Abstract:
:Hypercalcemia is very uncommon in small cell (oat cell) carcinoma of the lung. Two cases of this neoplasm associated with symptomatic hypercalcemia are described. Despite normal skeletal roentgenograms, metastatic bone disease was demonstrated by abnormal bone scans and bone biopsies in both patients. The combination of conventional antihypercalcemia therapy, cytotoxic cancer chemotherapy, and synthetic salmon calcitonin corrected the hypercalcemia despite progression of the small cell carcinoma. One patient with elevated serum immunoreactive parathyroid hormone (PTH) had a parathyroid adenoma at autopsy. This association emphasizes that in cases of bronchogenic small cell carcinoma with hypercalcemia, conincidental primary hyperparathyroidism should be considered.
journal_name
Cancerjournal_title
Cancerauthors
Bowman DM,Dubé WJ,Levitt Mdoi
10.1002/1097-0142(197509)36:3<1067::aid-cncr282036subject
Has Abstractpub_date
1975-09-01 00:00:00pages
1067-71issue
3eissn
0008-543Xissn
1097-0142journal_volume
36pub_type
杂志文章相关文献
CANCER文献大全abstract:BACKGROUND:The current study was performed to describe frequencies and risk factors of altered oral health and odontogenesis in childhood cancer survivors. METHODS:In total, 9308 survivors who were diagnosed between 1970 and 1986 and 2951 siblings from the Childhood Cancer Survivor Study completed a survey that contai...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.24670
更新日期:2009-12-15 00:00:00
abstract:BACKGROUND:Cancer rates in immigrant populations are frequently found to be intermediate between the country of origin and the adopted country. Such observations play an important role in establishing the environmental origin of cancer. Chinese now constitute the third largest group immigrating to New York City. METHO...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19940215)73:4<1270::aid-cncr2820
更新日期:1994-02-15 00:00:00
abstract::One-hundred-eighty-eight children up to 16 years of age were randomized in the second National Wilms' Tumor Study (NWTS) with tumors that were confined to the kidney and that had been totally excised (Group I). Most fared well whether treated for six or for 15 months with both actinomycin D (AMD) and vincristine (VCR)...
journal_title:Cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/1097-0142(19810501)47:9<2302::aid-cncr2820
更新日期:1981-05-01 00:00:00
abstract::Patients with congenital and acquired immunodeficiencies are at increased risk for the development of B-cell lymphoproliferative disorders. When the appropriate tests have been performed, the Epstein-Barr virus (EBV) nuclear antigen (EBNA) or EBV DNA has been found in tissues from these tumors. These data have provide...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19871215)60:12<2941::aid-cncr282
更新日期:1987-12-15 00:00:00
abstract:BACKGROUND:Atypia of undetermined significance is a controversial category in thyroid fine-needle aspiration (FNA), not only for its questioned clinical utility, but also for its very existence as an expression of uncertainty. The current study was performed to investigate the potential impact of eliminating this categ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncy.20039
更新日期:2009-10-25 00:00:00
abstract:BACKGROUND:The combination of paclitaxel with cisplatin or carboplatin has become the preferred chemotherapy regimen in the treatment of epithelial ovarian carcinoma. Anthracyclines also have activity in this disease. We conducted a Phase II study by using the combination of paclitaxel, cisplatin, and epirubicin for th...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/1097-0142(20001001)89:7<1547::aid-cncr19>3
更新日期:2000-10-01 00:00:00
abstract::A prospective randomized trial was performed to evaluate the role of adjuvant local immunostimulation with bacillus Calmette-Guérin (BCG) in resected Stage I and Stage II non-small cell bronchogenic carcinoma. The patients were stratified according to extent of resection and surgical stage, and randomized to treatment...
