Elevations in serum alpha-fetoprotein levels in patients with chronic hepatitis B.

Abstract:

:In a retrospective analysis of 166 patients with chronic hepatitis B followed for up to 8 years, 22 patients had 29 episodes of elevations in serum alpha-fetoprotein (AFP) levels. Twenty-five episodes were due to a transient exacerbation of the underlying hepatitis and 11 of these episodes were followed by a loss of hepatitis B e antigen (HBeAg) from serum and a remission in disease. Two patients were found to have hepatocellular carcinoma. No apparent cause could be found in a further two episodes of AFP elevation. In comparison to 144 patients with normal levels, the 22 with AFP elevations were more likely to have cirrhosis (61% versus 13%, P = 0.01), to die a liver-related death (27% versus 0.7%, P = 0.0007) and to have hepatocellular carcinoma (HCC) (9% versus 0%, P = 0.002). These findings confirm that AFP can be used to screen for HCC in high-risk patients with chronic hepatitis B. The majority of AFP elevations, however, will be found to be due to exacerbations of disease, with or without loss of HBeAg from serum, especially in white patients with severe disease and cirrhosis.

journal_name

Cancer

journal_title

Cancer

authors

Di Bisceglie AM,Hoofnagle JH

doi

10.1002/1097-0142(19891115)64:10<2117::aid-cncr282

subject

Has Abstract

pub_date

1989-11-15 00:00:00

pages

2117-20

issue

10

eissn

0008-543X

issn

1097-0142

journal_volume

64

pub_type

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