Pregnancy outcome in cancer patients. Experience in a large cooperative group.

Abstract:

:To evaluate the potential teratogenicity and mutagenicity of modern cancer treatment, the authors enumerated from a cooperative clinical trial group 133 pregnancies in 66 women with malignant neoplasms (53% with Hodgkin's disease, 26% with other lymphomas and leukemia, and 21% with solid tumors). The gestations were divided into the following groups: Group 1, 43 pregnancies ending before therapy; Group 2, therapy given at conception or during 32 pregnancies; and Group 3, 58 pregnancies after therapy. Although the total frequencies of abnormalities were similar in Groups 1 and 2 (23% of 35 pregnancies not electively aborted and 28% of 25, respectively), there were slightly more elective abortions and birth defects related to radiation exposure at a susceptible time of gestation in Group 2. Still, there were eight normal infants among the ten fetuses who were liveborn and had first trimester exposure to chemotherapy alone; so, drug therapy early in pregnancy is not inevitably teratogenic. The apparent and surprising excess of abnormal outcomes in Group 3, 40% of 50 pregnancies, was due to low birth weight and premature terminations of pregnancy, rather than an excess of congenital anomalies. The type of unfavorable outcomes in Group 3 and their concentration in the first year posttherapy suggested they could represent defects in factors (e.g., uterine or hormonal) that normally maintain gestations, and not genetic damage to oocytes. Limitations of the data, collected by mail from physicians and their patients, included biases of self-reporting and low statistical power. Prospective study, probably through interinstitutional collaboration, seems necessary, if accurate estimates are to be made of the frequency of certain outcomes, such as spontaneous abortion and minor anomalies.

journal_name

Cancer

journal_title

Cancer

authors

Mulvihill JJ,McKeen EA,Rosner F,Zarrabi MH

doi

10.1002/1097-0142(19870901)60:5<1143::aid-cncr2820

subject

Has Abstract

pub_date

1987-09-01 00:00:00

pages

1143-50

issue

5

eissn

0008-543X

issn

1097-0142

journal_volume

60

pub_type

杂志文章

相关文献

CANCER文献大全
  • Nutrition education of the cancer patient and family. Myths and realities.

    abstract::Common myths about nutrition education and care of cancer patients are debunked and realities are discussed. First, frequently held misconceptions of nonspecialized health professionals are considered. These include the myths that diet change in the population will be rapid now that dietary guidelines to prevent cance...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19861015)58:8+<1887::aid-cncr282

    authors: Dwyer J

    更新日期:1986-10-15 00:00:00

  • Breast cancer and paraneoplastic cerebellar degeneration.

    abstract::Of the remote effects of cancer on the neurologic system, paraneoplastic cerebellar degeneration (PCD), characterized by global cerebellar dysfunction, is second only to paraneoplastic neuropathies in frequency. Recent evidence, including the finding of anti-Purkinje cell (now termed anti-Yo) antibodies directed again...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/1097-0142(19911015)68:8<1835::aid-cncr2820

    authors: Waterhouse DM,Natale RB,Cody RL

    更新日期:1991-10-15 00:00:00

  • Treatment of the patient with cancer using parenteral electronic drug administration.

    abstract::Oncologic therapy demands technologic sophistication to meet the clinical challenges of proper drug administration for chemotherapeutic agents, pain management, antibiotics, hydration, antiemetic drugs, and total parenteral nutrition. Drug administration systems for patient-controlled analgesia include benefits of imp...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:

    authors: Shaw HL

    更新日期:1992-08-15 00:00:00

  • Are prognostic factors for local control of breast cancer treated by primary radiotherapy significant for patients treated by mastectomy?

    abstract::Recent follow-up studies of patients with mammary carcinoma treated with breast-conserving primary radiotherapy identified a triad of pathologic features significantly associated with local treatment failure. These unfavorable characteristics of the primary tumor were: poor or undifferentiated nuclear grade; intraduct...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19860401)57:7<1415::aid-cncr2820

    authors: Rosen PP,Kinne DW,Lesser M,Hellman S

    更新日期:1986-04-01 00:00:00

  • Cost-effectiveness of alternating magnetic resonance imaging and digital mammography screening in BRCA1 and BRCA2 gene mutation carriers.

