What is the best treatment for patients with human papillomavirus-positive and -negative oropharyngeal cancer?

abstract：BACKGROUND:The purported lack of long term modern prostate brachytherapy outcome data continues to lead many physicians to recommend other, more traditional treatments. This concern for long term results has encouraged the authors to supplement their earlier 10-year follow-up of patients receiving brachytherapy; in the...

journal_title：Cancer

authors： Ragde H,Korb LJ,Elgamal AA,Grado GL,Nadir BS

更新日期：2000-07-01 00:00:00

abstract：BACKGROUND:Interactions between bone marrow-derived cytokines, growth factors, and tumors play a critical role in both the homing of tumors to the bone and the development of bone metastasis. Bone is a storehouse of latent growth factors produced by stromal cells and osteoblasts that, when activated during osteoclastic...

journal_title：Cancer

authors： David Roodman G

更新日期：2003-02-01 00:00:00

abstract：BACKGROUND:Immune checkpoint inhibitors (ICIs) represent an appealing treatment for patients with advanced urothelial cancer (aUC) and a poor performance status (PS). However, the benefit of ICIs for patients with a poor PS remains unknown. It was hypothesized that a poor Eastern Cooperative Oncology Group (ECOG) PS (≥...

journal_title：Cancer

authors： Khaki AR,Li A,Diamantopoulos LN,Bilen MA,Santos V,Esther J,Morales-Barrera R,Devitt M,Nelson A,Hoimes CJ,Shreck E,Assi H,Gartrell BA,Sankin A,Rodriguez-Vida A,Lythgoe M,Pinato DJ,Drakaki A,Joshi M,Isaacsson Velho P

更新日期：2020-03-15 00:00:00

abstract：BACKGROUND:This year, the 7th edition of the AJCC staging manual has for the first time attributed a unique pTNM staging to intrahepatic cholangiocarcinoma (IHCC) that is intended to replace the 2 Western and ideally also the 2 Eastern systems currently in use. This proposal, which has not yet been validated, was teste...

journal_title：Cancer

authors： Farges O,Fuks D,Le Treut YP,Azoulay D,Laurent A,Bachellier P,Nuzzo G,Belghiti J,Pruvot FR,Regimbeau JM

更新日期：2011-05-15 00:00:00

abstract：BACKGROUND:The authors established the genotype frequencies of cytochrome P450 (CYP1A1/MspI, CYP2E1/PstI, and CYP2E1/DraI), glutathione-S-transferase (GSTM1 and GSTT1), and p53 (exon 4/AcclI and intron 3/16-base pair duplication) gene polymorphisms in cervical carcinoma patients and controls and evaluated the associati...

journal_title：Cancer

authors： Kim JW,Lee CG,Park YG,Kim KS,Kim IK,Sohn YW,Min HK,Lee JM,Namkoong SE

更新日期：2000-05-01 00:00:00

abstract：BACKGROUND:Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is the only treatment with a curative potential for myelodysplastic syndrome (MDS) patients. Allo-HSCT has substantial risks, particularly in the elderly, and its role for older MDS patients has yet to be defined. METHODS:We analyzed 88 MDS pati...

journal_title：Cancer

authors： Yucel OK,Saliba RM,Rondon G,Ahmed S,Alousi A,Bashir Q,Ciurea SO,Popat U,Khouri I,Marin D,Rezvani K,Kebriaei P,Shpall EJ,Champlin RE,Oran B

更新日期：2017-07-15 00:00:00

abstract：BACKGROUND:Little is understood about the factors that influence survival in patients who undergo gamma-knife stereotactic radiosurgery (SRS) for brain metastases. METHODS:Demographic, disease, treatment, and survival data on 334 patients with intracranial metastases who underwent initial SRS from 1998 to 2004 were ab...

journal_title：Cancer

authors： DiLuna ML,King JT Jr,Knisely JP,Chiang VL

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Pathologically, benign prostatic hyperplasia (BPH) is not considered a precursor for prostate carcinoma. However, because the two conditions share not only a similar hormonal environment within the prostate but also several common risk factors, it is possible that men with BPH may be at increased risk of pro...

journal_title：Cancer

authors： Chokkalingam AP,Nyrén O,Johansson JE,Gridley G,McLaughlin JK,Adami HO,Hsing AW

更新日期：2003-10-15 00:00:00

abstract：:A 29-year-old man with metastatic extraadrenal pheochromocytoma developed paraplegia which reversed completely after megavoltage irradiation of the dorsolumbar spine. Later, treated with cyclophosphamide, vincristine, and dacarbazine, he had a temporary decrease in plasma norepinephrine concentration, a partial recalc...

journal_title：Cancer

authors： Siddiqui MZ,Von Eyben FE,Spanos G

更新日期：1988-08-15 00:00:00

abstract：:A 48-year-old male presented with the nephrotic syndrome 3 years after resection and irradiation of a thymoma. Renal biopsy revealed membranous glomerulonephritis by electron microscopy. IgA, IgG, and C3 deposition were present in the glomerular basement membrane by immunofluorescence. There was no evidence of other a...

