Abstract:
BACKGROUND:Preoperative chemoradiation improves survival in esophageal and gastroesophageal junction (GEJ) cancer. We evaluated irinotecan and cisplatin as induction chemotherapy followed by concurrent chemoradiation in esophageal cancer. METHODS:Patients with uT1N1M0 or uT2-4NanyM0 resectable squamous cancer or adenocarcinoma of the esophagus or GEJ received irinotecan 65 mg/m(2) and cisplatin 30 mg/m(2) for 4 treatments in weeks 1 through 5, followed by 4 treatments in weeks 7 through 11 with 50.4 Gy in daily fractions, followed by surgery. The primary endpoint was pathologic complete response (pCR). Positron emission tomography (PET) scan was performed prior to chemotherapy and as restaging prior to radiotherapy. RESULTS:Fifty-five patients were evaluable, 75% of whom had adenocarcinoma and 65% of whom had uT3N1 disease. Thirty-eight patients underwent R0 resection (69%). The incidence of pCR was 16% (95% confidence interval, 8%-29%). Median overall survival was 31.7 months. An exploratory analysis of PET response to induction chemotherapy indicated a correlation with pCR (32% vs 4%), R0 resection (84% vs 57%), progression-free survival (24.1 vs 7.7 months), and overall survival (40.2 vs 25.5 months). CONCLUSIONS:Weekly treatment with irinotecan, cisplatin, and radiation achieved results no better and potentially inferior to other phase 2 chemoradiotherapy trials with a low rate of pCR. The use of PET scan after induction chemotherapy to direct chemotherapy during subsequent radiotherapy merits further study.
journal_name
Cancerjournal_title
Cancerauthors
Ilson DH,Minsky BD,Ku GY,Rusch V,Rizk N,Shah M,Kelsen DP,Capanu M,Tang L,Campbell J,Bains Mdoi
10.1002/cncr.26591subject
Has Abstractpub_date
2012-06-01 00:00:00pages
2820-7issue
11eissn
0008-543Xissn
1097-0142journal_volume
118pub_type
杂志文章相关文献
CANCER文献大全abstract:BACKGROUND:The incidence of adenocarcinoma of the cervix did not decline in Western countries in the 1970s and 1980s despite the availability and use of cervical cytologic screening. The impact of improved endocervical sampling and better recognition of the cytologic precursors to adenocarcinoma during the 1990s in red...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.11835
更新日期:2003-12-25 00:00:00
abstract::A study of pneumococcal bacteremia in 56 patients with neoplastic disease from January 1, 1972 to June 30, 1980 is presented and compared to an earlier study between 1955 and 1971. Patients at highest risk were those with Hodgkin's disease who had been splenectomized, multiple myeloma and chronic lymphocytic leukemia ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19830415)51:8<1546::aid-cncr2820
更新日期:1983-04-15 00:00:00
abstract:BACKGROUND:The objective of the current study was to examine the impact of adherence to guidelines on stage-specific survival outcomes in patients with stage III and high-risk stage II colon cancer. The National Comprehensive Cancer Network (NCCN) has established working, expert consensus, and evidence-based guidelines...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.27935
更新日期:2013-04-15 00:00:00
abstract:BACKGROUND:Although delay to diagnosis after a breast screening abnormality causes anxiety, its effect on prognosis is unknown. METHODS:Using pooled data from five Canadian organized breast cancer screening programs, the authors used unconditional logistic regression to evaluate the effect of delay to diagnosis on pro...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.10453
更新日期:2002-04-15 00:00:00
abstract:BACKGROUND:Approximately 5-10% of patients with rhabdomyosarcomas (RMS) are diagnosed during the first year of life, and their clinical characteristics have been well documented. However, because RMS rarely occurs during the neonatal period, little is known about neonatal RMS. METHODS:Four patients with neonatal RMS w...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(20010915)92:6<1613::aid-cncr1487
更新日期:2001-09-15 00:00:00
abstract::A growing body of research shows that a majority of patients with cancer report having religious and spiritual (R/S) beliefs, engaging in R/S behaviors, or deriving comfort from R/S experiences. These studies have been reviewed but not subjected to rigorous critical analysis. A meta-analytic approach is needed to prov...
