Lung cancer as a second primary.

Abstract:

:An unusually high association of other primary cancers (9.7%) was found during the analysis of 403 consecutive cases of carcinoma of the lung diagnosed at DGMC between 1960 and 1975. Incidence by stage included 17.3% for Stage I (75 cases) and 16.9% for Stage II (59 cases). Median survival by stage was not adversely affected by the associated malignancy. Incidence by histologic type was 15.6% for adenocarcinoma (132 cases), 7.7% for epidermoid (130 cases), 1.5% for oat (small cell) (67 cases), 12.5% for large cell (40 cases) and 11.8% for undifferentiated anaplastic type (34 cases). Of 31 cases of Stage I adenocarcinoma, 9 (29%) had second malignancies. Both adenocarcinoma and epidermoid carcinoma exhibited decreasing association of second malignances with increasing stage of lung cancer. The head and neck region was the location of the nonlung malignancy in 22 cases and the GU system in 11 cases. Two cases each of colon carcinoma and basal cell skin carcinoma were found and there was one case each of carcinoma of the pancreas, lymphoma and melanoma. The diagnosis of lung cancer was made first in only 3 instances. The appearance of solitary nodules in patients with known malignancy should receive strong consideration for vigorous diagnostic and therapeutic procedures. Future studies should consider carcinogenic stimuli that may be common etiologic factors in both malignancies.

journal_name

Cancer

journal_title

Cancer

authors

Reynolds RD,Pajak TF,Greenberg BR,Shirley JH,Lucas RN,Hill RP,Schacht LR

doi

10.1002/1097-0142(197812)42:6<2887::aid-cncr282042

subject

Has Abstract

pub_date

1978-12-01 00:00:00

pages

2887-93

issue

6

eissn

0008-543X

issn

1097-0142

journal_volume

42

pub_type

杂志文章

相关文献

CANCER文献大全
  • Sarcoid reaction mimicking intrathoracic dissemination of testicular cancer.

    abstract::The close observation of patients treated for testicular cancer led to the suspicion of intrathoracic and/or mediastinal metastases on radiologic examination in a number of patients without other evidence of relapse. This report presents two patients with combined seminomatous and nonseminomatous germ cell tumors with...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19901115)66:10<2221::aid-cncr282

    authors: Looijen R,Hoekstra HJ,Sleijfer DT,Postmus P,Oosterhuis JW,de Boer WJ,Schraffordt Koops H

    更新日期:1990-11-15 00:00:00

  • Phase I and pharmacokinetic study of a stable, polyethylene-glycolated liposomal doxorubicin in patients with solid tumors: the relation between pharmacokinetic property and toxicity.

    abstract:BACKGROUND:Compared with free drug, sterically stabilized liposomal drug has prolonged circulation time and, thereby, higher tumor selectivity and antitumor activity. The stability in plasma is an important consideration in the formulation of clinically useful liposomal drug. A Phase I study of a stable liposomal doxor...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章

    doi:

    authors: Hong RL,Tseng YL

    更新日期:2001-05-01 00:00:00

  • Primary combined malignant melanoma and ductal carcinoma of the breast. A report of two cases.

    abstract:BACKGROUND:Tumors consisting of a combination of malignant melanoma and carcinoma are very rare. The authors report two such cases occurring as primary breast tumors. METHODS:The breast tumors were analyzed by histologic, immunohistochemical, and ultrastructural techniques. RESULTS:Histologically, the tumors were com...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:

    authors: Padmore RF,Lara JF,Ackerman DJ,Gales T,Sigurdson ER,Ehya H,Cooper HS,Patchefsky AS

    更新日期:1996-12-15 00:00:00

  • Bacteria-associated hemophagocytic syndrome.

