Treatment of children with epipodophyllotoxin-induced secondary acute myeloid leukemia.

Abstract:

BACKGROUND:Secondary acute myeloid leukemia (AML) after treatment with epipodophyllotoxins is being observed with increased frequency. Therapeutic options are limited for patients with secondary AML and the role of bone marrow transplantation is unclear. METHODS:The authors report the treatment outcome of a cohort of 17 children who developed epipodophyllotoxin-induced secondary AML after therapy for childhood acute lymphoblastic leukemia (ALL) that included etoposide but no irradiation or alkylating agents. Thirteen patients (76%) had 11q23 chromosomal abnormalities that were not present at the initial diagnosis of ALL. RESULTS:Remission induction was attempted in 16 children, with 13 (81%) achieving a complete remission. After consolidation, 9 of these 13 patients received a bone marrow transplant (BMT): 2 with 4-hydroperoxycyclophosphamide-purged autologous marrow, 4 from a human leukocyte antigen (HLA)-identical sibling, 1 from a mismatched parental donor, and 2 from a matched unrelated donor. One additional child underwent allogeneic BMT without an attempt at reinduction. Of the 10 patients who received transplants, 2 were alive and well 27+ and 36+ months, respectively, after BMT. Of the 7 patients who did not receive a transplant, at last follow-up 1 had survived off therapy for 8 months for recurrent ALL whereas 6 died of AML. CONCLUSIONS:These data confirm the poor prognosis of secondary AML after epipodophyllotoxin treatment for childhood ALL. Although patients with secondary AML can achieve a remission, it is usually of brief duration. Allogeneic BMT may offer the possibility of long term remission in some of these patients. More information is needed to better define the risks and benefits of epipodophyllotoxin therapy for childhood ALL.

journal_name

Cancer

journal_title

Cancer

authors

Sandler ES,Friedman DJ,Mustafa MM,Winick NJ,Bowman WP,Buchanan GR

doi

10.1002/(sici)1097-0142(19970301)79:5<1049::aid-cn

subject

Has Abstract

pub_date

1997-03-01 00:00:00

pages

1049-54

issue

5

eissn

0008-543X

issn

1097-0142

pii

10.1002/(SICI)1097-0142(19970301)79:5<1049::AID-CN

journal_volume

79

pub_type

杂志文章

相关文献

CANCER文献大全
  • Prognostic factors associated with progression of smoldering multiple myeloma to symptomatic form.

    abstract:BACKGROUND:Smoldering multiple myeloma (SMM) presents a high risk of progression to symptomatic MM (sy-MM). Herein, we analyzed some predictors of development of sy-MM. In 144 patients with SMM, we also compared the risk of progression predicted by bone marrow plasma cell (BMPC) involvement on the bone marrow biopsy (B...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.27657

    authors: Rago A,Grammatico S,Za T,Levi A,Mecarocci S,Siniscalchi A,De Rosa L,Felici S,Bongarzoni V,Piccioni AL,La Verde G,Pisani F,Franceschini L,Paviglianiti AL,Caravita T,Petrucci MT,De Stefano V,Cimino G,Multiple Myeloma GI

    更新日期:2012-11-15 00:00:00

  • The nitroblue tetrazolium test in patients with advanced neoplastic diseases.

    abstract::The nitroblue tetrazolium test (NBT) was evaluated in 111 patients with cancer. Patients were placed into control and "presumed infected" groups. The mean NBT score for the control group, 6.3, was significantly greater than the mean for a group of normal volunteers, 3.1, but the mean score for the "presumed infected" ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197505)35:5<1421::aid-cncr282035

    authors: Lehane DE,Watson S,Lane M

    更新日期:1975-05-01 00:00:00

  • Standardized activities for lay patient navigators in breast cancer care: Recommendations from a citywide implementation study.

    abstract:BACKGROUND:There is a need for guidelines on patient navigation activities to promote both the quality of patient navigation and the standards of reimbursement for these services because a lack of reimbursement is a major barrier to the implementation, maintenance, and sustainability of these programs. METHODS:A broad...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.32432

    authors: Freund KM,Haas JS,Lemon SC,Burns White K,Casanova N,Dominici LS,Erban JK,Freedman RA,James TA,Ko NY,LeClair AM,Moy B,Parsons SK,Battaglia TA

