Rapid rise of serum prostate specific antigen levels after discontinuation of the herbal therapy PC-SPES in patients with advanced prostate carcinoma: report of four cases.

Abstract:

BACKGROUND:PC-SPES is an herbal supplement whose mechanisms of action are poorly understood, but may be estrogenic. The objective of the current report is to describe the effects of discontinuing PC-SPES treatment in four patients with androgen-independent prostate carcinoma. METHODS:Patient charts were retrospectively reviewed. A MEDLINE search was performed to investigate whether these effects of PC-SPES had been previously reported. RESULTS:Four men whose metastatic prostate carcinoma progressed despite androgen ablation and subsequent PC-SPES treatment are described. All four patients developed a rapid increase in serum prostate specific antigen (PSA) within one month of stopping PC-SPES, ranging from 345% to 880%. Two patients increased their PSA levels to 1300% and 1400% after 7 weeks. Compared to the rate of rise of PSA levels prior to and during PC-SPES therapy, the rise after stopping this treatment was much higher than expected. Clinical symptoms remained relatively stable despite the serologic changes. CONCLUSIONS:Discontinuing PC-SPES therapy can be associated with a rapid rise in PSA. To the authors' knowledge, this effect has not been reported previously. This effect should be considered in the design of clinical trials as well as in the standard management of androgen-independent prostate carcinoma patients.

journal_name

Cancer

journal_title

Cancer

authors

Oh WK,George DJ,Kantoff PW

doi

10.1002/cncr.10269

subject

Has Abstract

pub_date

2002-02-01 00:00:00

pages

686-9

issue

3

eissn

0008-543X

issn

1097-0142

pii

10.1002/cncr.10269

journal_volume

94

pub_type

杂志文章

相关文献

CANCER文献大全
  • A comparison between combination chemotherapy and total body irradiation plus combination chemotherapy in non-Hodgkin's lymphoma.

    abstract::Thirty-nine untreated patients with either lymphocytic or nodular mixed/nodular histiocytic non-Hodgkin's lymphoma, stage II--IV, were randomized to treatment with total body irradiation (TBI), 100 rads in 10 fractions over 12 days, plus combination chemotherapy with either cyclophosphamide, vincristine and prednisone...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1002/1097-0142(197906)43:6<2227::aid-cncr282043

    authors: Brereton HD,Young RC,Longo DL,Kirkland LR,Berard CW,Jaffe ES,DeVita VT,Johnson RE

    更新日期:1979-06-01 00:00:00

  • Primary lymphoma of the central nervous system. Computerized tomography scan characteristics and treatment results for 12 cases.

    abstract::A retrospective analysis of 12 patients with primary central nervous system non-Hodgkin's lymphoma seen from 1958 to 1980 was carried out with emphasis on diagnostic evaluation and treatment results. Computerized tomography (CT) scans were found to be the most valuable diagnostic tool both for initial evaluation as we...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/1097-0142(19831201)52:11<1993::aid-cncr282

    authors: Mendenhall NP,Thar TL,Agee OF,Harty-Golder B,Ballinger WE Jr,Million RR

    更新日期:1983-12-01 00:00:00

  • Small cell carcinomas of the parotid gland. A clinicopathologic study of three cases.

    abstract::Clinical, histological and ultrastructural features of three small cell carcinomas arising in the parotid gland are presented. The light microscopic appearance of two of the neoplasms suggested neuroendocrine cell derivation, confirmed by electron microscopy in both instances. The fine structure of the third neoplasm ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19831201)52:11<2115::aid-cncr282

    authors: Kraemer BB,Mackay B,Batsakis JG

    更新日期:1983-12-01 00:00:00

  • Intracystic papillary carcinoma: a review of 917 cases.

