Fine-needle aspiration biopsy of granulocytic sarcoma: a clinicopathologic study of 27 cases.

Abstract:

BACKGROUND:Because of morphologic similarities, the differential diagnosis of granulocytic sarcoma (GS) in fine-needle aspiration (FNA) specimens includes non-Hodgkin or Hodgkin lymphoma, extramedullary hematopoiesis, poorly differentiated carcinoma, and infection. METHODS:Twenty-six FNAs and 1 pleural effusion fluid specimen of GS obtained from 23 patients were reviewed for cytomorphologic features and clinical characteristics. The cases were categorized as blastic, immature, or mature GS based on the population of the cells present on the smears. RESULTS:The patients included 18 men and 5 women (mean age, 54 years). Aspiration sites included subcutaneous or soft tissue (15 cases), lymph nodes (5 cases), bones (3 cases), testis (1 case), ileum (1 case), and liver (1 case). One sample of pleural effusion fluid also was included. Review of the patients' clinical history revealed that GS was secondary to chronic myelogenous leukemia (CML) in 17 patients, was secondary to chronic myelomonocytic leukemia (CMML) in 2 patients, and was secondary to acute myelogenous leukemia in 2 patients. GS preceded the manifestation of CML in one patient and of CMML in another patient. Based on the proportions of cells, morphologic classification was attempted and revealed blastic GS in 8 aspirates and 1 pleural effusion fluid specimen, immature GS in 13 aspirates, and mature GS in 5 aspirates. Twelve of 22 specimens from extranodal sites (55%) demonstrated lymphoglandular bodies in the background. Five aspirates showed rare eosinophilic myelocytes. Auer rods were not identified in any of the aspirates. Immunophenotypic and histochemical studies confirmed myeloid and/or myelomonocytic differentiation. CONCLUSIONS:GS especially can be confused with non-Hodgkin lymphoma because of morphologic similarities of the blasts to large cell lymphoma, the presence of lymphoglandular bodies, and the rarity of Auer rods and eosinophilic myelocytes. In conjunction with careful cytomorphologic evaluation, knowledge of the patient's clinical history and use of appropriate immunophenotypic studies should lead to a correct diagnosis.

journal_name

Cancer

journal_title

Cancer

authors

Suh YK,Shin HJ

subject

Has Abstract

pub_date

2000-12-25 00:00:00

pages

364-72

issue

6

eissn

0008-543X

issn

1097-0142

pii

10.1002/1097-0142(20001225)90:6<364::AID-CNCR7>3.3

journal_volume

90

pub_type

杂志文章

相关文献

CANCER文献大全
  • Correlation between microsatellite instability and metachronous disease recurrence after endoscopic mucosal resection in patients with early stage gastric carcinoma.

    abstract:BACKGROUND:Since endoscopic treatment was first evaluated and established as a treatment for patients with early stage gastric carcinoma, metachronous disease recurrence at other sites in the stomach after endoscopic treatment has become a major problem. METHODS:A retrospective case-control study was conducted on 10 p...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:

    authors: Kawamura A,Adachi K,Ishihara S,Katsube T,Takashima T,Yuki M,Amano K,Fukuda R,Yamashita Y,Kinoshita Y

    更新日期:2001-01-15 00:00:00

  • Ocular and orbital complications following radiation therapy of paranasal sinus malignancies and review of literature.

    abstract::During the period from March 1963 through March 1978, 30 patients with malignant neoplasms of the paranasal sinuses were treated with supervoltage technique at the University of Rochester Medical Center. Twenty-one patients had at least the medial portion of the orbit within the effective treatment volume and the rest...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/1097-0142(19830315)51:6<980::aid-cncr28205

    authors: Nakissa N,Rubin P,Strohl R,Keys H

    更新日期:1983-03-15 00:00:00

  • The role of postoperative chemoradiation for oropharynx carcinoma: a critical appraisal of the published literature and National Comprehensive Cancer Network guidelines.