    abstract::Histiocytic medullary reticulosis (HMR) was originally defined as a neoplastic disorder. Some cases reported as HMR have been characterized by a systemic proliferation of mature histiocytes showing hemophagocytosis, bone marrow necrosis, pancytopenia, hepatitis, and coagulopathy. Clinically, these patients have fever ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19841215)54:12<2968::aid-cncr282

    authors: Risdall RJ,Brunning RD,Hernandez JI,Gordon DH

    更新日期:1984-12-15 00:00:00

  • Cerebrospinal fluid-disseminated meningioma.

    abstract:BACKGROUND:Intracranial meningiomas are common and comprise 20% of all primary brain tumors. Meningiomas infrequently metastasize; however, to the authors' knowledge there are limited data regarding the spread of disease through cerebrospinal fluid (CSF). METHODS:Eight of 200 consecutive patients (4%) with meningiomas...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.20926

    authors: Chamberlain MC,Glantz MJ

    更新日期:2005-04-01 00:00:00

  • Radiation therapy alone or in combination with surgery in head and neck cancer.

    abstract::Radiation therapy alone, surgery alone, or the combination of these two modalities, remain the accepted treatments in the management of epidermoid carcinomas of the mucosa of the head and neck. These modalities of therapy produce comparable results; but, radiotherapy alone has the advantage that it can conserve anatom...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19850501)55:9+<2259::aid-cncr282

    authors: Marcial VA,Pajak TF

    更新日期:1985-05-01 00:00:00

  • Hiccups with high dose dexamethasone administration: a case report.

    abstract:BACKGROUND:A 59-year-old male developed intractable hiccups during monthly therapy with high dose dexamethasone for multiple myeloma. Hiccups would begin hours after his first dose and continue over the 4 days of therapy. He sought assistance after his attempt at home remedies failed and the hiccups became exhausting. ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0142(19980115)82:2<415::aid-cnc

    authors: Cersosimo RJ,Brophy MT

    更新日期:1998-01-15 00:00:00

  • The quantitative relationship of carcinoembryonic antigen to tumor cells of different organs.

    abstract::Carcinoembryonic antigen (CEA) was measured in extracts of cell suspensions from tumors of the colon, stomach, breast, lung and kidney. Cell suspensions were also obtained from normal tissue surrounding the primary tumors. The number of neoplastic cells in each cell suspension was determined by cytologic criteria. Hig...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197708)40:2<808::aid-cncr2820400

    authors: MacSween JM,Anderson GH

    更新日期:1977-08-01 00:00:00

  • The long-term effect of cisplatin on renal function.

    abstract::The long-term effect of cisplatin on renal function was studied in a follow-up investigation, 16 to 52 months after chemotherapy in 22 patients with disseminated nonseminomatous testicular cancer. The median cumulated cisplatin dose was 452 mg/m2 (range, 275-650 mg/m2). Prehydration with isotonic saline secured diures...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19861115)58:10<2214::aid-cncr282

    authors: Fjeldborg P,Sørensen J,Helkjaer PE

    更新日期:1986-11-15 00:00:00

  • Trichosporon sepsis and leukemia.

    abstract::Trichosporon cutaneum is a fungus known to cause superficial nodules over the distal third of hair shafts, mainly scalp hair, and to produce a clinical entity known as piedra. This superficial mycosis occurs mostly in temperate and tropical regions and is rarely seen in North America. Trichosporon cutaneum spesis is d...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197509)36:3<1106::aid-cncr282036

    authors: Rivera R,Cangir A

    更新日期:1975-09-01 00:00:00

  • A case of multiple myeloma with two subclones producing separately kappa and defective gamma chains.

    abstract::A case of multiple myeloma is described that contained two morphologically identical but immunologically diverse subpopulations. One of the subclones produced only kappa chains, whereas the other contained only gamma chains. Additional immunohistologic investigations revealed production by one of the subpopulations of...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19850915)56:6<1392::aid-cncr2820

    authors: Metz K,Leder LD

    更新日期:1985-09-15 00:00:00

  • Attitudes towards cancer. Development of the cancer attitudes questionnaire.