journal_title:Cancer
pub_type: 杂志文章,meta分析
doi:10.1002/cncr.29349
更新日期:2015-11-01 00:00:00
abstract:BACKGROUND:Although breast-conserving therapy (tumor excision, axillary node dissection, and postoperative radiation) for women with breast cancer yields survival and local recurrence rates comparable with those of modified radical mastectomy, studies suggest that postoperative radiation leads to capsular contractures ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19940515)73:10<2613::aid-cncr282
更新日期:1994-05-15 00:00:00
abstract:BACKGROUND:Bioimpedance spectroscopy (BIS) has enabled the early identification of breast cancer-related lymphedema. In this study, differences in health service metrics and in the incidence of breast cancer-related lymphedema are evaluated in an early surveillance model of care compared with a traditional referral mod...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.31873
更新日期:2019-03-15 00:00:00
abstract:BACKGROUND:Adequate prediction of survival is important in deciding on treatment for patients with symptomatic spinal metastases. The authors reviewed 342 patients with painful spinal metastases without neurologic impairment who were treated conservatively within a large, prospectively randomized radiotherapy trial. Re...
journal_title:Cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/cncr.20756
更新日期:2005-01-15 00:00:00
abstract::Patients with schistosomiasis of the urinary bladder (SB) associated with carcinoma of the bladder (SCB) or carcinoma of the prostate (SCP) have a variety of immunologic abnormalities, including the presence of HLA-DR+ and interleukin-2 receptor-positive (IL-2R+) T-lymphocytes in circulating blood. This study demonstr...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19900215)65:4<931::aid-cncr28206
更新日期:1990-02-15 00:00:00
abstract:BACKGROUND:Stereotactic radiation therapy is highly effective in the treatment of small brain metastases, regardless of the histology. This suggests that small extracranial malignancies may be curable with similar radiation therapy. The authors developed a novel treatment unit for administering such therapy. METHODS:T...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19980315)82:6<1062::aid-cn
更新日期:1998-03-15 00:00:00
abstract::Methionine-depleting total parenteral nutrition (methionine-depleting TPN), which infuses an amino acid solution devoid of L-methionine and L-cysteine as the sole protein source, showed enhancement of the effect of several anti-cancer agents. In this study, the combined effect of the methionine-depleting TPN with the ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19920401)69:7<1865::aid-cncr2820
更新日期:1992-04-01 00:00:00
abstract:BACKGROUND:Telomerase is a ribonucleoprotein enzyme that extends telomere specific repeats on the ends of chromosomes. Telomerase activity has been detected frequently in various types of human tumors and has been associated with cell immortality and oncogenesis. Human telomerase reverse transcriptase (hTERT), a telome...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.10793
更新日期:2002-09-01 00:00:00
abstract:BACKGROUND:Patient navigation programs are emerging that aim to address disparities in clinical trial participation among medically underserved populations, including racial/ethnic minorities. However, there is a lack of consensus on the role of patient navigators within the clinical trial process as well as outcome me...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/cncr.28570
更新日期:2014-04-01 00:00:00
abstract:BACKGROUND:Gastric carcinoids are uncommon, and are unlike carcinoids at other gastrointestinal sites, clinically and pathologically. METHODS:The authors studied specimens from 104 patients with gastric carcinoid, with study emphasis being placed on pathologic features, immunohistochemistry, clinical associations, and...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19940415)73:8<2053::aid-cncr2820
更新日期:1994-04-15 00:00:00
abstract::Carcinoembryonic antigen (CEA) values in 529 patients treated in two consecutive adjuvant chemotherapy protocols were analyzed to determine if CEA values correlated with disease-free status or prognostic utility. CEA values were evaluated preoperatively, before chemotherapy, at the conclusion of chemotherapy, and duri...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19890301)63:5<828::aid-cncr28206
更新日期:1989-03-01 00:00:00
abstract::The care of patients with cancer and chronic pain, often complicated and demanding, strains the resources of a single physician. Continuity of care programs, such as that developed by the Pain Service of Memorial Sloan-Kettering Cancer Center (New York), with good communication and liaison work between hospital and co...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19890601)63:11<2289::aid-cncr282
更新日期:1989-06-01 00:00:00
abstract:BACKGROUND:The objective of this study was to compare the quality of life (QOL) of younger (< or =50 years) versus older (>50 years) women on recent completion of treatment of breast carcinoma. METHODS:Data reported herein were obtained from a baseline assessment of 304 breast carcinoma patients. These patients were e...