    abstract::The National Comprehensive Cancer Network (NCCN) describes the presence of extracapsular spread and/or positive margins in oropharynx cancer (OPC) as an indication for the addition of chemotherapy to postoperative radiation. The guideline's category 1 consensus is based on what they term high-level evidence. For this ...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/cncr.29242

    authors: Sinha P,Piccirillo JF,Kallogjeri D,Spitznagel EL,Haughey BH

    更新日期:2015-06-01 00:00:00

  • Genetic variations in angiopoietin and pericyte pathways and clinical outcome in patients with resected colorectal liver metastases.

    abstract:BACKGROUND:Genes involved in the angiopoietin and pericyte pathways may become escape mechanisms under antivascular endothelial growth factor (anti-VEGF) therapy. The authors investigated whether variations within genes in these pathways are associated with clinical outcome in patients with colorectal liver metastases ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.29259

    authors: Stremitzer S,Zhang W,Yang D,Ning Y,Stintzing S,Sebio A,Sunakawa Y,Yamauchi S,Matsusaka S,El-Khoueiry R,Stift J,Wrba F,Gruenberger T,Lenz HJ

    更新日期:2015-06-01 00:00:00

  • Pulmonary metastasis of carcinoma of the cervix: a retrospective study.

    abstract::The medical records of 243 patients admitted over a five-year period with a diagnosis of carcinoma of the cervix were reviewed to determine (1) the frequency of pulmonary metastasis, (2) the relationship between the stage of the primary lesion and the incidence of pulmonary metastasis, and (3) the relationship between...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19820415)49:8<1705::aid-cncr2820

    authors: Tellis CJ,Beechler CR

    更新日期:1982-04-15 00:00:00

  • The immunochemical complexity of CEA: a golden dream or molecular nightmare?

    abstract::Carcinoembryonic antigen is only a tumor assoicated antigen and is less clinically useful than the original report suggested. However, the CEA assays in clinical use utilize reagents operationally defined by old criteria. There is now abundant evidence that "CEA" consists of a heterogenous family of related glycoprote...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197809)42:3+<1585::aid-cncr28204

    authors: Alpert E

    更新日期:1978-09-01 00:00:00

  • A framework for cancer health economics research.

    abstract:LAY SUMMARY:Cancer has substantial economic impacts for patients, their families and/or caregivers, employers, and the health care system. However, there is only limited understanding of how economic issues can affect access to cancer care services and the receipt of high-quality cancer care. Health economics research ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.33343

    authors: Halpern MT,Shih YT,Yabroff KR,Ekwueme DU,Bradley CJ,Davidoff AJ,Sabik LM,Lipscomb J

    更新日期:2020-11-25 00:00:00

  • Surgical palliation for recurrent rectal cancers ulcerating in the perineum.

    abstract::This report describes a unique palliative approach of radical surgical debridement for uncontrollable, recurrent pelvic tumors ulcerating through the perineum. All conservative treatment attempts with radiotherapy and chemotherapy had failed. Seven patients have been treated with resection of the tumor including a por...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19900301)65:5<1111::aid-cncr2820

    authors: Temple WJ,Ketcham AS

    更新日期:1990-03-01 00:00:00

  • Changes in management techniques and patterns of disease recurrence over time in patients with breast carcinoma treated with breast-conserving therapy at a single institution.

    abstract:BACKGROUND:The authors reviewed changes in the initial clinical presentation, management techniques, and patterns of disease recurrence over time (1981-1996) in patients with breast carcinoma treated with breast-conserving therapy (BCT) at a single institution. The goals of the current study were to determine the frequ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.20410

    authors: Pass H,Vicini FA,Kestin LL,Goldstein NS,Decker D,Pettinga J,Ingold J,Benitez P,Neumann K,Rebner M,Dekhne N,Martinez A

    更新日期:2004-08-15 00:00:00

  • Adoptive immunotherapy with allogeneic Epstein-Barr virus (EBV)-specific cytotoxic T-lymphocytes for recurrent, EBV-positive Hodgkin disease.

