Abstract:
BACKGROUND:Many studies have tried to identify prognostic factors to guide the selection of patients at high risk for metastases in penile carcinoma. The authors evaluated human papillomavirus (HPV) status with respect to clinical features, incidence of metastases, and prognosis of penile carcinoma. METHODS:Human papillomavirus DNA was detected using the polymerase chain reaction on paraffin embedded material from 82 patients with penile carcinoma. The following variables were recorded: age, marital status, clinical staging, tumor surgery extension, histologic grade, tumor thickness, lymphatic and venous embolization, corpora cavernosa and corpus spongiosum infiltration, urethral infiltration, mononuclear and eosinophilic infiltrate, and lymph node spread. Follow-up ranged from 0.1 to 453 months. RESULTS:Human papillomavirus DNA was detected in 30.5% (25 of 82) of samples. HPV-16 was the most frequent type detected (13 of 25, 52%). Human papillomavirus DNA positive tumors had less lymphatic embolization by neoplastic cells than HPV negative ones (P = 0.007). The logistic regression revealed that only lymphatic embolization was related to HPV status. There was no difference, however, between HPV DNA negative and HPV DNA positive patients according to presence of lymph node metastases (P = 0.386). No difference was found in the 10-year survival rate (68.4% vs. 69.1%; P = 0.830) between the two groups. CONCLUSIONS:These data suggest that HPV status does not influence prognosis in invasive penile carcinoma.
journal_name
Cancerjournal_title
Cancerauthors
Bezerra AL,Lopes A,Santiago GH,Ribeiro KC,Latorre MR,Villa LLsubject
Has Abstractpub_date
2001-06-15 00:00:00pages
2315-21issue
12eissn
0008-543Xissn
1097-0142pii
10.1002/1097-0142(20010615)91:12<2315::AID-CNCR126journal_volume
91pub_type
杂志文章相关文献
CANCER文献大全abstract:BACKGROUND:Medullary thyroid carcinoma (MTC), a rare malignancy with a variety of morphologic appearances, can mimic both primary and metastatic lesions of the thyroid gland and give rise to diagnostic problems when these tumors are aspirated. Although cytopathologic features of MTC have been well described, this study...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:1997-02-25 00:00:00
abstract::The clinical findings in 262 patients with melanoma were correlated with an assessment of their cellular-mediated immunity by delayed-type hypersensitivity (DTH) skin tests, by lymphocyte blastogenesis, and by leukocyte enumerations. Patients with systemic metastases (stage IV) and those with evidence of tumor burden ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197806)41:6<2165::aid-cncr282041
更新日期:1978-06-01 00:00:00
abstract::Local and systemic toxicities associated with hepatic arterial infusion of human recombinant tumor necrosis factor (rTNF) were studied in healthy adult mongrel dogs. The animals received saline containing human serum albumin with or without rTNF (0.02, 0.2, or 2.0 mg/m2). Arteriograms were made, and blood samples were...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19890601)63:11<2096::aid-cncr282
更新日期:1989-06-01 00:00:00
abstract:BACKGROUND:The focus on noncancer causes of death in patients with breast cancer (BC) remains superficial. The objective of the current study was to assess and quantify causes of death after BC diagnosis. METHODS:In total, 754,270 women with BC in the United States who were diagnosed during 2000 through 2015 and retri...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.32648
更新日期:2020-04-01 00:00:00
abstract::Malignant fibrous histiocytoma (MFH) was produced by injection of 9,10-dimethyl-1,2-benzanthracene (DMBA) into the rat knee joint. The tumor was observed in or around the knee in nearly all the animals 13 to 36 weeks after the initial DMBA administration. Histologically, these lesions were of the storiform-pleomorphic...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19860615)57:12<2313::aid-cncr282
更新日期:1986-06-15 00:00:00
abstract::Methotrexate with citrovorum rescue (MTX-CF) was administered as primary treatment in 106 patients with gestational trophoblastic disease (GTD). Ninety-six patients (90.6%) achieved complete remission with MTX-CF and 77 of these patients (80.2%) required only one course of MTX-CF to attain remission. MTX-CF induced su...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19821115)50:10<2024::aid-cncr282
更新日期:1982-11-15 00:00:00
abstract:BACKGROUND:Cancers of individual organs generally are composed of various histologic types, each with its own frequency and demographic patterns. For childhood cancers in particular, a classification of cancers by histologic type is important for understanding the etiology and progression of the disease. METHODS:Data ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19950101)75:1+<395::aid-cncr2820
更新日期:1995-01-01 00:00:00
abstract::A 42-year-old man was admitted to the Cancer Division of the American MedicalCenter in February, 1956. He had been treated for erythrocytosis beginning 6 months previously, with reduction of his hemoglobin to relatively normal values. On admission, a huge tumor of the left kidney was palable. Roentgenograms of the ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197506)35:6<1701::aid-cncr282035
更新日期:1975-06-01 00:00:00
abstract::The unusual genetic disorder epidermolysis bullosa dystrophica has been reported in several patients in whom the chronic cutaneous scars led to the development of cutaneous squamous cell carcinoma. However, only one of these previously reported cases involved the autosomal dominant form of the disease; the remainder o...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19810201)47:3<615::aid-cncr28204
