2020-12-01 00:00:00
abstract:BACKGROUND:The purpose of this study was to define an optimal administration schedule of granisetron for patients receiving moderately emetogenic chemotherapy by comparing the antiemetic efficacy and safety of 2 mg of the drug administrated orally. METHODS:In this double-blind, randomized, parallel study, 2-dose regim...
journal_title:Cancer
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1002/(SICI)1097-0142(19960701)78:1<144::AID-CNC
更新日期:1996-07-01 00:00:00
abstract:BACKGROUND:Factors contributing to the lower likelihood of urologist follow-up among African American (AA) men diagnosed with prostate cancer may not be strictly related to patient factors. The authors investigated the relationship between crime, poverty, and poor housing, among others, and postdiagnosis urologist visi...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.28894
更新日期:2014-11-01 00:00:00
abstract::A total of 289 cases with malignant pleuroperitoneal effusions were reviewed, and their prognosis were analyzed in relation to the following factors: (1) chronologically divided series; (2) previous tumorectomy of the primary lesion; (3) presence or absence of other metastases; (4) site of effusion; (5) site of the pr...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19830101)51:1<136::aid-cncr28205
更新日期:1983-01-01 00:00:00
abstract::A review of over 400 primary bone tumors yielded 11 lesions with features allowing classification as malignant fibrous histiocytoma on a purely histological basis. Correlation with roentgenograms and clinical data indicated that these tumors occurred as osteolytic lesions associated with a high incidence of pathologic...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.2820360925
更新日期:1975-12-01 00:00:00
abstract::In 186 women with breast cancer, there was a progressive increase in the proportion of axillary nodal involvement as the number of pregnancies increased from zero to two or more (P = 0.026). Logistic regression analysis demonstrated that this effect was independent of the known relationship of age and tumor size to no...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19920215)69:4<981::aid-cncr28206
更新日期:1992-02-15 00:00:00
abstract:BACKGROUND:Hypoxia inducible factor-1 (HIF-1) plays a critical role in angiogenesis during vascular development. The authors tested the hypothesis that HIF-1 expression correlates with progression and angiogenesis in brain tumors. METHODS:The authors investigated the expression of the HIF-1alpha and HIF-1beta subunits...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:2000-06-01 00:00:00
abstract::A case of a hemangiopericytoma tumor metastatic to the lung from a central nervous system primary tumor in the posterior fossa is reported. The tumor was not responsive to treatment with cyclophosphamide, Adriamycin (doxorubicin), vincristine, DTIC (CYVADIC), high-dose methotrexate with citrovorum factor rescue, aziri...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19870815)60:4<916::aid-cncr28206
更新日期:1987-08-15 00:00:00
abstract:BACKGROUND:Whether patient navigation improves outcomes for patients with comorbidities is unknown. The aims of this study were to determine the effect of comorbidities on the time to diagnostic resolution after an abnormal cancer screening test and to examine whether patient navigation improves the timeliness and like...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.30316
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Previous studies have suggested an excess cancer risk in patients with carcinoid tumors. This association was reexamined using truly population-based data. METHODS:By means of data from the Danish Cancer Registry all carcinoid tumors diagnosed in Denmark between 1978 and 1989 were identified. All patients w...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19950701)76:1<106::aid-cncr28207
更新日期:1995-07-01 00:00:00