    abstract:BACKGROUND:It has been shown that adoptive immunotherapy with Epstein-Barr virus (EBV)-specific cytotoxic T-lymphocytes (CTL) is effective for the treatment of EBV-induced lymphoproliferative disease in stem cell transplantation recipients and organ transplantation recipients. The role of EBV CTL in other tumors for wh...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章

    doi:10.1002/cncr.20188

    authors: Lucas KG,Salzman D,Garcia A,Sun Q

    更新日期:2004-05-01 00:00:00

  • New strategies are needed in diffuse malignant mesothelioma.

    abstract:BACKGROUND:Medical records of 50 patients with malignant mesothelioma were reviewed to determine the clinical features and factors influencing survival. METHODS:Charts of all patients whose conditions were diagnosed as malignant mesothelioma were abstracted and analyzed by statistical software. RESULTS:The male-to-fe...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19921215)70:12<2969::aid-cncr282

    authors: Sridhar KS,Doria R,Raub WA Jr,Thurer RJ,Saldana M

    更新日期:1992-12-15 00:00:00

  • Secondary sarcomas after radiotherapy for breast cancer: sustained risk and poor survival.

    abstract:BACKGROUND:Radiotherapy (RT) has been a risk factor for development of soft tissue sarcomas (STS). The objective of the current study was to quantify the risk of STS after RT and surgery for breast cancer (BCa), assess time trends, and compare long-term survival of patients with RT-associated and non-RT-associated angi...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.24462

    authors: Mery CM,George S,Bertagnolli MM,Raut CP

    更新日期:2009-09-15 00:00:00

  • Pretreatment and routine echocardiogram monitoring during chemotherapy for anthracycline-induced cardiotoxicity rarely identifies significant cardiac dysfunction or alters treatment decisions: a 5-year review at a single pediatric oncology center.

    abstract:BACKGROUND:The widespread use of anthracycline chemotherapy has contributed to improved outcomes in children with cancer. The most feared complication of the anthracyclines is cardiotoxicity. Routine echocardiographic monitoring typically is used before, during, and after treatment to minimize cardiotoxicity. The ideal...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.26481

    authors: Watts RG,George M,Johnson WH Jr

    更新日期:2012-04-01 00:00:00

  • Antioxidant supplement use after breast cancer diagnosis and mortality in the Life After Cancer Epidemiology (LACE) cohort.

    abstract:BACKGROUND:There is concern that antioxidant supplement use during chemotherapy and radiation therapy may decrease treatment effects, yet the effects of such supplements on recurrence and survival are largely unknown. METHODS:The authors prospectively examined the associations between antioxidant use after breast canc...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.26526

    authors: Greenlee H,Kwan ML,Kushi LH,Song J,Castillo A,Weltzien E,Quesenberry CP Jr,Caan BJ

    更新日期:2012-04-15 00:00:00

  • Surgical resection of colorectal carcinoma metastases to the liver. A prognostic scoring system to improve case selection, based on 1568 patients. Association Française de Chirurgie.

    abstract:BACKGROUND:Five-year survival rates after resection of liver metastases from colorectal carcinoma are close to 25%. Recurrences occur in two-thirds of the patients after surgery. Selection of patients likely to benefit from surgery remains controversial and subjective. METHODS:Data from 1568 patients with resected liv...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:

    authors: Nordlinger B,Guiguet M,Vaillant JC,Balladur P,Boudjema K,Bachellier P,Jaeck D

    更新日期:1996-04-01 00:00:00

  • Lymphomatoid granulomatosis: an analysis of clinical and immunologic characteristics.

    abstract::Six patients with lymphomatoid granulomatosis were studied. Two patients had eye involvement, a rare manifestation of this disease. Both had complete disappearance of disease in this area after radiation therapy. One patient presented with an autoimmune hemolytic anemia, which remitted completely with chemotherapy. Th...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19820515)49:10<2070::aid-cncr282

    authors: Sordillo PP,Epremian B,Koziner B,Lacher M,Lieberman P

    更新日期:1982-05-15 00:00:00

  • Adolescents' preferences for treatment decisional involvement during their cancer.