更新日期:1981-02-01 00:00:00
abstract:BACKGROUND:The balance among cell proliferation, cell differentiation, and cell death determines the cell number in a population as well as the size or even the stage of a tumor. Thus, to improve our understanding of the pathogenesis of neoplasms, it is important to investigate the regulation of both cell proliferation...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19980615)82:12<2373::aid-c
更新日期:1998-06-15 00:00:00
abstract::One hundred twenty-four patients with seminoma (119 primary testis, five primary extragonadal) were treated between 1968 and 1984 at the Joint Center for Radiation Therapy. Fifty-seven of the 124 patients were treated with irradiation to the mediastinum as well as to an infradiaphragmatic field. One patient received s...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19870815)60:4<772::aid-cncr28206
更新日期:1987-08-15 00:00:00
abstract:BACKGROUND:Optic pathway gliomas (OPGs) are commonly noted in pediatric oncology services. Radiotherapy is effective at controlling tumors, but has many undesirable late effects, especially in patients with neurofibromatosis. Chemotherapy is commonly used to preserve vision and delay or eliminate the need for radiother...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.29649
更新日期:2015-12-01 00:00:00
abstract:BACKGROUND:Young adults have historically been the least likely to have health insurance in the United States. Previous studies of survivors of childhood cancer found lower rates of insurance and less access to medical care compared with siblings; however, to the authors' knowledge, no studies to date have examined con...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.28685
更新日期:2014-08-01 00:00:00
abstract::Levels of immunoreactive ACTH and calcitonin (CT), as well as CEA, were determined serially in 144 patients with lung cancer and in 62 patients with metastatic carcinoma to the lungs. Patients with neoplasms not involving the lungs, with nonmalignant blood dyscrasias, and with chronic obstructive pulmonary disease wer...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19810515)47:10<2485::aid-cncr282
更新日期:1981-05-15 00:00:00
abstract::Balloon-mesh cytologic screening for esophageal cancer done in 255 asymptomatic high-risk United States veterans (age greater than 40 years, ethanol abuse for greater than 20 years, and cigarette smoking greater than 20 pack years) identified 37 patients with squamous cell dysplasia. Of the 37 patients with dysplasia,...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19900615)65:12<2731::aid-cncr282
更新日期:1990-06-15 00:00:00
abstract:BACKGROUND:Typhlitis is increasingly recognized in children undergoing chemotherapy but is poorly characterized. The authors investigated the demographic, clinical, and imaging (ultrasonography and computed tomography [CT] scans) variables related to the diagnosis, risk, and outcome of typhlitis. METHODS:The authors r...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.21134
更新日期:2005-07-15 00:00:00
abstract::A patient is presented who developed a peritoneal malignant mesothelioma in association with severe persistent and recurrent diverticulitis. The case is unusual in that a spectrum of mesothelial proliferation was documented beginning initially as benign foci of mesothelial proliferation and passing through a stage of ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19810701)48:1<134::aid-cncr28204
更新日期:1981-07-01 00:00:00
abstract::Biopsy specimens from 62 human single primary squamous cell carcinomas (SCC) of the head and neck were xenografted into nude mice. To evaluate the prognostic significance of successful heterotransplantation, the 62 cases were retrospectively examined for survival, adjusting for possible confounders by multivariate ana...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19900701)66:1<145::aid-cncr28206
更新日期:1990-07-01 00:00:00
abstract::In this review, I describe the polymerase chain reaction (PCR) and its application to cancer diagnostics. I present recent improvements to PCR methodology, and describe some state-of-the-art detection methods and approaches used to diagnose various cancer markers, including ras genes, BCR/abl translocations, and G-pro...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(19920315)69:6+<1527::aid-cncr282
更新日期:1992-03-15 00:00:00
abstract:BACKGROUND:A retrospective clinicopathologic study was performed to identify the influence of diagnostic and therapeutic procedures on the outcomes of patients with the follicular variant of papillary thyroid carcinoma (FVPTC). METHODS:The results of 37 patients with FVPTC were compared with those of 37 randomly selec...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19940115)73:2<424::aid-cncr28207
更新日期:1994-01-15 00:00:00
abstract::Adrenal cortical carcinoma is an uncommon neoplasm in children. Only a handful of congenital adrenal cortical carcinoma cases have been described. A newborn who had metastatic adrenal cortical carcinoma (skin metastases and cerebral lesions) is described. This patient underwent surgical resection of the right adrenal ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19880801)62:3<507::aid-cncr28206
更新日期:1988-08-01 00:00:00
abstract:BACKGROUND:: Although platinum-based combinations are considered the best option of care for patients with advanced nonsmall cell lung cancer (NSCLC), single-agent therapy is the preferred treatment for older patients. Since the late 1990s, various combinations of third-generation agents (gemcitabine [G], vinorelbine, ...
