Abstract:
BACKGROUND:Scarce data exist concerning the outcome of very elderly patients with head and neck squamous cell carcinoma (HNSCC). METHODS:The clinical files of 316 patients aged > or = 80 years with HNSCC who were included in the authors' hospital database between 1987 and 2006 were reviewed retrospectively. RESULTS:Approximately 88% of patients received locoregional treatment, 31% of patients underwent surgery, and 57% of patients received definitive radiotherapy. The median disease-specific survival (DSS) was 21.3 months, and a plateau was observed after 5 years. The median overall survival (OS) was 13.0 months. Both the median DSS and the median OS were longer for patients with stage I/II HNSCC than for patients with stage III/IV HNSCC (median DSS, not reached vs 11.4 months; P < .001; median OS, 41.9 months vs 7.9 months; P < .001). On multivariate analysis, stage I/II disease, treatment with curative intent, and evidence of locoregional control were independent predictors of improved survival. CONCLUSIONS:The outcome of patients with stage I/II HNSCC aged > or = 80 years was similar to that of younger patients, and the current results indicated that age should not be used to deny them optimal treatment. Elderly patients with stage III/IV HNSCC had poor survival. Geriatric tools should be used to identify elderly patients who are eligible for optimal locoregional treatment.
journal_name
Cancerjournal_title
Cancerauthors
Italiano A,Ortholan C,Dassonville O,Poissonnet G,Thariat J,Benezery K,Vallicioni J,Peyrade F,Marcy PY,Bensadoun RJdoi
10.1002/cncr.23931subject
Has Abstractpub_date
2008-12-01 00:00:00pages
3160-8issue
11eissn
0008-543Xissn
1097-0142journal_volume
113pub_type
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