journal_title:Cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/1097-0142(19861201)58:11<2411::aid-cncr282
更新日期:1986-12-01 00:00:00
abstract::Since single drug therapy of chronic lymphocytic leukemia (CLL) has not resulted in prolonged remissions of advanced disease, we initiated a program of combination chemotherapy, COP (cycloposphamide, vincristine sulfate, prednisone) for CLL patients with increasing adenopathy, spenomegaly, and/or signs of marrow failu...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197805)41:5<1664::aid-cncr282041
更新日期:1978-05-01 00:00:00
abstract::Chlorozotocin was administered by rapid intravenous infusion to 35 patients with advanced cancer on either single-day of five-consecutive-day schedules. Total doses per course ranged from 12.5 to 200 mg/m2. On either administration schedule, dose limiting toxicities were thrombocytopenia and leukopenia at total doses ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197906)43:6<2189::aid-cncr282043
更新日期:1979-06-01 00:00:00
abstract::From November 1985 to August 1988, the National Study Group for Oesophageal Cancer collected and centralized data on 1926 new cases of oesophageal cancer in South Africa. A standard data sheet was used to record the age, sex, and condition of the patients, the site, length, and circumferential extent of the tumor, the...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19891215)64:12<2604::aid-cncr282
更新日期:1989-12-15 00:00:00
abstract:BACKGROUND:Patients who have aggressive, refractory or recurrent non-Hodgkin lymphomas (NHLs) that are refractory to first-line anthracycline-containing regimens (ACRs) have a dismal outcome. Achieving complete remission (CR) is essential for a favorable outcome. To improve the CR rate in these patients, the authors de...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.21150
更新日期:2005-08-01 00:00:00
abstract::Fifty-one patients with confirmed bladder cancer have enrolled in a prospective evaluation of BCG immunotherapy. Following resection of existing tumors, patients were stratified according to tumor grade and number of previous recurrences and randomly assigned to control or BCG treatment groups. Immunotherapy consisted...
journal_title:Cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/1097-0142(19810701)48:1<82::aid-cncr282048
更新日期:1981-07-01 00:00:00
abstract::This trial determines the feasibility for patients with resectable Stages III/IV head and neck cancer who achieved a complete response to induction chemotherapy of eliminating surgery from their treatment program. Thirty patients were treated with three cycles of cisplatin and 5-fluorouracil (5-FU), followed by reendo...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/1097-0142(19870915)60:6<1178::aid-cncr2820
更新日期:1987-09-15 00:00:00
abstract::The expression of the Thomsen-Friedenreich antigen (T-antigen) in normal and neoplastic urothelium was investigated using paraffin-processed and fresh frozen tissue sections obtained by biopsy from 56 patients. The T-antigen was detected through its binding to the peanut agglutinin (PNA) with two methods: a biotin-avi...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19860915)58:6<1236::aid-cncr2820
更新日期:1986-09-15 00:00:00
abstract:BACKGROUND:Patients with advanced soft tissue sarcomas (STS) have limited therapeutic options. Sorafenib (BAY 43-9006) is a multitargeted tyrosine kinase inhibitor of raf, vascular endothelial growth factor receptors 1 (VEGFR1) through 3, platelet-derived growth factor B, fms-like tyrosine kinase 3, and c-kit, and some...
journal_title:Cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/cncr.26334
更新日期:2012-02-01 00:00:00
abstract::Sarcoma of the breast represents less than 1% of primary mammary malignancies; this study reports 25 such cases. The largest group had malignant fibrous histiocytoma (44%), followed by liposarcoma (24%) and fibrosarcoma (16%). Also represented were clear cell sarcoma, neurogenic sarcoma, leiomyosarcoma, and alveolar s...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19900901)66:5<941::aid-cncr28206
更新日期:1990-09-01 00:00:00
abstract:BACKGROUND:This randomized pilot trial investigated whether primary chemotherapy was feasible in terms of efficacy, survival, toxicity profile, and quality of life compared with whole-brain radiotherapy (WBRT) given first in chemotherapy-naive patients nonsmall cell lung cancer (NSCLC) with synchronous brain metastasis...
