Abstract:
:Werner's syndrome, a relatively rare and autosomal recessive disorder, is well known to be characterized by a high frequency of malignant neoplasm. The occurrence of familial neoplasm in patients with this condition, however, has been recorded only once before in the literature. Reported are the findings with regard to the occurrence of sarcomas in three siblings with Werner's syndrome. Two of the current three cases were of malignant fibrous histiocytomas, one in a 36-year-old man and one in a 32-year-old woman. The other case was of a leiomyosarcoma in a 26-year-old man. Two of the patients died of the tumors, although the third is still alive. The exact cause of the high incidence of malignant tumor in this family remains unknown, as is still so in other cases of Werner's syndrome.
journal_name
Cancerjournal_title
Cancerauthors
Usui M,Ishii S,Yamawaki S,Hirayama Tdoi
10.1002/1097-0142(19841201)54:11<2580::aid-cncr282subject
Has Abstractpub_date
1984-12-01 00:00:00pages
2580-6issue
11eissn
0008-543Xissn
1097-0142journal_volume
54pub_type
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