journal_title:Cancer
pub_type: 杂志文章,meta分析
doi:10.1002/cncr.24207
更新日期:2009-05-01 00:00:00
abstract:BACKGROUND:Conflicting results have been obtained regarding blood flow distribution to liver tumors. The emphasis on portal vein perfusion has had a great impact on the design of treatment protocols. METHODS:Double microsphere technique with reference organ sampling was used for the measurement of hepatic artery and p...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19941101)74:9<2454::aid-cncr2820
更新日期:1994-11-01 00:00:00
abstract::An 11-year-old female with a large embryonal carcinoma of the left ovary was treated by unilateral salpingo-oophorectomy combined with a systemic chemotherapy of a total dose of 1.9 mg of dactinomycin. The preoperative serum alpha-fetoprotein (AFP) level of 70,350 ng/ml decreased to 270 ng/ml 5 weeks after the operati...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19831015)52:8<1470::aid-cncr2820
更新日期:1983-10-15 00:00:00
abstract:BACKGROUND:Tyrosine kinases, such as c-KIT, c-ABL, and platelet-derived growth factor-beta (PDGFR-beta), are important regulators of cell growth. Highly potent and selective inhibitors of tyrosine kinases are being investigated as alternatives to standard chemotherapy. One such inhibitor, imatinib mesylate, is being us...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.11561
更新日期:2003-08-15 00:00:00
abstract::The American Cancer Society estimates that nearly a million new cases of cancer will occur and that approximately a half million lives will be lost in 1987. These figures may double by the year 2000 primarily because of our aging population, with age being the leading risk factor for cancer. It is believed that the ma...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19880601)61:11+<2382::aid-cncr28
更新日期:1988-06-01 00:00:00
abstract::The relationships between cigarette smoking, occupational exposures, dietary vitamin A and lung cancer is explored in a case-control study. The study is based on 1002 primary lung cancers among white men and 1119 white male controls between 35 and 79 years of age admitted to Roswell Park Memorial Institute from 1957 t...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19850815)56:4<910::aid-cncr28205
更新日期:1985-08-15 00:00:00
abstract:BACKGROUND:Patients with renal masses are at risk for having or developing chronic kidney disease (CKD) stage 3 (glomerular filtration rate [GFR] <60 mL per minute/1.73 m2). In this study, the authors investigated whether the Screening for Occult Renal Disease (SCORED) model could identify patients with renal masses wh...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.23850
更新日期:2008-11-15 00:00:00
abstract:BACKGROUND:Soft tissue sarcomas of the hand and foot present unique management challenges. The purpose of the current study study was to determine oncologic outcome, particularly with respect to factors affecting local recurrence, distant recurrence, and disease-specific survival. METHODS:A retrospective study was per...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.10750
更新日期:2002-08-15 00:00:00
abstract::The authors report the accuracy of mammographically guided fine-needle aspiration (FNA) for the diagnosis of nonpalpable breast lesions in a series of 71 patients. Each mammographically guided FNA was immediately followed by hookwire localization and open biopsy. Seven malignancies were identified cytologically, but t...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19911101)68:9<2007::aid-cncr2820
更新日期:1991-11-01 00:00:00