Relation of comorbidities and patient navigation with the time to diagnostic resolution after abnormal cancer screening.


BACKGROUND:Whether patient navigation improves outcomes for patients with comorbidities is unknown. The aims of this study were to determine the effect of comorbidities on the time to diagnostic resolution after an abnormal cancer screening test and to examine whether patient navigation improves the timeliness and likelihood of diagnostic resolution for patients with comorbidities in comparison with no navigation. METHODS:A secondary analysis of comorbidity data collected by Patient Navigation Research Program sites using the Charlson Comorbidity Index (CCI) was conducted. The participants were 6,349 patients with abnormal breast, cervical, colon, or prostate cancer screening tests between 2007 and 2011. The intervention was patient navigation or usual care. The CCI data were highly skewed across projects and cancer sites, and the CCI scores were categorized as 0 (CCI score of 0 or no comorbidities identified; 76% of cases); 1 (CCI score of 1; 16% of cases), or 2 (CCI score ≥ 2; 8% of cases). Separate adjusted hazard ratios for each site and cancer type were obtained, and then they were pooled with a meta-analysis random effects methodology. RESULTS:Patients with a CCI score ≥ 2 had delayed diagnostic resolution after an abnormal cancer screening test in comparison with those with no comorbidities. Patient navigation reduced delays in diagnostic resolution, with the greatest benefits seen for those with a CCI score ≥ 2. CONCLUSIONS:Persons with a CCI score ≥ 2 experienced significant delays in timely diagnostic care in comparison with patients without comorbidities. Patient navigation was effective in reducing delays in diagnostic resolution among those with CCI scores > 1. Cancer 2017;123:312-318. © 2016 American Cancer Society.






Whitley EM,Raich PC,Dudley DJ,Freund KM,Paskett ED,Patierno SR,Simon M,Warren-Mears V,Snyder FR,Patient Navigation Research Program Investigators.




Has Abstract


2017-01-01 00:00:00














  • Long-term treatment results of postoperative radiation therapy for advanced stage oropharyngeal carcinoma.

    abstract:BACKGROUND:The authors report the long-term treatment results for advanced stage base of tongue (BOT) and tonsillar fossa (TF) carcinomas treated with surgery and postoperative radiation therapy (RT) at Memorial Sloan-Kettering Cancer Center. METHODS:Between 1973 and 1986, 51 patients with squamous cell carcinoma of t...


    pub_type: 杂志文章


    authors: Zelefsky MJ,Harrison LB,Armstrong JG

    更新日期:1992-11-15 00:00:00

  • Prognostic significance of HER-2/neu oncoprotein expression in node-positive breast cancer. The influence of the pattern of immunostaining and adjuvant therapy.

    abstract:BACKGROUND:The influence of HER-2/neu on prognosis of breast cancer is controversial. The authors investigated by immunohistochemistry in node-positive disease the influence of the pattern of immunostaining (membranous or cytoplasmic) on outcome and the prognostic significance of this marker in patients receiving or no...


    pub_type: 杂志文章,多中心研究


    authors: Têtu B,Brisson J

    更新日期:1994-05-01 00:00:00

  • Metastatic patterns at autopsy in patients with ovarian carcinoma.

    abstract:BACKGROUND:Previously published studies concerning autopsy findings in ovarian cancer failed to consider the broad differences in factors that influence the course of disease. Furthermore, those studies were conducted when the currently accepted standards in diagnostics and therapy had not been fully established. The o...


    pub_type: 杂志文章


    authors: Güth U,Huang DJ,Bauer G,Stieger M,Wight E,Singer G

    更新日期:2007-09-15 00:00:00

  • Transcatheter hepatic arterial embolization followed by hepatic resection for the spontaneous rupture of hepatocellular carcinoma.

    abstract::In three cases of the spontaneous rupture of hepatocellular carcinoma, emergent transcatheter hepatic arterial embolization was performed for controlling the intraperitoneal hemorrhage. No more transfusions were required after embolization. Operation was carried out on the 10th, 5th, and 5th day, respectively, after l...


    pub_type: 杂志文章


    authors: Chen MF,Jan YY,Lee TY

    更新日期:1986-07-15 00:00:00

  • Angioinvasive plasma cell granulomas of the lung.

    abstract::A series of eight plasma cell granulomas of the lung were examined. Their clinical, pathologic, and immunohistochemical characteristics as well as the ultrastructural features of one case are in agreement with those found in the literature. One patient died after a surgical intervention complicated by invasion of pulm...


    pub_type: 杂志文章


    authors: Warter A,Satge D,Roeslin N

    更新日期:1987-02-01 00:00:00

  • Dietary carcinogens and mammary carcinogenesis. Induction of rat mammary carcinomas by administration of heterocyclic amines in cooked foods.

