High expression levels of survivin protein independently predict a poor outcome for patients who undergo surgery for clear cell renal cell carcinoma.


BACKGROUND:In a previous study of gene array data, the authors identified survivin as a candidate marker of aggressiveness in clear cell renal cell carcinoma (ccRCC). What remained in question was whether survivin expression at the protein level is an independent predictor of disease progression and cancer-specific survival. METHODS:Between 1990 and 1994, 312 patients underwent nephrectomy for ccRCC at Mayo Clinic Rochester and had paraffin tissue available. The authors performed immunohistochemistry with antisurvivin antibody, quantitated the expression by using an image-analysis system, and analyzed the association of survivin expression with disease progression and cancer-specific survival. RESULTS:Within the cohort, 97 patients (31.1%) had high levels of survivin expression. Patients who had high survivin expression levels were at significantly increased risk of death from RCC compared with patients who had low expression levels (risk ratio [RR], 5.3; 95% confidence interval [95% CI], 3.5-7.9). The 5-year cancer-specific survival rate was 43.0% for patients with high survivin expression and 87.2% for patients with low survivin expression. In multivariate analysis, survivin expression remained associated with death from RCC even after adjusting for the Eastern Cooperative Oncology Group performance status; 2002 Tumor, Lymph Node, Metastases (TNM) stage groupings and nuclear grade (RR, 2.4; 95%CI, 1.5-3.8); and the Mayo Clinic composite TNM stage groupings, tumor size, nuclear grade, and tumor necrosis (SSIGN) score (RR, 1.8; 95%CI, 1.1-2.9). Among 273 patients who had localized ccRCC, survivin expression was associated significantly with cancer progression (RR, 3.9; 95%CI, 2.4-6.2). CONCLUSIONS:Survivin expression is an independent predictor of ccRCC progression and death from RCC. Thus, survivin has the potential to offer additional prognostic information and to provide a novel target for the development of new adjuvant therapies.






Parker AS,Kosari F,Lohse CM,Houston Thompson R,Kwon ED,Murphy L,Riehle DL,Blute ML,Leibovich BC,Vasmatzis G,Cheville JC




Has Abstract


2006-07-01 00:00:00














  • Hepatic dearterialization for nonrespectable primary and secondary tumors of the liver.

    abstract::Seventeen patients with primary or secondary liver tumors were treated by dearterialization of the liver and intraportal infusion of cytotoxic drugs. In 14 cases, ligation of the main (10), right and left (1), right and middle (1), and right (2) hepatic arteries was performed. In three in whom hepatic artery ligation ...


    pub_type: 杂志文章


    authors: Nagasue N,Inokuchi K,Kobayashi M,Ogawa Y,Iwaki A

    更新日期:1976-12-01 00:00:00

  • Prognostic implications of patterns of failure for gastrointestinal leiomyosarcomas.

    abstract::One hundred ninety-one patients with gastrointestinal leiomyosarcomas were analyzed to determine the prevalence in patterns of failure and the factors predicting those at higher risk of relapse at specific sites. Of 100 assessable patients who died of disease, 89% were found to have peritoneal tumor, 78% had liver met...


    pub_type: 杂志文章


    authors: Ng EH,Pollock RE,Romsdahl MM

    更新日期:1992-03-15 00:00:00

  • Superior vena caval obstruction syndrome in small cell lung cancer.

    abstract::In a series of 643 patients with small cell lung cancer (SCLC), 55 patients (8.6%) had signs or symptoms of superior vena caval obstruction syndrome (SVCO). Relatively long intervals from the onset of the first symptoms of SVCO to the start of therapy were observed, and invasive diagnostic procedures were safely perfo...


    pub_type: 杂志文章


    authors: Sculier JP,Evans WK,Feld R,DeBoer G,Payne DG,Shepherd FA,Pringle JF,Yeoh JL,Quirt IC,Curtis JE

    更新日期:1986-02-15 00:00:00

  • A correlation of argyrophilic nucleolar organizer regions with stages of hepatocellular carcinoma.

    abstract:BACKGROUND:Recently, the number and morphologic features of argyrophilic nucleolar organizer regions (AgNOR), silver-stained nucleolar organizer regions, were thought to reflect the cellular proliferative activity and the grade of malignancy. In liver diseases, it has been reported that AgNOR scores for hepatocellular ...