    abstract:BACKGROUND:Intracystic papillary carcinoma (IPC) is an uncommon breast neoplasm. To the authors' knowledge there are limited data regarding its epidemiology and only small studies focusing on outcomes. By using a large, population-based database, this study aimed to identify specific characteristics of patients with IP...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.23723

    authors: Grabowski J,Salzstein SL,Sadler GR,Blair S

    更新日期:2008-09-01 00:00:00

  • Cancer in the families of children with soft tissue sarcoma.

    abstract::The cancer experience among 754 first-degree relatives (mothers, fathers, and siblings) of a population-based series of 177 children with soft tissue sarcoma is reported. The current study represents an extension of our earlier work in which the authors found an excess of breast cancer in the mothers of 143 of these c...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19901115)66:10<2239::aid-cncr282

    authors: Birch JM,Hartley AL,Blair V,Kelsey AM,Harris M,Teare MD,Jones PH

    更新日期:1990-11-15 00:00:00

  • Autologous stem cell transplantation for patients with chronic myeloid leukemia. The Argentine Group of Bone Marrow Transplantation (GATMO) experience.

    abstract:BACKGROUND:The objective of this analysis was to evaluate the role of autologous stem cell transplantation (ASCT) in prolonging disease free survival (DFS) and overall survival (OS) in patients with chronic myeloid leukemia (CML) who received autografts of Philadelphia chromosome (Ph) positive or Ph negative cell harve...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.10931

    authors: Koziner B,Dengra C,Lucero G,Klein G,Cánepa C,Milovic V,Milone G,Robinson A,Cerutti I,Saporito G,Kusminsky G,Milone J,Bordone J,Lastiri F,Argentine Group of Bone Marrow Transplantation.

    更新日期:2002-12-01 00:00:00

  • Role of the gallium scan in Hodgkin's disease.

    abstract::The reports of 240 gallium scans on 165 patients with Hodgkin's disease were reviewed to compare results with higher doses with those in earlier studies that employed lower doses. Tracer concentrations in specific sites were correlated with radiologic and pathologic reports and with the clinical courses of the patient...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19900301)65:5<1090::aid-cncr2820

    authors: Hagemeister FB,Fesus SM,Lamki LM,Haynie TP

    更新日期:1990-03-01 00:00:00

  • Performance status and comorbidity in elderly cancer patients compared with young patients with neoplasia and elderly patients without neoplastic conditions.

    abstract:BACKGROUND:Elderly people constitute a heterogeneous group and are at an increased risk for the development of cancer. It is not clear whether comorbid conditions and functional status influence clinical decisions and the pattern of referral in elderly cancer patients. The current study investigated functional status m...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:

    authors: Repetto L,Venturino A,Vercelli M,Gianni W,Biancardi V,Casella C,Granetto C,Parodi S,Rosso R,Marigliano V

    更新日期:1998-02-15 00:00:00

  • Prognostically favorable immunogens of human breast cancer tissue: antigenic similarity to murine mammary tumor virus.

    abstract::A leukocyte migration procedure was utilized to test cellular hypersensitivity of breast cancer patients' leukocytes to autologous and homologous breast cancer tissues and to murine milk containing murine mammary tumor virus (MuMTV). The in vitro responsiveness of the leukocytes and the antigenicity of breast cancer t...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197501)35:1<121::aid-cncr2820350

    authors: Black MM,Zachrau RE,Shore B,Moore DH,Leis HP Jr

    更新日期:1975-01-01 00:00:00

  • Association of area sociodemographic characteristics and capacity for treatment with disparities in colorectal cancer care and mortality.

    abstract:BACKGROUND:Disparities in treatment and mortality for colorectal cancer (CRC) may reflect differences in access to specialized care or other characteristics of the area where an individual lives. METHODS:Surveillance, Epidemiology and End Results Program-Medicare data for seniors diagnosed with CRC were linked to area...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.26034

    authors: Haas JS,Brawarsky P,Iyer A,Fitzmaurice GM,Neville BA,Earle C

    更新日期:2011-09-15 00:00:00

  • Malignant mesothelioma of the tunica vaginalis testis: report of first case with preoperative diagnosis.