    abstract:BACKGROUND:This qualitative study investigated the medical decision-making preferences of adolescent oncology patients and the parental and clinician behaviors that adolescents report to be supportive of their preferred level of decision-making involvement. METHODS:Interviews were conducted with 40 adolescents between...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.29663

    authors: Weaver MS,Baker JN,Gattuso JS,Gibson DV,Sykes AD,Hinds PS

    更新日期:2015-12-15 00:00:00

  • Comparison of doubling times of serum carcinoembryonic antigen produced by various metastatic lesions in recurrent gastric and colorectal carcinomas.

    abstract::The authors measured the serial serum carcinoembryonic antigen (CEA) levels in patients with recurrent gastric or colorectal carcinoma. Among the 45 patients with recurrent gastric carcinomas, those with lung metastases showed the most prolonged CEA doubling time (CEA-DT), followed by those with liver and peritoneal m...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19930615)71:12<4055::aid-cncr282

    authors: Umehara Y,Kimura T,Yoshida M,Oba N,Harada Y

    更新日期:1993-06-15 00:00:00

  • Psychologic intervention improves survival for breast cancer patients: a randomized clinical trial.

    abstract:BACKGROUND:The question of whether stress poses a risk for cancer progression has been difficult to answer. A randomized clinical trial tested the hypothesis that cancer patients coping with their recent diagnosis but receiving a psychologic intervention would have improved survival compared with patients who were only...

    journal_title:Cancer

    pub_type: 杂志文章,随机对照试验

    doi:10.1002/cncr.23969

    authors: Andersen BL,Yang HC,Farrar WB,Golden-Kreutz DM,Emery CF,Thornton LM,Young DC,Carson WE 3rd

    更新日期:2008-12-15 00:00:00

  • A multi-institutional phase 2 trial of stereotactic body radiotherapy in the treatment of bone metastases in pediatric and young adult patients with sarcoma.

    abstract:BACKGROUND:Metastasectomy is standard of care for pediatric patients with metastatic sarcoma with limited disease. For patients with unresectable disease, stereotactic body radiotherapy (SBRT) may serve as an alternative. Herein, the authors report the results of a prospective, multi-institutional phase 2 trial of SBRT...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.33306

    authors: Elledge CR,Krasin MJ,Ladra MM,Alcorn SR,Han P,Gibbs IC,Hiniker SM,Laack NN,Terezakis SA

    更新日期:2020-11-10 00:00:00

  • Growth rate of 147 mammary carcinomas.

    abstract::In 147 cases of mammary carcinoma, 388 serial mammographies were performed before final treatment. The average retrospective observation time was 27 months with a range of two months to 11 years. The number of serial mammographies per case ranged between two and 11. The tumor volume doubling times (TV); obtained by me...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19800415)45:8<2198::aid-cncr2820

    authors: von Fournier D,Weber E,Hoeffken W,Bauer M,Kubli F,Barth V

    更新日期:1980-04-15 00:00:00

  • Gynecologic cancer treatment: risk factors for therapeutically induced neoplasia.

    abstract::Therapeutic intervention in a course of illness, while producing the desired result, also may have some adverse long-term effects on the patient. Second malignancies are one of the known complications of therapy. The treatments of gynecologic cancers by surgery, irradiation and chemotherapy have been associated with s...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/1097-0142(19810715)48:1+<442::aid-cncr2820

    authors: Messerschmidt GL,Hoover R,Young RC

    更新日期:1981-07-15 00:00:00

  • Metastatic carcinoma. The lung as the site for the clinically undiagnosed primary.

    abstract::Of 387 patients who died with lung cancer, 28 cases were reviewed (7.2%) which were clinically undiagnosed. The male:female ratio was 3.6 and mean age was 64 years in the males, 47 years in the females. The most frequent presenting symptoms were neurologic. Prior to death, 21 patients had known or suspected metastatic...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19830115)51:2<362::aid-cncr28205

    authors: Clary CF,Michel RP,Wang NS,Hanson RE

    更新日期:1983-01-15 00:00:00

  • Patterns of the first lymph node metastases in patients with cutaneous malignant melanoma of axial localization.

