Relationship between CA 125 and progesterone production in women with ovarian carcinoma.

Abstract:

:CA 125 and steroid production is compared in a group of 48 women with ovarian epithelial carcinoma. The histologic types were I C (n = 20), II C (n = 5), III C (n = 11), or V (n = 12). The number of patients in Stage I was six; Stage II, 11; Stage III, 16; and Stage IV, 15. All patients were naturally or surgically postmenopausal. Blood samples were taken at the first admission to the hospital and 14 cases with large tumors were followed with monthly sampling during chemotherapy, and in 13 cases until a recurrence of the tumor. CA 125 and steroid production were analyzed using radioimmunoassay. The results show a high correlation between initial CA 125 and especially progesterone plasma concentration. Both decreases during chemotherapy parallel the shrinkage of the tumor and increase 1 to 4 months before recurrence. Progesterone and CA 125 together predicted all recurrences but none of the factors alone. The prognostic value for 5-year survival was somewhat higher for progesterone than CA 125. CA 125 correlated highly with sex hormone binding globulin (SHBG) and negatively with albumin. The correlation may be due to the intercorrelation with tumor burden.

journal_name

Cancer

journal_title

Cancer

authors

Mählck CG,Grankvist K,Kjellgren O,Bäckström T

doi

10.1002/1097-0142(19900501)65:9<2058::aid-cncr2820

subject

Has Abstract

pub_date

1990-05-01 00:00:00

pages

2058-63

issue

9

eissn

0008-543X

issn

1097-0142

journal_volume

65

pub_type

杂志文章

相关文献

CANCER文献大全
  • A retrospective analysis of 10-year survivors from carcinoma of the lung.

    abstract::From 1949 to 1972, 4732 patients with carcinomas of the lung were seen. Of these, 118 patients were found alive at 10 years from their initial diagnosis and treatment. This number represents only 2.5% of all lung cancers seen because many have been lost to follow-up within the first ten years, and their true status is...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19840315)53:6<1405::aid-cncr2820

    authors: Temeck BK,Flehinger BJ,Martini N

    更新日期:1984-03-15 00:00:00

  • Chemotherapy of advanced salivary gland neoplasms.

    abstract::Fourteen patients with advanced salivary gland malignancies were treated with combination chemotherapy. Five of 13 patients responded to cyclophosphamide and adriamycin and two patients in the responding groups underwent further potentially curable treatment, rendering them disease-free. Three patients with mucoepider...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章

    doi:10.1002/1097-0142(19821201)50:11<2261::aid-cncr282

    authors: Posner MR,Ervin TJ,Weichselbaum RR,Fabian RL,Miller D

    更新日期:1982-12-01 00:00:00

  • Familial bilateral papillary cystadenoma of the epididymis: report of three cases in siblings.

    abstract::This paper describes an unusual, familial bilateral papillary cystadenoma of the epididymis found in three siblings. The histological characteristics of the tumor were: 1) papillary proliferation of clear cells, consisting of both tall columnar and round ovoid cells, in the efferent duct epithelium; and 2) cystic dila...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197604)37:4<1831::aid-cncr282037

    authors: Tsuda H,Fukushima S,Takahashi M,Hikosaka Y,Hayashi K

    更新日期:1976-04-01 00:00:00

  • Extranodal small lymphocytic proliferation: a clinicopathologic and immunocytochemical study.

    abstract::Twelve patients who presented with extranodal small lymphocytic proliferations were studied. The patients ranged in age from 33 to 67 years; six were male and six female. Locations of the initial lesion included the conjunctiva and orbit, lung, stomach, small bowel, skin, and subcutis. The histopathologic picture in a...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19820101)49:1<84::aid-cncr282049

    authors: Evans HL

    更新日期:1982-01-01 00:00:00

  • Retrospective cohort study evaluating the impact of intraperitoneal morcellation on outcomes of localized uterine leiomyosarcoma.

