Abstract:
:Tumor cell DNA (ploidy) content was measured prospectively in samples from 320 patients resected for colorectal cancer with a minimum follow-up time of 2 years. All patients were followed and those with recurrence were investigated carefully. There was no correlation between tumors with an abnormal cellular DNA content (aneuploid or tetraploid) and patient age, sex, tumor site, pathologic stage, or histologic grade. In 236 patients who underwent potentially curative operations, 75 (32%) had local and/or distant recurrence. The recurrence rate was significantly higher (test statistic, 4.3; P = 0.04) for those patients with aneuploid tumors (52 of 142, 37%) compared with those with diploid tumors (23 of 94, 24%). The subgroups of patients where ploidy exerted an effect were in patients with Stage B tumors or mobile tumors and in patients over 65 years of age. Further analysis showed that there was a twofold increase in local recurrence and a threefold increase in distant recurrence in patients with aneuploid tumors, but no excess of patients who had both local and distant recurrence. Measurement of DNA ploidy can identify a group of patients undergoing curative surgery for colorectal cancer at high risk for recurrence. In combination with clinicopathologic factors, DNA ploidy may be useful in analyzing the results of trials and in planning adjuvant therapy.
journal_name
Cancerjournal_title
Cancerauthors
Armitage NC,Ballantyne KC,Sheffield JP,Clarke P,Evans DF,Hardcastle JDdoi
10.1002/1097-0142(19910515)67:10<2599::aid-cncr282subject
Has Abstractpub_date
1991-05-15 00:00:00pages
2599-604issue
10eissn
0008-543Xissn
1097-0142journal_volume
67pub_type
杂志文章相关文献
CANCER文献大全abstract:BACKGROUND:Obesity has been associated with inferior outcomes in operable breast cancer, but the relation between body mass index (BMI) and outcomes by breast cancer subtype has not been previously evaluated. METHODS:The authors evaluated the relation between BMI and outcomes in 3 adjuvant trials coordinated by the Ea...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.27527
更新日期:2012-12-01 00:00:00
abstract::During a retrospective case-control study of recent laryngeal cancer patients, several associated factors were studied to determine possible changes in the epidemiology of laryngeal cancer between 1956 and 1974. The large sex difference noted in the early survey (male: female ratio of 14.9:1) diminished considerably i...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197610)38:4<1591::aid-cncr282038
更新日期:1976-10-01 00:00:00
abstract:BACKGROUND:Primary small cell carcinoma arising in organs other than the lung were thought to be relatively rare. However, with the increasing technical sophistication of pathology departments, tumors with foci of small cell neuroendocrine components are being identified more frequently. The pattern of disease involvem...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19941215)74:12<3159::aid-cncr282
更新日期:1994-12-15 00:00:00
abstract:BACKGROUND:Skin cancer affects more Americans than any other type of cancer. Children are prime targets for prevention education, because sun overexposure in early childhood may affect the development of skin cancer later in life. Preventive behaviors adopted early in life may be less resistant to change than those acq...
journal_title:Cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/1097-0142(19950115)75:2+<651::aid-cncr2820
更新日期:1995-01-15 00:00:00
abstract::Forty seven patients with early gastric cancer received a 30-minute intravenous injection of bromodeoxyuridine (BrdU), 1000 mg each 1 hour before laparotomy, to label tumor cells in the S phase. In 13 of 47 patients, specimens obtained by endoscopic biopsy were cultured in vitro at 37 degrees C for 1 hour under three ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19891015)64:8<1665::aid-cncr2820
更新日期:1989-10-15 00:00:00
abstract::The relative value of each lactic dehydrogenase isoenzyme (iso LDH) was measured by electrophoretic separation in the serum and the pleural fluid of 100 patients. In each case, the cause of the pleural effusion was known. Two types of LDH isoenzyme pattern were found in the serum: a normal type with a low value of LDH...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19840801)54:3<507::aid-cncr28205
更新日期:1984-08-01 00:00:00
abstract:BACKGROUND:Prostate adenocarcinoma is predominantly a disease of older men. Males younger than 50 years account for 1% of all patients with prostate cancer. The authors retrospectively examined cases of prostate adenocarcinoma in patients younger than 50 years of age to determine the natural history and prognosis of th...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19940915)74:6<1768::aid-cncr2820
更新日期:1994-09-15 00:00:00
abstract::The geographic and demographic data obtained during the Third National Cancer Survey have provided a perspective on etiologic factors and incidence trends for cancers of low frequency. The incidence of cancer of the lip, oral cavity and skin from this survey was compared to similar studies in 1947 and intra-regional p...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197707)40:1<343::aid-cncr2820400
更新日期:1977-07-01 00:00:00
abstract:BACKGROUND:In a previous phase 2 trial, axitinib was active and well tolerated in patients with advanced thyroid cancer. In this second phase 2 trial, the efficacy and safety of axitinib were evaluated further in this population, and pharmacokinetic/pharmacodynamic relationships and patient-reported outcomes were asses...
