Abstract:
BACKGROUND:The authors originally demonstrated the tissue-specific expression of the rab3A gene in the mouse brain. In the current study, they analyze the activity of this gene in fresh human tumors associated with neuronal phenotype compared with normal and malignant cells from other origins. METHODS:The authors studied the transcription levels of the rab3A gene by Northern blot in 81 fresh tumors. RESULTS:A high rab3A gene expression was observed in tumor samples derived from the neural tube (i.e., neuroblastomas, ganglioneuroblastomas, and adult nervous system neoplasms). In addition, this tissue-specific expression extended to neuroendocrine tumors of the gut, small cell lung cancers, and pheochromocytomas. CONCLUSIONS:These results suggest a specific restriction pattern to human cells derived from the neural tube and neural crests. The GTP/GDP-binding rab3A protein may be a useful differentiation marker of neuro-endocrine cells in the characterization of undifferentiated neoplasms.
journal_name
Cancerjournal_title
Cancerauthors
Culine S,Rousseau-Merck MF,Honoré N,Nezelof C,Olofsson Bdoi
10.1002/1097-0142(19921115)70:10<2552::aid-cncr282subject
Has Abstractpub_date
1992-11-15 00:00:00pages
2552-6issue
10eissn
0008-543Xissn
1097-0142journal_volume
70pub_type
杂志文章相关文献
CANCER文献大全abstract:BACKGROUND:Apricoxib, a novel once-daily selective cyclooxygenase-2 inhibitor, was investigated in combination with erlotinib for recurrent stage IIIB/IV nonsmall cell lung cancer to determine the maximum tolerated dose, dose-limiting toxicity, and recommended phase II dose (RP2D) based on changes in urinary prostaglan...
journal_title:Cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/cncr.25473
更新日期:2011-02-15 00:00:00
abstract::Adenoid cystic carcinoma (ACC) of the breast is a rare histologic type of breast cancer associated with a good prognosis. A woman who earlier had a pulmonary metastasis surgically resected 6 years postmastectomy developed clinically symptomatic bleeding from a renal metastasis 12 years postmastectomy. An atypical angi...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19910901)68:5<1015::aid-cncr2820
更新日期:1991-09-01 00:00:00
abstract:BACKGROUND:Treatment with traditional cytotoxic chemotherapy regimens containing streptozocin or dacarbazine has resulted in only marginal benefit for patients with metastatic neuroendocrine tumors. The use of these regimens has been further limited by their potential toxicity. Gemcitabine is generally well tolerated a...
journal_title:Cancer
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1002/cncr.20466
更新日期:2004-09-01 00:00:00
abstract:BACKGROUND:The FHIT gene, located at human chromosome 3p14.2, frequently is deleted in a number of human tumors, including breast carcinoma. Its protein product (Fhit) is presumed to have tumor suppressor function. Loss of expression of a tumor suppressor gene is an important step in tumor progression from premalignant...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:2000-03-15 00:00:00
abstract:BACKGROUND:Carcinomas of the small intestine are rare, but the risk is greatly increased in patients with hereditary nonpolyposis colorectal cancer (HNPCC) due to an inherited mismatch repair (MMR) gene mutation, most commonly affecting the genes MLH1 or MSH2. Defective MMR is characterized by microsatellite instabilit...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.11197
更新日期:2003-03-15 00:00:00
abstract:BACKGROUND:Screening over many years is required to optimize reductions in colorectal cancer (CRC) mortality. However, no prior trials have compared strategies for obtaining long-term adherence. METHODS:Systems of Support to Increase Colorectal Cancer Screening and Follow-Up was implemented in an integrated health car...