    更新日期:2019-12-15 00:00:00

  • Aggressive angiomyxoma: a clinicopathologic study of 29 female patients.

    abstract:BACKGROUND:Aggressive angiomyxoma is an uncommon mesenchymal tumor that preferentially involves the pelvic and perineal regions of females. Since its initial description in 1983, approximately 65 cases have been reported in the English literature. METHODS:The clinical and pathologic features of 29 cases of aggressive ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/(SICI)1097-0142(19960701)78:1<79::AID-CNCR

    authors: Fetsch JF,Laskin WB,Lefkowitz M,Kindblom LG,Meis-Kindblom JM

    更新日期:1996-07-01 00:00:00

  • Risk factors for infections with multidrug-resistant Stenotrophomonas maltophilia in patients with cancer.

    abstract:BACKGROUND:Stenotrophomonas maltophilia is responsible for an increasing number of infections, especially in hospitalized patients. Therapy options are limited and trimethoprim/sulfamethoxazole (TMP/SMX) is often the main treatment option for this infection. In the current study, the risk factors were determined for th...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.22705

    authors: Ansari SR,Hanna H,Hachem R,Jiang Y,Rolston K,Raad I

    更新日期:2007-06-15 00:00:00

  • An unusual presentation of a large tumor coexisting with an unusually high nonspecific immune responsiveness. A case report.

    abstract::The authors present the case of a 40-year-old white man with an obstructing laryngeal mass. Despite considerable tumor size, results of repeated biopsies revealed widespread carcinoma in situ with chronic inflammation within the subcutaneous tissues, and only after extensive endoscopic "debulking" of the mass was a sm...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19850801)56:3<490::aid-cncr28205

    authors: Eskinazi DP,Mihail R,Dichtel WG

    更新日期:1985-08-01 00:00:00

  • Bone sarcomas associated with Ollier's disease.

    abstract::Of 55 patients with Ollier's disease seen at the Mayo Clinic between 1907 and 1985, 16 had malignant bone neoplasms: 12 chondrosarcomas, two dedifferentiated chondrosarcomas, one chordoma, and one osteosarcoma. One patient had a chondrosarcoma in two different bones. These findings suggest that approximately 30% of pa...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19870401)59:7<1376::aid-cncr2820

    authors: Liu J,Hudkins PG,Swee RG,Unni KK

    更新日期:1987-04-01 00:00:00

  • Automated analysis of mammographic densities and breast carcinoma risk.

    abstract:BACKGROUND:There is considerable evidence that one of the strongest risk factors for breast carcinoma can be assessed from the mammographic appearance of the breast. However, the magnitude of the risk factor and the reliability of the prediction depend on the method of classification. Subjective classification requires...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0142(19970701)80:1<66::aid-cncr

    authors: Byng JW,Yaffe MJ,Lockwood GA,Little LE,Tritchler DL,Boyd NF

    更新日期:1997-07-01 00:00:00

  • Functional insulin receptors are overexpressed in thyroid tumors: is this an early event in thyroid tumorigenesis?

    abstract:BACKGROUND:Insulin receptor (IR), a member of the receptor tyrosine kinase family, is expressed in normal thyroid cells and affects thyroid cell proliferation and differentiation. METHODS:The authors measured IR content in benign and malignant thyroid tumors by three independent methods: a specific radioimmunoassay, 1...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0142(19990115)85:2<492::aid-cnc

    authors: Frittitta L,Sciacca L,Catalfamo R,Ippolito A,Gangemi P,Pezzino V,Filetti S,Vigneri R

    更新日期:1999-01-15 00:00:00

  • Determinants of receiving breast-conserving surgery. The Surveillance, Epidemiology, and End Results Program, 1983-1986.

    abstract:BACKGROUND:Although breast-conserving surgery was used with increasing frequency during the 1980s for management of breast cancer, most women still undergo mastectomy, and a substantial variation has been documented in the proportion of women receiving breast-conserving surgery across regions of the country. Using data...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19940501)73:9<2344::aid-cncr2820

    authors: Samet JM,Hunt WC,Farrow DC

    更新日期:1994-05-01 00:00:00

  • The relation of flow cytometry to clinical and biologic characteristics in women with node negative primary breast cancer.