    abstract::Grilled or fried meat and fish contain various mutagenic heterocyclic amines, and structures of at least 19 compounds have already been determined. Among these, 10 have been examined for long term carcinogenicity, all proving to be positive. 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), for example, preferen...


    pub_type: 杂志文章


    authors: Nagao M,Ushijima T,Wakabayashi K,Ochiai M,Kushida H,Sugimura T,Hasegawa R,Shirai T,Ito N

    更新日期:1994-08-01 00:00:00

  • Leukocyte function in children with malignancies.

    abstract::Blood was obtained on 414 occasions from 106 children with acute lymphocytic leukemia (ALL) or solid tumors. Resting and stimulated hexose monophosphate shunt (HMPS) activity and unstimulated and stimulated nitroblue tetrazolium (NBT) dye reduction were assessed on each sample. The values obtained were compared to sim...


    pub_type: 杂志文章


    authors: Pickering LK,Anderson DC,Choi S,Feigin RD

    更新日期:1975-05-01 00:00:00

  • Long-term comparison of results of a drug sensitivity assay in vitro with patient response in lymphatic neoplasms.

    abstract::A short-term differential staining cytotoxicity (DiSC) assay was used to assess the sensitivity of tumor cells in vitro from patients with chronic lymphocytic leukemia (CLL) and non-Hodgkin's lymphoma to various cytotoxic drugs. The results have been correlated with drug sensitivities of the tumors in vivo. The chemos...


    pub_type: 杂志文章


    authors: Bird MC,Bosanquet AG,Forskitt S,Gilby ED

    更新日期:1988-03-15 00:00:00

  • Are we missing an opportunity for cancer prevention? Human papillomavirus vaccination for survivors of pediatric and young adult cancers.

    abstract::Survivors of pediatric and young adult cancers remain at risk for subsequent diseases, including those related to human papillomavirus (HPV) infection. Prevention of HPV acquisition through vaccination has become possible over the last decade. HPV vaccines have been shown to be safe and effective, yet rates of vaccina...


    pub_type: 杂志文章,评审


    authors: Temkin SM,Seibel NL

    更新日期:2015-10-01 00:00:00

  • Tissue components of weight loss in cancer patients. A new method of study and preliminary observations.

    abstract::A new approach using anthropometric, radiographic, biochemical, and ultrasonic methods allowed partition of body weight into fat, fat-free mass, skeletal muscle, and volume of heart, liver, kidneys, spleen, and tumor. These methods were used to evaluate body composition longitudinally in a pilot group of nine cancer p...


    pub_type: 杂志文章


    authors: Heymsfield SB,McManus CB

    更新日期:1985-01-01 00:00:00

  • Molecular predictors of outcome in a phase 3 study of gemcitabine and erlotinib therapy in patients with advanced pancreatic cancer: National Cancer Institute of Canada Clinical Trials Group Study PA.3.

    abstract:BACKGROUND:National Cancer Institute of Canada Clinical Trials Group PA.3 (NCIC CTG PA.3) was a phase 3 study (n = 569) that demonstrated benefits for overall survival and progression-free survival with the addition of the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) erlotinib to gemcitabine ...


    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: da Cunha Santos G,Dhani N,Tu D,Chin K,Ludkovski O,Kamel-Reid S,Squire J,Parulekar W,Moore MJ,Tsao MS

    更新日期:2010-12-15 00:00:00

  • Impact of weekend admissions on quality of care and outcomes in patients with acute myeloid leukemia.

    abstract:BACKGROUND:Hospital services are expectantly reduced over the weekend, which may result in a delay in treatment or in obtainment of medical procedures. The authors investigated quality of care and clinical outcomes of newly diagnosed acute myeloid leukemia (AML) patients who were hospitalized on weekends versus weekday...


    pub_type: 杂志文章


    authors: Bejanyan N,Fu AZ,Lazaryan A,Fu R,Kalaycio M,Advani A,Sobecks R,Copelan E,Maciejewski JP,Sekeres MA

    更新日期:2010-08-01 00:00:00

  • Local environmental influences on uveal melanoma: vitreous humor promotes uveal melanoma invasion, whereas the aqueous can be inhibitory.

    abstract:BACKGROUND:Uveal melanomas of the choroid and ciliary body are aggressive tumors causing the death of approximately 50% of patients. In contrast, iris melanomas only infrequently metastasize; why these differences exist is not known. The local environment can regulate cancer growth and development, and it is probable t...


    pub_type: 杂志文章


    authors: Canovas D,Rennie IG,Nichols CE,Sisley K

    更新日期:2008-04-15 00:00:00

  • Phase II study of doxorubicin plus ifosfamide/mesna in patients with advanced breast cancer.