journal_title:Cancer
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1002/cncr.30908
更新日期:2017-11-15 00:00:00
abstract:BACKGROUND:Parathyroid hormone-related peptide (PTHrP) is a tumor-derived circulating factor that has been associated with hypercalcemia of malignancy. The role of PTHrP as a prognostic indicator remains unclear. Studies suggest that it may function as a growth factor; and, recently, the ability of PTHrP to induce cyto...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.20972
更新日期:2005-05-01 00:00:00
abstract::In a pathologic review of 1224 cases of endometrial carcinoma, 1023 were confirmed cases of endometrial carcinoma. Fifty-six (5.5%) were clear-cell adenocarcinoma (CCE). Fifteen cases of "secretory carcinoma" (SCE) were examined for comparison. Fifty-five patients with CCE and all with SCE were followed for at least f...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19820415)49:8<1511::aid-cncr2820
更新日期:1982-04-15 00:00:00
abstract:BACKGROUND:Conditional survival is clinically useful, particularly for patients with malignant disease who have a poor prognosis. However, there are no published data on the conditional median survival of patients with advanced carcinoma on a population basis. METHODS:Data on 217,573 patients with breast, colorectal, ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(20011015)92:8<2211::aid-cncr1565
更新日期:2001-10-15 00:00:00
abstract:BACKGROUND:The causal relation between high-risk human papillomavirus (HPV) and cervical cancer and its precursor lesions has led to the use of sensitive HPV molecular tests for screening. This study examined the impact of the baseline HPV status on the future risk of cervical intraepithelial neoplasia grade 2 or worse...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.31788
更新日期:2019-01-15 00:00:00
abstract:BACKGROUND:Brain metastases from esophageal carcinoma are extremely rare, and information regarding the natural history, results of treatment, and possible prognostic factors in these patients is limited. METHODS:The records of 36 patients with brain metastases from esophageal carcinoma who were treated between 1986 a...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.10271
更新日期:2002-02-01 00:00:00
abstract::Recent studies have indicated that the nuclear DNA content of certain malignant neoplasms can be used as an adjunct in predicting their biologic behavior. The DNA content of 99 ovarian carcinomas was determined by flow cytometric analysis of nuclei obtained from paraffin-embedded tissue. Of the 99 tumors, 51 were dipl...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19900101)65:1<141::aid-cncr28206
更新日期:1990-01-01 00:00:00
abstract::The authors studied 11 pediatric intrathoracic neoplasms that share clinicopathologic features and constitute a specific tumor in children. These neoplasms were intrapulmonary, mediastinal, or pleural-based masses. A common histologic feature was the presence of small, primitive cells with blastematous qualities separ...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(19881015)62:8<1516::aid-cncr2820
更新日期:1988-10-15 00:00:00
abstract::Five patients with angiosarcoma of the breast were treated with surgery, radiotherapy and an adjuvant Adriamycin containing regimen. Two patients remain disease-free at 38+ and 20+ months. The median survival of previously reported cases is 22 months with only five patients disease-free at five years. Possible hormona...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19821115)50:10<2000::aid-cncr282
更新日期:1982-11-15 00:00:00
abstract::Acute nonlymphocytic leukemia (ANLL) developed in four patients 66 to 157 months following the diagnosis of nodular poorly differentiated lymphocytic lymphoma (PDL-N). The ANLL was signalled by increasing anemia and thrombocytopenia. A characteristic cytologic pattern of the leukemia was found. In each patient, a panm...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197710)40:4<1748::aid-cncr282040
更新日期:1977-10-01 00:00:00
abstract:BACKGROUND:Age-related disparities in colon cancer treatment exist, with older patients being less likely to receive recommended therapy. However, to the authors' knowledge, few studies to date have focused on receipt of surgery. The objective of the current study was to describe patterns of surgery in patients aged ≥ ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.27765
更新日期:2013-02-01 00:00:00
abstract:BACKGROUND:DNA flow cytometry of hepatocellular carcinoma (HCC) cells has been investigated in many studies, but, to the best of our knowledge, there are no data on DNA analysis of cirrhotic parenchyma around the HCC. In this study, cell kinetics and ploidy of parenchymal cells around HCC were performed to ascertain if...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0142(19960915)78:6<1195::AID-CN
更新日期:1996-09-15 00:00:00
abstract:BACKGROUND:Pediatric renal cell carcinoma (RCC) is clinically distinct from adult RCC. Characterization of the unique biological and clinical features of pediatric RCC are required. METHODS:A retrospective review and biological analysis of all RCC cases presenting to Cincinnati Children's Hospital Medical Center (CCHM...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.23331