    abstract::A questionnaire evaluating attitudes towards cancer (the Cancer Attitudes Questionnaire) was constructed to compare the attitudes of first-year medical students before and after taking a clinical oncology program with those of students who did not participate in the program. A factor and reliability analysis revealed ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19840915)54:6<1124::aid-cncr2820

    authors: Lebovits AH,Croen LG,Goetzel RZ

    更新日期:1984-09-15 00:00:00

  • Metastatic carcinoma. The lung as the site for the clinically undiagnosed primary.

    abstract::Of 387 patients who died with lung cancer, 28 cases were reviewed (7.2%) which were clinically undiagnosed. The male:female ratio was 3.6 and mean age was 64 years in the males, 47 years in the females. The most frequent presenting symptoms were neurologic. Prior to death, 21 patients had known or suspected metastatic...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19830115)51:2<362::aid-cncr28205

    authors: Clary CF,Michel RP,Wang NS,Hanson RE

    更新日期:1983-01-15 00:00:00

  • Etiology of gastric remnant cancer with special reference to the effects of denervation of the gastric mucosa.

    abstract:BACKGROUND:Gastric mucosal blood flow, secretion of mucin, and renewal of the gastric mucosal cells are considered to be defensive factors against gastric mucosal injuries. These factors are regulated by the nervous system and neuropeptides. Gastrectomy may affect this regulation and induce gastric mucosal changes, suc...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19950315)75:6+<1490::aid-cncr282

    authors: Kaminishi M,Shimizu N,Shiomoyama S,Yamaguchi H,Ogawa T,Sakai S,Kuramoto S,Oohara T

    更新日期:1995-03-15 00:00:00

  • Indomethacin sensitive suppressor-cell activity in head and neck cancer patients. The role of the adherent mononuclear cell.

    abstract::Head and neck cancer (H&N CA) patients have known depression of cell-mediated immunity. There is suggestive evidence that prostaglandin (PGE2)-secreting cells may be a major factor. The authors have sought to determine the role of PGE2-releasing monocytes-macrophages in this immune depression by determining the effect...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19880201)61:3<462::aid-cncr28206

    authors: Wanebo HJ,Riley T,Katz D,Pace RC,Johns ME,Cantrell RW

    更新日期:1988-02-01 00:00:00

  • Three-dimensional conformal radiotherapy for portal vein thrombosis of hepatocellular carcinoma.

    abstract:BACKGROUND:Portal vein thrombosis (PVT) is a common complication in patients with advanced-stage hepatocellular carcinoma (HCC). The authors evaluated the impact of radiotherapy (RT) for PVT of HCC and analyzed the dose-response relation between RT and PVT. METHODS:Between March 1995 and December 2003, 59 patients dia...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.21043

    authors: Kim DY,Park W,Lim DH,Lee JH,Yoo BC,Paik SW,Kho KC,Kim TH,Ahn YC,Huh SJ

    更新日期:2005-06-01 00:00:00

  • A prospective, observational cohort study comparing cancer clinical trial availability and enrollment between early adolescents/young adults and children.

    abstract:BACKGROUND:Poor enrollment of adolescents and young adults (AYAs) (ages 15-39 years) onto cancer clinical trials (CCTs) may contribute to inferior survival gains compared with children. In this study, the authors assessed whether differences in CCT availability would explain lower CCT enrollment for early AYAs (eAYAs) ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.31127

    authors: Thomas SM,Malvar J,Tran H,Shows J,Freyer DR

    更新日期:2018-03-01 00:00:00

  • Granulocytic sarcoma of the cervix as a primary manifestation: case without overt leukemic features for 26 months.

    abstract::A case of granulocytic sarcoma involving the uterine cervix as primary manifestation without evidence of leukemia is presented. It was followed by neurological symptoms 19 months later and a right breast mass 26 months after the initial cervical lesion, but still with no evidence of leukemia. Two years and four months...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197712)40:6<3030::aid-cncr282040

    authors: Seo IS,Hull MT,Pak HY

    更新日期:1977-12-01 00:00:00

  • Quality of care received and patient-reported regret in prostate cancer: Analysis of a population-based prospective cohort.