    abstract::The cytologic, histologic and ultrastructural features of a malignant carcinomatous mesothelioma of the tunica vaginalis testis in a 30-year old patient are described. This is the first such case with preoperative diagnosis by cytologic examination of hydrocele fluid and the second with documented history of exposure ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19820101)49:1<119::aid-cncr28204

    authors: Japko L,Horta AA,Schreiber K,Mitsudo S,Karwa GL,Singh G,Koss LG

    更新日期:1982-01-01 00:00:00

  • Oral fluorouracil therapy of hepatoma.

    abstract::Oral fluorouracil was administered weekly to 12 consecutive patients with unresectable hepatoma. Six patients showed an objective response with a significant increase in survival duration compared to nonresponders and to untreated patients. The clinical features of these cases are discussed, along with details of ther...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197705)39:5<1930::aid-cncr282039

    authors: Kennedy PS,Lehane DE,Smith FE,Lane M

    更新日期:1977-05-01 00:00:00

  • Mammography in the symptomatic woman.

    abstract::This is a statistical analysis of the use of mammography in the symptomatic patient. Eighty-eight percent of women older than 50 years who had a palpable cancer of the breast had a positive mammogram; only 57% of women younger than 51 years of age had a positive mammogram. When the cancer presented as nipple discharge...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19890401)63:7<1412::aid-cncr2820

    authors: Edeiken S

    更新日期:1989-04-01 00:00:00

  • Cervical cancer incidence in the United States in the US-Mexico border region, 1998-2003.

    abstract:BACKGROUND:Cervical cancer mortality rates have declined in the United States, primarily because of Papanicolaou testing. However, limited information is available about the incidence of the disease in the US-Mexico border region, where some of the poorest counties in the United States are located. This study was under...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.23748

    authors: Coughlin SS,Richards TB,Nasseri K,Weiss NS,Wiggins CL,Saraiya M,Stinchcomb DG,Vensor VM,Nielson CM

    更新日期:2008-11-15 00:00:00

  • The abdominoinguinal incision in limb salvage and resection of pelvic tumors.

    abstract::The abdominoinguinal incision is a new method for exposure and resection of tumors in the pelvis with lateral fixation that were previously called unresectable or were treated with hemipelvectomy. This procedure has been used in 22 patients referred from other centers following unsuccessful resection attempts. Twelve ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19841201)54:11<2543::aid-cncr282

    authors: Karakousis CP

    更新日期:1984-12-01 00:00:00

  • Phase 2 study of intrathecal, long-acting liposomal cytarabine in the prophylaxis of lymphomatous meningitis in human immunodeficiency virus-related non-Hodgkin lymphoma.

    abstract:BACKGROUND:Patients with aggressive non-Hodgkin lymphoma (NHL) develop central nervous system (CNS) progression or recurrence during the course of their disease. Patients with human immunodeficiency virus (HIV)-NHL often develop CNS progression despite the use of prophylaxis. Liposomal cytarabine (DepoCyte) has shown a...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.24922

    authors: Spina M,Chimienti E,Martellotta F,Vaccher E,Berretta M,Zanet E,Lleshi A,Canzonieri V,Bulian P,Tirelli U

    更新日期:2010-03-15 00:00:00

  • Non-Hodgkin's lymphomas of stage III extent. Is total lymphoid irradiation appropriate treatment?

    abstract::Many investigators have regarded Stage III lymphomas as a generalized form of disease and have accordingly recommended systemic treatment programs. Between 1961 and 1973, 68 patients with clinical or pathologic Stage III non-Hodgkin's lymphomas were seen in the Division of Radiation Therapy at Stanford University Medi...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197606)37:6<2806::aid-cncr282037

    authors: Glatstein E,Fuks Z,Goffinet DR,Kaplan HS

    更新日期:1976-06-01 00:00:00

  • Pathologic findings and clinical outcome of patients undergoing retroperitoneal lymph node dissection after multiple chemotherapy regimens for metastatic testicular germ cell tumors.