journal_title：Cancer

authors： Posner MR,Prout MN,Berk S

更新日期：1980-01-15 00:00:00

abstract：:The authors evaluated specific gamma-GTP isoenzyme (specific gamma-GTP) found in sera of patients with hepatocellular carcinoma (HCC). In addition to band II and II' which had been reported in our previous publication, band I' also had a high specificity for HCC. One or more of these bands were detectable in 109 (55%)...

journal_title：Cancer

authors： Sawabu N,Nakagen M,Ozaki K,Wakabayashi T,Toya D,Hattori N,Ishii M

更新日期：1983-01-15 00:00:00

abstract：BACKGROUND:Recent preclinical explorations strongly support the tumorigenic potential of bile on laryngopharyngeal mucosa. Herein, the authors describe, in bile-related human hypopharyngeal squamous cell carcinoma (HSCC), NF-κB-related messenger RNA (mRNA) and microRNA (miRNA) oncogenic phenotypes similar to those prev...

journal_title：Cancer

authors： Sasaki CT,Doukas SG,Costa J,Vageli DP

更新日期：2019-10-15 00:00:00

abstract：BACKGROUND:The induction of estrogen and progesterone receptors (ER and PGR) has been reported in breast and endometrial cancer cells exposed to human fibroblast interferon-beta (hIFN-beta). Clinical verification of this finding might provide the rationale for new therapeutic approaches. This study was designed to eval...

journal_title：Cancer

authors： Codegoni AM,Landoni F,Lomonico S,Losa G,Mangioni C,Taverna M,Lucchini V,D'Incalci M

更新日期：1996-08-01 00:00:00

abstract：BACKGROUND:Interleukin-2 (IL-2) is used in the treatment of solid tumors and hematologic malignancies. Sudden death is a rare complication of IL-2 treatment. METHODS:A patient with lymphoma underwent chemoradiotherapy myeloablation and autologous stem cell transplantation. The stem cells were cultured in IL-2 (6000 IU...

journal_title：Cancer

authors： Truica CI,Hansen CH,Garvin DF,Meehan KR

更新日期：1998-09-15 00:00:00

abstract：:Although cancer often is referred to as "a disease of the genes," it is indisputable that the (epi)genetic properties of individual cancer cells are highly variable, even within the same tumor. Hence, preexisting resistant clones will emerge and proliferate after therapeutic selection that targets sensitive clones. He...

journal_title：Cancer

authors： Napel S,Mu W,Jardim-Perassi BV,Aerts HJWL,Gillies RJ

更新日期：2018-12-15 00:00:00

abstract：:In 25 patients under treatment or during follow-up for acute lymphoblastic leukemia magnetic resonance imaging (MRI) of both knees was compared to history and physical examination to detect osteonecrosis. Results of MRI were classified as: O, normal bone marrow (BM); 1, diffuse decrease in signal intensity; 2, circums...

journal_title：Cancer

authors： Pieters R,van Brenk AI,Veerman AJ,van Amerongen AH,van Zanten TE,Golding RP

更新日期：1987-12-15 00:00:00

abstract：BACKGROUND:Current research is inconclusive regarding the relation between alcohol consumption and prostate cancer risk. In this study, the authors examined the associations of total alcohol, type of alcoholic beverage, and drinking pattern with the risk of total, low-grade, and high-grade prostate cancer. METHODS:Dat...

journal_title：Cancer

authors： Gong Z,Kristal AR,Schenk JM,Tangen CM,Goodman PJ,Thompson IM

更新日期：2009-08-15 00:00:00

abstract：BACKGROUND:To determine whether high-risk patients with hematuria receive evaluation according to guideline recommendations. METHODS:We recently performed a screening study for bladder cancer using a urine-based tumor marker in 1502 subjects at high risk based on aged > or = 50 years, > or = 10-year smoking history, a...

journal_title：Cancer

authors： Elias K,Svatek RS,Gupta S,Ho R,Lotan Y

更新日期：2010-06-15 00:00:00

abstract：:The 136 patients who underwent total laryngectomy as the primary treatment for squamous cell carcinoma of the glottis at the Mayo Clinic in 1970 through 1981 were followed by retrospective record review for at least 4 years or until death, local recurrence, neck recurrence, or delayed neck metastasis. Cancer recurred ...

journal_title：Cancer

authors： Foote RL,Buskirk SJ,Stanley RJ,Grambsch PM,Olsen KD,DeSanto LW,Earle JD,Weiland LH

更新日期：1989-07-01 00:00:00

abstract：:We have reviewed the records of 76 patients with Stage I or II extranodal non-Hodgkin's lymphoma who were referred to the Division of Radiation Oncology, Mallinckrodt Institute of Radiology, during the years 1964 through 1974. The histologic slides were reviewed in the 67 cases in which they were available. Forty-thre...