    abstract:BACKGROUND:Meeting quality of care standards in oncology is recognized as important by physicians, professional organizations, and payers. Data from a population-based cohort of patients with prostate cancer were used to examine whether receipt of care was consistent with published consensus metrics and whether receivi...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.30315

    authors: Holmes JA,Bensen JT,Mohler JL,Song L,Mishel MH,Chen RC

    更新日期:2017-01-01 00:00:00

  • Hyperglycemia in patients with acute myeloid leukemia is associated with increased hospital mortality.

    abstract:BACKGROUND:Hyperglycemia is often observed in medically ill patients. Previous studies have shown that patients with hyperglycemia during induction therapy for acute lymphoblastic leukemia develop more infections and have shorter disease-free survival. The authors hypothesized that hyperglycemia may be associated with ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.22777

    authors: Ali NA,O'Brien JM Jr,Blum W,Byrd JC,Klisovic RB,Marcucci G,Phillips G,Marsh CB,Lemeshow S,Grever MR

    更新日期:2007-07-01 00:00:00

  • Chemotherapy as a substitute for surgery in the treatment advanced resectable head and neck cancer. A report from the Northern California Oncology Group.

    abstract::This trial determines the feasibility for patients with resectable Stages III/IV head and neck cancer who achieved a complete response to induction chemotherapy of eliminating surgery from their treatment program. Thirty patients were treated with three cycles of cisplatin and 5-fluorouracil (5-FU), followed by reendo...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章

    doi:10.1002/1097-0142(19870915)60:6<1178::aid-cncr2820

    authors: Jacobs C,Goffinet DR,Goffinet L,Kohler M,Fee WE

    更新日期:1987-09-15 00:00:00

  • Leukemia relapse in long-term survivors of acute leukemia.

    abstract::Between 1964 and 1982, 862 patients with acute leukemia who were collected from medical institutions throughout the country had a survival of 5 years or longer. Their remission has been achieved mainly with a combination therapy of vincristine and prednisone in childhood acute leukemia and daunomycin, cytosine arabino...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19850701)56:1<88::aid-cncr282056

    authors: Kawashima K,Nagura E,Yamada K,Hamajima N

    更新日期:1985-07-01 00:00:00

  • Human monoclonal antibodies derived from lymph nodes of a patient with breast carcinoma react with MuMTV polypeptides.

    abstract::Nine human hybridoma cell lines were established from a fusion of axillary lymph node lymphocytes of a patient with breast ductal carcinoma with a human lymphoblastoid cell line. The human hybridoma nature of the fusion products was confirmed by chromosomal analysis and HLA typing. The hybridomas are stable over a yea...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19870101)59:1<43::aid-cncr282059

    authors: Shoenfeld Y,Hizi A,Tal R,Smorodinsky NI,Lavie G,Mor C,Schteren S,Mammon Z,Pinkhas J,Keydar T

    更新日期:1987-01-01 00:00:00

  • Pemetrexed in combination with cisplatin versus cisplatin monotherapy in patients with recurrent or metastatic head and neck cancer: final results of a randomized, double-blind, placebo-controlled, phase 3 study.

    abstract:BACKGROUND:Recurrent or metastatic squamous cell carcinoma of the head and neck (SCCHN) is associated with poor survival. Platinum-based chemotherapy is often a first-line treatment. Pemetrexed has shown single-agent activity in SCCHN and in combination with cisplatin for other tumors. This trial examined the efficacy ...

    journal_title:Cancer

    pub_type: 杂志文章,随机对照试验

    doi:10.1002/cncr.27449

    authors: Urba S,van Herpen CM,Sahoo TP,Shin DM,Licitra L,Mezei K,Reuter C,Hitt R,Russo F,Chang SC,Hossain AM,Frimodt-Moller B,Koustenis A,Hong RL