journal_title:Cancer
pub_type: 杂志文章,多中心研究
doi:
更新日期:1999-11-01 00:00:00
abstract::Epithelioid sarcoma is an uncommon tumor characterized by its appearance in the distal extremities (especially the forearm, wrist, and ankle), the tendency to recur locally, and high probability of spread to regional lymph nodes. Most patients have been treated surgically, and the potential role of radiation therapy a...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19830915)52:6<1022::aid-cncr2820
更新日期:1983-09-15 00:00:00
abstract::The purpose of this study is to evaluate benign and/or malignant thyroid tumors with 201TI thyroid scan. We studied 76 cases of histologically verified thyroid tumors, all seen as cold nodules on the 123I thyroid scan. 201TI thyroid scan was performed 5-15 minutes (early scan) and 3-5 hours (delayed scan) after intrav...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19820715)50:2<236::aid-cncr28205
更新日期:1982-07-15 00:00:00
abstract::Two cases of primary linitis plastica of the large intestine will be presented and discussed. Characteristic clinical features of this type of adenocarcinoma of the large intestine include younger age of presentation, low incidence of hepatic metastasis and a high incidence of ovarian, lymph node and peritoneal metast...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(197806)41:6<2420::aid-cncr282041
更新日期:1978-06-01 00:00:00
abstract::Major findings are presented from a workshop on Quality of Life Assessment in Cancer Symptom Management Trials, sponsored by the National Cancer Institute. Data-driven research reports focused on 3 topics, 1) the rationale and utility of health-related quality of life (HRQOL) assessment, 2) conceptual models, and 3) m...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.22893
更新日期:2007-10-01 00:00:00
abstract:BACKGROUND:Breast conservation is now established treatment for patients with small breast cancers. The authors reviewed a large series of patients with long term follow-up who underwent conservative treatment. Clinical and pathologic factors were analyzed to identify patients at an increased risk of relapse in the bre...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19951201)76:11<2260::aid-cncr282
更新日期:1995-12-01 00:00:00
abstract:BACKGROUND:Chemotherapy intensification may lead to new forms of toxicity such as hemolytic uremic syndrome. METHODS:Three patients are described who developed this complication 4 to 6 months after high dose chemotherapy followed by autologous stem cell support. The literature on this subject is reviewed. RESULTS:One...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(19951201)76:11<2338::aid-cncr282
更新日期:1995-12-01 00:00:00
abstract:BACKGROUND:Transitional cell carcinoma (TCC) is rare in the female genital tract. Although it is most common in the ovary, small series of cases in the cervix have been reported, with isolated cases described in the fallopian tube, adnexa uteri, and endometrium. METHODS:Eight cases of primary TCC involving the endomet...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:1997-05-15 00:00:00
abstract::The value of image analysis in predicting the malignant potential of oral epithelial lesions showing either hyperplasia or dysplasia was investigated; 5-micron formalin-fixed sections of 16 oral epithelial lesions, of which eight had later transformed to carcinoma and eight had not transformed during a follow-up of 10...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19881101)62:9<1981::aid-cncr2820
更新日期:1988-11-01 00:00:00
abstract::Kaposi's sarcoma of the gingiva and skin developed in an HIV-negative renal transplant patient while he was receiving cyclosporine therapy. The Kaposi's sarcoma developed shortly after the patient had an acute infection with cytomegalovirus (CMV). Electron microscopy of the tumor's established cell line showed two typ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19900201)65:3<492::aid-cncr28206
更新日期:1990-02-01 00:00:00
abstract:BACKGROUND:Inhibitors of the mammalian target of rapamycin (mTOR) are emerging as promising therapies for metastatic renal cell carcinoma (RCC). Because rational treatment strategies require understanding the activation status of the underlying signaling pathway being targeted at the desired stage of disease, the autho...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.25402
更新日期:2011-01-15 00:00:00
abstract::A number of problems inherent to quality of care evaluation have been described above. Although issues such as limited resources and clinical staff resistance may not be specific to cancer care, they certainly impact on the evaluation of the quality of care offered to cancer patients. Other issues such as complexity o...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19890701)64:1+<302::aid-cncr2820
更新日期:1989-07-01 00:00:00
abstract:BACKGROUND:Sixty cases of axillary metastases from clinically occult breast cancer were analyzed. All cases had histologic evidence of metastatic nodes compatible with breast carcinoma. METHODS:Thirty-three patients underwent breast surgery at the time of histologic diagnosis of the axillary metastases, 6 patients wer...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19920715)70:2<504::aid-cncr28207
更新日期:1992-07-15 00:00:00