Genetic and pathologic findings in a kindred with hereditary sarcoma, breast cancer, brain tumors, leukemia, lung, laryngeal, and adrenal cortical carcinoma.

abstract：BACKGROUND:Disseminated intravascular coagulation (DIC) and primary fibrinolysis have both been reported in association with prostate carcinoma. The correct diagnosis of the coagulopathy can be difficult and the appropriate management controversial. METHODS:A case is presented of a man in whom DIC and soft tissue hemo...

journal_title：Cancer

authors： Cooper DL,Sandler AB,Wilson LD,Duffy TP

更新日期：1992-08-01 00:00:00

abstract：BACKGROUND:Reflex human papillomavirus (HPV) testing for atypical squamous cells of undetermined significance (ASC-US) has improved the sensitivity and specificity in detecting high-grade squamous dysplasia (cervical intraepithelial neoplasia [CIN]2+). However, to the authors' knowledge there are no guidelines for perf...

journal_title：Cancer

authors： Chen L,Yang B

更新日期：2008-08-25 00:00:00

abstract：BACKGROUND:The authors attempted to obtain shared proteins among lung carcinoma cells by column chromatographies. A glycoprotein with approximately 500 kDa isolated from QG56 cells showed an identical amino acid sequence to 90K/Mac-2 binding protein (M2BP). This protein has been reported to be highly expressed and to m...

journal_title：Cancer

authors： Ozaki Y,Kontani K,Hanaoka J,Chano T,Teramoto K,Tezuka N,Sawai S,Fujino S,Yoshiki T,Okabe H,Ohkubo I

更新日期：2002-11-01 00:00:00

abstract：:Laryngeal edema persisting for more than three months following radiotherapy developed in 38 of 247 (15.4%) patients irradiated for carcinoma of the vocal cord. In 17 (44.7%) of these patients, the laryngeal edema was associated with persistent or recurrent disease, although only 25.4% of the patients with uncontrolle...

journal_title：Cancer

authors： Fu KK,Woodhouse RJ,Quivey JM,Phillips TL,Dedo HH

更新日期：1982-02-15 00:00:00

abstract：BACKGROUND:In the attempt to characterize the genetic bases of recurrent head and neck squamous cell carcinoma (HNSCC) after radiotherapy (RT), the authors compared the molecular profiles of primary tumors and recurrences. METHODS:TP53 gene status and instability at 10 microsatellite markers were determined in pre-RT ...

journal_title：Cancer

authors： Deganello A,Franchi A,Sardi I,Pignataro L,Leemans CR,Gallo O

更新日期：2010-03-01 00:00:00

abstract：:The establishment and characterization of 11 human lung cancer cell lines are described in this article. Nine of these cell lines were established over a 5-year period, from 1983 to 1988, from patients treated at the Kingston Regional Cancer Centre. These include eight definite or probable small cell lung cancer (SCLC...

journal_title：Cancer

authors： Campling BG,Haworth AC,Baker HM,Greer DL,Holden JJ,Bradley EC,Pym J,Dexter DF

更新日期：1992-04-15 00:00:00

abstract：:Seventeen patients with adenocystic carcinoma have received 34 adequate trials of chemotherapy at Princess Margaret Hospital since 1969. There have been five objective responses to chemotherapy in 4 cases, lasting from five to 24 months, and 3 other patients have had stabilized disease for a period of five to seven mo...

journal_title：Cancer

authors： Tannock IF,Sutherland DJ

更新日期：1980-08-01 00:00:00

abstract：BACKGROUND:The widespread use of anthracycline chemotherapy has contributed to improved outcomes in children with cancer. The most feared complication of the anthracyclines is cardiotoxicity. Routine echocardiographic monitoring typically is used before, during, and after treatment to minimize cardiotoxicity. The ideal...

journal_title：Cancer

authors： Watts RG,George M,Johnson WH Jr

更新日期：2012-04-01 00:00:00

abstract：BACKGROUND:Hepatocellular carcinoma (HCC) complicating cirrhosis has a high intrahepatic recurrence rate after treatment by surgical resection or percutaneous ethanol injection (PEI). In this study, certain clinical, biochemical, and pathologic parameters were evaluated as risk factors for intrahepatic tumor recurrence...

journal_title：Cancer

authors： Pompili M,Rapaccini GL,de Luca F,Caturelli E,Astone A,Siena DA,Villani MR,Grattagliano A,Cedrone A,Gasbarrini G

更新日期：1997-04-15 00:00:00

abstract：:The correlation between clinicopathologic findings and point mutation in codon 12 of c-Ki-ras gene was examined in primary lung adenocarcinomas using polymerase chain reaction and oligonucleotide hybridization techniques. The mutation was detected in ten of 67 cases (15%). Microscopically, mutation-positive cases reve...