    abstract:BACKGROUND:Current clinical guidelines recommend earlier, more intensive breast cancer screening with both magnetic resonance imaging (MRI) and mammography for women with breast cancer susceptibility gene (BRCA) mutations. Unspecified details of screening schedules are a challenge for implementing guidelines. METHODS:...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.27864

    authors: Cott Chubiz JE,Lee JM,Gilmore ME,Kong CY,Lowry KP,Halpern EF,McMahon PM,Ryan PD,Gazelle GS

    更新日期:2013-03-15 00:00:00

  • Sequential testicular biopsies in childhood acute lymphocytic leukemia.

    abstract::Between August 1978 and November 1981, 33 boys with acute lymphocytic leukemia (ALL) (26 non-T, 7 T-cell) younger than 16 years underwent bilateral wedge testicular biopsies at the time of initial diagnosis. Seven (4 non-T, 3 T-cell) demonstrated focal leukemic infiltrates. Rebiopsy after successful induction therapy ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19860301)57:5<1038::aid-cncr2820

    authors: Kim TH,Hargreaves HK,Chan WC,Brynes RK,Alvarado C,Woodard J,Ragab AH

    更新日期:1986-03-01 00:00:00

  • Dysgerminoma of the ovary. An immunohistochemical study of tumor-infiltrating lymphoreticular cells and tumor cells.

    abstract:BACKGROUND:Human neoplasms often are accompanied by an inflammatory infiltrate. It has been proposed that this represents an immunologic response to the tumor. Dysgerminoma, a germ cell tumor of the ovary, is a classic example of this phenomenon. The authors investigated the immunophenotype of the tumor-infiltrating ly...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19930415)71:8<2562::aid-cncr2820

    authors: Dietl J,Horny HP,Ruck P,Kaiserling E

    更新日期:1993-04-15 00:00:00

  • Phase 1b study of the mammalian target of rapamycin inhibitor sirolimus in combination with nanoparticle albumin-bound paclitaxel in patients with advanced solid tumors.

    abstract:BACKGROUND:The optimal weekly oral dose of sirolimus and intravenous nanoparticle albumin-bound paclitaxel (nab-paclitaxel) were evaluated. METHODS:A phase 1b study was performed to evaluate escalating doses of oral sirolimus (5-60 mg) on days 2, 9, and 16 with intravenous nab-paclitaxel (100 mg/m(2) ) on days 1, 8, a...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.29254

    authors: Abu-Khalaf MM,Baumgart MA,Gettinger SN,Doddamane I,Tuck DP,Hou S,Chen N,Sullivan C,Lezon-Geyda K,Zelterman D,Hatzis C,Deshpande H,Digiovanna MP,Azodi M,Schwartz PE,Harris LN

    更新日期:2015-06-01 00:00:00

  • Malignant eccrine poroma. Case report and review of the literature.

    abstract::A case of malignant eccrine poroma with lymph node metastases is described. The patient had a nodular growth of the right thigh 2 years before its first excision. Local recurrence in the scar occurred in 6 months, and by 8 months a right groin lymph node was involved. Subsequent skin nodules of the right thigh occurre...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/1097-0142(19840401)53:7<1579::aid-cncr2820

    authors: Bottles K,Sagebiel RW,McNutt NS,Jensen B,Deveney K

    更新日期:1984-04-01 00:00:00

  • Deferred therapy in patients with advanced disease.

    abstract::Disease that is known to have extended beyond the prostatic capsule is unlikely to be cured by radical surgical excision, although the primary tumor may be controlled by external irradiation. The development of progressive (metastatic) disease is common and may be retarded by hormonal therapy. The timing of such treat...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/1097-0142(19930201)71:3+<1074::aid-cncr282

    authors: Smith PH

    更新日期:1993-02-01 00:00:00

  • Lymphoma of the spinal extradural space.

