Acute lymphoblastic leukemia. An unusual case of primary relapse in the uterine cervix.

Abstract:

:Female genital tract involvement by hematologic neoplasms is uncommon and is usually associated with disseminated disease. Lymphoid neoplasms, which involve the cervix and uterus primarily, are usually of either diffuse large cell or small cleaved cell type, and rarely Burkitt's (small non-cleaved) lymphoma or granulocytic sarcoma. In this report the authors describe young woman with acute stem cell leukemia which was terminal deoxyribonucleotidyl transferase positive, and involved the bone marrow and peripheral blood. After induction of remission and a 2-year disease-free interval, she relapsed with involvement localized to the uterus and cervix. At relapse the leukemic cells expressed CD1, CD2, CD5, CD7, and CD4 or CD8, antigens of the common thymocyte compartment. The authors postulate that the T-cell antigens, known extracellular matrix receptors, may have determined the tissue infiltration: an unusual pattern of relapse.

journal_name

Cancer

journal_title

Cancer

authors

Zutter MM,Gersell DJ

doi

10.1002/1097-0142(19900901)66:5<1002::aid-cncr2820

subject

Has Abstract

pub_date

1990-09-01 00:00:00

pages

1002-4

issue

5

eissn

0008-543X

issn

1097-0142

journal_volume

66

pub_type

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