journal_title:Cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/cncr.28766
更新日期:2014-09-01 00:00:00
abstract::An Epstein-Barr virus (EBV)-negative lymphoma line (JBL) was established in vitro from pleural effusion of an EBV-seropositive 29-year-old Japanese female with Burkitt's lymphoma. JBL cells as well as her original lymphoma cells bore monoclonal surface IgM with lambda light chains. The JBL line grew in single cell sus...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197712)40:6<2999::aid-cncr282040
更新日期:1977-12-01 00:00:00
abstract:BACKGROUND:The purpose of this study is to examine changes over time in survival for African American (AA) and white women diagnosed with cervical cancer (CC). METHODS:Surveillance, Epidemiology, and End Results (SEER) Program data from 1985 to 2009 were used for this analysis. Racial differences in survival were eval...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.28261
更新日期:2013-10-15 00:00:00
abstract::Levels of glycoprotein:sialyltransferase activity (EC 2.4.99.1; CMP-acetyl-neuraminate:D-galactosyl-glycoprotein N-acetylneuraminyl-transferase) were measured in plasma of patients with neoplastic disease, and were found elevated above normal control values in 85% of patients examined. There was a correlation between ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197703)39:3<1129::aid-cncr282039
更新日期:1977-03-01 00:00:00
abstract::Clinically benign whole, untrimmed prostates and pelvic lymph nodes were obtained from 105 patients at autopsy. All 105 patients had premortem serum from which prostate-specific antigen (PSA) levels were obtained. Sixty-eight did not have carcinoma of the prostate (CAP), 28 had CAP less than 1 ml and 9 had CAP larger ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19911001)68:7<1592::aid-cncr2820
更新日期:1991-10-01 00:00:00
abstract::Small cell carcinoma is primarily a pulmonary neoplasm that rarely arises in extrapulmonic sites including salivary glands of the head and neck. Twelve cases of small cell carcinoma of salivary gland origin were retrieved from the Armed Forces Institute of Pathology files. Six tumors occurred in the parotid gland and ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19860801)58:3<705::aid-cncr28205
更新日期:1986-08-01 00:00:00
abstract:BACKGROUND:African Americans are diagnosed more frequently with colorectal carcinoma at a later stage compared with Caucasians. One potential reason for the disparity is a lower rate of screening examinations. METHODS:Using Outpatient and Physician-Supplier claims for all Medicare beneficiaries age > or = 65 years in ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.20014
更新日期:2004-01-15 00:00:00
abstract::Activities of glucosephosphate isomerase, lactate dehydrogenase, and NADP-isocitrate dehydrogenase were significantly elevated in breast cancer specimens from patients who responded favorably to combination cytotoxic chemotherapy regimens compared with those in carcinomas from patients failing to respond to the same c...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197608)38:2<695::aid-cncr2820380
更新日期:1976-08-01 00:00:00
abstract::Eighteen patients with isolated vaginal recurrence of their previously treated endometrial carcinoma were treated with radiation therapy at North Carolina Baptist Hospital, Winston-Salem between 1971 and 1982. Most patients received external beam irradiation which were followed by boost treatments that were delivered ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19870801)60:3<419::aid-cncr28206
更新日期:1987-08-01 00:00:00
abstract:BACKGROUND:The diagnosis of melanomas at an early stage is associated with improved survival, so the recognition of changes in pigmented skin lesions over time is important. We have developed a computer imaging system with the aim of assisting clinicians in differentiating early melanomas from benign pigmented skin les...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0142(19960715)78:2<252::AID-CNC
更新日期:1996-07-15 00:00:00
abstract:BACKGROUND:The incidence of primary central nervous system lymphoma (PCNSL) has increased over time in both immunocompetent and immunodeficient individuals. The reasons for the increase among immunocompetent patients are unclear. METHODS:The authors conducted a case-control study of PCNSL at the Mayo Clinic based on c...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:1998-03-01 00:00:00