    pub_type: 杂志文章


    authors: Shiro T,Seki T,Naitoh Y,Inoue K,Okamura A

    更新日期:1993-01-01 00:00:00

  • Pathology of small hepatocellular carcinoma. A proposal for a new gross classification.

    abstract::Review of 61 surgically resected small hepatocellular carcinomas (HCC) less than or equal to 3 cm in diameter yielded a simple gross classification system of five types based on tumor shape, which is highly correlated with microscopic and clinical features, including prognosis. Type 1 (single nodular type) tumors (n =...


    pub_type: 杂志文章


    authors: Kanai T,Hirohashi S,Upton MP,Noguchi M,Kishi K,Makuuchi M,Yamasaki S,Hasegawa H,Takayasu K,Moriyama N

    更新日期:1987-08-15 00:00:00

  • Malignant lymphoma with primary manifestation in the gonad: a clinicopathologic study of 38 patients.

    abstract::This study is based on 38 patients, each of whom had a malignant lymphoma in which the gonad was the site of the main tumor mass at the time of diagnosis. Histiocytic lymphoma was the predominant type in the 27 male patients; in the 11 female patients, poorly differentiated lymphocytic lymphoma was the most frequent t...


    pub_type: 杂志文章


    authors: Paladugu RR,Bearman RM,Rappaport H

    更新日期:1980-02-01 00:00:00

  • Eosinophilic granular ceels in oligodendrogliomas. An ultrastructural study.

    abstract::In three cases of oligodendrogliomas, atypical cells rich in eosinophilic cytoplasm, resembling plump astroyctic or astroblastic cells, were studied under the electron microscopy. These cells showed finely granular cytoplasm with routine hematoxylin-eosin preparation; ultrastructurally, they exhibited abundant, round ...


    pub_type: 杂志文章


    authors: Takei Y,Mirra SS,Miles ML

    更新日期:1976-11-01 00:00:00

  • Prolactin and pituitary gonadotropin values and responses to acute luteinizing hormone-releasing hormone (LHRH) challenge in patients having long-term treatment with a depot LHRH analogue.

    abstract::Sixty patients with advanced prostatic carcinoma were treated with monthly subcutaneous injections of a depot formulation of goserelin, a luteinizing hormone-releasing hormone (LHRH) analogue (Zoladex, ICI Pharma, Destelbergen, Belgium). All patients were regularly evaluated with measurements of luteinizing hormone (L...


    pub_type: 杂志文章


    authors: Mahler C,Verhelst J,Chaban M,Denis L

    更新日期:1991-02-01 00:00:00

  • Poorly differentiated carcinomas of the thyroid with trabecular, insular, and solid patterns: a clinicopathologic study of 183 patients.

    abstract:BACKGROUND:The term poorly differentiated (PD) carcinoma was proposed 20 years ago to define aggressive, follicular-derived thyroid carcinomas with behavior intermediate between follicular/papillary and anaplastic carcinomas. Among the variable histologic patterns recognized in such tumors, trabecular-insular-solid (TI...


    pub_type: 杂志文章


    authors: Volante M,Landolfi S,Chiusa L,Palestini N,Motta M,Codegone A,Torchio B,Papotti MG

    更新日期:2004-03-01 00:00:00

  • Community health status and outcomes after allogeneic hematopoietic cell transplantation in the United States.

    abstract:BACKGROUND:The association of community factors and outcomes after hematopoietic cell transplantation (HCT) has not been comprehensively described. Using the County Health Rankings and Roadmaps (CHRR) and the Center for International Blood and Marrow Transplant Research (CIBMTR), this study evaluated the impact of comm...


    pub_type: 杂志文章


    authors: Hong S,Brazauskas R,Hebert KM,Ganguly S,Abdel-Azim H,Diaz MA,Beattie S,Ciurea SO,Szwajcer D,Badawy SM,Gratwohl AA,LeMaistre C,Aljurf MDSM,Olsson RF,Bhatt NS,Farhadfar N,Yared JA,Yoshimi A,Seo S,Gergis U,Beitinjane

    更新日期:2021-02-15 00:00:00

  • Methyl CCNU and adriamycin for patients with metastatic sarcomas: a Southwest Oncology Group study.

