Abstract:
:A 42-year-old man was admitted to the Cancer Division of the American MedicalCenter in February, 1956. He had been treated for erythrocytosis beginning 6 months previously, with reduction of his hemoglobin to relatively normal values. On admission, a huge tumor of the left kidney was palable. Roentgenograms of the chest demonstrated small bilateral pulmonary metastases. A left nephrectomy was per formed, followed by wedge resection of a total of 16 metastatic nodules, 12 of which showed metasticrenal carcinoma. It is now 18 years since the last thoracotomy and the patient is well, leading a normal life, and free of any demonstrable malignant disease and any evidenceof erythrocytosis.
journal_name
Cancerjournal_title
Cancerauthors
Downing V,Levine Sdoi
10.1002/1097-0142(197506)35:6<1701::aid-cncr282035subject
Has Abstractpub_date
1975-06-01 00:00:00pages
1701-5issue
6eissn
0008-543Xissn
1097-0142journal_volume
35pub_type
杂志文章相关文献
CANCER文献大全abstract::Twenty-three leukemic children were studied prospectively to detect chronic effects of therapy. All patients received CNS prophylaxis, including 2400 R cranial irradiation, and intermittent maintenance therapy with intravenous methotrexate, cyclophosphamide and cytosine arabinoside. Neurologic symptoms were observed i...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197602)37:2<853::aid-cncr2820370
更新日期:1976-02-01 00:00:00
abstract::The prognostic importance of various factors was analyzed for 347 patients registered by the Mycosis Fungoides Cooperative Group (MFCG). Extent of skin involvement at the time of registration and number of sites of clinically enlarged lymph nodes were clearly the most important prognostic variables, and were combined ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19810601)47:11<2671::aid-cncr282
更新日期:1981-06-01 00:00:00
abstract::The purpose of this study was to determine whether the presence of more than 5% blasts in a differential count of cytocentrifuged cerebrospinal fluid (CSF) with less than 6 leukocytes/microliter was predictive of central nervous system (CNS) relapse in children with acute lymphoblastic leukemia (ALL). A double concent...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19901015)66:8<1748::aid-cncr2820
更新日期:1990-10-15 00:00:00
abstract::The authors measured the serial serum carcinoembryonic antigen (CEA) levels in patients with recurrent gastric or colorectal carcinoma. Among the 45 patients with recurrent gastric carcinomas, those with lung metastases showed the most prolonged CEA doubling time (CEA-DT), followed by those with liver and peritoneal m...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19930615)71:12<4055::aid-cncr282
更新日期:1993-06-15 00:00:00
abstract:BACKGROUND:Cisplatin, 5-flourouracil (5-FU), and leucovorin (PFL) chemotherapy has been reported to be effective in the treatment of cancers but severe mucositis or neutropenia are dose limiting toxicities. This Phase II study evaluated the anticancer effect and the toxicities of a new weekly 24-hour infusional PFL che...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/1097-0142(19951201)76:11<2186::aid-cncr282
更新日期:1995-12-01 00:00:00
abstract::Tumor necrosis factor-alpha (TNF-alpha), a product of activated macrophages that is cytotoxic to tumor cells, could be used to purge tumor cells from bone marrow before autologous bone marrow transplantation for hematologic malignancies and/or solid tumors. To determine whether exposure to TNF-alpha would have an inhi...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19871215)60:12<2965::aid-cncr282
更新日期:1987-12-15 00:00:00
abstract::From November 1985 to August 1988, the National Study Group for Oesophageal Cancer collected and centralized data on 1926 new cases of oesophageal cancer in South Africa. A standard data sheet was used to record the age, sex, and condition of the patients, the site, length, and circumferential extent of the tumor, the...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19891215)64:12<2604::aid-cncr282
更新日期:1989-12-15 00:00:00
abstract:BACKGROUND:This paper gives an outline of the Casley-Smith method for the treatment of lymphedema of the arm. It includes a brief summary of the development of manual techniques and the terminology applied to them. METHODS:The four principles of this method are skin care, manual lymphatic drainage, compression in the ...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/(sici)1097-0142(19981215)83:12b+<2843::aid
更新日期:1998-12-15 00:00:00