    abstract::Flow cytometry (FC) analysis including DNA index (ploidy status) and cell kinetics (%S and %S + G2/M) was done on frozen tissue of the primary lesions of 101 women with node negative (N-) breast cancer who were studied prospectively. Currently, 19% (19/101) of the patients have recurred. No significant relations have ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19891101)64:9<1894::aid-cncr2820

    authors: Muss HB,Kute TE,Case LD,Smith LR,Booher C,Long R,Kammire L,Gregory B,Brockschmidt JK

    更新日期:1989-11-01 00:00:00

  • Nucleolar organizer regions in small nodular lesions representing early stages of human hepatocarcinogenesis.

    abstract:BACKGROUND:It is believed that in the early stages of hepatocarcinogenesis, some adenomatous hyperplasias (AH) progress to early hepatocellular carcinoma (eHCC), and that many eHCC develop into overt hepatocellular carcinoma (HCC) through nodule-in-nodule formation. However, the proliferative activity of these small no...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19940115)73:2<289::aid-cncr28207

    authors: Aoki K,Sakamoto M,Hirohashi S

    更新日期:1994-01-15 00:00:00

  • Hereditary diffuse gastric cancer: diagnosis, genetic counseling, and prophylactic total gastrectomy.

    abstract:BACKGROUND:A subset of patients with diffuse gastric cancer harbor deleterious cancer-causing germline mutations in the type 1 E-cadherin (epithelial) gene (CDH1), which predisposes to the autosomal dominantly inherited hereditary diffuse gastric cancer (HDGC) syndrome. These mutations are associated with a 70% life-ti...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.23501

    authors: Lynch HT,Kaurah P,Wirtzfeld D,Rubinstein WS,Weissman S,Lynch JF,Grady W,Wiyrick S,Senz J,Huntsman DG

    更新日期:2008-06-15 00:00:00

  • Clinicopathologic features of patients with hepatocellular carcinoma surviving >10 years after hepatic resection.

    abstract:BACKGROUND:This study was performed to clarify the clinicopathologic features of hepatocellular carcinoma (HCC) patients surviving >10 years after hepatic resection. METHODS:Between January 1971 and April 1987, 142 patients underwent hepatic resection. Thirty-nine patients who died of surgical morbidity (surgical mort...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:

    authors: Shirabe K,Shimada M,Kajiyama K,Gion T,Ikeda Y,Hasegawa H,Taguchi K,Takenaka K,Sugimachi K

    更新日期:1998-12-01 00:00:00

  • Intramedullary spinal cord germinoma producing HCG and precocious puberty in a boy.

    abstract::Extremely high concentrations of human chorionic gonadotropin in the cerebrospinal fluid were found in a 5-year-old boy presenting sexual precocity and leg pain. An intramedullary spinal cord tumor was revealed by myelogram and metrizamide computerized tomography, and a biopsy specimen taken at laminectomy. Histologic...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19850615)55:12<2845::aid-cncr282

    authors: Hisa S,Morinaga S,Kobayashi Y,Ojima M,Chikaoka H,Sasano N

    更新日期:1985-06-15 00:00:00

  • Combined analysis of germline polymorphisms of p53, GSTM1, GSTT1, CYP1A1, and CYP2E1: relation to the incidence rate of cervical carcinoma.

    abstract:BACKGROUND:The authors established the genotype frequencies of cytochrome P450 (CYP1A1/MspI, CYP2E1/PstI, and CYP2E1/DraI), glutathione-S-transferase (GSTM1 and GSTT1), and p53 (exon 4/AcclI and intron 3/16-base pair duplication) gene polymorphisms in cervical carcinoma patients and controls and evaluated the associati...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0142(20000501)88:9<2082::aid-cn

    authors: Kim JW,Lee CG,Park YG,Kim KS,Kim IK,Sohn YW,Min HK,Lee JM,Namkoong SE

    更新日期:2000-05-01 00:00:00

  • Astrocytomas of the cerebellum. A comparative clinicopathologic study of pilocytic and diffuse astrocytomas.

    abstract:BACKGROUND:The majority of patients with astrocytomas of the cerebellum have an excellent prognosis; however, a small percentage of patients continue to do poorly. To clarify the clinical, pathologic, and treatment characteristics that determine prognosis and therapeutic recommendations, a large group of patients with ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19930801)72:3<856::aid-cncr28207

    authors: Hayostek CJ,Shaw EG,Scheithauer B,O'Fallon JR,Weiland TL,Schomberg PJ,Kelly PJ,Hu TC