journal_title：Cancer

authors： Kobayashi T,Tsuda H,Noguchi M,Hirohashi S,Shimosato Y,Goya T,Hayata Y

更新日期：1990-07-15 00:00:00

abstract：BACKGROUND:Telomerase is a ribonucleoprotein enzyme that extends telomere specific repeats on the ends of chromosomes. Telomerase activity has been detected frequently in various types of human tumors and has been associated with cell immortality and oncogenesis. Human telomerase reverse transcriptase (hTERT), a telome...

journal_title：Cancer

authors： Tomoda R,Seto M,Tsumuki H,Iida K,Yamazaki T,Sonoda J,Matsumine A,Uchida A

更新日期：2002-09-01 00:00:00

abstract：BACKGROUND:Although p53 and HER-2/neu overexpression are found in 30% of breast carcinomas in women of all ages and are associated with high rates of lymph node metastases, their role in women age < 30 years has not been studied extensively. METHODS:The institutional breast cancer data base was searched to identify yo...

journal_title：Cancer

authors： Maru D,Middleton LP,Wang S,Valero V,Sahin A

更新日期：2005-03-01 00:00:00

abstract：BACKGROUND:The purpose of the current study was to examine patient selection for an aromatase inhibitor in breast cancer patients who were free from adverse events 5 years after treatment with tamoxifen. METHODS:In all, 471 women were treated with breast-conserving surgery, axillary lymph node dissection, and radiatio...

journal_title：Cancer

authors： Freedman GM,Anderson P,Li T,Ross E,Swaby R,Goldstein L

更新日期：2006-12-01 00:00:00

abstract：:An adequate operation for colorectal carcinoma involves removal of the primary tumor and wide excision of the mesentery with its contained regional lymph nodes and lymphovascular pathways. Enker and DeCosse state that radical resection, i.e., total mesenteric lymphadenectomy encompassing the origins of the complete ar...

journal_title：Cancer

authors： Leffall LD Jr

更新日期：1983-06-15 00:00:00

abstract：BACKGROUND:The severity of myelotoxicity after radioimmunotherapy has been predicted from body and blood radiation doses to marrow. However, marrow radiation can be increased substantially if the marrow or skeleton contains the malignancy targeted by the radiolabeled monoclonal antibodies. A study of 29 patients treate...

journal_title：Cancer

authors： DeNardo DA,DeNardo GL,O'Donnell RT,Lim SM,Shen S,Yuan A,DeNardo SJ

更新日期：1997-12-15 00:00:00

abstract：BACKGROUND:Historically, patients with nonmetastatic renal cell carcinoma (RCC) involving adjacent organs have been considered inoperable and incurable. The oncologic efficacy of an aggressive surgical approach was evaluated in a selected subpopulation of RCC patients. Further, an attempt was made to define the clinica...

journal_title：Cancer

authors： Margulis V,Sánchez-Ortiz RF,Tamboli P,Cohen DD,Swanson DA,Wood CG

更新日期：2007-05-15 00:00:00

abstract：BACKGROUND:Breast cancer is the most common cancer and the second leading cause of cancer death among women in the United States; annual breast cancer deaths are exceeded only by those for lung cancer. METHODS:Data from the Surveillance, Epidemiology, and End Results (SEER) program registry of the National Cancer Inst...

journal_title：Cancer

authors： Berg JW,Hutter RV

更新日期：1995-01-01 00:00:00

abstract：BACKGROUND:Prostate carcinoma is often associated with perineural (PN) invasion. The common occurrence of this phenomenon has led to speculation regarding the mechanisms of this association, yet to date there have been no studies that clearly define biologic differences between PN and nonperineural (NPN) carcinoma cell...

journal_title：Cancer

authors： Yang G,Wheeler TM,Kattan MW,Scardino PT,Thompson TC

更新日期：1996-09-15 00:00:00

abstract：:The existing system for solid tumor evaluation is criticized and revised criteria are proposed. The foundation for this analysis is a tumor stimulation experiment to determine the distribution associated with measurement of solid tumors. This tumor simulation experiment was conducted among 26 oncologists in order to a...

journal_title：Cancer

authors： Lavin PT,Flowerdew G

更新日期：1980-09-01 00:00:00

abstract：BACKGROUND:Tamoxifen has been used in the treatment of patients with metastatic malignant melanoma either as a single agent or, more commonly, in combination with other chemotherapeutic agents. The aim of the current study was to summarize the available clinical evidence on the role of the tamoxifen in different combin...

