A nomogram predicting long-term biochemical recurrence after radical prostatectomy.

Abstract:

BACKGROUND:Men who undergo radical prostatectomy (RP) are at long-term risk of biochemical recurrence (BCR). In this report, the authors have described a model capable of predicting BCR up to at least 15 years after RP that can adjust predictions according to the disease-free interval. METHODS:Cox regression was used to model the probability of BCR (a prostate-specific antigen level>0.1 ng/mL and rising) in 601 men who underwent RP with a median follow-up of 11.4 years. The statistical significance of nomogram predictors was confirmed with a competing-risks regression model. The model was validated internally with 200 bootstraps and externally at 5 years, 10 years, and 15 years in 2 independent cohorts of 2963 and 3178 contemporary RP patients from 2 institutions. RESULTS:The 5-year, 10-year, 15-year, and 20-year actuarial rates of BCR-free survival were 84.8%, 71.2%, 61.1%, and 58.6%, respectively. Pathologic stage, surgical margin status, pathologic Gleason sum, type of RP, and adjuvant radiotherapy represented independent predictors of BCR in both Cox and competing-risks regression models and constituted the nomogram predictor variables. In internal validation, the nomogram accuracy was 79.3%, 77.2%, 79.7%, and 80.6% at 5 years, 10 years, 15 years, and 20 years, respectively, after RP. In external validation, the nomogram was 77.4% accurate at 5 years in the first cohort and 77.9%, 79.4%, and 86.3% accurate at 5 years, 10 years, and 15 years, respectively, in the second cohort. CONCLUSIONS:Patients who undergo RP remain at risk of BCR beyond 10 years after RP. The nomogram described in this report distinguishes itself from other tools by its ability to accurately predict the conditional probability of BCR up to at least 15 years after surgery.

journal_name

Cancer

journal_title

Cancer

authors

Suardi N,Porter CR,Reuther AM,Walz J,Kodama K,Gibbons RP,Correa R,Montorsi F,Graefen M,Huland H,Klein EA,Karakiewicz PI

doi

10.1002/cncr.23293

subject

Has Abstract

pub_date

2008-03-15 00:00:00

pages

1254-63

issue

6

eissn

0008-543X

issn

1097-0142

journal_volume

112

pub_type

杂志文章

相关文献

CANCER文献大全
  • Epidermal growth factor receptor expression correlates with poor survival in patients who have breast carcinoma treated with doxorubicin-based neoadjuvant chemotherapy.

    abstract:BACKGROUND:To the authors' knowledge there are few data that correlate the expression of the epidermal growth factor receptor (EGFR) with the outcome of patients who have breast carcinoma and are treated with anthracycline chemotherapy. METHODS:Pretreatment tumor tissue samples were available from 82 patients who had ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.21217

    authors: Buchholz TA,Tu X,Ang KK,Esteva FJ,Kuerer HM,Pusztai L,Cristofanilli M,Singletary SE,Hortobagyi GN,Sahin AA

    更新日期:2005-08-15 00:00:00

  • Improving cancer-specific outcomes in solid organ transplant recipients: Where to begin?

    abstract::In an article published in this issue of Cancer, D'Arcy et al link the incidence of cancer among recipients of solid organ transplantation (SOT) in the Scientific Registry of Transplant Recipients with data from regional and statewide cancer registries to examine cancer-specific mortality for common malignancies in SO...

    journal_title:Cancer

    pub_type: 评论,杂志文章

    doi:10.1002/cncr.31963

    authors: Koff JL,Waller EK

    更新日期:2019-03-15 00:00:00

  • Central neurocytomas express photoreceptor differentiation.

    abstract:BACKGROUND:Central neurocytomas are composed of mature neuronal elements, frequently arranged in rosettes similar to those present in pineocytomas. This suggests the possibility of similar patterns of differentiation, including photoreceptor differentiation. The authors analyzed the immunoreactivity of central neurocyt...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:

    authors: Mena H,Morrison AL,Jones RV,Gyure KA

    更新日期:2001-01-01 00:00:00

  • Results of laparotomy in immunoproliferative small intestinal disease.