journal_title：Cancer

authors： Mill WB,Lee FA,Franssila KO

更新日期：1980-02-15 00:00:00

abstract：:Sixty percent of all cancer occurs in persons aged > or =65 years. This article provides an overview of aspects of the burden of cancer in the elderly, highlighting certain demographic and epidemiologic data. It served as a frame of reference for participants in the Oncology Geriatric Education Retreat, San Juan, Puer...

journal_title：Cancer

authors： Yancik R

更新日期：1997-10-01 00:00:00

abstract：BACKGROUND:Children of different racial/ethnic backgrounds have varying risks of cancer. However, to the authors' knowledge, few studies to date have examined cancer occurrence in children of mixed ancestry. METHODS:This population-based case-control study examined cancer among children aged <15 years using linked can...

journal_title：Cancer

authors： Chow EJ,Puumala SE,Mueller BA,Carozza SE,Fox EE,Horel S,Johnson KJ,McLaughlin CC,Reynolds P,Von Behren J,Spector LG

更新日期：2010-06-15 00:00:00

abstract：BACKGROUND:Atypia of undetermined significance is a controversial category in thyroid fine-needle aspiration (FNA), not only for its questioned clinical utility, but also for its very existence as an expression of uncertainty. The current study was performed to investigate the potential impact of eliminating this categ...

journal_title：Cancer

authors： Shi Y,Ding X,Klein M,Sugrue C,Matano S,Edelman M,Wasserman P

更新日期：2009-10-25 00:00:00

abstract：:After a series of studies on the linkage of reserpine with breast cancer, both evidence and interpretation appeared to be in conflict. Our case-control survey of long-term, comprehensive records from the Kaiser Foundation Medical Care Program, on 108 hypertensive breast cancer cases and 324 hypertensive controls, matc...

journal_title：Cancer

authors： Kodlin D,McCarthy N

更新日期：1978-02-01 00:00:00

abstract：:The individual medical histories in the files of the Oxford Record Linkage Study for the years 1963 to 1967 were analyzed to ascertain any previously unsuspected associations between cancers of the large bowel and other diseases in individuals, and to quantify the relative risks of disorders already known to be associ...

journal_title：Cancer

authors： Adelstein P,Baldwin JA,Fedrich J

更新日期：1979-06-01 00:00:00

abstract：BACKGROUND:The effects of relaxin (RLX) on the human breast adenocarcinoma cell line MCF-7 have been evaluated. METHODS:The cells were maintained in culture with Dulbecco's modified Eagle's medium with 1% and 10% fetal calf serum. Highly purified porcine RLX was added at concentrations ranging between 10(-11) and 10(-...

journal_title：Cancer

authors： Bigazzi M,Brandi ML,Bani G,Sacchi TB

更新日期：1992-08-01 00:00:00

abstract：BACKGROUND:Cisplatin, 5-flourouracil (5-FU), and leucovorin (PFL) chemotherapy has been reported to be effective in the treatment of cancers but severe mucositis or neutropenia are dose limiting toxicities. This Phase II study evaluated the anticancer effect and the toxicities of a new weekly 24-hour infusional PFL che...

journal_title：Cancer

authors： Chi KH,Chan WK,Shu CH,Law CK,Chen SY,Yen SH,Chen KY

更新日期：1995-12-01 00:00:00

abstract：BACKGROUND:The role of adjuvant therapy in the management of patients with malignant mixed Müllerian tumors (MMMT) of the uterus has not been defined. The outcome of planned multimodality therapy for patients with apparent early stage disease was assessed. METHODS:A pilot study was performed on 38 patients with clinic...

journal_title：Cancer

authors： Manolitsas TP,Wain GV,Williams KE,Freidlander M,Hacker NF

更新日期：2001-04-15 00:00:00

abstract：:A tumor that affects the central nervous system can have a dramatic impact on the individual affected, as well as his or her family and friends. The tumor, regardless of extent or location, may affect the physical, social, vocational, and emotional capabilities of the individual. Basic aspects of rehabilitation for pa...

journal_title：Cancer

authors： Kirshblum S,O'Dell MW,Ho C,Barr K

更新日期：2001-08-15 00:00:00

abstract：BACKGROUND:The phosphatidylinositol-3 kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) pathway is dysregulated in patients with metastatic renal cell carcinoma (mRCC). Buparlisib is a pan-PI3K inhibitor with activity in advanced solid tumors. The primary objective of the current study was to determine the maximum...

journal_title：Cancer

authors： McKay RR,De Velasco G,Werner L,Bellmunt J,Harshman L,Sweeney C,Rosenberg JE,Hirsch M,Signoretti S,Van Allen EM,Walsh M,Vaishampayan U,McDermott DF,Choueiri TK

更新日期：2016-08-01 00:00:00