journal_title：Cancer

authors： Lens MB,Reiman T,Husain AF

更新日期：2003-10-01 00:00:00

abstract：:Malignant fibrous histiocytoma of soft tissues (MFH), a mesenchymal tumor of varied morphologic patterns and cell types, sometimes contains bone and cartilage. Such bony and cartilaginous elements in a pleomorphic MFH may pose a difficult diagnostic challenge. An MFH with bone and cartilage can be distinguished from e...

journal_title：Cancer

authors： Bhagavan BS,Dorfman HD

更新日期：1982-02-01 00:00:00

abstract：BACKGROUND:Hereditary nonpolyposis colorectal cancer (HNPCC or Lynch syndrome) is an autosomal dominant disease characterized by early-onset intestinal neoplasms, localization of tumors in the proximal colon, and frequent association with cancers at other sites, especially the endometrium, skin, and stomach. The identi...

journal_title：Cancer

authors： Ponz de Leon M,Sassatelli R,Benatti P,Roncucci L

更新日期：1993-06-01 00:00:00

abstract：BACKGROUND:The relationship between serum levels of matrix metalloproteinase-2 (MMP-2) and MMP-3 and recurrence in patients with urothelial carcinoma after complete resection was studied to determine whether the enzymes could be a new predictor of recurrence. METHODS:Serum levels of MMP-2 and MMP-3 in 146 healthy cont...

journal_title：Cancer

authors： Gohji K,Fujimoto N,Komiyama T,Fujii A,Ohkawa J,Kamidono S,Nakajima M

更新日期：1996-12-01 00:00:00

abstract：BACKGROUND:Children receiving immunosuppressive treatment for cancer are at high risk for invasive pneumococcal disease. The 13-valent pneumococcal conjugate vaccine (PCV13) can prevent pneumococcal disease in healthy children; however, there is an absence of literature regarding the benefit of PCV13 in immunocompromis...

journal_title：Cancer

authors： Hung TY,Kotecha RS,Blyth CC,Steed SK,Thornton RB,Ryan AL,Cole CH,Richmond PC

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND:Cytotoxic analogs of somatostatin (SST), such as AN-238, which consists of 2-pyrrolinodoxorubicin (AN-201) linked to the SST carrier RC-121, can be targeted to tumors that express SST receptors. Because SST receptors are present in ovarian carcinoma cells, the authors evaluated the effect of AN-238 on the UC...

journal_title：Cancer

authors： Plonowski A,Schally AV,Koppan M,Nagy A,Arencibia JM,Csernus B,Halmos G

更新日期：2001-09-01 00:00:00

abstract：:The treatment of locally advanced rectal cancer (LARC) has benefited from improved surgical techniques and from the implementation of neoadjuvant chemoradiotherapy (CRT), which have markedly decreased the rates of local recurrence. However, distant metastatic disease remains the most significant cause of death for the...

journal_title：Cancer

authors： Ludmir EB,Palta M,Willett CG,Czito BG

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND:Disparities in treatment and mortality for colorectal cancer (CRC) may reflect differences in access to specialized care or other characteristics of the area where an individual lives. METHODS:Surveillance, Epidemiology and End Results Program-Medicare data for seniors diagnosed with CRC were linked to area...

journal_title：Cancer

authors： Haas JS,Brawarsky P,Iyer A,Fitzmaurice GM,Neville BA,Earle C

更新日期：2011-09-15 00:00:00

abstract：:Blood vessel invasion and axillary lymph node involvement were examined in 175 breast cancer patients. The incidence of blood vessel invasion was 35%. The presence of blood vessel invasion was highly associated with early disease recurrence. The association of poor prognosis with blood vessel invasion was independent ...

journal_title：Cancer

authors： Weigand RA,Isenberg WM,Russo J,Brennan MJ,Rich MA

更新日期：1982-09-01 00:00:00

abstract：:The cases of three patients with primary carcinoid tumor of the testis were reported. The patients were 41, 44, and 83 years of age. At initial examination, all three had testicular masses with or without associated pain, and none had the carcinoid syndrome. The tumors measured 4.3 cm, 3.0 cm, and 6.5 cm in dimension....

journal_title：Cancer

authors： Zavala-Pompa A,Ro JY,el-Naggar A,Ordóñez NG,Amin MB,Pierce PD,Ayala AG

更新日期：1993-09-01 00:00:00

abstract：BACKGROUND:Although pediatric cancer mortality and survival have improved in the United States over the past 40 years, differences exist by age, race/ethnicity, cancer site, and economic status. To assess progress, this study examined recent mortality and survival data for individuals younger than 20 years. METHODS:Ag...

journal_title：Cancer

authors： Siegel DA,Richardson LC,Henley SJ,Wilson RJ,Dowling NF,Weir HK,Tai EW,Buchanan Lunsford N

更新日期：2020-10-01 00:00:00