    abstract:BACKGROUND:Uterine leiomyosarcoma (ULMS) is identified in 0.1% to 0.2% of hysterectomy specimens of presumed leiomyoma. To date, there is no preoperative technique that reliably differentiates ULMS from uterine leiomyoma. Increasing use of minimally invasive approaches for the management of leiomyomas may result in ina...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.28844

    authors: George S,Barysauskas C,Serrano C,Oduyebo T,Rauh-Hain JA,Del Carmen MG,Demetri GD,Muto MG

    更新日期:2014-10-15 00:00:00

  • Serum HER-2/neu and relative resistance to trastuzumab-based therapy in patients with metastatic breast cancer.

    abstract:BACKGROUND:Previous reports based on small patient numbers suggested that changes in serum HER-2/neu levels may predict response or lack of response to trastuzumab-based therapies in metastatic breast cancer (MBC). The objectives of this study were to pool data from 307 patients with MBC from 7 medical institutions to ...

    journal_title:Cancer

    pub_type: 杂志文章,多中心研究

    doi:10.1002/cncr.23689

    authors: Ali SM,Carney WP,Esteva FJ,Fornier M,Harris L,Köstler WJ,Lotz JP,Luftner D,Pichon MF,Lipton A,Serum HER-2\/neu Study Group.

    更新日期:2008-09-15 00:00:00

  • Management of asparaginase induced hemorrhagic pancreatitis complicated by pseudocyst.

    abstract::Asparaginase induced hemorrhagic pancreatitis is a rare but serious development occurring in less than 0.5% of patients treated with this drug. Severe pancreatitis with progressive abdominal distention, toxemia, hypotension and respiratory insufficiency occurred in an 18-year-old patient with acute lymphoblastic leuke...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197902)43:2<718::aid-cncr2820430

    authors: Greenstein R,Nogeire C,Ohnuma T,Greenstein A

    更新日期:1979-02-01 00:00:00

  • Antitumor effect of methionine-depleting total parenteral nutrition with doxorubicin administration on Yoshida sarcoma-bearing rats.

    abstract::Methionine-depleting total parenteral nutrition (methionine-depleting TPN), which infuses an amino acid solution devoid of L-methionine and L-cysteine as the sole protein source, showed enhancement of the effect of several anti-cancer agents. In this study, the combined effect of the methionine-depleting TPN with the ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19920401)69:7<1865::aid-cncr2820

    authors: Goseki N,Yamazaki S,Endo M,Onodera T,Kosaki G,Hibino Y,Kuwahata T

    更新日期:1992-04-01 00:00:00

  • A phase 2 trial of combination therapy with thalidomide, arsenic trioxide, dexamethasone, and ascorbic acid (TADA) in patients with overlap myelodysplastic/myeloproliferative neoplasms (MDS/MPN) or primary myelofibrosis (PMF).

    abstract:BACKGROUND:Primary myelofibrosis (PMF) and overlap myelodysplastic/myeloproliferative neoplasms (MDS/MPN) are clonal hematopoietic disorders that share similar clinical features and molecular abnormalities, such as the Janus kinase 2 (JAK2) valine to phenylalanine mutation at codon 617 (V617F) and the tet methylcytosin...

    journal_title:Cancer

    pub_type: 杂志文章,多中心研究

    doi:10.1002/cncr.26741

    authors: Bejanyan N,Tiu RV,Raza A,Jankowska A,Kalaycio M,Advani A,Chan J,Saunthararajah Y,Mooney L,Maciejewski JP,Sekeres MA

    更新日期:2012-08-15 00:00:00

  • Pinealoma. A report of twelve irradiated cases.

    abstract::The records of 12 patients with a diagnosis of pinealoma or ectopic pinealoma irradiated at Montefiore Hospital and Medical Center between 1961 and 1971 were reviewed. Diagnosis was made clinically and radiographically. Histology is available in three cases. Eight cases were treated with small fields (4 X 4 to 6 X 8 c...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197606)37:6<2713::aid-cncr282037

    authors: Mincer F,Meltzer J,Botstein C

    更新日期:1976-06-01 00:00:00

  • The role of Fas ligand and transforming growth factor beta in tumor progression: molecular mechanisms of immune privilege via Fas-mediated apoptosis and potential targets for cancer therapy.