abstract:BACKGROUND:Previous studies have shown that matrix metalloproteinase-2 (MMP-2) (a 72-kilodalton Type IV collagenase/gelatinase A) is associated with breast carcinoma, but to the authors' knowledge there are no reports showing that it is prognostic for overall survival. METHODS:Expression of the immunoreactive protein ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19980915)83:6<1153::aid-cn
更新日期:1998-09-15 00:00:00
abstract::A 54-year-old man with hepatocellular carcinoma (HCC) of the typical trabecular pattern exhibiting unusual histologic features, both osteoid and bone formations, is reported. The tumor was associated with well-developed cirrhosis; thus, this may be different from mixed hepatic tumors of adults with bone formations bec...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19860101)57:1<134::aid-cncr28205
更新日期:1986-01-01 00:00:00
abstract:BACKGROUND:Increased pretreatment serum interleukin (IL)-6 levels among patients with head and neck squamous cell carcinoma (HNSCC) have been shown to correlate with poor prognosis, but sample sizes in prior studies have been small and thus unable to control for other known prognostic variables. METHODS:A longitudinal...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.23615
更新日期:2008-08-15 00:00:00
abstract::Over the last decade, new cytotoxic treatments and targeted therapies have altered treatment paradigms for patients with metastatic non-small cell lung cancer (NSCLC). We sought to analyze the impact of histology and biomarker selection criteria on outcomes of clinical trials in metastatic NSCLC reported over the last...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.28956
更新日期:2014-12-15 00:00:00
abstract:BACKGROUND:Ewing sarcoma family of tumors (ESFTs) are the second most common bone tumor, that most often affects persons ages 3-40 years. The ESFTs rely on signaling through the insulin-like growth factor-1 receptor (IGF-1R) for growth and transformation. The current studies were performed to determine the levels of IG...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(20011201)92:11<2941::aid-cncr100
更新日期:2001-12-01 00:00:00
abstract:BACKGROUND:Alpha-interferon and dexamethasone are each effective in patients with multiple myeloma and have a combined inhibitory effect on the in vitro growth of myeloma colonies. The effect of combined therapy in newly diagnosed patients is unknown. METHODS:Fifty-one consecutive patients with previously untreated mu...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19931101)72:9<2589::aid-cncr2820
更新日期:1993-11-01 00:00:00
abstract::Arylsulfatase B activity has been determined in 24-hour urine samples from 243 patients with colorectal cancer. Elevated activity of the enzyme was obsereved in 172 out of 243 (71%) patients. Employing Dukes' modified classification of colorectal cancer, urine arylsulfatase B activity was elevated in Dukes' A lesions-...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197512)36:6<2337::aid-cncr282036
更新日期:1975-12-01 00:00:00
abstract::On the basis of previous findings at this institution, VM-26 and Cytosine Arabinoside (ara-C) were used in combination to treat 33 children with refractory acute lymphocytic leukemia (ALL). Chemotherapy was given by vein twice a week for four weeks at dosage of 300 mg/m2 for ara-C and 50, 75, 110, 165, or 200 mg/m2 fo...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19800315)45:6<1284::aid-cncr2820
更新日期:1980-03-15 00:00:00
abstract:BACKGROUND:Insular thyroid carcinoma was described originally as a tumor with aggressive behavior. However, whether a predominant insular component is an independent factor for poor prognosis is unclear. METHODS:The authors compared the clinical behavior of tumors in three groups of patients with thyroid carcinoma--13...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.10947
更新日期:2002-11-15 00:00:00
abstract:BACKGROUND:The development of novel therapeutic approaches for cancer therapy is important, especially for tumors that have poor response or develop resistance to standard chemotherapy and radiation. We discovered that noninvasive radiofrequency (RF) fields can affect cancer cells but not normal cells, inhibit progress...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.28895
更新日期:2014-11-01 00:00:00
abstract:BACKGROUND:In recent years numerous reports have discussed the relationship between the human leukocyte antigen and lung cancer. However, the genetic background of lung cancer has not yet been precisely clarified. METHODS:To investigate the genetic background of lung cancer, the human leukocyte antigens in 159 normal ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19940215)73:4<1184::aid-cncr2820
更新日期:1994-02-15 00:00:00