    abstract::At the Finsen Institute, Copenhagen, from 1971 to 1981, 134 patients were treated for lymph node metastases from primary cutaneous malignant melanoma of axial localization (e.g., in the head and neck and trunk), where metastases to regional lymph node groups were the first sign of dissemination. Due to the lack of suf...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19881101)62:9<2073::aid-cncr2820

    authors: Lock-Andersen J,Partoft S,Jensen MG

    更新日期:1988-11-01 00:00:00

  • Occult testicular leukemia: testicular biopsy at three years continuous complete remission of childhood leukemia: a Southwest Oncology Group Study.

    abstract::Between June 1977 and December 1978, occult testicular leukemia (OTL) was discovered at three years of continual complete remission (CCR) from the time of diagnosis of acute lymphoblastic leukemia (ALL) in 5 of 59 (8.5%) of males undergoing bilateral wedge testicular biopsy at 1 of 15 participating Southwest Oncology ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19810201)47:3<470::aid-cncr28204

    authors: Askin FB,Land VJ,Sullivan MP,Ragab AH,Steuber CP,Dyment PG,Talbert J,Moore T

    更新日期:1981-02-01 00:00:00

  • Hypercalcemia in small cell (oat cell) carcinoma of the lung. Coincident parathyroid adenoma in one case.

    abstract::Hypercalcemia is very uncommon in small cell (oat cell) carcinoma of the lung. Two cases of this neoplasm associated with symptomatic hypercalcemia are described. Despite normal skeletal roentgenograms, metastatic bone disease was demonstrated by abnormal bone scans and bone biopsies in both patients. The combination ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197509)36:3<1067::aid-cncr282036

    authors: Bowman DM,Dubé WJ,Levitt M

    更新日期:1975-09-01 00:00:00

  • Thymoma in a 12-year-old boy.

    abstract::A case of thymoma in a 12-year-old boy is presented. The patient had a history of thymic irradiation in infancy, and a family history of leukemia. The mass was readily resected and the patient is well 10 years later. The tumor contained an unusual admixture of normal thymic tissue with the neoplastic epithelial elemen...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197602)37:2<953::aid-cncr2820370

    authors: Chatten J,Katz SM

    更新日期:1976-02-01 00:00:00

  • Impact of the coronavirus disease 2019 (COVID-19) pandemic on pediatric oncology care in the Middle East, North Africa, and West Asia region: A report from the Pediatric Oncology East and Mediterranean (POEM) group.

    abstract:BACKGROUND:Childhood cancer is a highly curable disease when timely diagnosis and appropriate therapy are provided. A negative impact of the coronavirus disease 2019 (COVID-19) pandemic on access to care for children with cancer is likely but has not been evaluated. METHODS:A 34-item survey focusing on barriers to ped...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.33075

    authors: Saab R,Obeid A,Gachi F,Boudiaf H,Sargsyan L,Al-Saad K,Javakhadze T,Mehrvar A,Abbas SS,Abed Al-Agele YS,Al-Haddad S,Al Ani MH,Al-Sweedan S,Al Kofide A,Jastaniah W,Khalifa N,Bechara E,Baassiri M,Noun P,El-Houdzi J,K

    更新日期:2020-09-15 00:00:00

  • Randomized, placebo-controlled trial of Saforis for prevention and treatment of oral mucositis in breast cancer patients receiving anthracycline-based chemotherapy.

    abstract:BACKGROUND:Oral mucositis (OM) is a frequent complication of mucotoxic cancer therapy, causing significant oral pain, increased infection risk, and impaired functioning. The efficacy and safety of Saforis (glutamine) powder in UpTec for oral suspension was evaluated for the prevention and treatment of OM. METHODS:Thre...

    journal_title:Cancer

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1002/cncr.22384

    authors: Peterson DE,Jones JB,Petit RG 2nd

    更新日期:2007-01-15 00:00:00

  • Multifocal adenocarcinoma of the jejunum.

    abstract::We report on an 89-year-old female admitted with signs of intestinal obstruction in whom three independent adenocarcinomas of the proximal jejunum were found. Multiple foci of pyloric gland metaplasia, glandular hyperplasia and dysplasia, carcinoma-in-situ, and several varieties of adenocarcinoma were identified on mi...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/1097-0142(197909)44:3<1142::aid-cncr282044

    authors: Warner TF,Peralta J

    更新日期:1979-09-01 00:00:00