journal_title:Cancer
pub_type: 杂志文章,随机对照试验
doi:10.1002/cncr.23526
更新日期:2008-07-01 00:00:00
abstract::Twenty-three leukemic children were studied prospectively to detect chronic effects of therapy. All patients received CNS prophylaxis, including 2400 R cranial irradiation, and intermittent maintenance therapy with intravenous methotrexate, cyclophosphamide and cytosine arabinoside. Neurologic symptoms were observed i...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197602)37:2<853::aid-cncr2820370
更新日期:1976-02-01 00:00:00
abstract::Myelography was performed on 78 patients with breast cancer who had signs or symptoms compatible with spinal cord compression. Of 42 patients (54%) with extradural defects, 21 (50%) had a complete block. All patients with positive myelograms (M+) had a positive bone scan and 41 of 42 (97%) had positive skeletal x-rays...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19850615)55:12<2839::aid-cncr282
更新日期:1985-06-15 00:00:00
abstract:BACKGROUND:Prior literature has suggested synergy between immune checkpoint therapy (ICT) and radiotherapy (RT) for the treatment of brain metastases (BrM), but to the authors' knowledge the optimal timing of therapy to maximize this synergy is unclear. METHODS:A total of 199 patients with melanoma and non-small cell ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.33196
更新日期:2020-12-15 00:00:00
abstract::The authors report on five patients with secondary leukemia (SL) and one of the "specific" chromosomal rearrangements usually encountered in de novo acute nonlymphoblastic leukemia: inv(16), t(15;17), t(8;21), and t(9;11). They were characterized by solid tumor as the primary malignancy in four of five cases, absence ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19890615)63:12<2505::aid-cncr282
更新日期:1989-06-15 00:00:00
abstract::This study investigated whether an endoscopic surveillance program for patients with "benign" gastric ulcers and gastric cancer leads to early detection of neoplasms and improves survival. The clinical course of all patients diagnosed between 1977 and 1986 as having either gastric ulcers or gastric cancer was followed...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19920115)69:2<301::aid-cncr28206
更新日期:1992-01-15 00:00:00
abstract:BACKGROUND:The 5-year survival rate of patients with submucosal (sm) esophageal carcinoma continues to be much worse than that with intramucosal (m) lesions. The reasons are unclear, but matrix metalloproteinases (MMPs) and membrane type matrix metalloproteinases (MT-MMPs) are known to be involved in degradation of ext...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:2000-05-15 00:00:00
abstract::This report describes a patient referred at 14 years in 1971, after one year's surveillance by the family physician, for a persistently elevated erythrocyte sedimentation rate, leukopenia, and relative lymphocytosis. Despite the documented myeloproliferative syndrome of seven years, significant physiologic impairment ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19810901)48:5<1164::aid-cncr2820
更新日期:1981-09-01 00:00:00
abstract::The establishment and characterization of 11 human lung cancer cell lines are described in this article. Nine of these cell lines were established over a 5-year period, from 1983 to 1988, from patients treated at the Kingston Regional Cancer Centre. These include eight definite or probable small cell lung cancer (SCLC...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19920415)69:8<2064::aid-cncr2820
更新日期:1992-04-15 00:00:00
abstract:BACKGROUND:To the authors' knowledge, there are few studies to date regarding colorectal cancer (CRC) beliefs, knowledge, and screening among multiple Asian American populations, who are reported to have lower CRC screening rates compared with white individuals. The current study was performed to assess knowledge and b...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.31216
更新日期:2018-04-01 00:00:00
abstract::Over the last decade, new cytotoxic treatments and targeted therapies have altered treatment paradigms for patients with metastatic non-small cell lung cancer (NSCLC). We sought to analyze the impact of histology and biomarker selection criteria on outcomes of clinical trials in metastatic NSCLC reported over the last...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.28956
更新日期:2014-12-15 00:00:00
abstract::The relative value of each lactic dehydrogenase isoenzyme (iso LDH) was measured by electrophoretic separation in the serum and the pleural fluid of 100 patients. In each case, the cause of the pleural effusion was known. Two types of LDH isoenzyme pattern were found in the serum: a normal type with a low value of LDH...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19840801)54:3<507::aid-cncr28205
更新日期:1984-08-01 00:00:00
abstract:OBJECTIVE:The objective was to study the association of race, comorbid illness, and lymph node dissection (LND) with complications in patients undergoing hysterectomy for endometrial carcinoma. METHODS:The Health Care Cost Utilization Project analysis studied women undergoing hysterectomy for endometrial carcinoma in ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(20010815)92:4<950::aid-cncr1405>
更新日期:2001-08-15 00:00:00
abstract:BACKGROUND:Telomeres are protective structures at the ends of linear chromosomes, regulated by a host of associated proteins. When telomeres become dysfunctional, genomic instability ensues. The vast majority of cells undergo apoptosis, although a rare cell may survive and become tumorigenic. METHODS:The authors used ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.25328
更新日期:2010-09-15 00:00:00