    更新日期:2012-10-01 00:00:00

  • The natural five-year course in bronchial carcinoma. Epidemiologic results.

    abstract::A series of 273 unselected patients with bronchial carcinoma, comprising a total prospective 5-year study from a Swedish county with an observed 5-year survival of 7.0%, is presented. The autopsy rate in deceased patients was 94%. All diagnoses were histologically or cytologically verified. The 5-year survival rates f...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19840515)53:10<2211::aid-cncr282

    authors: Nõu E

    更新日期:1984-05-15 00:00:00

  • The combination of cisplatin, doxorubicin, and mitomycin (PAM) compared with the FAM regimen in treating advanced gastric carcinoma. A phase II randomized trial of the Italian Oncology Group for Clinical Research.

    abstract:BACKGROUND:In a randomized Phase II study, the authors evaluated the activity and toxicity of the new cisplatin, doxorubicin, and mitomycin C (PAM) combination, that includes cisplatin (P) instead of 5-fluorouracil as in the 5-fluorouracil, doxorubicin, and mitomycin C (FAM) combination, in patients with advanced gastr...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1002/(SICI)1097-0142(19960115)77:2<245::AID-CNC

    authors: De Lisi V,Cocconi G,Angelini F,Cavicchi F,Di Costanzo F,Gilli G,Rodinò C,Soldani M,Tonato M,Finardi C

    更新日期:1996-01-15 00:00:00

  • Pathobiology of preoperative chemotherapy: findings from the National Surgical Adjuvant Breast and Bowel (NSABP) protocol B-18.

    abstract:BACKGROUND:Examination was performed on pathologic material from patients enrolled in the National Surgical Adjuvant Breast Project (NSABP) protocol B-18, in which the clinical effects of preoperative (preop) and postoperative (postop) doxorubicin and cyclophosphamide (AC) were compared. METHODS:Of the total number of...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1002/cncr.10741

    authors: Fisher ER,Wang J,Bryant J,Fisher B,Mamounas E,Wolmark N

    更新日期:2002-08-15 00:00:00

  • Low incidence of estrogen receptor in breast carcinomas with rapid rates of cellular replication.

    abstract::The results of assay for estrogen receptor (ER) in the tumor cytosol and thymidine labeling indices (TLI) of 63 primary invasive carcinomas of the breast were analyzed. The ER assay was performed by using dextran-charcoal to adsorb unbound tritiated estradiol-17beta (E2) in cytosol. The TLI was measured as the number ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197711)40:5<2290::aid-cncr282040

    authors: Meyer JS,Rao BR,Stevens SC,White WL

    更新日期:1977-11-01 00:00:00

  • Malignant lymphoepithelial lesion of the parotid gland: poorly differentiated squamous cell carcinoma with lymphoid stroma.

    abstract::The case of a European patient with a malignant lymphoepithelial lesion of epithelial type is presented. This type of tumor has an exceptionally high incidence among Eskimos. To the authors' knowledge this is the first case reported with an ultrastructural study that demonstrates the squamous nature of the tumor cells...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19810715)48:2<289::aid-cncr28204

    authors: Redondo C,Garcia A,Vazquez F

    更新日期:1981-07-15 00:00:00

  • Treatment of patients with advanced nonsmall cell lung carcinoma using docetaxel and gemcitabine plus granulocyte-colony stimulating factor.

    abstract:BACKGROUND:A combination regimen comprised of docetaxel, gemcitabine, and granulocyte-colony stimulating factor (G-CSF) was studied in patients with advanced nonsmall cell lung carcinoma (NSCLC) to determine its antitumor efficacy and tolerance. METHODS:Thirty-four patients with advanced measurable NSCLC (3 patients w...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章

    doi:

    authors: Hejna M,Kornek GV,Raderer M,Ulrich-Pur H,Fiebiger WC,Marosi L,Schneeweiss B,Greul R,Scheithauer W

    更新日期:2000-08-01 00:00:00