    abstract::Despite the fact that expression of Fas ligand (FasL) in cytotoxic T lymphocytes (CTLs) and in natural killer (NK) cells plays an important role in Fas-mediated tumor killing, During tumor progression FasL-expressing tumor cells are involved in counterattacking to kill tumor-infiltrating lymphocytes (TILs). Soluble Fa...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/cncr.20270

    authors: Kim R,Emi M,Tanabe K,Uchida Y,Toge T

    更新日期:2004-06-01 00:00:00

  • The use of prostate specific antigen density to improve the sensitivity of prostate specific antigen in detecting prostate carcinoma.

    abstract:BACKGROUND:Prostate specific antigen (PSA) is useful as a tumor marker for monitoring patients with prostate cancer after definitive therapy. Limitations have been noted when PSA was used for the early detection of prostate cancer. The use of prostate specific antigen density [PSAD = PSA (ng/ml)/prostate volume (cc)] h...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19941201)74:11<2991::aid-cncr282

    authors: Bretton PR,Evans WP,Borden JD,Castellanos RD

    更新日期:1994-12-01 00:00:00

  • Prostate-specific antigen response after short-term hormone therapy plus external-beam radiotherapy and outcome in patients treated on Radiation Therapy Oncology Group study 9413.

    abstract:BACKGROUND:The objective of this study was to assess the impact of a prostate-specific antigen (PSA) complete response (PSA-CR), measured at the end of external-beam radiotherapy and short-term hormone therapy, on treatment outcomes. METHODS:The phase 3 Radiation Therapy Oncology Group 9413 trial, as part of its origi...

    journal_title:Cancer

    pub_type: 杂志文章,随机对照试验

    doi:10.1002/cncr.28019

    authors: Cury FL,Hunt D,Roach M 3rd,Shipley W,Gore E,Hsu IC,Krisch RE,Seider MJ,Sandler H,Lawton C

    更新日期:2013-06-01 00:00:00

  • Malignant mucosal melanoma of the head and neck: review of the literature and report of 14 patients.

    abstract:BACKGROUND:Fortunately, primary malignant mucosal melanoma of the head and neck is a rare entity. A paucity of data elucidating the predictive factors as well as the unpredictable and aggressive biologic behavior of mucosal melanoma compound the vexing clinical situation. This review summarizes what the literature reve...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/(sici)1097-0142(19971015)80:8<1373::aid-cn

    authors: Manolidis S,Donald PJ

    更新日期:1997-10-15 00:00:00

  • Ifosfamide-induced renal tubular defects.

    abstract::Unexpected nephrotoxicity has been described in high-dose, bolus ifosfamide (IFF) therapy. Renal injury is not thought to occur in patients receiving fractionated schedules, although microscopic hematuria from bladder irritation is not uncommon. IFF is undergoing trials in patients with malignant lymphomas, gynecologi...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19890215)63:4<649::aid-cncr28206

    authors: Patterson WP,Khojasteh A

    更新日期:1989-02-15 00:00:00

  • Prognostic factors in pediatric spinal cord astrocytoma.

    abstract:BACKGROUND:Factors that could optimize the management of pediatric spinal cord astrocytoma remain unclear and controversial. METHODS:To determine the factors that influence the prognosis of pediatric patients with spinal cord astrocytomas, a series of 73 consecutive patients at 13 French treatment centers with histolo...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0142(19981201)83:11<2391::aid-c

    authors: Bouffet E,Pierre-Kahn A,Marchal JC,Jouvet A,Kalifa C,Choux M,Dhellemmes P,Guérin J,Tremoulet M,Mottolese C

    更新日期:1998-12-01 00:00:00

  • T-antigen in normal and neoplastic urothelium.

