Identification of novel immunogenic human leukocyte antigen-A 2402-binding epitopes of human papillomavirus type 16 E7 for immunotherapy against human cervical cancer.

abstract：BACKGROUND:Podoplanin is a mucin-like glycoprotein that is important in lymphangiogenesis but not blood vessel formation. Recent studies suggested a potential role of podoplanin in certain tumor cells. The purpose of the current study was to determine the role of podoplanin in head and neck squamous cell carcinoma (HNS...

journal_title：Cancer

authors： Yuan P,Temam S,El-Naggar A,Zhou X,Liu DD,Lee JJ,Mao L

更新日期：2006-08-01 00:00:00

abstract：BACKGROUND:The Akt/mammalian target of the rapamycin (mTOR) signaling pathway represents a promising target for cancer therapy. The phosphorylation status of Akt and of mTOR's phosphorylation target eukaryotic initiation factor 4E-binding protein 1 (4E-BP1) is often used to assess the activity of Akt and mTOR signaling...

journal_title：Cancer

authors： Akcakanat A,Sahin A,Shaye AN,Velasco MA,Meric-Bernstam F

更新日期：2008-06-01 00:00:00

abstract：BACKGROUND:Because of the structural and biochemical similarities between the antitumor p53 and p73 proteins, the authors hypothesized that individuals who carry high-risk genotypes of p53 codon 72 and p73 G4C14-to-A4T14 polymorphisms have a higher risk of developing second primary malignancy (SPM) after index squamous...

journal_title：Cancer

authors： Zhang Y,Sturgis EM,Huang Z,Zafereo ME,Wei Q,Li G

更新日期：2012-01-15 00:00:00

abstract：:From November 1987 to April 1989, 1000 women 40 years or older underwent screening vaginal sonography at the University of Kentucky Medical Center (Lexington, KY). Patients included in this investigation were all asymptomatic and had no known pelvic abnormalities. Each ovary was measured in three planes and ovarian vo...

journal_title：Cancer

authors： van Nagell JR Jr,Higgins RV,Donaldson ES,Gallion HH,Powell DE,Pavlik EJ,Woods CH,Thompson EA

更新日期：1990-02-01 00:00:00

abstract：:Flow cytometric analysis of nuclear DNA content was performed on excised malignant tissue of the esophagus. The DNA ploidy pattern was compared with a variety of histologic parameters and the subsequent clinical course to determine whether or not this pattern is associated with the mode of malignant potentiality. Of t...

journal_title：Cancer

authors： Kaketani K,Saito T,Kobayashi M

更新日期：1989-08-15 00:00:00

abstract：BACKGROUND:The current study was performed to determine whether neuropsychologic functioning differs in breast cancer survivors 6 months after the completion of adjuvant treatment compared with women without cancer. METHODS:Participants were 187 women who were diagnosed with ductal carcinoma in situ or stage I or stag...

journal_title：Cancer

authors： Jim HS,Donovan KA,Small BJ,Andrykowski MA,Munster PN,Jacobsen PB

更新日期：2009-04-15 00:00:00

abstract：BACKGROUND:Ovarian tumors of borderline malignancy have a less aggressive behavior and tend to occur at a younger age than their invasive counterparts. The role and extent of fertility-sparing conservative treatments is under continuous evaluation. METHODS:The current study was a retrospective review of 82 patients wi...

journal_title：Cancer

authors： Gotlieb WH,Flikker S,Davidson B,Korach Y,Kopolovic J,Ben-Baruch G

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND:The regulation of parathyroid hormone-related protein (PTH-rP) mRNA levels and immunoreactive (ir)PTH-rP formation by peptide growth factors, particularly transforming growth factor-beta (TGF-beta) and epidermal growth factor (EGF), in squamous cell carcinomas of gynecologic origin is largely unknown. METHO...

journal_title：Cancer

authors： Tait DL,MacDonald PC,Casey ML

更新日期：1994-03-01 00:00:00

abstract：BACKGROUND:Radiotherapy with its advantage of organ preservation has been used to treat laryngeal cancer (LC) for several decades. However, the impact of radiation on overall survival (OS) in a large population-based study has not been evaluated to date. METHODS:The authors analyzed all patients who had localized and/...

journal_title：Cancer

authors： Zhang H,Travis LB,Chen R,Hyrien O,Milano MT,Newlands SD,Chen Y

更新日期：2012-03-01 00:00:00

abstract：BACKGROUND:It is believed that atypical cells identified by nipple duct lavage (NDL) indicate an increased risk for breast carcinoma similar to atypical ductal hyperplasia diagnosed by tissue biopsy, but many basic performance characteristics of NDL currently are undefined. METHODS:NDL was performed in 108 patients un...