更新日期:2008-04-01 00:00:00
abstract:BACKGROUND:There is limited published evidence regarding the efficacy of total skin electron beam radiation for patients with the diffuse erythrodermic form of mycosis fungoides. METHODS:Forty-five patients with erythrodermic mycosis fungoides were managed at McMaster University in Hamilton, Ontario, Canada (n=34), an...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/(sici)1097-0142(19990501)85:9<1985::aid-cn
更新日期:1999-05-01 00:00:00
abstract:BACKGROUND:The increasing incidence of human papillomavirus (HPV)-related head and neck squamous cell carcinoma (HNSCC) highlights the need for simple and effective tools to evaluate head and neck lesions and their HPV status. The main objective of the current study was to investigate the association between abnormal c...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.28909
更新日期:2014-11-15 00:00:00
abstract::The cytologic results of 34 fine-needle aspiration (FNA) biopsies of the central nervous system (CNS) are reported. There were 31 intraoperative biopsies performed at the time of craniotomy. All the cases were diagnosed using direct smear preparations stained with Papanicolaou and Diff-Quik (Harleco, NJ) stains. The s...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19860901)58:5<1117::aid-cncr2820
更新日期:1986-09-01 00:00:00
abstract:BACKGROUND:Multimodality treatment has dramatically improved the outcome of patients with Ewing sarcoma. However, there appears to be little information concerning treatment-related complications in patients who are long-term survivors. METHODS:Forty-one patients with Ewing sarcoma who were treated between 1960-1980 a...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.11891
更新日期:2003-12-15 00:00:00
abstract:BACKGROUND:The combination of paclitaxel with cisplatin or carboplatin has become the preferred chemotherapy regimen in the treatment of epithelial ovarian carcinoma. Anthracyclines also have activity in this disease. We conducted a Phase II study by using the combination of paclitaxel, cisplatin, and epirubicin for th...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/1097-0142(20001001)89:7<1547::aid-cncr19>3
更新日期:2000-10-01 00:00:00
abstract::The myeloproliferative neoplasms (MPNs) essential thrombocythemia (ET), polycythemia vera (PV), and primary myelofibrosis (MF) are malignancies that frequently harbor the recurrent somatic point mutation JAK2(V617F). The discovery of this mutation has fueled the development of Janus kinase 2 (JAK2) inhibitors. Availab...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.26359
更新日期:2012-02-15 00:00:00
abstract:BACKGROUND:The authors compared the survival outcomes of radiotherapy+/-salvage surgery to surgery+/-postoperative radiotherapy for patients with squamous cell cancer of the hypopharynx. There was no evidence beyond observational studies and no consensus on the which treatment is most effective for this patient group. ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.24635
更新日期:2009-12-15 00:00:00
abstract:BACKGROUND:The p53 tumor suppressor gene encodes a nuclear phosphoprotein that is thought to be important to cell cycle regulation and DNA repair and that also may regulate induction of apoptosis by ionizing radiation. Somatic p53 gene mutations occur in 30-50% of breast carcinomas and are associated with poor prognosi...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:2000-03-01 00:00:00
abstract:BACKGROUND:A high prevalence of thrombocytosis in malignant mesothelioma has been reported, although its pathogenesis remains unknown. METHODS:The case of a patient with marked thrombocytosis in peritoneal malignant mesothelioma is reported. To investigate the cytokines responsible for thrombocytosis in this patient, ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19921015)70:8<2105::aid-cncr2820
更新日期:1992-10-15 00:00:00
abstract::Over a 7 year period, 85 cancer patients were managed by the nutrition service of St. Joseph's Hospital, Toronto. All these patients were nutritionally depleted, had obstruction to the gastrointestinal tract, or had postoperative complications such as enterocutaneous fistulas, evisceration or intraabdominal sepsis, wh...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197806)41:6<2359::aid-cncr282041
更新日期:1978-06-01 00:00:00
abstract:BACKGROUND:Gastric carcinoma is one of the most common malignancies worldwide, with an overall survival of about 10%. Improvement in therapy awaits better understanding of the biologic behavior of this tumor. Establishment of cell lines permits detailed analysis of the biology of gastric cancer. The authors report on t...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19930801)72:3<649::aid-cncr28207
更新日期:1993-08-01 00:00:00
abstract::Two cases of occult seminoma were observed which showed left-sided lymph node metastases without clinically demonstrable testicular tumors. The peculiar histology of the lymph node metastases, namely PAS-positive tumor cells with clear cytoplasm together with a granulomatous stromal reaction, was highly suggestive of ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197907)44:1<245::aid-cncr2820440
更新日期:1979-07-01 00:00:00