    更新日期:1993-08-01 00:00:00

  • Fine-needle aspiration biopsy of Hurthle cell lesions of the thyroid gland: A cytomorphologic study of 139 cases with statistical analysis.

    abstract:BACKGROUND:Lesions of the thyroid gland composed of Hurthle cells encompass pathologic entities ranging from hyperplastic nodules with Hurthle cell metaplasia to Hurthle cell carcinomas. The cytologic distinction between these entities can be diagnostically challenging. Many cytologic features of Hurthle cell lesions t...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.21716

    authors: Elliott DD,Pitman MB,Bloom L,Faquin WC

    更新日期:2006-04-25 00:00:00

  • A prospective trial of recombinant human interferon alpha 2B in previously untreated patients with hepatocellular carcinoma. The Gastrointestinal Tumor Study Group.

    abstract::The Gastrointestinal Tumor Study Group performed a two-stage trial of alpha-2B interferon in 30 hepatocellular carcinoma patients. Two patients did not receive the treatment and are not considered in the analysis. Only two (7%) short-lived objective responses were observed and the median survival time was 22 weeks. To...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章

    doi:10.1002/1097-0142(19900701)66:1<135::aid-cncr28206

    authors:

    更新日期:1990-07-01 00:00:00

  • Metastatic ependymoma of the sacrum.

    abstract::Ependymomas originating in the sacrum or extraspinal parasacral soft tissues are rare tumors. The majority are of the myxopapillary type and may be locally destructive. Even though metastases are not uncommon in retrosacral ependymomas, they have been rarely described in intrasacral locations. A case is reported of a ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19900515)65:10<2353::aid-cncr282

    authors: Miralbell R,Louis DN,O'Keeffe D,Rosenberg AE,Suit HD

    更新日期:1990-05-15 00:00:00

  • A phase 2 trial of combination therapy with thalidomide, arsenic trioxide, dexamethasone, and ascorbic acid (TADA) in patients with overlap myelodysplastic/myeloproliferative neoplasms (MDS/MPN) or primary myelofibrosis (PMF).

    abstract:BACKGROUND:Primary myelofibrosis (PMF) and overlap myelodysplastic/myeloproliferative neoplasms (MDS/MPN) are clonal hematopoietic disorders that share similar clinical features and molecular abnormalities, such as the Janus kinase 2 (JAK2) valine to phenylalanine mutation at codon 617 (V617F) and the tet methylcytosin...

    journal_title:Cancer

    pub_type: 杂志文章,多中心研究

    doi:10.1002/cncr.26741

    authors: Bejanyan N,Tiu RV,Raza A,Jankowska A,Kalaycio M,Advani A,Chan J,Saunthararajah Y,Mooney L,Maciejewski JP,Sekeres MA

    更新日期:2012-08-15 00:00:00

  • Abdominal computed tomography scans in the selection of patients with malignant peritoneal mesothelioma for comprehensive treatment with cytoreductive surgery and perioperative intraperitoneal chemotherapy.

    abstract:BACKGROUND:Malignant peritoneal mesothelioma is a rare and fatal disease. Until recently, the treatment options were very limited and ineffective. The new comprehensive approach of cytoreductive surgery with perioperative intraperitoneal chemotherapy offers improved survival rates at a cost of considerable morbidity an...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.20836

    authors: Yan TD,Haveric N,Carmignani CP,Chang D,Sugarbaker PH

    更新日期:2005-02-15 00:00:00

  • Cervical cancer survival in the United States by race and stage (2001-2009): Findings from the CONCORD-2 study.

    abstract:BACKGROUND:Overall, cervical cancer survival in the United States has been reported to be among the highest in the world, despite slight decreases over the last decade. Objective of the current study was to describe cervical cancer survival trends among US women and examine differences by race and stage. METHODS:This ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.30906

    authors: Benard VB,Watson M,Saraiya M,Harewood R,Townsend JS,Stroup AM,Weir HK,Allemani C

    更新日期:2017-12-15 00:00:00

  • Prognostic factors for lymphedema after primary treatment of breast carcinoma.