    abstract::Four courses of ifosfamide with mesna given by intravenous infusions were combined with bolus doxorubicin in a phase II trial to treat patients with breast cancer. Ifosfamide can deplete intracellular glutathione levels and because doxorubicin resistance may be associated with elevated levels of intracellular glutathi...


    pub_type: 杂志文章


    authors: Millward MJ,Harris AL,Cantwell BM

    更新日期:1990-06-01 00:00:00

  • Hand-mirror variant of acute lymphoblastic leukemia. Evidence for early T-cell lineage in two cases by evaluation with monoclonal antibodies.

    abstract::Lymphoid cells from two patients with hand-mirror variant of acute lymphoblastic leukemia (ALL) were studied with various monoclonal antibodies in attempts to determine their derivation and differentiation. The predominant feature of the malignant bone marrow cells was strong reactivity with antibody 3A1, which stains...


    pub_type: 杂志文章


    authors: Gramatzki M,Strong DM,Duval-Arnould B,Morstyn G,Schumacher HR

    更新日期:1985-01-01 00:00:00

  • Breast carcinomas of limited extent: frequency, radiologic-pathologic characteristics, and surgical margin requirements.

    abstract:BACKGROUND:Clinical trials established the value of breast-conserving treatment (BCT) including the macroscopic removal of the tumor followed by local radiation therapy (RT) for Stage I and II invasive carcinomas. The occurrence of local tumor recurrence is related to the extent and multifocality of the tumor. Various ...


    pub_type: 杂志文章


    authors: Faverly DR,Hendriks JH,Holland R

    更新日期:2001-02-15 00:00:00

  • Diploid predominance in hereditary nonpolyposis colorectal carcinoma evaluated by flow cytometry.

    abstract::Fifty-nine colorectal carcinomas of patients with verified cancer family syndrome (CFS) were analyzed for DNA ploidy using flow cytometry. Sixty-eight percent of the tumors were diploid, and 32% were aneuploid. The aneuploid tumors had a median DNA index of 1.24 (range, 1.12-1.97). In 90% of all tumors the DNA index w...


    pub_type: 杂志文章


    authors: Kouri M,Laasonen A,Mecklin JP,Järvinen H,Franssila K,Pyrhönen S

    更新日期:1990-04-15 00:00:00

  • Mesenchymal tumors of the uterus. V. Intravenous leiomyomatosis. A clinical and pathologic study of 14 cases.

    abstract::Fourteen examples of intravenous leiomyomatosis in the FIP files were studied. Growth beyond the uterus occurred in 10 of the 14 examples, largely in vessels in the broad ligament and in uterine and iliac veins. Metastasis to the heart occurred in 1 example. The study provides evidence that is consistent with both the...


    pub_type: 杂志文章


    authors: Norris HJ,Parmley T

    更新日期:1975-12-01 00:00:00

  • Anaphylactoid reactions to methotrexate.

    abstract:BACKGROUND:Methotrexate is a chemotherapeutic agent frequently utilized for the treatment of malignant, rheumatic, and pulmonary diseases. Although this agent has been extensively used for more than 45 years, there are few reports of immediate systemic hypersensitivity reactions. The reported immediate reactions includ...


    pub_type: 杂志文章,评审


    authors: Alkins SA,Byrd JC,Morgan SK,Ward FT,Weiss RB

    更新日期:1996-05-15 00:00:00

  • Leiomyosarcoma in the mediastinum presenting as superior vena cava syndrome.

    abstract::The authors report a case of leiomyosarcoma in the mediastinum presenting with superior vena cava obstruction, and also demonstrate the aggressive nature of this tumor in spite of radiotherapy. Where technically feasible, surgery appears to be the treatment of choice. The pathologic and electron microscopic features o...


    pub_type: 杂志文章


    authors: Sunderrajan EV,Luger AM,Rosenholtz MJ,Maltby JD

    更新日期:1984-06-01 00:00:00

  • Dose escalation of gemcitabine concomitant with radiation and cisplatin for nonsmall cell lung cancer: a phase 1-2 study.

    abstract:BACKGROUND:The current study was conducted to evaluate the maximum tolerable dose of weekly gemcitabine administered simultaneously with radiation and cisplatin in patients with locally advanced nonsmall cell lung cancer (NSCLC). METHODS:Patients with stage IIIA/B NSCLC received concurrently 63 grays radiation and 20 ...


    pub_type: 杂志文章


    authors: Momm F,Kaden M,Tannock I,Schumacher M,Hasse J,Henke M

    更新日期:2010-10-15 00:00:00

  • The prognostic significance of nuclear DNA content in prostatic carcinoma.

    abstract::The prognostic significance of ploidy level was studied in prostatic carcinoma and compared with the prognostic significance of morphologic grade and clinical stage. A nonselected group of 145 patients was studied in whom prostatic carcinoma was diagnosed by fine-needle aspiration biopsy at the Karolinska Hospital in ...


