Abstract:
:Three patients with biopsy-proven lentigo maligna were treated with topical 5-fluorouracil. Treatment consisted of twice daily application of 5% 5-fluorouracil cream for 13, 6, and 9 weeks, respectively. Two patients demonstrated presence of invasive melanoma; in one the melanoma was evident before chemotherapy, and in the other the lesion became evident after chemotherapy. In both the lentigo was treated topically and the melanoma excised locally. Posttreatment followup times through April 1, 1974 have been 42, 24, and 22 months, respectively. There has been no evidence of metastases in any patient. Topical chemotherapy with 5-fluorouracil cream appears to offer an encouraging alternative method of therapy for lentigo maligna of the face.
journal_name
Cancerjournal_title
Cancerauthors
Litwin MS,Krementz ET,Mansell PW,Reed RJdoi
10.1002/1097-0142(197503)35:3<721::aid-cncr2820350subject
Has Abstractpub_date
1975-03-01 00:00:00pages
721-33issue
3eissn
0008-543Xissn
1097-0142journal_volume
35pub_type
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