    abstract::This protocol study (SWOG-7431) combining adriamycin and methyl CCNU (MAD) for metastatic sarcomas was initially used on patients who were refractory to cytoxan, vincristine, and/or actinomycin-D. After the initial good results, the study was expanded to include any untreated patients with metastatic sarcoma. The init...


    pub_type: 杂志文章


    authors: Rivkin SE,Gottlieb JA,Thigpen T,El Mawla NG,Saiki J,Dixon DO

    更新日期:1980-08-01 00:00:00

  • Risk factors for primary central nervous system lymphoma: a case-control study.

    abstract:BACKGROUND:The incidence of primary central nervous system lymphoma (PCNSL) has increased over time in both immunocompetent and immunodeficient individuals. The reasons for the increase among immunocompetent patients are unclear. METHODS:The authors conducted a case-control study of PCNSL at the Mayo Clinic based on c...


    pub_type: 杂志文章


    authors: Schiff D,Suman VJ,Yang P,Rocca WA,O'Neill BP

    更新日期:1998-03-01 00:00:00

  • Evaluation and radiotherapy implications of chest relapse patterns in small cell lung carcinoma treated with radiotherapy-chemotherapy: study of 34 cases and review of the literature.

    abstract::Evaluation and radiotherapy implications of chest relapse patterns in small cell lung carcinoma treated with chemotherapy and radiotherapy to the chest and brain. Emphasis was placed on analysis of patterns of chest disease relapse, chest complications, and sites of initial chest disease relapse in relation to volume ...


    pub_type: 杂志文章


    authors: Mira JG,Livingston RB

    更新日期:1980-12-15 00:00:00

  • Results with chemotherapy comprised of cyclophosphamide, doxorubicin, vincristine, and prednisone followed by radiotherapy with or without prechemotherapy surgical debulking for patients with bulky, aggressive lymphoma.

    abstract:BACKGROUND:The authors performed a case-control analysis of local control, progression free survival, and overall survival in patients with Stage I-II aggressive lymphomas measuring > or = 7 cm in greatest dimension who were treated initially with or without surgical debulking: All patients then received cyclophosphami...


    pub_type: 杂志文章


    authors: Wilder RB,Romaguera JE,Tucker SL,Ha CS,Hess MA,Cabanillas F,Cox JD

    更新日期:2002-02-01 00:00:00

  • Imaging characteristics of large lipoma and angiomyolipoma of the liver. Case reports.

    abstract::A large lipoma and a large angiomyolipoma of the liver, one case each, are described. In the first case, a 24 X 14-cm homogeneous mass demonstrated a fatty density (-96H) on computed tomography (CT), echogenicity on sonography, and fine neovascular vessels on angiography in the right lobe of the liver. Histopathologic...


    pub_type: 杂志文章


    authors: Takayasu K,Shima Y,Muramatsu Y,Moriyama N,Yamada T,Makuuchi M,Hirohashi S

    更新日期:1987-03-01 00:00:00

  • Treatment of malignant melanoma with dacarbazin (DTIC-DOME) with special reference to urinary excretion of 5-S-cysteinyldopa.

    abstract::Seventeen patients were given DTIC, 200 mg/m2/day in five-day courses every four to six weeks. In four patients (stage II) treated on an adjuvant basis, tumor recurrence has been verified in three. Four of the palliatively treated patients were also given DTIC by regional intra-arterial infusion with minimal positive ...


    pub_type: 杂志文章


    authors: Jönsson PE,Agrup G,Arnbjörnsson E,Hafström L,Rorsman H

    更新日期:1980-01-15 00:00:00

  • The Akt/mammalian target of rapamycin pathway is activated and associated with adverse prognosis in soft tissue leiomyosarcomas.

    abstract:BACKGROUND:The Akt/mammalian target of rapamycin (mTOR) pathway mediates cell survival and proliferation and contributes to tumor progression. Soft tissue leiomyosarcoma continues to show poor prognosis, and little is known about its mechanisms of tumor progression. Here the authors investigated the significance of act...


    pub_type: 杂志文章


    authors: Setsu N,Yamamoto H,Kohashi K,Endo M,Matsuda S,Yokoyama R,Nishiyama K,Iwamoto Y,Dobashi Y,Oda Y