abstract:BACKGROUND:A -160 C --> A polymorphism in the promoter region of E-cadherin has been shown to decrease gene transcription. This allelic variation might be a potential genetic marker for identifying individuals at risk for cancer. There remains no report regarding the polymorphism of E-cadherin in gastric carcinoma (GC)...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.10371
更新日期:2002-03-01 00:00:00
abstract:BACKGROUND:The purpose of this study was to evaluate the feasibility, toxicity, and efficacy of the combination of paclitaxel, carboplatin, and long-term continuous infusion 5-fluorouracil (5-FU) in the treatment of advanced squamous carcinomas of various primary sites. METHODS:Patients were eligible for this trial if...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/1097-0142(20010801)92:3<642::aid-cncr1365>
更新日期:2001-08-01 00:00:00
abstract::Patients with non-Hodgkin's lymphomas who failed to respond to chemotherapy were treated with low dose fractionated total body irradiation (TBI). Prior to during and after scheduled therapy, their clinical status was evaluated and peripheral blood studies were performed to enumerate EAC and E rosetting cells and to me...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197809)42:3<1204::aid-cncr282042
更新日期:1978-09-01 00:00:00
abstract::Estradiol and testosterone levels in the peripheral and ovarian circulation of patients with endometrial cancer and of postmenopausal women were studied. These levels proved to be the same in the two groups. The ovaries of neither group secreted estradiol. The testosterone level in the ovarian circulation of all exami...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197911)44:5<1809::aid-cncr282044
更新日期:1979-11-01 00:00:00
abstract::Twenty patients with malignant hepatoma were treated with sequential intraarterial doxorubicin (72-hour continuous infusion) followed by systemic 5-fluorouracil (5-FU) and semustine (methyl CCNU). Objective tumor responses were seen in three patients (15%). The durations of response were 6, 19, and 27+ months, respect...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19880915)62:6<1041::aid-cncr2820
更新日期:1988-09-15 00:00:00
abstract:BACKGROUND:Most cases of granulosa cell tumor of the ovary are characterized by relatively good outcome; however, some tumors behave aggressively, and some tend to recur many years after the initial diagnosis. Because DNA ploidy has been shown to predict biologic behavior better than conventional prognostic variables i...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19950501)75:9<2295::aid-cncr2820
更新日期:1995-05-01 00:00:00
abstract:BACKGROUND:The objective of this study was to determine the potential economic implications resulting from using exemestane (EXE), a new steroidal, irreversible aromatase inactivator, compared with megestrol acetate (MA) in patients with advanced breast carcinoma. METHODS:The model used the clinical results from the m...
journal_title:Cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/1097-0142(20010201)91:3<484::aid-cncr1026>
更新日期:2001-02-01 00:00:00
abstract::One hundred twenty two children with non-Hodgkin's lymphoma were studied from January 1966 to December 1975. The first group (1966-1972) did not receive an uniform treatment. The second group (1973-1975) entered in a G.A.T.L.A. protocol consisting of: vincristine-prednisone plus surgery and/or radiotherapy as inductio...
journal_title:Cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/1097-0142(197806)41:6<2372::aid-cncr282041
更新日期:1978-06-01 00:00:00
abstract::Adenoid cystic carcinoma of the esophagus is a relatively rare lesion which characteristically exhibits a clinically aggressive behavior. In spite of this aggressive nature, it is most often referred to as a counterpart of the more common adenoid cystic carcinoma of salivary gland origin, a comparatively indolent tumo...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(19840301)53:5<1131::aid-cncr2820
更新日期:1984-03-01 00:00:00
abstract:BACKGROUND:Hemangiopericytomas and malignant solitary fibrous tumors (HPC/SFT) are rare, closely related sarcomas with unpredictable behavior that respond infrequently to chemotherapy. An optimal systemic treatment strategy for advanced HPC/SFT has not yet been identified. METHODS:We retrospectively analyzed the recor...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.26098
更新日期:2011-11-01 00:00:00
abstract:BACKGROUND:There is an increasing number of articles regarding the long term follow-up of Papanicolaou (Pap) smears with the diagnosis of atypical squamous cells of undetermined significance (ASCUS). Much controversy exists regarding the management of patients with this diagnosis. In a prior study in 1992, the authors ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19971225)81:6<348::aid-cnc
更新日期:1997-12-25 00:00:00