    abstract::Ninety-four patients with lymphoma involving the extradural space with spinal cord compression proven at the time of laminectomy were reviewed. There were about three times as many patients with non-Hodgkin's lymphoma than with Hodgkin's disease. The majority of those with Hodgkin's disease had a proven histologic dia...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197610)38:4<1862::aid-cncr282038

    authors: Haddad P,Thaell JF,Kiely JM,Harrison EG,Miller RH

    更新日期:1976-10-01 00:00:00

  • Preparation of murine B7.1-glycosylphosphatidylinositol and transmembrane-anchored staphylococcal enterotoxin. A dual-anchored tumor cell vaccine and its antitumor effect.

    abstract:BACKGROUND:The authors have previously reported a tumor cell vaccine modified with superantigen staphylococcal enterotoxin A (SEA) and its antitumor effect. The tumor cell vaccines modified with multiple immune activators frequently elicited stronger immune responses against established tumors than single-modified vacc...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.20943

    authors: Yi P,Yu H,Ma W,Wang Q,Minev BR

    更新日期:2005-04-01 00:00:00

  • High-dose etoposide and marrow transplantation.

    abstract::Etoposide underwent conventional Phase I testing in the 1970s. The dose-limiting toxicity in these studies was mild myelosuppression; other toxicities were infrequent. If a greater degree of myelosuppression is accepted, higher than standard doses could be given. This approach takes advantage of the steep dose-respons...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/1097-0142(19910101)67:1+<292::aid-cncr2820

    authors: Herzig RH

    更新日期:1991-01-01 00:00:00

  • Fas (CD95/APO-1) and Fas ligand expression in normal pancreas and pancreatic tumors. Implications for immune privilege and immune escape.

    abstract:BACKGROUND:Fas (CD95/APO-1) and Fas ligand (FasL) play key roles in immunologic homeostasis and immune privilege and may regulate normal cell turnover. Earlier studies had suggested that FasL-positive pancreatic carcinoma cell lines can induce apoptosis in T cells, thereby evading host immune surveillance. In the curre...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.10549

    authors: Bernstorff WV,Glickman JN,Odze RD,Farraye FA,Joo HG,Goedegebuure PS,Eberlein TJ

    更新日期:2002-05-15 00:00:00

  • Correlation of cell-cycle kinetics, hormone receptors, histopathology, and nodal status in human breast cancer.

    abstract::DNA ploidy and percent of (%S-phase) S-phase cells were determined from the DNA content distribution of 21 benign and 76 malignant (69 primary, 7 metastatic) breast tumors using flow cytometry. All of the benign tumors were diploid, whereas 89% of the malignant tumors had measurable aneuploidy. Multiple stem-lines wer...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19841015)54:8<1586::aid-cncr2820

    authors: Moran RE,Black MM,Alpert L,Straus MJ

    更新日期:1984-10-15 00:00:00

  • Hematogenous metastases to the stomach. A review of 67 cases.

    abstract::Metastatic tumors to the mucosa of the stomach are unusual occurrences that can cause clinical and pathologic problems in diagnosis. The authors report 67 cases from the files of the Veterans Administration Center at Houston. Ten cases were found on endoscopic biopsy and 57 at necropsy. Each patient endoscopically eva...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19900401)65:7<1596::aid-cncr2820

    authors: Green LK

    更新日期:1990-04-01 00:00:00

  • Kaposi's sarcoma in immunosuppression. Possibly the result of a dual viral infection.

    abstract::Kaposi's sarcoma of the gingiva and skin developed in an HIV-negative renal transplant patient while he was receiving cyclosporine therapy. The Kaposi's sarcoma developed shortly after the patient had an acute infection with cytomegalovirus (CMV). Electron microscopy of the tumor's established cell line showed two typ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19900201)65:3<492::aid-cncr28206

    authors: Siegal B,Levinton-Kriss S,Schiffer A,Sayar J,Engelberg I,Vonsover A,Ramon Y,Rubinstein E