    pub_type: 杂志文章


    authors: Forsslund G,Esposti PL,Nilsson B,Zetterberg A

    更新日期:1992-03-15 00:00:00

  • Once weekly total and subtotal skin electron beam therapy for Kaposi's sarcoma.

    abstract::Although Kaposi's sarcoma (KS) usually appears with solitary skin lesions, in a large percentage of these patients the disease progresses eventually to involve large extensive segments of the skin. In the past, the most frequently used approach is the irradiation of isolated lesions as they arose, hence the so-called ...


    pub_type: 杂志文章


    authors: Nisce LZ,Safai B,Poussin-Rosillo H

    更新日期:1981-02-15 00:00:00

  • Preirradiation gemcitabine chemotherapy for newly diagnosed glioblastoma. A phase II study.

    abstract:BACKGROUND:The median survival for patients with glioblastoma is reported to be 12 months. To improve the outcome for glioblastoma patients, the authors evaluated the therapeutic efficacy of preirradiation gemcitabine chemotherapy followed by standard radiotherapy. METHODS:Twenty-one patients with newly diagnosed glio...


    pub_type: 临床试验,杂志文章


    authors: Weller M,Streffer J,Wick W,Kortmann RD,Heiss E,Küker W,Meyermann R,Dichgans J,Bamberg M

    更新日期:2001-01-15 00:00:00

  • Low-dose Adriamycin remission maintenance therapy for pediatric solid tumors.

    abstract::A low-dose maintenance schedule of Adriamycin was evaluated in six children whose metastatic solid tumors regressed following toxic induction therapy with Adriamycin. Three of these children are now disease-free more than one year following discontinuation of therapy. Adriamycin can be given on a low-dose maintenance ...


    pub_type: 杂志文章


    authors: Hvizdala EV,Komp DM,Arnold JB

    更新日期:1977-06-01 00:00:00

  • Temozolomide for recurrent low-grade spinal cord gliomas in adults.

    abstract:BACKGROUND:There is no standard therapy for surgery- and radiotherapy-resistant, recurrent, low-grade spinal cord gliomas. Therefore, a retrospective study of temozolomide (TMZ) in adults with recurrent low-grade spinal cord gliomas with a primary objective of determining progression-free survival (PFS) was performed. ...


    pub_type: 杂志文章


    authors: Chamberlain MC

    更新日期:2008-09-01 00:00:00

  • Functional insulin receptors are overexpressed in thyroid tumors: is this an early event in thyroid tumorigenesis?

    abstract:BACKGROUND:Insulin receptor (IR), a member of the receptor tyrosine kinase family, is expressed in normal thyroid cells and affects thyroid cell proliferation and differentiation. METHODS:The authors measured IR content in benign and malignant thyroid tumors by three independent methods: a specific radioimmunoassay, 1...


    pub_type: 杂志文章


    authors: Frittitta L,Sciacca L,Catalfamo R,Ippolito A,Gangemi P,Pezzino V,Filetti S,Vigneri R

    更新日期:1999-01-15 00:00:00

  • Silent cirrhosis in patients with hepatocellular carcinoma. Implications for screening in high-incidence and low-incidence areas.

    abstract::We assessed the frequency of silent (i.e., clinically asymptomatic) cirrhosis among 305 patients with hepatocellular carcinoma (HCC) and cirrhosis in relation to the patients' country of birth, the cause of the cirrhosis, clinical features, and hepatitis B surface antigen (HBsAg) status. Overall, 56% of the patients h...


    pub_type: 杂志文章


    authors: Zaman SN,Johnson PJ,Williams R

    更新日期:1990-04-01 00:00:00

  • Tumor-associated antigen 43-9F is of prognostic value in squamous cell carcinoma of the lung. A retrospective immunohistochemical study.

    abstract:BACKGROUND:Squamous cell lung carcinoma (SLC), the most frequent type of lung cancer, generally is treated surgically and its prognosis is poor. The only current clinically useful prognostic criterion is lymph node staging (TNM classification). Expression of a novel tumor-associated carbohydrate epitope Gal beta 1-3[Fu...


    pub_type: 杂志文章


    authors: Battifora H,Sorensen HR,Mehta P,Ahn C,Niland J,Hage E,Pettijohn DE,Olsson L

    更新日期:1992-10-01 00:00:00

  • The use of prognostic factors in clinical trials.

    abstract::Numerous examples exist of prognostic factors that have been conclusively established and that can segregate the target patient population into subgroups with vastly different outcomes. At the same time, we can expect, in the majority of trials being conducted, that if a new treatment turns out to be successful, it ge...


    pub_type: 杂志文章


    authors: Sather HN

    更新日期:1986-07-15 00:00:00