    abstract::Immunoproliferative small intestinal diseases (IPSID), previously known as Mediterranean Lymphomas, constitute more than 60% of the non-Burkitt's small intestinal lymphomas in Tunisia. A multidisciplinary study of IPSID was undertaken by the Tunisian/French Lymphoma Study Group in 1980 to reach a better understanding ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19880415)61:8<1699::aid-cncr2820

    authors: Tabbane F,Mourali N,Cammoun M,Najjar T

    更新日期:1988-04-15 00:00:00

  • Elective versus therapeutic radical neck dissection in epidermoid carcinoma of the oral cavity: results of a randomized clinical trial.

    abstract::This study concerns 75 patients with squamous cell carcinoma of the oral cavity who were patients at the Gustave-Roussy Institute between December 1966 and July 1973. These patients were divided into two groups. The first group was comprised of 39 patients who underwent elective radical neck dissection; nodal involvem...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1002/1097-0142(19800715)46:2<386::aid-cncr28204

    authors: Vandenbrouck C,Sancho-Garnier H,Chassagne D,Saravane D,Cachin Y,Micheau C

    更新日期:1980-07-15 00:00:00

  • Prognostic importance of histologic grading in papillary thyroid carcinoma.

    abstract:BACKGROUND:The influence of various clinicopathologic features on survival of patients with papillary thyroid carcinoma has been examined. In particular, histologic grade, which was obtained by a combined assessment of nuclear atypia, tumor necrosis, and vascular invasion (VAN score) was studied. According to this, his...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19931101)72:9<2680::aid-cncr2820

    authors: Akslen LA

    更新日期:1993-11-01 00:00:00

  • Lung carcinoma arising in bronchopulmonary sequestration.

    abstract::A squamous cell carcinoma arising in intralobar bronchopulmonary sequestration of the right lower lobe is described in a 69-year-old man. One other reported case was found. Other complications of bronchopulmonary sequestration include nonspecific infections and tuberculosis. ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197907)44:1<334::aid-cncr2820440

    authors: Bell-Thomson J,Missier P,Sommers SC

    更新日期:1979-07-01 00:00:00

  • Sensitive detection of circulating hepatocellular carcinoma cells in peripheral venous blood.

    abstract:BACKGROUND:This study was performed to develop a sensitive method for the detection of circulating hepatocellular carcinoma (HCC) cells in peripheral blood, in advance of the diagnosis of distant metastasis of HCC by conventional means. METHODS:Peripheral blood (5 ml) samples were obtained from 64 patients with HCC an...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19950501)75:9<2214::aid-cncr2820

    authors: Komeda T,Fukuda Y,Sando T,Kita R,Furukawa M,Nishida N,Amenomori M,Nakao K

    更新日期:1995-05-01 00:00:00

  • Cancer incidence in the rural community of Tecumseh, Michigan: a pattern of increased lymphopoietic neoplasms.

    abstract:BACKGROUND:The Tecumseh Community Health Study (TCHS), initiated in 1959 at the University of Michigan School of Public Health, has provided a resource for long term prospective studies of the incidence of cancer in the setting of a midwestern rural farming community. METHODS:A survey of total and site specific cancer...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.1996.2820770402

    authors: Waterhouse D,Carman WJ,Schottenfeld D,Gridley G,McLean S

    更新日期:1996-02-15 00:00:00

  • Acupressure bands do not improve chemotherapy-induced nausea control in pediatric patients receiving highly emetogenic chemotherapy: A single-blinded, randomized controlled trial.

    abstract:BACKGROUND:Chemotherapy-induced nausea and vomiting remain common, distressing side effects of chemotherapy. It has been reported that acupressure prevents chemotherapy-induced nausea in adults, but it has not been well studied in children. METHODS:In this multicenter, prospective, randomized, single-blind, sham-contr...

    journal_title:Cancer

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1002/cncr.31198

    authors: Dupuis LL,Kelly KM,Krischer JP,Langevin AM,Tamura RN,Xu P,Chen L,Kolb EA,Ullrich NJ,Sahler OJZ,Hendershot E,Stratton A,Sung L,McLean TW