    更新日期:2012-03-15 00:00:00

  • Beta-benzene hexachloride in breast adipose tissue and risk of breast carcinoma.

    abstract:BACKGROUND:Epidemiologic studies have recently related benzene hexachloride (BHC) to breast carcinoma risk. Experimental studies have also shown that beta-BHC is weakly estrogenic, hence supporting the alleged association. By directly comparing beta-BHC levels in breast adipose tissue from incident breast carcinoma cas...


    pub_type: 杂志文章


    authors: Zheng T,Holford TR,Mayne ST,Owens PH,Ward B,Carter D,Dubrow R,Zahm SH,Boyle P,Tessari J

    更新日期:1999-05-15 00:00:00

  • Differences in the angiogenesis of benign and malignant ovarian tumors, demonstrated by analyses of color Doppler ultrasound, immunohistochemistry, and microvessel density.

    abstract:BACKGROUND:To clarify the differences in angiogenesis between benign and malignant ovarian tumors, the authors examined the immunohistochemical characteristics and the density of tumor vessels in both tumor groups. Intratumoral vascularization was observed preoperatively by transvaginal color Doppler ultrasound. METHO...


    pub_type: 杂志文章


    authors: Emoto M,Iwasaki H,Mimura K,Kawarabayashi T,Kikuchi M

    更新日期:1997-09-01 00:00:00

  • Zoledronic acid suppresses lung metastases and prolongs overall survival of osteosarcoma-bearing mice.

    abstract:BACKGROUND:Although there is no doubt that bisphosphonates (BPs), specific inhibitors of osteoclasts, are beneficial for the treatment of bone metastases, their effects on visceral metastases are unclear. The effect of zoledronic acid (ZOL) was examined in vivo on lung metastasis progression and animal survival, and in...


    pub_type: 杂志文章


    authors: Ory B,Heymann MF,Kamijo A,Gouin F,Heymann D,Redini F

    更新日期:2005-12-01 00:00:00

  • Serum ferritin in patients undergoing bone marrow transplantation.

    abstract::Serum ferritin levels were monitored in nine patients with acute lymphoblastic leukemia (ALL), nine patients with acute nonlymphoblastic leukemia (ANLL), four patients with chronic myelogenous leukemia (CML), three patients with non-Hodgkin's lymphoma (NHL), and three patients with severe aplastic anemia (SAA) undergo...


    pub_type: 杂志文章


    authors: Or R,Matzner Y,Konijn AM

    更新日期:1987-09-01 00:00:00

  • Gastric pseudolymphoma. Its three subtypes and relation to lymphoma.

    abstract::Three separate histologic types of gastric pseudolymphoma (GPL) are described: (1) the common "inflammatory" type usually accompanied by ulceration and extensive fibrosis; (2) the entity known as "nodular lymphoid hyperplasia," which was associated with multiple intestinal lesions; and (3) the third reported case of a...


    pub_type: 杂志文章,评审


    authors: Brooks JJ,Enterline HT

    更新日期:1983-02-01 00:00:00

  • p53 codon 72 polymorphisms in human papillomavirus-negative and human papillomavirus-positive squamous cell carcinomas of the oropharynx.

    abstract:BACKGROUND:Tobacco smoking, alcohol abuse, and high-risk human papillomavirus (HPV) are risk factors in the etiology of oropharyngeal squamous cell carcinomas (SCCs). The TP53 polymorphism, in which an arginine (R) is changed to proline (P) at codon 72, is functionally significant and could therefore be a predisposing ...


    pub_type: 杂志文章


    authors: Perrone F,Mariani L,Pastore E,Orsenigo M,Suardi S,Marcomini B,DaRiva L,Licitra L,Carbone A,Pierotti MA,Pilotti S

    更新日期:2007-06-15 00:00:00

  • The combination of cisplatin, doxorubicin, and mitomycin (PAM) compared with the FAM regimen in treating advanced gastric carcinoma. A phase II randomized trial of the Italian Oncology Group for Clinical Research.

    abstract:BACKGROUND:In a randomized Phase II study, the authors evaluated the activity and toxicity of the new cisplatin, doxorubicin, and mitomycin C (PAM) combination, that includes cisplatin (P) instead of 5-fluorouracil as in the 5-fluorouracil, doxorubicin, and mitomycin C (FAM) combination, in patients with advanced gastr...