journal_title：Cancer

authors： Johnson-Maddux A,Ashfaq R,Cler L,Naftalis E,Leitch AM,Hoover S,Euhus DM

更新日期：2005-03-15 00:00:00

abstract：:Cancer-related fatigue (CRF) has been documented as 1 of the most distressing symptoms reported by breast cancer survivors. CRF affects functioning and impacts quality of life. Possible causal factors include physical conditions, affective and cognitive states, proinflammatory cytokines, and metabolic factors. Several...

journal_title：Cancer

authors： Berger AM,Gerber LH,Mayer DK

更新日期：2012-04-15 00:00:00

abstract：:Adrenal cortical carcinoma is an uncommon neoplasm in children. Only a handful of congenital adrenal cortical carcinoma cases have been described. A newborn who had metastatic adrenal cortical carcinoma (skin metastases and cerebral lesions) is described. This patient underwent surgical resection of the right adrenal ...

journal_title：Cancer

authors： Saracco S,Abramowsky C,Taylor S,Silverman RA,Berman BW

更新日期：1988-08-01 00:00:00

abstract：BACKGROUND:This study was conducted to investigate the influence of therapeutic parameters on local control (LC) in the sphincter-conserving treatment of T2-T3 anal carcinoma. METHODS:From 1976 to 1993, 137 patients with anal carcinoma classified as T2 (85 patients) or T3 (52 patients) were treated curatively by radio...

journal_title：Cancer

authors： Allal AS,Mermillod B,Roth AD,Marti MC,Kurtz JM

更新日期：1997-06-15 00:00:00

abstract：BACKGROUND:Breast cancer is the most common cancer and the second leading cause of cancer death among women in the United States; annual breast cancer deaths are exceeded only by those for lung cancer. METHODS:Data from the Surveillance, Epidemiology, and End Results (SEER) program registry of the National Cancer Inst...

journal_title：Cancer

authors： Berg JW,Hutter RV

更新日期：1995-01-01 00:00:00

abstract：:Spindle cell lipoma is a specific type of lipoma that is easily mistaken for a liposarcoma. An analysis of 114 cases of this tumor from the files of the Armed Forces Institute of Pathology reveals that is occurs chiefly in male patients between 45 and 70 years of age and affects the regions of the shoulder and posteri...

journal_title：Cancer

authors： Enzinger FM,Harvey DA

更新日期：1975-11-01 00:00:00

abstract：BACKGROUND:The clinical relevance of DNA image cytometry (ICM) and flow cytometry (FCM) remains under investigation in breast carcinoma. The objective of the current work was to study the prognostic value of DNA ICM and FCM in a series of patients randomized in a control trial. A multivariate analysis has been performe...

journal_title：Cancer

authors： Mandard AM,Denoux Y,Herlin P,Duigou F,van De Vijver MJ,Clahsen PC,van Den Broek L,Sahmoud TM,Henry-Amar M,van De Velde CJ

更新日期：2000-10-15 00:00:00

abstract：:This report describes a patient with small-cell carcinoma of the lung associated with blindness. The serum of this patient was tested for immunoreactivity with retinal sections because there was no evidence of tumor metastasis to the central nervous system and because neuroendocrine cells of the lung share common anti...

journal_title：Cancer

authors： Kornguth SE,Klein R,Appen R,Choate J

更新日期：1982-10-01 00:00:00

abstract：:The clinical course of melanoma of the skin diagnosed during pregnancy was compared with a control population of women with melanoma that occurred during the childbearing years, as recorded by the Connecticut Tumor Registry. The survival at three and five years for the 12 patients whose melanoma developed during pregn...

journal_title：Cancer

authors： Houghton AN,Flannery J,Viola MV

更新日期：1981-07-15 00:00:00

abstract：BACKGROUND:The current study analyzed the feasibility and outcome of stereotactic radiosurgery (SRS) for treatment of brain metastases from breast carcinoma. METHODS:During an 8-year period, 151 patients with a combined total of 620 brain metastases from breast carcinoma underwent 197 outpatient SRS procedures. Sixty-...

journal_title：Cancer

authors： Muacevic A,Kreth FW,Tonn JC,Wowra B

更新日期：2004-04-15 00:00:00

abstract：:Patients with non-Hodgkin's lymphomas who failed to respond to chemotherapy were treated with low dose fractionated total body irradiation (TBI). Prior to during and after scheduled therapy, their clinical status was evaluated and peripheral blood studies were performed to enumerate EAC and E rosetting cells and to me...

journal_title：Cancer

authors： Yonkosky DM,Feldman MI,Cathcart ES,Kim S

更新日期：1978-09-01 00:00:00

abstract：:In this retrospective study, the degree of differentiation of atypical lymphoid cells was assessed in pretreatment cutaneous biopsy specimens from 248 patients with cutaneous T-cell lymphomas (mycosis fungoides and Sézary syndrome) and the findings were correlated with the subsequent therapeutic results. Overall, pati...