    abstract:BACKGROUND:Postchemotherapy surgery is an essential component in the management of patients with metastatic germ cell tumors (GCT). The authors assessed their institutional experience of retroperitoneal lymph node dissection (RPLND) after multiple chemotherapy regimens for advanced GCT. METHODS:By analyzing the instit...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.22440

    authors: Eggener SE,Carver BS,Loeb S,Kondagunta GV,Bosl GJ,Sheinfeld J

    更新日期:2007-02-01 00:00:00

  • High-dose chemotherapy and unpurged autologous bone marrow transplantation for acute leukemia in second or subsequent remission.

    abstract::The authors administered high-dose chemotherapy with cyclophosphamide, BCNU (carmustine) and VP-16 (etoposide) plus autologous bone marrow transplantation (ABMT) to 22 adult patients with relapsed acute leukemia in second or subsequent remission. The marrow was not treated ex vivo. The long-term, disease-free survival...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19900815)66:4<619::aid-cncr28206

    authors: Spinolo JA,Dicke KA,Horwitz LJ,Jagannath S,McCredie K,Estey E,Kantarjian H,Zander AR,Keating M,Spitzer G

    更新日期:1990-08-15 00:00:00

  • Circulating CD44 and intercellular adhesion molecule-1 levels in low grade non-hodgkin lymphoma and B-cell chronic lymphocytic leukemia patients during interferon-alpha-2a treatment.

    abstract:BACKGROUND:Despite published reports regarding the association of elevated circulating CD44 and CD54 levels with unfavorable outcome in non-Hodgkin lymphoma (NHL) and chronic lymphocytic leukemia (CLL), little is known about therapy-related changes in either adhesion molecule. In an attempt to evaluate the effect of in...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章

    doi:

    authors: Beksaç M,Arat M,Akan H,Koç H,Ilhan O,Ozcan M

    更新日期:2000-10-01 00:00:00

  • Weekly vinorelbine is an effective palliative regimen after failure with anthracyclines and taxanes in metastatic breast carcinoma.

    abstract:BACKGROUND:Currently, there is no gold standard for the treatment of patients with metastatic breast carcinoma who have experienced failure with anthracyclines and taxanes. A biologic rationale suggests that the mechanism of taxane resistance could be because of an excess of depolymerized tubulin that could enhance sen...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章

    doi:10.1002/1097-0142(20011101)92:9<2267::aid-cncr1572

    authors: Zelek L,Barthier S,Riofrio M,Fizazi K,Rixe O,Delord JP,Le Cesne A,Spielmann M

    更新日期:2001-11-01 00:00:00

  • Dietary vitamins A and C and lung cancer risk in Louisiana.

    abstract::The authors describe the results of a hospital-based incident case-control study of lung cancer conducted in a high-risk region of southern Louisiana from January 1979 through April 1982. Dietary intake of carotene, retinol, and vitamin C was estimated from food frequency questionnaires administered to 1253 cases and ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19881115)62:10<2267::aid-cncr282

    authors: Fontham ET,Pickle LW,Haenszel W,Correa P,Lin YP,Falk RT

    更新日期:1988-11-15 00:00:00

  • Comparison of doubling times of serum carcinoembryonic antigen produced by various metastatic lesions in recurrent gastric and colorectal carcinomas.

    abstract::The authors measured the serial serum carcinoembryonic antigen (CEA) levels in patients with recurrent gastric or colorectal carcinoma. Among the 45 patients with recurrent gastric carcinomas, those with lung metastases showed the most prolonged CEA doubling time (CEA-DT), followed by those with liver and peritoneal m...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19930615)71:12<4055::aid-cncr282

    authors: Umehara Y,Kimura T,Yoshida M,Oba N,Harada Y

    更新日期:1993-06-15 00:00:00

  • Early lung cancer action project: overall design and findings from baseline screening.