    abstract::The expression of the Thomsen-Friedenreich antigen (T-antigen) in normal and neoplastic urothelium was investigated using paraffin-processed and fresh frozen tissue sections obtained by biopsy from 56 patients. The T-antigen was detected through its binding to the peanut agglutinin (PNA) with two methods: a biotin-avi...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19860915)58:6<1236::aid-cncr2820

    authors: Limas C,Lange P

    更新日期:1986-09-15 00:00:00

  • Referral of lung cancer patients to university hospital cancer centers. A population-based study in two rural states.

    abstract::To determine whether the referral of lung cancer patients to university cancer centers was related to nonclinical factors, the medical charts were reviewed for almost all lung cancer patients diagnosed during the period of 1973-1976 in New Hampshire and Vermont. Greater distance from a cancer center, lower functional ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19881015)62:8<1647::aid-cncr2820

    authors: Greenberg ER,Dain B,Freeman D,Yates J,Korson R

    更新日期:1988-10-15 00:00:00

  • Long term results of stereotactic brachytherapy used in the initial treatment of patients with glioblastomas.

    abstract:BACKGROUND:Despite optimal therapy with surgery and radiotherapy, the prognosis of patients with glioblastomas remains poor. Stereotactic brachytherapy involves the accurate placement of radioactive isotopes within brain tumors, significantly increasing the dose of radiation that can be delivered to the tumor bed witho...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章

    doi:10.1002/1097-0142(19940615)73:12<3029::aid-cncr282

    authors: Wen PY,Alexander E 3rd,Black PM,Fine HA,Riese N,Levin JM,Coleman CN,Loeffler JS

    更新日期:1994-06-15 00:00:00

  • Chromosome rearrangement at 17q25 and xp11.2 in alveolar soft-part sarcoma: A case report and review of the literature.

    abstract:BACKGROUND:Despite the characteristic histopathologic appearance of alveolar soft-part sarcoma (ASPS), its histogenesis remains unclear, and cytogenetic analysis of ASPS is limited to eight cases so far because of the extreme rarity of this disease. METHODS:The authors document a cytogenetic study of a primary case of...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:

    authors: Joyama S,Ueda T,Shimizu K,Kudawara I,Mano M,Funai H,Takemura K,Yoshikawa H

    更新日期:1999-10-01 00:00:00

  • Sentinel lymph node biopsy in patients with papillary thyroid carcinoma.

    abstract:BACKGROUND:It remains controversial whether modified radical neck dissection (MRND) for patients with papillary thyroid carcinoma improves prognosis. However, it is highly probable that the incidence of local recurrence is reduced by lymph node dissection. Sentinel lymph node (SLN) biopsy (SLNB) for patients with melan...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(20011201)92:11<2868::aid-cncr101

    authors: Fukui Y,Yamakawa T,Taniki T,Numoto S,Miki H,Monden Y

    更新日期:2001-12-01 00:00:00

  • Treatment of the patient with cancer using parenteral electronic drug administration.

    abstract::Oncologic therapy demands technologic sophistication to meet the clinical challenges of proper drug administration for chemotherapeutic agents, pain management, antibiotics, hydration, antiemetic drugs, and total parenteral nutrition. Drug administration systems for patient-controlled analgesia include benefits of imp...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:

    authors: Shaw HL

    更新日期:1992-08-15 00:00:00

  • Genetic variations in angiopoietin and pericyte pathways and clinical outcome in patients with resected colorectal liver metastases.

    abstract:BACKGROUND:Genes involved in the angiopoietin and pericyte pathways may become escape mechanisms under antivascular endothelial growth factor (anti-VEGF) therapy. The authors investigated whether variations within genes in these pathways are associated with clinical outcome in patients with colorectal liver metastases ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.29259

    authors: Stremitzer S,Zhang W,Yang D,Ning Y,Stintzing S,Sebio A,Sunakawa Y,Yamauchi S,Matsusaka S,El-Khoueiry R,Stift J,Wrba F,Gruenberger T,Lenz HJ

    更新日期:2015-06-01 00:00:00

  • Growth rate of 147 mammary carcinomas.