    更新日期:1990-02-01 00:00:00

  • Intratumoral hemorrhage among children with newly diagnosed, diffuse brainstem glioma.

    abstract:BACKGROUND:Children with diffuse brainstem glioma (BSG) commonly undergo novel therapies because their outcome is poor with radiation therapy (RT). Although recent clinical trials using new biologic agents documented intratumoral hemorrhage (IH) among several children with BSG, to the authors' knowledge little is known...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.21749

    authors: Broniscer A,Laningham FH,Kocak M,Krasin MJ,Fouladi M,Merchant TE,Kun LE,Boyett JM,Gajjar A

    更新日期:2006-03-15 00:00:00

  • COMB (cyclophosphamide, oncovin, methyl-CCNU, and bleomycin): a four-drug combination in solid tumors.

    abstract::One hundred eighty-nine patients received a four-drug combination consisting of cyclophosphamide, Oncovin (vincristine), methyl CCNU, and bleomycin (COMB), according to three different drug regimens, performed sequentially. Of the 189, 62 had a partial response (33%) including 11/33 with squamous lung cancer, 11/32 wi...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197508)36:2<327::aid-cncr2820360

    authors: Livingston RB,Einhorn LH,Bodey GP,Burgess MA,Freireich EJ,Gottlieb JA

    更新日期:1975-08-01 00:00:00

  • Incidence of multiple myeloma in Olmsted County, Minnesota: Trend over 6 decades.

    abstract:BACKGROUND:Previous studies have indicated that the incidence and mortality rates for multiple myeloma have increased in the United States. The authors reported on the incidence of multiple myeloma in Olmsted County, Minnesota, between 1991 and 2001 and on trends in multiple myeloma incidence over the last 56 years. M...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.20652

    authors: Kyle RA,Therneau TM,Rajkumar SV,Larson DR,Plevak MF,Melton LJ 3rd

    更新日期:2004-12-01 00:00:00

  • Flexible fiberoptic bronchoscopy in metastatic cancer to the lungs.

    abstract::Seventy-eight patients with metastatic cancer to the lungs underwent flexible fiberoptic bronchoscopy for diagnosis. The patients were divided into two groups by presenting radiographic pattern as: (I) diffuse linear interstitial infiltrations (55 patients); and (II) localized or multiple nodular opacities (23 patient...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19831115)52:10<1949::aid-cncr282

    authors: Chuang MT,Padilla ML,Teirstein AS

    更新日期:1983-11-15 00:00:00

  • Chemoimmunotherapy of metastatic large bowel cancer: nonspecific stimulation with BCG and levamisole.

    abstract::The administration of two chemoimmunotherapy programs to 103 consecutive patients with metastatic colorectal cancer resulted in improved survival for patients who achieved either objective tumor regressions or disease stabilization for more than 8 weeks. Objective tumor regression was observed in 47% of patients treat...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197711)40:5+<2731::aid-cncr28204

    authors: Valdivieso M,Bedikian A,Burgess MA,Rodriguez V,Hersh EM,Bodey GP,Mavligit GM

    更新日期:1977-11-01 00:00:00

  • Clinical stage II non-small cell lung cancer treated with radiation therapy alone. The significance of clinically staged ipsilateral hilar adenopathy (N1 disease).

    abstract:BACKGROUND:The prognosis of patients with clinically staged hilar nodal involvement (Stage N1) or clinical Stage II non-small cell lung cancer (NSCLC, Stage T1-2N1M0) treated with radiation therapy (RT) alone is not well established. METHODS:Records of 758 patients with clinical Stage I-III NSCLC treated with RT were ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19921115)70:10<2410::aid-cncr282

    authors: Rosenthal SA,Curran WJ Jr,Herbert SH,Hughes EN,Sandler HM,Stafford PM,McKenna WG

