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Locally advanced melanoma: results of postoperative hypofractionated radiation therapy.

Abstract：

BACKGROUND:High rates of locoregional recurrence have been reported from surgical series of locally advanced melanoma. In this study, the outcomes of patients treated with surgery and postoperative hypofractionated radiation therapy were reviewed to assess local recurrence and survival. METHODS:From 1989 to 1998, 174 patients with International Union Against Cancer Stage I-III melanoma received postoperative radiation therapy, either as a component of their initial management or following surgery for recurrence. Radiation was delivered to the primary site in 35 cases and involved regional lymph nodes in 139. The indications for irradiation included microscopically positive surgical margins or other adverse pathologic features. All patients received a hypofractionated schedule of 30-36 grays (Gy) in 5-7 fractions over 2.5 weeks. RESULTS:Recurrence within the radiation fields was identified in 20 patients (11%) at a median time of 6 months. There was no difference in recurrence rates for patients with microscopically positive margins compared with other indications for adjuvant treatment. The main complication of treatment was symptomatic arm lymphedema in 58% of patients following axillary dissection and postoperative irradiation. The median disease specific survival for the entire group was 25 months from radiation therapy, and the 5-year survival was 41%. The only factor that predicted significantly for decreased survival was infield recurrence (the median survival periods were 13 months and 35 months for those with and without infield recurrence, P < 0.0001). The median time to the development of distant metastasis was 19 months. CONCLUSIONS:Despite the high incidence of distant metastasis, locoregional control remains an important goal in the management of melanoma. Compared with published surgical data, postoperative adjuvant radiation therapy given according to a hypofractionated schedule was effective in reducing local recurrence in patients at high risk of locoregional failure.

journal_name

Cancer

journal_title

Cancer

authors

Stevens G,Thompson JF,Firth I,O'Brien CJ,McCarthy WH,Quinn MJ

doi

10.1002/(sici)1097-0142(20000101)88:1<88::aid-cncr

subject

Has Abstract

pub_date

2000-01-01 00:00:00

pages

88-94

issue

eissn

0008-543X

issn

1097-0142

pii

10.1002/(SICI)1097-0142(20000101)88:1<88::AID-CNCR

journal_volume

pub_type

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Locally advanced melanoma: results of postoperative hypofractionated radiation therapy.