    abstract::In 147 cases of mammary carcinoma, 388 serial mammographies were performed before final treatment. The average retrospective observation time was 27 months with a range of two months to 11 years. The number of serial mammographies per case ranged between two and 11. The tumor volume doubling times (TV); obtained by me...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19800415)45:8<2198::aid-cncr2820

    authors: von Fournier D,Weber E,Hoeffken W,Bauer M,Kubli F,Barth V

    更新日期:1980-04-15 00:00:00

  • A proposed staging system for primary gastric lymphoma.

    abstract:BACKGROUND:Although primary gastric lymphoma is the most common extranodal lymphoma, no specific staging system exists. METHODS:The authors reviewed 98 cases histologically classified according to the Working Formulation, including low grade B-cell lymphoma of mucosa-associated lymphoid tissue type. Survival rates wer...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19940601)73:11<2709::aid-cncr282

    authors: Shimodaira M,Tsukamoto Y,Niwa Y,Goto H,Hase S,Hayakawa T,Nagasaka T

    更新日期:1994-06-01 00:00:00

  • Histogenesis of spontaneous regression of cervical intraepithelial neoplasias.

    abstract::It is justifiable to assume that a spontaneous regression of cervical intraepithelial neoplasia is in progress when pathologic epithelium is replaced by normal epithelium. Very rare histologic pictures of this process are shown. Dysplastic squamous epithelium or intraepithelial carcinomas become detached from their ba...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(1984)54:4<616::aid-cncr282054040

    authors: Bajardi F

    更新日期:1984-08-15 00:00:00

  • Macroregenerative nodule of the liver. A clinicopathologic study of 345 autopsy cases of chronic liver disease.

    abstract::The livers of 345 autopsy cases of chronic liver disease were examined for macroregenerative nodule (MRN), a large nodular lesion more than 10 mm in diameter. A total of 86 lesions of MRN was found in 49 cases (14.2%): 32 were from 191 cases of hepatocellular carcinoma (HCC), 16 were from 148 cases of cirrhosis only, ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19880101)61:1<99::aid-cncr282061

    authors: Furuya K,Nakamura M,Yamamoto Y,Togei K,Otsuka H

    更新日期:1988-01-01 00:00:00

  • Breast carcinoma with noninflammatory skin involvement (T4b): time to abandon an historic relic from the TNM classification.

    abstract:BACKGROUND:In this study, the authors evaluated the clinical presentation of patients with T4b breast carcinoma, analyzed the impact of noninflammatory skin involvement on long-term survival, and addressed the question whether the T4 tumor category still has any justification. METHODS:The clinical course of a study gr...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.21394

    authors: Guth U,Wight E,Schotzau A,Langer I,Dieterich H,Rochlitz C,Herberich L,Holzgreve W,Singer G

    更新日期:2005-11-01 00:00:00

  • Adjuvant therapy of osteosarcoma--A Phase II trial: Southwest Oncology Group study 9139.

    abstract:BACKGROUND:The objective of this study was to estimate the time to treatment failure and survival rate of the three-drug combination of doxorubicin, cisplatin, and ifosfamide as primary and postoperative, adjunctive treatment for teenagers and adults with osteosarcoma (OS). METHODS:Sixty-three eligible patients with n...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1002/cncr.20021

    authors: Zalupski MM,Rankin C,Ryan JR,Lucas DR,Muler J,Lanier KS,Budd GT,Biermann JS,Meyers FJ,Antman K

    更新日期:2004-02-15 00:00:00

  • Low participation rates and disparities in participation in interventional clinical trials for myelodysplastic syndromes.

    abstract:BACKGROUND:The development of novel therapies for the myelodysplastic syndromes (MDS) is hampered by inadequate trial recruitment. Factors contributing to low trial accrual are incompletely understood. METHODS:This study analyzed a pooled patient database from institutions of the US MDS Clinical Research Consortium to...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.33105

    authors: Brierley CK,Zabor EC,Komrokji RS,DeZern AE,Roboz GJ,Brunner AM,Stone RM,Sekeres MA,Steensma DP

    更新日期:2020-11-01 00:00:00