    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: De Lisi V,Cocconi G,Angelini F,Cavicchi F,Di Costanzo F,Gilli G,Rodinò C,Soldani M,Tonato M,Finardi C

    更新日期:1996-01-15 00:00:00

  • The use and effectiveness of rituximab maintenance in patients with follicular lymphoma diagnosed between 2004 and 2007 in the United States.

    abstract:BACKGROUND:The authors examined the "real-world" effectiveness of rituximab (R) maintenance therapy (R-maintenance) compared with observation after R-based induction therapy in patients with previously untreated follicular lymphoma (FL) in the United States. METHODS:The National LymphoCare Study is a prospective, mult...


    pub_type: 杂志文章,多中心研究


    authors: Nastoupil LJ,Sinha R,Byrtek M,Zhou X,Taylor MD,Friedberg JW,Link BK,Cerhan JR,Dawson K,Flowers CR

    更新日期:2014-06-15 00:00:00

  • Significance of urinary neopterin in patients with malignant tumors of the genitourinary tract.

    abstract::The urinary neopterin excretion was measured by high-performance liquid chromatography in 417 healthy subjects and in 76 patients with clinically and pathohistologically verified neoplasias of the urinary tract (bladder tumor, carcinoma of the prostate, and renal cell carcinoma). The patients with early tumor stages b...


    pub_type: 杂志文章


    authors: Aulitzky W,Frick J,Fuchs D,Hausen A,Reibnegger G,Wachter H

    更新日期:1985-03-01 00:00:00

  • A VM 26-based regimen for patients with previously untreated non-Hodgkin lymphoma. Prolonged disease-free survival in patients younger than 60 years of age: a phase II trial of the eastern Cooperative Oncology Group.

    abstract:BACKGROUND:The epidophyllotoxin VM 26 has been shown to have single-agent activity in patients with diffuse aggressive lymphoma. In an attempt to determine its activity in combination with other agents known to be effective in lymphoma, a Phase II trial of a novel chemotherapy regimen was conducted. METHODS:Forty-two ...


    pub_type: 临床试验,杂志文章


    authors: Gordon LI,Andersen J,Gregory S,Mazza J,Chervenick P,Hahn RG,O'Connell MJ

    更新日期:1993-01-15 00:00:00

  • Extended-field radiation therapy for carcinoma of the cervix.

    abstract::The survival of cervical carcinoma patients with paraaortic/high common iliac nodal metastases was evaluated by retrospective chart review during a 13-year interval. Thirty-three patients with cervical carcinoma and surgically documented nodal metastases received primary, extended-field radiation therapy. Overall 2-ye...


    pub_type: 杂志文章


    authors: Podczaski E,Stryker JA,Kaminski P,Ndubisi B,Larson J,DeGeest K,Sorosky J,Mortel R

    更新日期:1990-07-15 00:00:00

  • Measuring the significance of workload on performance of cytotechnologists in gynecologic cytology: a study using rapid prescreening.

    abstract:BACKGROUND:Workload is extensively regulated and often used as a measure of quality in gynecologic cytology. Whether workload correlates with the sensitivity of screening in gynecologic cytology is not known. METHODS:The sensitivity of gynecologic cytology screening was measured over an 8-month period using the result...


    pub_type: 杂志文章


    authors: Deschenes M,Renshaw AA,Auger M

    更新日期:2008-06-25 00:00:00

  • Genetic and pathologic findings in a kindred with hereditary sarcoma, breast cancer, brain tumors, leukemia, lung, laryngeal, and adrenal cortical carcinoma.

    abstract::A familial cancer aggregation comprising sarcomas, brain tumors, leukemias, and carcinomas of breast, larynx, lung, adrenal, cortex, and other sites has been studied from a pathologic--genetic standpoint. Based upon sibships segregating for cancer, the genetic segregation parameter is estimated to be 45.6 +/- 11% whi...


    pub_type: 杂志文章


    authors: Lynch HT,Mulcahy GM,Harris RE,Guirgis HA,Lynch JF

    更新日期:1978-05-01 00:00:00