    更新日期:2018-03-15 00:00:00

  • Occult primary tumors of the head and neck: lack of benefit from positron emission tomography imaging with 2-[F-18]fluoro-2-deoxy-D-glucose.

    abstract:BACKGROUND:Patients who present with squamous cell carcinoma metastatic to cervical lymph nodes and no clinically apparent primary site present a therapeutic dilemma. Positron emission tomography imaging with 2-[F-18]fluoro-2-deoxy-D-glucose (FDG-PET) has been shown to be useful for the examination of known primary tum...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0142(19990701)86:1<114::aid-cnc

    authors: Greven KM,Keyes JW Jr,Williams DW 3rd,McGuirt WF,Joyce WT 3rd

    更新日期:1999-07-01 00:00:00

  • Italian Cooperative Study for the treatment of children and young adults with localized Ewing sarcoma of bone: a preliminary report of 6 years of experience.

    abstract:BACKGROUND:In 1991, the Italian Association for Pediatric Hematology-Oncology and the National Council of Research (CNR) initiated an Italian Cooperative Study (SE 91-CNR Protocol) with the main objective of improving the overall survival (SUR) and the event free survival (EFS) of children and young adults with localiz...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1002/(sici)1097-0142(19990801)86:3<421::aid-cnc

    authors: Rosito P,Mancini AF,Rondelli R,Abate ME,Pession A,Bedei L,Bacci G,Picci P,Mercuri M,Ruggieri P,Frezza G,Campanacci M,Paolucci G

    更新日期:1999-08-01 00:00:00

  • Surgical treatment of colon cancer in patients aged 80 years and older : analysis of 31,574 patients in the SEER-Medicare database.

    abstract:BACKGROUND:Age-related disparities in colon cancer treatment exist, with older patients being less likely to receive recommended therapy. However, to the authors' knowledge, few studies to date have focused on receipt of surgery. The objective of the current study was to describe patterns of surgery in patients aged ≥ ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.27765

    authors: Neuman HB,O'Connor ES,Weiss J,Loconte NK,Greenblatt DY,Greenberg CC,Smith MA

    更新日期:2013-02-01 00:00:00

  • Epidemiology of cancer of the vulva. A case-control study.

    abstract::Few epidemiologic studies have been undertaken to investigate the etiology of cancer of the vulva. To identify risk factors associated with this cancer, a case-control study was conducted in 149 patients with histologically proven vulvar carcinoma and the same number of control patients matched for age, race, marital ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19850415)55:8<1843::aid-cncr2820

    authors: Mabuchi K,Bross DS,Kessler II

    更新日期:1985-04-15 00:00:00

  • Can immunohistochemical markers and mitotic rate improve prognostic precision in patients with primary melanoma?

    abstract:BACKGROUND:In addition to tumor thickness, several other prognostic parameters have been identified in primary human melanomas. Some are available readily (localization, gender, age, and ulceration). Others must be evaluated with a moderate or even substantial amount of work (mitoses and immunohistochemical markers). T...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章

    doi:10.1002/(sici)1097-0142(19990601)85:11<2391::aid-c

    authors: Ostmeier H,Fuchs B,Otto F,Mawick R,Lippold A,Krieg V,Suter L

    更新日期:1999-06-01 00:00:00

  • Changes associated with the development of resistance to imatinib (STI571) in two leukemia cell lines expressing p210 Bcr/Abl protein.

    abstract:BACKGROUND:Although various mechanisms have been recognized as being associated with the development of resistance to imatinib mesylate in vitro and in clinical situations, their relative significance and contributions remain poorly understood, as is the sequence of events leading to the selection of the resistant phen...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.20131

    authors: Scappini B,Gatto S,Onida F,Ricci C,Divoky V,Wierda WG,Andreeff M,Dong L,Hayes K,Verstovsek S,Kantarjian HM,Beran M

    更新日期:2004-04-01 00:00:00

  • Malignant peritoneal mesothelioma after remote abdominal radiation.