abstract::In contrast with the expectations of the authors and with reports suggesting a decline in risk for scrotal cancer, Connecticut Tumor Registry data neither showed detectable decrease in risk over the 45-year-period for all 95 scrotal malignancies nor for the 71 epithelial cancers. The age distribution of scrotal cancer...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19840801)54:3<596::aid-cncr28205
更新日期:1984-08-01 00:00:00
abstract::Transcriptional dysregulation induced by disease-defining genetic alterations of proteins in transcriptional machinery is a key feature of cancers. Mediator complex subunit 12 (MED12) is the central architectural subunit in the kinase module of Mediator, a large transcriptional regulatory complex that controls essenti...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/cncr.32672
更新日期:2020-03-01 00:00:00
abstract::Unnecessary, inappropriate, and futile care are given in all areas of health care including cancer care. Not only does such care increase costs and waste precious resources, but patients may have adverse outcomes when the wrong care is given. One of the ways to address this issue is to measure performance with the use...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19980515)82:10+<2016::aid-
更新日期:1998-05-15 00:00:00
abstract:BACKGROUND:Peritoneal metastases are one reason for the poor prognosis of scirrhous gastric cancer. However, the mechanism of peritoneal metastasis remains unclear. We therefore investigated the interaction between gastric cancer cells and peritoneal fibroblasts, in vivo and in vitro. METHODS:A human scirrhous gastric...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0142(19960415)77:8<1668::AID-CN
更新日期:1996-04-15 00:00:00
abstract:BACKGROUND:The p53 tumor suppressor gene encodes a nuclear phosphoprotein that is thought to be important to cell cycle regulation and DNA repair and that also may regulate induction of apoptosis by ionizing radiation. Somatic p53 gene mutations occur in 30-50% of breast carcinomas and are associated with poor prognosi...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:2000-03-01 00:00:00
abstract:BACKGROUND:Activating mutations in RAS are frequently present in patients with acute myeloid leukemia (AML), but their overall prognostic impact is not clear. METHODS:A retrospective analysis was performed to establish the clinical characteristics of patients with RAS-mutated (RAS(mut) ) AML, to analyze their outcome ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.27596
更新日期:2012-11-15 00:00:00
abstract::The European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire-Lung Cancer 13 (QLQ-LC13) covers 13 typical symptoms of lung cancer patients and was the first module developed in conjunction with the EORTC core quality-of-life (QL) questionnaire. This review investigates how the mo...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/cncr.29682
更新日期:2015-12-15 00:00:00
abstract:BACKGROUND:Immediate or early postmastectomy breast reconstruction is performed infrequently. To the authors' knowledge, little is known regarding surgeon or patient perspectives on reconstruction treatment decisions. The purpose of the current study was to identify patient attitudes and preferences associated with bre...
journal_title:Cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/cncr.21444
更新日期:2005-12-01 00:00:00
abstract:BACKGROUND:Breast carcinoma commonly metastasizes to the skeleton in patients with advanced disease to cause bone destruction and the associated pain, hypercalcemia, fracture, and nerve-compression syndromes. In this scenario, the bone destruction is mediated by the osteoclast. Tumor-produced parathyroid hormone-relate...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(20000615)88:12+<2892::aid-cncr2>
更新日期:2000-06-15 00:00:00
abstract:BACKGROUND:LAMP3 is a newly described hypoxia regulated gene of potential interest in hypoxia-induced therapy resistance and metastasis. The prognostic value of LAMP3 in breast cancer was investigated. METHODS:Expression levels of LAMP3 in breast cancer cell lines and patient tissues were determined by real-time polym...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.25938
更新日期:2011-08-15 00:00:00
abstract:BACKGROUND:Quantified, human hemoglobin (Hb)-specific, immunochemical fecal occult blood test (IFOBT) measurements are now used for colorectal cancer (CRC) screening. The objective was to evaluate sensitivity and specificity for CRC and advanced adenomatous polyps (APs) by the fecal Hb threshold used to determine a pos...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.25012
更新日期:2010-05-01 00:00:00