    abstract:BACKGROUND:The Early Lung Cancer Action Project (ELCAP) is designed to evaluate baseline and annual repeat screening by low radiation dose computed tomography (low-dose CT) in persons at high-risk for lung cancer. The authors report on the baseline screening experience. For full evaluation of screening, they await the ...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章

    doi:10.1002/1097-0142(20001201)89:11+<2474::aid-cncr26

    authors: Henschke CI

    更新日期:2000-12-01 00:00:00

  • Experimental radioimmunotherapy. A brief overview.

    abstract::This overview highlights the use of experimental models in selecting monoclonal antibodies and radiolabels with promise for clinical radioimmunotherapy, discusses some of the experimental therapeutic approaches being studies in these models, and reviews some of the limitations of animal models caused by the allometric...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/1097-0142(19940201)73:3+<989::aid-cncr2820

    authors: Wahl RL

    更新日期:1994-02-01 00:00:00

  • Long-term outcome of patients with insular carcinoma of the thyroid: the insular histotype is an independent predictor of poor prognosis.

    abstract:BACKGROUND:Insular thyroid carcinoma was described originally as a tumor with aggressive behavior. However, whether a predominant insular component is an independent factor for poor prognosis is unclear. METHODS:The authors compared the clinical behavior of tumors in three groups of patients with thyroid carcinoma--13...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.10947

    authors: Pellegriti G,Giuffrida D,Scollo C,Vigneri R,Regalbuto C,Squatrito S,Belfiore A

    更新日期:2002-11-15 00:00:00

  • HL-A in cancer family "N".

    abstract::Actual HL-A typing has been performed on 115 members of cancer family N, a large kindred (over 1000 members ascertained) showing the findings consistent with the cancer family syndrome. In the cancer-prone line (branches C and D) of the family, 20 of 21 members with cancer had one HL-A haplotype, HL-A2-HL-A12 (relativ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197510)36:4<1315::aid-cncr282036

    authors: Lynch HT,Thomas RJ,Terasaki PI,Ting A,Guirgis HA,Kaplan AR,Magee H,Lynch J,Kraft C,Chaperon E

    更新日期:1975-10-01 00:00:00

  • B-cell lymphoma in severe combined immunodeficiency not associated with the Epstein-Barr virus.

    abstract::Patients with congenital and acquired immunodeficiencies are at increased risk for the development of B-cell lymphoproliferative disorders. When the appropriate tests have been performed, the Epstein-Barr virus (EBV) nuclear antigen (EBNA) or EBV DNA has been found in tissues from these tumors. These data have provide...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19871215)60:12<2941::aid-cncr282

    authors: Garcia CR,Brown NA,Schreck R,Stiehm ER,Hudnall SD

    更新日期:1987-12-15 00:00:00

  • Brain metastasis from renal cell carcinoma: presentation, recurrence, and survival.

    abstract:BACKGROUND:Patients with renal cell carcinoma brain metastases (RCCBM) are frequently excluded from trials and to the authors' knowledge no guidelines currently exist regarding central nervous system (CNS) surveillance or treatment. The objective of the current study was to assist in the creation of treatment guideline...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.23769

    authors: Shuch B,La Rochelle JC,Klatte T,Riggs SB,Liu W,Kabbinavar FF,Pantuck AJ,Belldegrun AS

    更新日期:2008-10-01 00:00:00

  • Bone marrow staging of patients with non-Hodgkin lymphoma by flow cytometry: correlation with morphology.

    abstract:BACKGROUND:Immunophenotypic analysis is an established tool in the diagnosis and classification of many hematolymphoid disorders; however, the role of flow cytometry (FC) in detecting bone marrow involvement during the staging of non-Hodgkin lymphoma (NHL) has yet to be defined. METHODS:The authors retrospectively ana...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:

    authors: Duggan PR,Easton D,Luider J,Auer IA

    更新日期:2000-02-15 00:00:00