    abstract::Peritoneal mesothelioma in a 61-year-old man, occurred 26 years after abdominal radiotherapy for a testicular seminoma. The patient had no history of asbestos exposure. After asbestos, radiation is the second most frequent defined cause of mesothelioma in North America, but the number of well-documented cases is small...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/1097-0142(19880515)61:10<2019::aid-cncr282

    authors: Gilks B,Hegedus C,Freeman H,Fratkin L,Churg A

    更新日期:1988-05-15 00:00:00

  • Disparities in hepatocellular carcinoma incidence by race/ethnicity and geographic area in California: Implications for prevention.

    abstract:BACKGROUND:The incidence of hepatocellular carcinoma (HCC) has been rising rapidly in the United States. California is an ethnically diverse state with the largest number of incident HCC cases in the country. Characterizing HCC disparities in California may inform priorities for HCC prevention. METHODS:By using data f...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.31598

    authors: Yang B,Liu JB,So SK,Han SS,Wang SS,Hertz A,Shariff-Marco S,Lin Gomez S,Rosenberg PS,Nguyen MH,Hsing AW

    更新日期:2018-09-01 00:00:00

  • MAGE, BAGE, and GAGE gene expression in patients with esophageal squamous cell carcinoma and adenocarcinoma of the gastric cardia.

    abstract:BACKGROUND:The MAGE, BAGE, and GAGE gene families code for distinct, tumor specific antigens that are recognized by cytotoxic T lymphocytes in the context of HLA molecules. The purpose of this study was to analyze MAGE, BAGE, and GAGE gene expression in the two major histologic types of esophageal carcinoma, squamous c...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:

    authors: Zambon A,Mandruzzato S,Parenti A,Macino B,Dalerba P,Ruol A,Merigliano S,Zaninotto G,Zanovello P

    更新日期:2001-05-15 00:00:00

  • Bisphosphonates in the management of prostate carcinoma metastatic to the skeleton.

    abstract:BACKGROUND:Prostate carcinoma metastasizes frequently to the skeleton, causing significant morbidity, particularly severe bone pain. Metastatic lesions typically are osteosclerotic, but there is experimental, histologic, and biochemical evidence of increased bone resorption. Furthermore, bone resorption rates appear to...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/1097-0142(20000615)88:12+<3047::aid-cncr22

    authors: Papapoulos SE,Hamdy NA,van der Pluijm G

    更新日期:2000-06-15 00:00:00

  • A population-based study of prevalence of complementary methods use by cancer survivors: a report from the American Cancer Society's studies of cancer survivors.

    abstract:BACKGROUND:The use of complementary methods (CMs) is widespread and increasing in the United States. Most literature on CM use among cancer survivors focuses on the treatment period, whereas only a few studies address use further along the cancer continuum. METHODS:This study analyzed the prevalence and the medical an...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.23659

    authors: Gansler T,Kaw C,Crammer C,Smith T

    更新日期:2008-09-01 00:00:00

  • Sequential combination chemotherapy in patients with advanced nonsmall cell lung carcinoma: carboplatin and gemcitabine followed by paclitaxel.

    abstract:BACKGROUND:The objective of this Phase II study was to evaluate the concept of sequential chemotherapy in the treatment of patients with advanced nonsmall cell lung carcinoma (NSCLC) by the administration of carboplatin plus gemcitabine followed by of paclitaxel. METHODS:Patients with Stage IIIB (pleural effusion) or ...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章

    doi:10.1002/1097-0142(20010701)92:1<146::aid-cncr1302>

    authors: Edelman MJ,Gandara DR,Lau DH,Lara P,Lauder IJ,Tracy D

    更新日期:2001-07-01 00:00:00

  • Restaging surgery for women with borderline ovarian tumors: results of a French multicenter study.

    abstract:BACKGROUND:The purpose of the current study was to examine the surgical management of women with borderline ovarian tumors and the adequacy of initial staging according to the guidelines of the International Federation of Gynecology and Obstetrics; to evaluate the impact of restaging operations; and to identify risk fa...