    更新日期:1992-11-15 00:00:00

  • Intrahepatic infusional therapy for metastatic ovarian carcinoma.

    abstract::Twenty-four women with ovarian carcinoma that had metastasized to the liver were treated with intrahepatic infusional therapy. No consistent drug regimen was used. There were no complete responders; however, 33% had a partial response. All responses were noticed after the first course of therapy. The median length of ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19870601)59:11<1866::aid-cncr282

    authors: Malone JM Jr,Gershenson DM,Carrasco CH,Charansangavej C,Copeland LJ,Larson DM,Kavanagh JJ,Edwards CL,Wallace S

    更新日期:1987-06-01 00:00:00

  • Myeloma of the head of the pancreas. A case report.

    abstract::A 45-year-old man was diagnosed with multiple myeloma, IgA-kappa, in 1975. Thirteen years later he presented with obstructive jaundice. Computed tomography (CT) showed a 6-cm mass in the head of the pancreas. Needle aspiration showed myeloma. The jaundice resolved after treatment with radiotherapy. Extraosseous involv...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19910201)67:3<681::aid-cncr28206

    authors: Fischer A,Suhrland MJ,Vogl SE

    更新日期:1991-02-01 00:00:00

  • Primary leptomeningeal B-cell lymphoma in a 8-year-old child.

    abstract::A case of primary leptomeningeal B-cell lymphoma in an 8-year-old, previously healthy child is described. The child was found to have hypogammaglobulinemia, and the Epstein-Barr virus genome was identified in cultured tumor cells despite blood serology being negative for the virus. The patient was treated with cycloph...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19901015)66:8<1856::aid-cncr2820

    authors: Hayani A,Venger BH,Rouah E,Laurent JP,Mahoney DH,McClain KL

    更新日期:1990-10-15 00:00:00

  • Cystic adrenal neoplasms.

    abstract:BACKGROUND:Cystic lesions of the adrenal gland are uncommon and demonstrate a spectrum of histologic changes and may vary from pseudocysts to malignant cystic neoplasms. METHODS:The authors analyzed a series of primary cystic lesions of the adrenal gland to evaluate the clinicopathologic features and histologic spectr...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.20555

    authors: Erickson LA,Lloyd RV,Hartman R,Thompson G

    更新日期:2004-10-01 00:00:00

  • Adjuvant therapy in prostatic cancer.

    abstract:BACKGROUND:Prostatic cancer is an unusual malignancy because, commonly, it is slowly progressive and occurs at an age where the patient's life expectancy is short as a result of considerable competing mortality rates from other diseases. In addition, the place of radical surgery, i.e., radical prostatectomy is still no...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19930201)71:3+<992::aid-cncr2820

    authors: Smith PH,Parmar MK

    更新日期:1993-02-01 00:00:00

  • Tn, a carcinoma-associated antigen, reacts with anti-Tn of normal human sera.

    abstract::Tn antigen is the immediate precursor of the carcinoma (CA)-associated T antigen; both are masked in non-CA tissues. Tn antigen was detected by absorption of human anti-Tn antibody in 46 of 50 primary breast CAs and in all 6 metastases originating from Tn-positive primary CAs. Thirteen of 25 (52%) anaplastic CAs, but ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19850201)55:3<561::aid-cncr28205

    authors: Springer GF,Taylor CR,Howard DR,Tegtmeyer H,Desai PR,Murthy SM,Felder B,Scanlon EF

    更新日期:1985-02-01 00:00:00

  • Getting key players to work together and defending against diversion--California.

    abstract::In 1988, Californians passed Proposition 99, which raised the tobacco tax from 10 cents to 35 cents and allocated 20% of the resulting revenues, approximately $100 million, for tobacco education and 5% for tobacco-related research. Seventy percent was allocated for health care costs and 5% for the environment. In this...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0142(19981215)83:12a+<2697::aid

    authors: Martin CB,Beerline D,Breslow L

    更新日期:1998-12-15 00:00:00