    abstract:BACKGROUND:Lymphedema of the arm is a serious consequence of breast carcinoma treatment. Postmastectomy lymphedema of the upper limb usually is related to certain risk factors such as axillary surgery, radiotherapy, obesity, venous outflow obstruction, delayed wound healing, and infection. The objective of the current ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(20011001)92:7<1783::aid-cncr1694

    authors: Herd-Smith A,Russo A,Muraca MG,Del Turco MR,Cardona G

    更新日期:2001-10-01 00:00:00

  • Overcoming sociodemographic factors in the care of patients with testicular cancer at a safety net hospital.

    abstract:BACKGROUND:The objective of this study was to determine whether standardized treatment of germ cell tumors (GCTs) could overcome sociodemographic factors limiting patient care. METHODS:The records of all patients undergoing primary treatment for GCTs at both a public safety net hospital and an academic tertiary care c...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.33076

    authors: Chertack N,Ghandour RA,Singla N,Freifeld Y,Hutchinson RC,Courtney K,Bowman IA,Arafat W,Meng X,Moore JA,Aydin AM,Sagalowsky AI,Margulis V,Lotan Y,Woldu SL,Bagrodia A

    更新日期:2020-10-01 00:00:00

  • High-grade tumor differentiation is an indicator of poor prognosis in African Americans with colonic adenocarcinomas.

    abstract:BACKGROUND:To identify the factors that contribute to poorer colon carcinoma survival rates for African Americans compared with Caucasians, the authors evaluated survival differences based on the histologic grade (differentiation) of the tumor. METHODS:All 169 African Americans and 229 randomly selected non-Hispanic C...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.21021

    authors: Alexander D,Jhala N,Chatla C,Steinhauer J,Funkhouser E,Coffey CS,Grizzle WE,Manne U

    更新日期:2005-05-15 00:00:00

  • Infiltration of dendritic cells in relation to tumor invasion and lymph node metastasis in human gastric cancer.

    abstract::The infiltration of dendritic cells determined in 210 patients with gastric carcinoma was investigated from the standpoint of tumor invasion, lymph node metastasis, and prognosis. Dendritic cell infiltration was graded as "slight" and "marked." The 39% frequency in the marked infiltration group at the mucosal stage di...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19901101)66:9<2012::aid-cncr2820

    authors: Tsujitani S,Kakeji Y,Watanabe A,Kohnoe S,Maehara Y,Sugimachi K

    更新日期:1990-11-01 00:00:00

  • Methotrexate with citrovorum factor rescue as primary therapy for gestational trophoblastic disease.

    abstract::Methotrexate with citrovorum rescue (MTX-CF) was administered as primary treatment in 106 patients with gestational trophoblastic disease (GTD). Ninety-six patients (90.6%) achieved complete remission with MTX-CF and 77 of these patients (80.2%) required only one course of MTX-CF to attain remission. MTX-CF induced su...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19821115)50:10<2024::aid-cncr282

    authors: Berkowitz RS,Goldstein DP,Bernstein MR

    更新日期:1982-11-15 00:00:00

  • Historical time to disease progression and progression-free survival in patients with recurrent/refractory neuroblastoma treated in the modern era on Children's Oncology Group early-phase trials.

    abstract:BACKGROUND:Early-phase trials in patients with recurrent neuroblastoma historically used an objective "response" of measureable disease (Response Evaluation Criteria In Solid Tumors [RECIST], without bone/bone marrow assessment) to select agents for further study. Historical cohorts may be small and potentially biased;...

    journal_title:Cancer

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/cncr.30934

    authors: London WB,Bagatell R,Weigel BJ,Fox E,Guo D,Van Ryn C,Naranjo A,Park JR

    更新日期:2017-12-15 00:00:00

  • Follicular variant of papillary thyroid carcinoma. A clinicopathologic study.

    abstract:BACKGROUND:A retrospective clinicopathologic study was performed to identify the influence of diagnostic and therapeutic procedures on the outcomes of patients with the follicular variant of papillary thyroid carcinoma (FVPTC). METHODS:The results of 37 patients with FVPTC were compared with those of 37 randomly selec...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19940115)73:2<424::aid-cncr28207

    authors: Tielens ET,Sherman SI,Hruban RH,Ladenson PW

    更新日期:1994-01-15 00:00:00