    journal_title:Cancer

    pub_type: 杂志文章,多中心研究

    doi:10.1002/cncr.20098

    authors: Fauvet R,Boccara J,Dufournet C,David-Montefiore E,Poncelet C,Daraï E

    更新日期:2004-03-15 00:00:00

  • Congenital self-healing histiocytosis (Hashimoto-Pritzker). An ultrastructural and immunohistochemical study.

    abstract::Congenital self-healing histiocytosis (CSHH) is a rare primary histiocytic skin disorder. Only a few cases have been studied by ultrastructure and immunohistochemistry. Here we report a new case that was investigated using an electron microscope and a panel of monoclonal (MCA) and polyclonal (PCA) antibodies. CSHH cel...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/1097-0142(19880201)61:3<508::aid-cncr28206

    authors: Kanitakis J,Zambruno G,Schmitt D,Cambazard F,Jacquemier D,Thivolet J

    更新日期:1988-02-01 00:00:00

  • Primary intestinal lymphoma with paraproteinemia.

    abstract::Five cases of primary intestinal lymphoma are described. The main clinical features included abdominal pain, diarrhea, and marked weight loss, together with radiologic and some laboratory findings suggestive of malabsorption. Laparatomy perfomed in four cases revealed dilatation of the small intestine, with mesenteric...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197503)35:3<848::aid-cncr2820350

    authors: Shahid MJ,Alami SY,Nassar VH,Balikian JB,Salem AA

    更新日期:1975-03-01 00:00:00

  • Improved accuracy in differentiating malignant from benign mammographic abnormalities: a simple, improved magnetic resonance imaging method.

    abstract:BACKGROUND:Although several refinements have been reported for breast magnetic resonance imaging (MRI), there has been no uniform agreement by researchers on the optimal method. The authors report a simple and effective MRI method that incorporated the best qualities of other breast MRI methods yet eliminated the compl...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(20010801)92:3<471::aid-cncr1345>

    authors: Khatri VP,Stuppino JJ,Espinosa MH,Pollack MS

    更新日期:2001-08-01 00:00:00

  • Presentation and subsequent publication rates of phase I oncology clinical trials.

    abstract:BACKGROUND:Many trials submitted to scientific meetings are not reported in peer-reviewed journals. Results may vary substantially and the lack of final publication constitutes a form of reporting bias. The authors sought to determine the presentation and publication rates of Phase I trials submitted to a major oncolog...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.21337

    authors: Camacho LH,Bacik J,Cheung A,Spriggs DR

    更新日期:2005-10-01 00:00:00

  • An analysis of abnormalities of the retinoblastoma gene in human ovarian and endometrial carcinoma.

    abstract::The altered expression of the human retinoblastoma (RB) gene has been demonstrated to play an important role in the pathogenesis of RB and other tumors. To determine whether the RB gene might be involved in the pathogenesis of human ovarian and endometrial cancer, DNA from 24 human ovarian tumors, 3 normal ovaries, 3 ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19901115)66:10<2150::aid-cncr282

    authors: Sasano H,Comerford J,Silverberg SG,Garrett CT

    更新日期:1990-11-15 00:00:00

  • Bleomycin-sensitivity test: application for human squamous cell carcinoma.

    abstract::Bleomycin (BLM)-inactivating enzyme activity, which is probably a parameter for the efficacy of this antibiotic in cancer therapy, was determined in biopsies from human carcinomas in the head and neck region. Twenty-three cases were studied. It was found that highly differentiated as well as moderately differentiated ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197712)40:6<2787::aid-cncr282040

    authors: Müller WE,Schmidseder R,Rohde HJ,Zahn RK,Scheunemann H

    更新日期:1977-12-01 00:00:00

  • What is the best treatment for patients with human papillomavirus-positive and -negative oropharyngeal cancer?

    abstract::The discovery that the human papilloma virus (HPV) is associated with a high and increasing percentage of oropharyngeal squamous cell carcinomas (SCCs) is among the most significant advances in the field of head and neck oncology. HPV-positive oropharyngeal cancer (HPVOPC) has clinical, etiologic, pathologic, and mole...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/cncr.28595

    authors: Urban D,Corry J,Rischin D

    更新日期:2014-05-15 00:00:00