journal_title：Cancer

authors： Vonderheid EC,Tam DW,Johnson WC,Van Scott EJ,Wallner PE

更新日期：1981-01-01 00:00:00

abstract：:A new Hodgkin's cell line, designated HD-70, was established from the peripheral blood of a 69-year-old man with Hodgkin's disease of nodular sclerosing type. The cell line grows in a single cell suspension and has a doubling time of 28 hours. The cells have a round or irregular nucleus or multiple nuclei in relativel...

journal_title：Cancer

authors： Kanzaki T,Kubonishi I,Eguchi T,Yano S,Sonobe H,Ohyashiki JH,Ohyashiki K,Toyama K,Ohtsuki Y,Miyoshi I

更新日期：1992-02-15 00:00:00

abstract：BACKGROUND:Sipuleucel-T is an investigational active cellular immunotherapy product designed to stimulate an immune response against prostate cancer. The safety and efficacy of sipuleucel-T was evaluated in 2 identically designed, randomized, double-blind, placebo-controlled trials (D9901 and D9902A) conducted in men w...

journal_title：Cancer

authors： Higano CS,Schellhammer PF,Small EJ,Burch PA,Nemunaitis J,Yuh L,Provost N,Frohlich MW

更新日期：2009-08-15 00:00:00

abstract：:Non-Hodgkin's lymphoma localized to the mediastinum and adjacent structures occurred in 12 of 215 (6+) non-Hodgkin's lymphoma patients seen at the Massachusetts General Hospital between 1975 and 1979. Lymphangiography, radionuclide scanning and whole body computerized tomography were used to exclude patients with extr...

journal_title：Cancer

authors： Levitt LJ,Aisenberg AC,Harris NL,Linggood RM,Poppema S

更新日期：1982-12-01 00:00:00

abstract：:A leukocyte migration procedure was utilized to test cellular hypersensitivity of breast cancer patients' leukocytes to autologous and homologous breast cancer tissues and to murine milk containing murine mammary tumor virus (MuMTV). The in vitro responsiveness of the leukocytes and the antigenicity of breast cancer t...

journal_title：Cancer

authors： Black MM,Zachrau RE,Shore B,Moore DH,Leis HP Jr

更新日期：1975-01-01 00:00:00

abstract：BACKGROUND:The incidence of adenocarcinoma of the cervix did not decline in Western countries in the 1970s and 1980s despite the availability and use of cervical cytologic screening. The impact of improved endocervical sampling and better recognition of the cytologic precursors to adenocarcinoma during the 1990s in red...

journal_title：Cancer

authors： Mitchell H,Hocking J,Saville M

更新日期：2003-12-25 00:00:00

abstract：BACKGROUND:Langerhans cell histiocytosis (LCH) is a rare myeloid neoplasm characterized by the presence of abnormal CD1a-positive (CD1a+ )/CD207+ histiocytes. Hemophagocytic lymphohistiocytosis (HLH) represents a spectrum of hyperinflammatory syndromes typified by the dysregulated activation of the innate and adaptive ...

journal_title：Cancer

authors： Chellapandian D,Hines MR,Zhang R,Jeng M,van den Bos C,Santa-María López V,Lehmberg K,Sieni E,Wang Y,Nakano T,Williams JA,Fustino NJ,Astigarraga I,Dunkel IJ,Abla O,van Halteren AGS,Pei D,Cheng C,Weitzman S,Sung L,N

更新日期：2019-03-15 00:00:00

abstract：:There are three principal disturbances in bone remodelling that occur in neoplasia affecting the skeleton. The first is an increase in bone turnover that in solid tumors may be confined to sites of metastases or be a generalized phenomenon, most likely related to the secretion of parathyroid hormone-related protein. I...

journal_title：Cancer

authors： Kanis JA,McCloskey EV

更新日期：1997-10-15 00:00:00

abstract：BACKGROUND:It remains unclear whether health-related quality of life (HRQoL) measurements from patients and staff can be combined with medical data to predict survival in patients with terminal cancer. METHODS:The correlations between survival and potential health-related quality-of-life (HRQoL) prognostic variables w...

journal_title：Cancer

authors： Vigano A,Donaldson N,Higginson IJ,Bruera E,Mahmud S,Suarez-Almazor M

更新日期：2004-09-01 00:00:00

abstract：BACKGROUND:Cyclin D1 expression has been reported in a subset of patients with diffuse large B-cell leukemia (DLBCL), but studies have been few and generally small, and they have demonstrated no obvious clinical implications attributable to cyclin D1 expression. METHODS:The authors reviewed 1435 patients who were diag...

journal_title：Cancer

authors： Ok CY,Xu-Monette ZY,Tzankov A,O'Malley DP,Montes-Moreno S,Visco C,Møller MB,Dybkaer K,Orazi A,Zu Y,Bhagat G,Richards KL,Hsi ED,Han van Krieken J,Ponzoni M,Farnen JP,Piris MA,Winter JN,Medeiros LJ,Young KH

更新日期：2014-06-15 00:00:00